HIT-result

Type	Detail
Target ID	T02AK2
Protein Name	Receptor-interacting serine/threonine-protein kinase 2
Uniprot ID	O43353
Protein Name Alias	EC 2.7.11.1; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD-containing IL-1 beta ICE-kinase; RIP-like-interacting CLARP kinase; Receptor-interacting protein 2; RIP-2; Tyrosine-protein kinase RIPK2; EC 2.7.10.2
Gene ID	8767
Gene Symbol	RIPK2
Gene Alias	CARDIAK; RICK; RIP2
TTD	T92463: Clinical Trial target
Pfam	PF00619 ; PF07714
GO	0042802:identical protein binding 0034142:toll-like receptor 4 signaling pathway 0004672:protein kinase activity 0070498:interleukin-1-mediated signaling pathway 0106310:protein serine kinase activity 0005829:cytosol 0004674:protein serine/threonine kinase activity 0002250:adaptive immune response 0106311:protein threonine kinase activity 0042098:T cell proliferation 0006915:apoptotic process 0032755:positive regulation of interleukin-6 production 0097202:activation of cysteine-type endopeptidase activity 0000187:activation of MAPK activity 0010942:positive regulation of cell death 0032727:positive regulation of interferon-alpha production 0032735:positive regulation of interleukin-12 production 0070431:nucleotide-binding oligomerization domain containing 2 signaling pathway 0046330:positive regulation of JNK cascade 0051092:positive regulation of NF-kappaB transcription factor activity 0071224:cellular response to peptidoglycan 0032729:positive regulation of interferon-gamma production 0002827:positive regulation of T-helper 1 type immune response 0050852:T cell receptor signaling pathway 0032722:positive regulation of chemokine production 0070673:response to interleukin-18 0005524:ATP binding 0004706:JUN kinase kinase kinase activity 0071225:cellular response to muramyl dipeptide 0050731:positive regulation of peptidyl-tyrosine phosphorylation 0046641:positive regulation of alpha-beta T cell proliferation 0032092:positive regulation of protein binding 0031398:positive regulation of protein ubiquitination 0031982:vesicle 0050700:CARD domain binding 0005856:cytoskeleton 0007257:activation of JUN kinase activity 0007254:JNK cascade 0032743:positive regulation of interleukin-2 production 0070374:positive regulation of ERK1 and ERK2 cascade 0032728:positive regulation of interferon-beta production 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0004715:non-membrane spanning protein tyrosine kinase activity 0006954:inflammatory response 0070423:nucleotide-binding oligomerization domain containing signaling pathway 0032991:protein-containing complex 0001961:positive regulation of cytokine-mediated signaling pathway 0033091:positive regulation of immature T cell proliferation 0045627:positive regulation of T-helper 1 cell differentiation 0043065:positive regulation of apoptotic process 0032731:positive regulation of interleukin-1 beta production 1904417:positive regulation of xenophagy 0070427:nucleotide-binding oligomerization domain containing 1 signaling pathway 0043330:response to exogenous dsRNA 0005102:signaling receptor binding 0032760:positive regulation of tumor necrosis factor production 0004714:transmembrane receptor protein tyrosine kinase activity 0042803:protein homodimerization activity 0005737:cytoplasm 0050830:defense response to Gram-positive bacterium 0010800:positive regulation of peptidyl-threonine phosphorylation 0007165:signal transduction 0071223:cellular response to lipoteichoic acid 0033138:positive regulation of peptidyl-serine phosphorylation 0034134:toll-like receptor 2 signaling pathway 0031663:lipopolysaccharide-mediated signaling pathway 0089720:caspase binding 0070671:response to interleukin-12 0045944:positive regulation of transcription by RNA polymerase II 0007249:I-kappaB kinase/NF-kappaB signaling 0043066:negative regulation of apoptotic process 0030274:LIM domain binding 0045087:innate immune response
PDB	6ES0 ; 6FU5 ; 6HMX ; 5W5O ; 5J79 ; 5NG3 ; 5YRN ; 5J7B ; 6RNA ; 2N7Z ; 6RN8 ; 6GFJ ; 5W5J ; 5AR5 ; 5AR8 ; 6UL8 ; 5AR2 ; 6GGS ; 5AR3 ; 6S1F ; 5AR4 ; 5NG0 ; 5AR7 ; 4C8B ; 6SZE ; 6SZJ ; 2N83 ; 5NG2
Drugbank	DB12010
KEGG	hsa:8767

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Name: Gefitinib

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0629	Xi Xin	细辛	Siebold wildginger	Asarum sieboldii