HIT-result

Type	Detail
Target ID	T03G09
Protein Name	Tumor necrosis factor ligand superfamily member 11
Uniprot ID	O14788
Protein Name Alias	Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCE; CD antigen CD254
Gene ID	8600
Gene Symbol	TNFSF11
Gene Alias	OPGL; RANKL; TRANCE
TTD	T21334: Successful target
Pfam	PF00229
GO	0030316:osteoclast differentiation 0051091:positive regulation of DNA-binding transcription factor activity 0002548:monocyte chemotaxis 0070371:ERK1 and ERK2 cascade 0071848:positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling 0005615:extracellular space 0045780:positive regulation of bone resorption 0034112:positive regulation of homotypic cell-cell adhesion 0055074:calcium ion homeostasis 0038001:paracrine signaling 0033209:tumor necrosis factor-mediated signaling pathway 0071847:TNFSF11-mediated signaling pathway 1902533:positive regulation of intracellular signal transduction 0060749:mammary gland alveolus development 0005164:tumor necrosis factor receptor binding 0051466:positive regulation of corticotropin-releasing hormone secretion 2001206:positive regulation of osteoclast development 0042802:identical protein binding 0033598:mammary gland epithelial cell proliferation 0071812:positive regulation of fever generation by positive regulation of prostaglandin secretion 0005576:extracellular region 0044691:tooth eruption 0005886:plasma membrane 0005737:cytoplasm 0002158:osteoclast proliferation 0045672:positive regulation of osteoclast differentiation 0005887:integral component of plasma membrane 0007257:activation of JUN kinase activity 0046330:positive regulation of JNK cascade 1904616:regulation of actin binding 0005125:cytokine activity 0045944:positive regulation of transcription by RNA polymerase II 0036035:osteoclast development 1990830:cellular response to leukemia inhibitory factor 0045453:bone resorption 0006955:immune response 0019221:cytokine-mediated signaling pathway 0001503:ossification 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0050870:positive regulation of T cell activation 0032813:tumor necrosis factor receptor superfamily binding 0051092:positive regulation of NF-kappaB transcription factor activity 0051897:positive regulation of protein kinase B signaling 0043406:positive regulation of MAP kinase activity 0019722:calcium-mediated signaling
PDB	3URF ; 5BNQ
Drugbank	DB06643 ; DB06511 ; DB11582 ; DB00480
KEGG	hsa:8600

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0180	Lu Zhu Gen	芦竹根	Giantreed rhizome	Arundo donax
H0357	Ren Shen	人参	Ginseng	Panax ginseng
H0790	Zhang Shu Zi	樟树子	Camphor tree	Cinnamomum camphora
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1181	Hei Zhi Ma	黑芝麻	Oriental sesame	Sesamum indicum
H1086	Bai Hua Cai Zi	白花菜子	Common spiderflower seed	Cleome gynandra
H0154	Ai Ye You	艾叶油	Argy wormwood leaf	Artemisia argyi
H0026	Jiang	姜	Soybean paste	Glycine max
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0708	Yuan Hua Gen	芫花根	Lilac daphne root	Daphne genkwa
H0967	Di Er Cao	地耳草	Japanese stJohn’swort	Hypericum japonicum
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H1095	Ge Gen Gan Jin Gao	葛根干浸膏	Lobed kudzuvine root	Pueraria lobata
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max
H1055	Bai Guo Ren	白果仁	ginkgo	Ginkgo biloba
H1207	Hu Ma	胡麻	white seed of oriental sesame	Sesamum indicum
H0956	Dang Gui Gan Jin Gao	当归干浸膏	NA	Angelica sinensis
H1124	Guang Jin Qian Cao	广金钱草	Snowbellleaf tickclover	Desmodium styracifolium
H1225	Huai Mi	槐米	NA	Sophora japonica
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H0693	Xue Xie	血蝎	Dragon's blood	Daemonorops draco
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H0901	Chun Gen Teng	春根藤	Twig and leaf of creeping psychotria	Psychotria serpens
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0024	Jia 蒟ye	假蒟叶	Sarmentose pepper	Piper sarmentosum
H0788	Zhang Nao Zi	樟脑子	Camphorar	Cinnamomum camphora
H0233	Mao Liang Mian Zhen	毛两面针	NA	Zanthoxylum nitidum
H0752	Yin Yang Huo Gan Gao Fen	淫羊藿干膏粉	Epimedium sagittatum	Epimedium brevicornum
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0751	Yin Yang Huo	淫羊藿	NA	Epimedium brevicornum
H0022	Jia Ju	假蒟	Sarmentose pepper	Piper sarmentosum
H0522	Tai Zi Shen	太子参	Heterophylly falsestarwort root	Radix pseudostellariae
H1094	Ge Gen	葛根	Lobed kudzuvine root	Pueraria lobata
H0979	Di Yu	地榆	Garden burnet	Sanguisorba officinalis
H0711	Yuan Hua Zhi Tiao	芫花枝条	stem of lilac daphne	Daphne genkwa
H0753	Yin Yang Huo Jin Gao	淫羊藿浸膏	Epimedium sagittatum	Epimedium brevicornum
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H0580	Tu Si Rou	菟丝肉	Dodder seed	Cuscuta australis
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0581	Tu Si Zi	菟丝子	Dodder seed	Cuscuta australis
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0750	Yin Xing Ye	银杏叶	Folium ginkgo	Ginkgo biloba
H0129	Le Xian Cai	勒苋菜	NA	Amaranthus spinosus
H0098	Ju Ye San Qi	菊叶三七	NA	Gynura japonica
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H1096	Ge Hua	葛花	flower bud of lobed kudzuvine	Pueraria lobata
H0786	Zhang Mu	樟木	Ligum cinmamomi camphorae	Cinnamomum camphora
H0918	Cu Yuan Hua	醋芫花	Lilac daphne	Daphne genkwa
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H0848	Zi Jin Niu	紫金牛	Japanese ardisia	Ardisia japonica
H0218	Man Jiu Jie	蔓九节	Creeping ninenode	Psychotria serpens
H1007	Dou You	豆油	Soybean oil	Glycine max
H0583	Tu Si Zi Teng	菟丝子藤	Dodder seed	Cuscuta australis
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1051	Bai Guo	白果	Ginkgo nut	Ginkgo biloba
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0995	Dong Chong Xia Cao	冬虫夏草	Aweto	Cordyceps sinensis
H0533	Teng Ku Shen	藤苦参	NA	Sophora flavescens
H0852	Zi Tan	紫檀	Burmacoast padauk	Pterocarpus indicus
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H0358	Ren Shen Ye	人参叶	Ginseng leaf	Panax ginseng
H0710	Yuan Hua Tiao	芫花条	stem of lilac daphne	Daphne genkwa
H0103	Ai Ye	艾叶	Argy wormwood leaf	Artemisia argyi
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0707	Yuan Hua	芫花	Lilac daphne	Daphne genkwa
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0006	Bai Qu Cai	白屈菜	Greater celandine	Chelidonium majus
H0938	Da Suan	大蒜	Garlic	Allium sativum
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H0096	Ju San Qi	菊三七	NA	Gynura japonica
H0629	Xi Xin	细辛	Siebold wildginger	Asarum sieboldii
H0295	Bi Ba	荜茇	Long pepper	Piper longum
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0906	Ci Wan	刺苋	spiny amaranth	Amaranthus spinosus
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1208	Hu Ma Ren	胡麻仁	white seed of oriental sesame	Sesamum indicum
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H0111	Ku Shen	苦参	Lightyellow sophora	Sophora flavescens
H0575	Tu Ku Shen	土苦参	all-grass of hooker winghead	Sophora flavescens
H0158	Liu Ling Ju	六棱菊	NA	Laggera alata
H0792	Zhang Yu	章鱼	Common atlantic octopus	Octopus vulgaris
H0787	Zhang Nao	樟脑	Camphorar	Cinnamomum camphora
H0789	Zhang Shu Gen	樟树根	Camphor tree	Cinnamomum camphora
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1080	Gan Ge	干葛	Lobed kudzuvine root	Pueraria lobata
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0416	Shan Shen	山参	NA	Panax ginseng
H0980	Di Yu Tan	地榆炭	Garden burnet	Sanguisorba officinalis
H0955	Dang Gui	当归	Chinese angelica	Angelica sinensis

Target Description

Related Compounds (Total: 8)

Related Herbs (Total: 93)