Compound Description

ID:   C0100 Common name:   Gefitinib
IUPAC:  N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine CAS:  NA
Chembl ID:   CHEMBL939 Pubchem ID:   CID:123631
Formula:  C22H24ClFN4O3 TCM-ID:  TCMC1235
Smiles:  COc1cc2ncnc(c2cc1OCCCN1CCOCC1)Nc1ccc(c(c1)Cl)F
Alias:

NA
Structure:

Related Targets  (Total: 27)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T43N2D Epidermal growth factor receptorEGFR P00533
A 20 Reference(s)
T97FEF Broad substrate specificity ATP-binding cassette transporter ABCG2ABCG2 Q9UNQ0
A 3 Reference(s)
T52CKD Pro-epidermal growth factorEGF P01133
A 4 Reference(s)
T56A9T Tyrosine-protein kinase TXKTXK P42681
A 3 Reference(s)
T02AK2 Receptor-interacting serine/threonine-protein kinase 2RIPK2 O43353
A 4 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
A 1 Reference(s)
T89Z7O NAFCGR1CP NA
A 1 Reference(s)
T14JZK Receptor tyrosine-protein kinase erbB-3ERBB3 P21860
A 1 Reference(s)
T84FSA Forkhead box protein O3FOXO3 O43524
A 1 Reference(s)
T38O11 Cyclin-G-associated kinaseGAK O14976
B 2 Reference(s)
T83P5X Inhibitor of nuclear factor kappa-B kinase subunit betaIKBKB O14920
B 1 Reference(s)
T84C2C Protein Tob1TOB1 P50616
B 1 Reference(s)
T08OIA Microtubule-associated proteins 1A/1B light chain 3AMAP1LC3A Q9H492
C 2 Reference(s)
T04WT7 FibronectinFN1 P02751
C 1 Reference(s)
T81I4T 5'-AMP-activated protein kinase catalytic subunit alpha-1PRKAA1 Q13131
C 1 Reference(s)
T92BZ2 Catenin beta-1CTNNB1 P35222
C 1 Reference(s)
T46K2X Heat shock 70 kDa protein 4HSPA4 P34932
C 1 Reference(s)
T51DHZ Protein C-ets-1ETS1 P14921
C 1 Reference(s)
T34N64 NAMIR29B1 NA
C 1 Reference(s)
T72TF8 Methylcytosine dioxygenase TET1TET1 Q8NFU7
C 1 Reference(s)
T68O49 Prostaglandin E2 receptor EP4 subtypePTGER4 P35408
C 1 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
C 1 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
C 1 Reference(s)
T96OOK Signal transducer and activator of transcription 3STAT3 P40763
C 1 Reference(s)
T32PI2 Programmed cell death 1 ligand 1CD274 Q9NZQ7
C 1 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
C 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 1)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0629 Xi Xin细辛 Siebold wildgingerAsarum sieboldii