HIT-result

Type	Detail
Target ID	T70VMI
Protein Name	Nitric oxide synthase, brain
Uniprot ID	P29475
Protein Name Alias	EC 1.14.13.39; Constitutive NOS; NC-NOS; NOS type I; Neuronal NOS; N-NOS; nNOS; Peptidyl-cysteine S-nitrosylase NOS1; bNOS
Gene ID	4842
Gene Symbol	NOS1
Gene Alias	NA
TTD	T16117: Clinical Trial target
Pfam	PF00258 ; PF02898 ; PF00175 ; PF00667 ; PF00595
GO	0005634:nucleus 0045454:cell redox homeostasis 0045776:negative regulation of blood pressure 0007263:nitric oxide mediated signal transduction 0018119:peptidyl-cysteine S-nitrosylation 0051926:negative regulation of calcium ion transport 0035066:positive regulation of histone acetylation 0001917:photoreceptor inner segment 0034618:arginine binding 1902514:regulation of calcium ion transmembrane transport via high voltage-gated calcium channel 0005829:cytosol 0097110:scaffold protein binding 0010181:FMN binding 0050660:flavin adenine dinucleotide binding 0046870:cadmium ion binding 0016709:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 0071944:cell periphery 0034617:tetrahydrobiopterin binding 0001666:response to hypoxia 0055117:regulation of cardiac muscle contraction 0006809:nitric oxide biosynthetic process 0006941:striated muscle contraction 0014069:postsynaptic density 0042738:exogenous drug catabolic process 0020037:heme binding 0005737:cytoplasm 0002028:regulation of sodium ion transport 0031284:positive regulation of guanylate cyclase activity 0007520:myoblast fusion 0042311:vasodilation 0010523:negative regulation of calcium ion transport into cytosol 1902307:positive regulation of sodium ion transmembrane transport 0005886:plasma membrane 0048471:perinuclear region of cytoplasm 0051346:negative regulation of hydrolase activity 0045121:membrane raft 1903779:regulation of cardiac conduction 0009408:response to heat 0005856:cytoskeleton 0098924:retrograde trans-synaptic signaling by nitric oxide 0043267:negative regulation of potassium ion transport 0045202:synapse 0016529:sarcoplasmic reticulum 0009725:response to hormone 0012506:vesicle membrane 0005516:calmodulin binding 0032991:protein-containing complex 0071363:cellular response to growth factor stimulus 0044325:ion channel binding 0045893:positive regulation of transcription, DNA-templated 0043197:dendritic spine 0005739:mitochondrion 0042383:sarcolemma 0048306:calcium-dependent protein binding 0060314:regulation of ryanodine-sensitive calcium-release channel activity 0032496:response to lipopolysaccharide 0005654:nucleoplasm 0006936:muscle contraction 0033138:positive regulation of peptidyl-serine phosphorylation 0016491:oxidoreductase activity 0033555:multicellular organismal response to stress 0050661:NADP binding 0004517:nitric-oxide synthase activity 0051612:negative regulation of serotonin uptake 0042136:neurotransmitter biosynthetic process 0098735:positive regulation of the force of heart contraction 0045944:positive regulation of transcription by RNA polymerase II 0017080:sodium channel regulator activity 0006527:arginine catabolic process
PDB	6NG4 ; 5UO3 ; 5VUX ; 6NHB ; 5ADG ; 6AV0 ; 5UO6 ; 5FVX ; 5VV5 ; 4UH5 ; 5UO5 ; 6PNH ; 6NG2 ; 5FVW ; 4V3U ; 6AV5 ; 6NHC ; 6POB ; 6AV2 ; 5VV4 ; 6PNF ; 5FVU ; 4D1N ; 6NGA ; 6NGD ; 6AUY ; 5UO2 ; 6PO7 ; 5VV3 ; 6NG1 ; 5VUZ ; 6PND ; 5VV0 ; 6POC ; 6PO9 ; 5VV1 ; 5ADI ; 5UO4 ; 6PNC ; 5VUY ; 6PNB ; 6CID ; 6PO8 ; 6AV4 ; 6CIC ; 4UH6 ; 5VUW ; 6PO5 ; 6AV3 ; 6NG5 ; 5FVV ; 5UO7 ; 5ADF ; 5UO1 ; 6AV1 ; 6NGB ; 6NGE ; 6PNE ; 6PNA ; 6POT ; 4UCH ; 6NG6 ; 6NG8 ; 5VV2 ; 6NGH ; 5VUV ; 6NG7 ; 6NGF ; 6NGI ; 6NGC ; 6AUZ ; 6PNG ; 6POA
Drugbank	DB02644 ; DB00843 ; DB03449 ; DB00997 ; DB04223 ; DB03144 ; DB02044 ; DB02143 ; DB01942 ; DB01221 ; DB09241 ; DB02991 ; DB03707 ; DB03147 ; DB08018 ; DB06096 ; DB08019 ; DB03892 ; DB03710 ; DB03247 ; DB02027 ; DB03461 ; DB02727 ; DB01821 ; DB00155 ; DB02077 ; DB01997
KEGG	hsa:4842

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0416	Shan Shen	山参	NA	Panax ginseng
H0629	Xi Xin	细辛	Siebold wildginger	Asarum sieboldii
H0121	La Jiao Jin Chu Ye	辣椒浸出液	Bush redpepper	Capsicum frutescens
H0242	Bei Sha Shen Liu Jin Gao	北沙参流浸膏	Glehnia littoralis	Glehnia littoralis
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0854	Zi Wei Gen Pi	紫葳根皮	NA	Campsis grandiflora
H0956	Dang Gui Gan Jin Gao	当归干浸膏	NA	Angelica sinensis
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0522	Tai Zi Shen	太子参	Heterophylly falsestarwort root	Radix pseudostellariae
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0955	Dang Gui	当归	Chinese angelica	Angelica sinensis
H0122	La Jiao Jin Gao	辣椒浸膏	Bush redpepper	Capsicum frutescens
H0119	La Jiao	辣椒	Bush redpepper	Capsicum frutescens
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0123	La Jiao Liu Jin Gao	辣椒流浸膏	Bush redpepper	Capsicum frutescens
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H0239	Bei Sha Shen	北沙参	Coastal glehnia	Glehnia littoralis

Target Description

Related Compounds (Total: 8)

Related Herbs (Total: 28)