Compound Description
| ID: C0135 | Common name: Icariin |
| IUPAC: 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one | CAS: CAS:489-32-7 |
| Chembl ID: CHEMBL553204 | Pubchem ID: CID:5318997 |
| Formula: C33H40O15 | TCM-ID: TCMC1360 |
| Smiles: CC1C(C(C(C(O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)OC4C(C(C(C(O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)O)O)O | |
| Alias:
4H-1-Benzopyran-4-one, 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-;
Icariin; 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one; Epimedium PE; Icariine; Icariln; Ieariline |
Structure:
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Related Targets (Total: 18)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
A | 1 Reference(s) |
| T03G09 | Tumor necrosis factor ligand superfamily member 11 | TNFSF11 |
O14788 |
A | 1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
A | 1 Reference(s) |
| T01E8J | Amyloid-beta precursor protein | APP |
P05067 |
A | 1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
A | 1 Reference(s) |
| T78C6N | Cathepsin K | CTSK |
P43235 |
A | 1 Reference(s) |
| T73ATB | Toll-like receptor 9 | TLR9 |
Q9NR96 |
A | 1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
B | 1 Reference(s) |
| T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
B | 1 Reference(s) |
| T80OPZ | NADPH oxidase 4 | NOX4 |
Q9NPH5 |
B | 1 Reference(s) |
| T49ORJ | Peroxisome proliferator-activated receptor alpha | PPARA |
Q07869 |
B | 1 Reference(s) |
| T61QXV | Nuclear respiratory factor 1 | NRF1 |
Q16656 |
B | 1 Reference(s) |
| T93YV8 | Tumor necrosis factor receptor superfamily member 11B | TNFRSF11B |
O00300 |
B | 1 Reference(s) |
| T88BXD | Troponin T, cardiac muscle | TNNT2 |
P45379 |
C | 1 Reference(s) |
| T91MKC | Runt-related transcription factor 2 | RUNX2 |
Q13950 |
C | 1 Reference(s) |
| T38JCD | DNA-binding protein inhibitor ID-1 | ID1 |
P41134 |
C | 1 Reference(s) |
| T19BO9 | Bone morphogenetic protein 4 | BMP4 |
P12644 |
C | 1 Reference(s) |
| T22OPB | Nuclear factor erythroid 2-related factor 2 | NFE2L2 |
Q16236 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 5)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0901 | Chun Gen Teng | 春根藤 | Twig and leaf of creeping psychotria | Psychotria serpens |
| H0753 | Yin Yang Huo Jin Gao | 淫羊藿浸膏 | Epimedium sagittatum | Epimedium brevicornum |
| H0752 | Yin Yang Huo Gan Gao Fen | 淫羊藿干膏粉 | Epimedium sagittatum | Epimedium brevicornum |
| H0751 | Yin Yang Huo | 淫羊藿 | NA | Epimedium brevicornum |
| H0218 | Man Jiu Jie | 蔓九节 | Creeping ninenode | Psychotria serpens |
Ckey description of the interaction between compound and target