HIT-result

Target Description

Type	Detail
Target ID	T73ATB
Protein Name	Toll-like receptor 9
Uniprot ID	Q9NR96
Protein Name Alias	CD antigen CD289
Gene ID	54106
Gene Symbol	TLR9
Gene Alias	NA
TTD	T11451: Clinical Trial target
Pfam	PF01582 ; PF13516 ; PF13855 ; PF18837
GO	0002755:MyD88-dependent toll-like receptor signaling pathway 0043410:positive regulation of MAPK cascade 0032725:positive regulation of granulocyte macrophage colony-stimulating factor production 0034162:toll-like receptor 9 signaling pathway 0005789:endoplasmic reticulum membrane 0016021:integral component of membrane 0007252:I-kappaB phosphorylation 1901224:positive regulation of NIK/NF-kappaB signaling 0032755:positive regulation of interleukin-6 production 0045577:regulation of B cell differentiation 0051607:defense response to virus 0032722:positive regulation of chemokine production 0030890:positive regulation of B cell proliferation 0032760:positive regulation of tumor necrosis factor production 1901895:negative regulation of ATPase-coupled calcium transmembrane transporter activity 0032757:positive regulation of interleukin-8 production 0032728:positive regulation of interferon-beta production 0032715:negative regulation of interleukin-6 production 0032640:tumor necrosis factor production 0032088:negative regulation of NF-kappaB transcription factor activity 0030277:maintenance of gastrointestinal epithelium 0005764:lysosome 0032733:positive regulation of interleukin-10 production 0042742:defense response to bacterium 0032009:early phagosome 0045322:unmethylated CpG binding 0032729:positive regulation of interferon-gamma production 0005576:extracellular region 0032717:negative regulation of interleukin-8 production 0035197:siRNA binding 0005886:plasma membrane 0005768:endosome 0038187:pattern recognition receptor activity 0045087:innate immune response 0051770:positive regulation of nitric-oxide synthase biosynthetic process 0046330:positive regulation of JNK cascade 0005737:cytoplasm 0005783:endoplasmic reticulum 0007249:I-kappaB kinase/NF-kappaB signaling 0005149:interleukin-1 receptor binding 0050829:defense response to Gram-negative bacterium 0032727:positive regulation of interferon-alpha production 0043507:positive regulation of JUN kinase activity 0045944:positive regulation of transcription by RNA polymerase II 0042803:protein homodimerization activity 0016323:basolateral plasma membrane 0050729:positive regulation of inflammatory response 0010008:endosome membrane 0006955:immune response 0002224:toll-like receptor signaling pathway 0004888:transmembrane signaling receptor activity 0050871:positive regulation of B cell activation 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0036020:endolysosome membrane 0010628:positive regulation of gene expression 0006954:inflammatory response 0034123:positive regulation of toll-like receptor signaling pathway 0002237:response to molecule of bacterial origin 0034163:regulation of toll-like receptor 9 signaling pathway 0000139:Golgi membrane 0051092:positive regulation of NF-kappaB transcription factor activity 0002639:positive regulation of immunoglobulin production 0036019:endolysosome 0034122:negative regulation of toll-like receptor signaling pathway 0032735:positive regulation of interleukin-12 production 0016324:apical plasma membrane 0032741:positive regulation of interleukin-18 production
PDB	NA
Drugbank	DB00608 ; DB05463 ; DB05475 ; DB05530 ; DB01611
KEGG	hsa:54106

Type

Detail

Target ID

T73ATB

Protein Name

Toll-like receptor 9

Uniprot ID

Q9NR96

Protein Name Alias

CD antigen CD289

Gene ID

54106

Gene Symbol

TLR9

Gene Alias

TTD

T11451: Clinical Trial target

Pfam

PF01582 ; PF13516 ; PF13855 ; PF18837

0002755:MyD88-dependent toll-like receptor signaling pathway

0043410:positive regulation of MAPK cascade

0032725:positive regulation of granulocyte macrophage colony-stimulating factor production

0034162:toll-like receptor 9 signaling pathway

0005789:endoplasmic reticulum membrane

0016021:integral component of membrane

0007252:I-kappaB phosphorylation

1901224:positive regulation of NIK/NF-kappaB signaling

0032755:positive regulation of interleukin-6 production

0045577:regulation of B cell differentiation

0051607:defense response to virus

0032722:positive regulation of chemokine production

0030890:positive regulation of B cell proliferation

0032760:positive regulation of tumor necrosis factor production

1901895:negative regulation of ATPase-coupled calcium transmembrane transporter activity

0032757:positive regulation of interleukin-8 production

0032728:positive regulation of interferon-beta production

0032715:negative regulation of interleukin-6 production

0032640:tumor necrosis factor production

0032088:negative regulation of NF-kappaB transcription factor activity

0030277:maintenance of gastrointestinal epithelium

0005764:lysosome

0032733:positive regulation of interleukin-10 production

0042742:defense response to bacterium

0032009:early phagosome

0045322:unmethylated CpG binding

0032729:positive regulation of interferon-gamma production

0005576:extracellular region

0032717:negative regulation of interleukin-8 production

0035197:siRNA binding

0005886:plasma membrane

0005768:endosome

0038187:pattern recognition receptor activity

0045087:innate immune response

0051770:positive regulation of nitric-oxide synthase biosynthetic process

0046330:positive regulation of JNK cascade

0005737:cytoplasm

0005783:endoplasmic reticulum

0007249:I-kappaB kinase/NF-kappaB signaling

0005149:interleukin-1 receptor binding

0050829:defense response to Gram-negative bacterium

0032727:positive regulation of interferon-alpha production

0043507:positive regulation of JUN kinase activity

0045944:positive regulation of transcription by RNA polymerase II

0042803:protein homodimerization activity

0016323:basolateral plasma membrane

0050729:positive regulation of inflammatory response

0010008:endosome membrane

0006955:immune response

0002224:toll-like receptor signaling pathway

0004888:transmembrane signaling receptor activity

0050871:positive regulation of B cell activation

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0036020:endolysosome membrane

0010628:positive regulation of gene expression

0006954:inflammatory response

0034123:positive regulation of toll-like receptor signaling pathway

0002237:response to molecule of bacterial origin

0034163:regulation of toll-like receptor 9 signaling pathway

0000139:Golgi membrane

0051092:positive regulation of NF-kappaB transcription factor activity

0002639:positive regulation of immunoglobulin production

0036019:endolysosome

0034122:negative regulation of toll-like receptor signaling pathway

0032735:positive regulation of interleukin-12 production

0016324:apical plasma membrane

0032741:positive regulation of interleukin-18 production

PDB

Drugbank

DB00608 ; DB05463 ; DB05475 ; DB05530 ; DB01611

KEGG

hsa:54106

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Name: Icariin

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Name: (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione

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Name: Cpg

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0751	Yin Yang Huo	淫羊藿	NA	Epimedium brevicornum
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0218	Man Jiu Jie	蔓九节	Creeping ninenode	Psychotria serpens
H0901	Chun Gen Teng	春根藤	Twig and leaf of creeping psychotria	Psychotria serpens
H0752	Yin Yang Huo Gan Gao Fen	淫羊藿干膏粉	Epimedium sagittatum	Epimedium brevicornum
H0753	Yin Yang Huo Jin Gao	淫羊藿浸膏	Epimedium sagittatum	Epimedium brevicornum
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 12)