Herb Description
| Herb ID: H0629 | Chinese Character: 细辛 |
| English Name: Siebold wildginger | Latin Name: Asarum sieboldii |
| Chinese Pin Yin : Xi Xin | TCM-ID: TCMH2239 |
| Therapeutic Function in Chinese : 解表 | Therapeutic Function in English: For relieving exterior syndrome |
| Herb Function: Dispel wind-cold, relieve nasal obstruction, alleviate pain and remove retained fluid | |
Related Targets (Total: 132)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T11GYO | Peroxisomal acyl-coenzyme A oxidase 1 | ACOX1 |
Q15067 |
1 Reference(s) |
| T08UWG | NADPH oxidase 3 | NOX3 |
Q9HBY0 |
1 Reference(s) |
| T87UKX | Glucose-6-phosphate 1-dehydrogenase | G6PD |
P11413 |
1 Reference(s) |
| T92UBJ | Acetyl-CoA carboxylase 1 | ACACA |
Q13085 |
1 Reference(s) |
| T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
2 Reference(s) |
| T25M2J | Anoctamin-1 | ANO1 |
Q5XXA6 |
1 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
2 Reference(s) |
| T09INZ | Transient receptor potential cation channel subfamily A member 1 | TRPA1 |
O75762 |
3 Reference(s) |
| T60XJI | Transient receptor potential cation channel subfamily M member 8 | TRPM8 |
Q7Z2W7 |
3 Reference(s) |
| T67KTV | Transient receptor potential cation channel subfamily V member 1 | TRPV1 |
Q8NER1 |
1 Reference(s) |
| T70KPE | Transient receptor potential cation channel subfamily V member 3 | TRPV3 |
Q8NET8 |
7 Reference(s) |
| T48J2C | Transient receptor potential cation channel subfamily M member 7 | TRPM7 |
Q96QT4 |
3 Reference(s) |
| T70LAB | UDP-glucuronosyltransferase 1A9 | UGT1A9 |
O60656 |
2 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
1 Reference(s) |
| T40LTN | Phospholipase A2, membrane associated | PLA2G2A |
P14555 |
1 Reference(s) |
| T30TYH | Phospholipase A2 | PLA2G1B |
P04054 |
9 Reference(s) |
| T64T6J | Beta-1 adrenergic receptor | ADRB1 |
P08588 |
17 Reference(s) |
| T92UWJ | Beta-2 adrenergic receptor | ADRB2 |
P07550 |
2 Reference(s) |
| T88QEV | Transient receptor potential cation channel subfamily M member 3 | TRPM3 |
Q9HCF6 |
2 Reference(s) |
| T91K6V | Voltage-dependent L-type calcium channel subunit alpha-1S | CACNA1S |
Q13698 |
1 Reference(s) |
| T38L2B | Voltage-dependent T-type calcium channel subunit alpha-1I | CACNA1I |
Q9P0X4 |
1 Reference(s) |
| T34DZ7 | Interleukin-2 | IL2 |
P60568 |
1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
4 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
3 Reference(s) |
| T38N69 | Lymphokine-activated killer T-cell-originated protein kinase | PBK |
Q96KB5 |
1 Reference(s) |
| T09BRP | NA | PKB_RS07820 |
NA |
1 Reference(s) |
| T83P5X | Inhibitor of nuclear factor kappa-B kinase subunit beta | IKBKB |
O14920 |
2 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
3 Reference(s) |
| T74LFK | Neurogenic locus notch homolog protein 1 | NOTCH1 |
P46531 |
1 Reference(s) |
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
20 Reference(s) |
| T97FEF | Broad substrate specificity ATP-binding cassette transporter ABCG2 | ABCG2 |
Q9UNQ0 |
3 Reference(s) |
| T52CKD | Pro-epidermal growth factor | EGF |
P01133 |
4 Reference(s) |
| T56A9T | Tyrosine-protein kinase TXK | TXK |
P42681 |
3 Reference(s) |
| T02AK2 | Receptor-interacting serine/threonine-protein kinase 2 | RIPK2 |
O43353 |
4 Reference(s) |
| T29MD1 | Mitogen-activated protein kinase 8 | MAPK8 |
P45983 |
1 Reference(s) |
| T89Z7O | NA | FCGR1CP |
NA |
1 Reference(s) |
| T14JZK | Receptor tyrosine-protein kinase erbB-3 | ERBB3 |
P21860 |
1 Reference(s) |
| T84FSA | Forkhead box protein O3 | FOXO3 |
O43524 |
1 Reference(s) |
| T88LSZ | Aromatase | CYP19A1 |
P11511 |
1 Reference(s) |
| T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
3 Reference(s) |
| T57L0X | Oxysterols receptor LXR-alpha | NR1H3 |
Q13133 |
1 Reference(s) |
| T31U13 | Cytochrome P450 2C19 | CYP2C19 |
P33261 |
1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
2 Reference(s) |
| T82G3R | Integrin beta-3 | ITGB3 |
P05106 |
1 Reference(s) |
| T78O6C | Mothers against decapentaplegic homolog 3 | SMAD3 |
P84022 |
1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
4 Reference(s) |
| T53YWQ | Pro-neuropeptide Y [Cleaved into: Neuropeptide Y | NPY |
P01303 |
1 Reference(s) |
| T16MRJ | Trifunctional enzyme subunit beta, mitochondrial | HADHB |
P55084 |
1 Reference(s) |
| T20HY9 | 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial | DECR1 |
Q16698 |
1 Reference(s) |
| T43FA8 | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | ACADM |
P11310 |
1 Reference(s) |
| T60LKM | Peroxisomal bifunctional enzyme | EHHADH |
Q08426 |
1 Reference(s) |
| T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
1 Reference(s) |
| T90ZS8 | Endothelin-converting enzyme 1 | ECE1 |
P42892 |
1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
4 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
1 Reference(s) |
| T14W2H | ATP-citrate synthase | ACLY |
P53396 |
1 Reference(s) |
| T69DAO | Enoyl-CoA delta isomerase 1, mitochondrial | ECI1 |
P42126 |
1 Reference(s) |
| T87DEX | Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase | XDH |
P47989 |
1 Reference(s) |
| T16A2X | Catalase | CAT |
P04040 |
1 Reference(s) |
| T84P70 | Urokinase-type plasminogen activator | PLAU |
P00749 |
1 Reference(s) |
| T69NG6 | Interleukin-10 | IL10 |
P22301 |
3 Reference(s) |
| T06Q1R | Amine oxidase [flavin-containing] B | MAOB |
P27338 |
2 Reference(s) |
| T69XVX | Cytochrome P450 1B1 | CYP1B1 |
Q16678 |
1 Reference(s) |
| T12WTT | Interleukin-5 | IL5 |
P05113 |
1 Reference(s) |
| T84W8G | Aryl hydrocarbon receptor | AHR |
P35869 |
1 Reference(s) |
| T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
2 Reference(s) |
| T30VNV | Myeloperoxidase | MPO |
P05164 |
3 Reference(s) |
| T02WX3 | RNA-binding protein FUS | FUS |
P35637 |
1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
5 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
1 Reference(s) |
| T32UNL | Lens fiber major intrinsic protein | MIP |
P30301 |
1 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
2 Reference(s) |
| T70JEM | Myosin-11 | MYH11 |
P35749 |
1 Reference(s) |
| T18LX5 | Neutrophil elastase | ELANE |
P08246 |
1 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
2 Reference(s) |
| T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
5 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
3 Reference(s) |
| T13KGH | Tyrosinase | TYR |
P14679 |
1 Reference(s) |
| T75PC7 | NA | MIR21 |
NA |
1 Reference(s) |
| T66G0O | NA | MIR30A |
NA |
1 Reference(s) |
| T38O11 | Cyclin-G-associated kinase | GAK |
O14976 |
2 Reference(s) |
| T84C2C | Protein Tob1 | TOB1 |
P50616 |
1 Reference(s) |
| T54SZZ | Endoplasmic reticulum chaperone BiP | HSPA5 |
P11021 |
1 Reference(s) |
| T20MBF | Serotransferrin | TF |
P02787 |
1 Reference(s) |
| T77M4W | Adenosine receptor A2a | ADORA2A |
P29274 |
1 Reference(s) |
| T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
1 Reference(s) |
| T44KU9 | Cytochrome P450 2B6 | CYP2B6 |
P20813 |
1 Reference(s) |
| T61OY3 | UDP-glucuronosyltransferase 1A1 | UGT1A1 |
P22309 |
1 Reference(s) |
| T20TB8 | NADPH oxidase 1 | NOX1 |
Q9Y5S8 |
1 Reference(s) |
| T33OSQ | Sterol regulatory element-binding protein 1 | SREBF1 |
P36956 |
1 Reference(s) |
| T93YV8 | Tumor necrosis factor receptor superfamily member 11B | TNFRSF11B |
O00300 |
1 Reference(s) |
| T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
2 Reference(s) |
| T03G09 | Tumor necrosis factor ligand superfamily member 11 | TNFSF11 |
O14788 |
1 Reference(s) |
| T42D4V | Histone deacetylase 1 | HDAC1 |
Q13547 |
1 Reference(s) |
| T42Q3K | Aspartate aminotransferase, cytoplasmic | GOT1 |
P17174 |
1 Reference(s) |
| T00EP2 | Tissue-type plasminogen activator | PLAT |
P00750 |
1 Reference(s) |
| T39M6J | ATP-binding cassette sub-family C member 2 | ABCC2 |
Q92887 |
1 Reference(s) |
| T95A39 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | UCHL1 |
P09936 |
1 Reference(s) |
| T06ADX | Tyrosine-protein kinase receptor UFO | AXL |
P30530 |
1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
1 Reference(s) |
| T76SUY | Solute carrier family 22 member 2 | SLC22A2 |
O15244 |
1 Reference(s) |
| T07VJT | Multidrug and toxin extrusion protein 1 | SLC47A1 |
Q96FL8 |
1 Reference(s) |
| T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
1 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
1 Reference(s) |
| T33M2V | Transferrin receptor protein 1 | TFRC |
P02786 |
2 Reference(s) |
| T70VMI | Nitric oxide synthase, brain | NOS1 |
P29475 |
1 Reference(s) |
| T21UJU | Troponin I, cardiac muscle | TNNI3 |
P19429 |
2 Reference(s) |
| T58K2N | Calmodulin-3;Calmodulin-1;Calmodulin-2 | CALM3;CALM1;CALM2 |
P0DP25;P0DP23;P0DP24 |
1 Reference(s) |
| T67ZT3 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN |
P60484 |
2 Reference(s) |
| T08OIA | Microtubule-associated proteins 1A/1B light chain 3A | MAP1LC3A |
Q9H492 |
2 Reference(s) |
| T04WT7 | Fibronectin | FN1 |
P02751 |
1 Reference(s) |
| T81I4T | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | PRKAA1 |
Q13131 |
1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
1 Reference(s) |
| T46K2X | Heat shock 70 kDa protein 4 | HSPA4 |
P34932 |
1 Reference(s) |
| T51DHZ | Protein C-ets-1 | ETS1 |
P14921 |
1 Reference(s) |
| T34N64 | NA | MIR29B1 |
NA |
1 Reference(s) |
| T72TF8 | Methylcytosine dioxygenase TET1 | TET1 |
Q8NFU7 |
1 Reference(s) |
| T68O49 | Prostaglandin E2 receptor EP4 subtype | PTGER4 |
P35408 |
1 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
1 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
1 Reference(s) |
| T32PI2 | Programmed cell death 1 ligand 1 | CD274 |
Q9NZQ7 |
1 Reference(s) |
| T53KY7 | Cystic fibrosis transmembrane conductance regulator | CFTR |
P13569 |
1 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
1 Reference(s) |
| T04HTN | Cyclic AMP-dependent transcription factor ATF-3 | ATF3 |
P18847 |
1 Reference(s) |
| T05XOE | Macrophage mannose receptor 1 | MRC1 |
P22897 |
1 Reference(s) |
| T49PL1 | Low-density lipoprotein receptor | LDLR |
P01130 |
1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
2 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
1 Reference(s) |
Related Compounds (Total: 23)
C0399
Name: Sesamin
C0219
Name: Methyleugenol
C0400
Name: Sesamol
C0064
Name: Eugenol
C0063
Name: Eucalyptol
key description of the interaction between compound and target