Target Description

Type Detail
Target ID T40NB1
Protein Name Ribosomal protein S6 kinase beta-1
Uniprot ID P23443
Protein Name Alias S6K-beta-1;  S6K1;  EC 2.7.11.1;  70 kDa ribosomal protein S6 kinase 1;  P70S6K1;  p70-S6K 1;  Ribosomal protein S6 kinase I;  Serine/threonine-protein kinase 14A;  p70 ribosomal S6 kinase alpha;  p70 S6 kinase alpha;  p70 S6K-alpha;  p70 S6KA
Gene ID 6198
Gene Symbol RPS6KB1
Gene Alias STK14A
TTD T94479: Clinical Trial target
Pfam PF00433 ; PF00069
GO
0005741:mitochondrial outer membrane

0033574:response to testosterone

0014732:skeletal muscle atrophy

0005634:nucleus

0043201:response to leucine

0003009:skeletal muscle contraction

0045202:synapse

0001662:behavioral fear response

0009636:response to toxic substance

0071549:cellular response to dexamethasone stimulus

0106311:protein threonine kinase activity

0005829:cytosol

0009986:cell surface

0048015:phosphatidylinositol-mediated signaling

0048661:positive regulation of smooth muscle cell proliferation

0034612:response to tumor necrosis factor

0014911:positive regulation of smooth muscle cell migration

0042277:peptide binding

0007616:long-term memory

2001237:negative regulation of extrinsic apoptotic signaling pathway

0004672:protein kinase activity

0014878:response to electrical stimulus involved in regulation of muscle adaptation

0048633:positive regulation of skeletal muscle tissue growth

0009611:response to wounding

0004712:protein serine/threonine/tyrosine kinase activity

0043066:negative regulation of apoptotic process

0032496:response to lipopolysaccharide

0045948:positive regulation of translational initiation

0042802:identical protein binding

0005654:nucleoplasm

0007281:germ cell development

0106310:protein serine kinase activity

0033762:response to glucagon

0030165:PDZ domain binding

0007165:signal transduction

0031667:response to nutrient levels

0071346:cellular response to interferon-gamma

0005524:ATP binding

0006915:apoptotic process

0046627:negative regulation of insulin receptor signaling pathway

0004674:protein serine/threonine kinase activity

0045471:response to ethanol

0009612:response to mechanical stimulus

0016477:cell migration

0000082:G1/S transition of mitotic cell cycle

0018105:peptidyl-serine phosphorylation

0009749:response to glucose

0046324:regulation of glucose import

0071363:cellular response to growth factor stimulus

0042493:response to drug

0044539:long-chain fatty acid import into cell

0032869:cellular response to insulin stimulus

0007568:aging

0045931:positive regulation of mitotic cell cycle

0043491:protein kinase B signaling

0007584:response to nutrient

0009408:response to heat

0043005:neuron projection

0005737:cytoplasm

0031929:TOR signaling

0048471:perinuclear region of cytoplasm

0004711:ribosomal protein S6 kinase activity

0045727:positive regulation of translation

0051721:protein phosphatase 2A binding

0005739:mitochondrion

PDB 3A60 ; 4L44 ; 5WBK ; 3A62 ; 3A61 ; 4RLP ; 5WBH ; 4L3J ; 3WF9 ; 3WF7 ; 4L3L ; 3WF8 ; 4RLO ; 4L46 ; 4L45 ; 4L43 ; 3WE4 ; 4L42 ; 3WF6 ; 3WF5
Drugbank NA
KEGG hsa:6198

Related Compounds  (Total: 8)

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C0004
Name: Delphinidin
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C0216
Name: Methyl Rosmarinate
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C0363
Name: Resveratrol
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C0374
Name: Rosmarinic Acid
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C0660
Name: Neferine


Related Herbs  (Total: 58)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0612 Cao Shan Hu Jin Gao草珊瑚浸膏 NASarcandra glabra
H1186 Hong Gen Cao红根草 Hispid sageSalvia prionitis
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0416 Shan Shen山参 NAPanax ginseng
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0965 Deng Zhan Xi Xin灯盏细辛 Shortscape fleabaneErigeron breviscapus
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0632 Xia Ku Cao夏枯草 Common selfhealPrunella vulgaris
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0673 Xin Jiang Zi Cao新疆紫草 Arnebia rootArnebia euchroma
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0670 Chai Pi Zhang豺皮樟 Oblong-leaved litseaLitsea rotundifolia
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0496 Shui Ze Lan水泽兰 NALycopus lucidus
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0002 Hui Xiang茴香 Fennel fruitFoeniculum vulgare
H0938 Da Suan大蒜 GarlicAllium sativum
H0522 Tai Zi Shen太子参 Heterophylly falsestarwort rootRadix pseudostellariae
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0060 Jin Si Ku Lian金丝苦楝 NACardiospermum halicacabum
H0074 Jing Jie Tan荆芥炭 NASchizonepetae herba
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0614 Wu Zhao Long五爪龙 Cairo morninggloryIpomoea cairica
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0357 Ren Shen人参 GinsengPanax ginseng
H0083 Jiu Jie Cha九节茶 Glabrous sarcandraSarcandra glabra
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum