Compound Description
| ID: C0739 | Common name: (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione |
| IUPAC: (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione | CAS: NA |
| Chembl ID: CHEMBL140 | Pubchem ID: CID:969516 |
| Formula: C21H20O6 | TCM-ID: TCMC43 |
| Smiles: COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O | |
| Alias:
NA
|
Structure:
|
Related Targets (Total: 161)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T30D9G | Superoxide dismutase [Cu-Zn] | SOD1 |
P00441 |
A | 1 Reference(s) |
| T58XLK | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 |
P18031 |
A | 1 Reference(s) |
| T27LA6 | DNA | DNMT1 |
P26358 |
A | 1 Reference(s) |
| T10ICM | Oxidized low-density lipoprotein receptor 1 | OLR1 |
P78380 |
A | 1 Reference(s) |
| T75F65 | Interleukin-2 receptor subunit alpha | IL2RA |
P01589 |
A | 1 Reference(s) |
| T38T1U | Caspase-8 | CASP8 |
Q14790 |
A | 1 Reference(s) |
| T77UWH | CCAAT/enhancer-binding protein beta | CEBPB |
P17676 |
A | 1 Reference(s) |
| T28I32 | Nuclear receptor subfamily 2 group C member 2 | NR2C2 |
P49116 |
A | 1 Reference(s) |
| T82S6C | Hexokinase-4 | GCK |
P35557 |
A | 1 Reference(s) |
| T41SFE | Histone acetyltransferase p300 | EP300 |
Q09472 |
A | 1 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
A | 1 Reference(s) |
| T80OJF | Interstitial collagenase | MMP1 |
P03956 |
A | 1 Reference(s) |
| T56IUI | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | PIK3CA |
P42336 |
A | 1 Reference(s) |
| T62N3I | Frizzled-1 | FZD1 |
Q9UP38 |
A | 1 Reference(s) |
| T60I6V | E3 SUMO-protein ligase PIAS3 | PIAS3 |
Q9Y6X2 |
A | 1 Reference(s) |
| T02WMA | Ornithine decarboxylase | ODC1 |
P11926 |
A | 1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
A | 1 Reference(s) |
| T00RT4 | Inosine-5'-monophosphate dehydrogenase 1 | IMPDH1 |
P20839 |
A | 1 Reference(s) |
| T42E30 | DNA fragmentation factor subunit beta | DFFB |
O76075 |
A | 1 Reference(s) |
| T84W8G | Aryl hydrocarbon receptor | AHR |
P35869 |
A | 1 Reference(s) |
| T58N83 | Serine/threonine-protein kinase STK11 | STK11 |
Q15831 |
A | 1 Reference(s) |
| T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
A | 1 Reference(s) |
| T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
A | 1 Reference(s) |
| T38EQ6 | NAD(P)H dehydrogenase [quinone] 1 | NQO1 |
P15559 |
A | 1 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
A | 1 Reference(s) |
| T17YBS | Transmembrane protease serine 11D | TMPRSS11D |
O60235 |
A | 1 Reference(s) |
| T87DEX | Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase | XDH |
P47989 |
A | 1 Reference(s) |
| T11TKN | Leucine-rich repeat serine/threonine-protein kinase 2 | LRRK2 |
Q5S007 |
A | 1 Reference(s) |
| T37WY2 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | PCK1 |
P35558 |
A | 1 Reference(s) |
| T91T8I | Glucose-6-phosphatase catalytic subunit 1 | G6PC1 |
P35575 |
A | 1 Reference(s) |
| T08DG3 | Histone acetyltransferase type B catalytic subunit | HAT1 |
O14929 |
A | 1 Reference(s) |
| T48XM4 | Glutathione S-transferase Mu 2 | GSTM2 |
P28161 |
A | 1 Reference(s) |
| T62F1Y | Glutathione S-transferase A2 | GSTA2 |
P09210 |
A | 1 Reference(s) |
| T76EHP | Glutathione S-transferase A1 | GSTA1 |
P08263 |
A | 1 Reference(s) |
| T87WYU | Glutathione S-transferase Mu 1 | GSTM1 |
P09488 |
A | 1 Reference(s) |
| T46AQJ | Glutathione S-transferase P | GSTP1 |
P09211 |
A | 1 Reference(s) |
| T09DI4 | Lysine-specific histone demethylase 1A | KDM1A |
O60341 |
A | 1 Reference(s) |
| T74LFK | Neurogenic locus notch homolog protein 1 | NOTCH1 |
P46531 |
A | 1 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
A | 1 Reference(s) |
| T69XEM | Tyrosine-protein kinase SYK | SYK |
P43405 |
A | 2 Reference(s) |
| T45WTI | UDP-glucuronosyltransferase 1A4 (UGT1A4) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 2) (hUG-BR2) (UDP-glucuronosyltransferase 1-4) (UDPGT 1-4) (UGT1*4) (UGT1-04) (UGT1.4) (UDP-glucuronosyltransferase 1-D) (UGT-1D) (UGT1D) | UGT1A4 |
P22310 |
A | 1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
A | 2 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
A | 2 Reference(s) |
| T21EGX | Multidrug resistance-associated protein 1 | ABCC1 |
P33527 |
A | 1 Reference(s) |
| T42D4V | Histone deacetylase 1 | HDAC1 |
Q13547 |
A | 1 Reference(s) |
| T30VNV | Myeloperoxidase | MPO |
P05164 |
B | 1 Reference(s) |
| T06Q1R | Amine oxidase [flavin-containing] B | MAOB |
P27338 |
B | 1 Reference(s) |
| T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
B | 1 Reference(s) |
| T80PUR | Caspase-7 | CASP7 |
P55210 |
B | 1 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
B | 1 Reference(s) |
| T90ORW | Bcl2-associated agonist of cell death | BAD |
Q92934 |
B | 1 Reference(s) |
| T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
B | 1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
B | 1 Reference(s) |
| T98RXH | Focal adhesion kinase 1 | PTK2 |
Q05397 |
B | 1 Reference(s) |
| T49PL1 | Low-density lipoprotein receptor | LDLR |
P01130 |
B | 1 Reference(s) |
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
B | 1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
B | 1 Reference(s) |
| T04PM9 | Transthyretin | TTR |
P02766 |
B | 1 Reference(s) |
| T29BIB | Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8) | MAPK15 |
Q8TD08 |
B | 1 Reference(s) |
| T05RAA | Inhibitor of nuclear factor kappa-B kinase subunit alpha | CHUK |
O15111 |
B | 2 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
C | 1 Reference(s) |
| T20JZ2 | Androgen receptor | AR |
P10275 |
C | 1 Reference(s) |
| T37ADS | Early growth response protein 1 | EGR1 |
P18146 |
C | 1 Reference(s) |
| T09KQF | Proliferating cell nuclear antigen | PCNA |
P12004 |
C | 1 Reference(s) |
| T01JSX | Carbonyl reductase [NADPH] 1 | CBR1 |
P16152 |
C | 1 Reference(s) |
| T68O49 | Prostaglandin E2 receptor EP4 subtype | PTGER4 |
P35408 |
C | 1 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
C | 1 Reference(s) |
| T97FEF | Broad substrate specificity ATP-binding cassette transporter ABCG2 | ABCG2 |
Q9UNQ0 |
C | 1 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
C | 1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
C | 1 Reference(s) |
| T07NML | P-selectin | SELP |
P16109 |
C | 1 Reference(s) |
| T24U57 | E-selectin | SELE |
P16581 |
C | 1 Reference(s) |
| T84TJB | Homeobox protein Nkx-3.1 | NKX3-1 |
Q99801 |
C | 1 Reference(s) |
| T83P5X | Inhibitor of nuclear factor kappa-B kinase subunit beta | IKBKB |
O14920 |
C | 1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
C | 1 Reference(s) |
| T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
C | 1 Reference(s) |
| T51DHZ | Protein C-ets-1 | ETS1 |
P14921 |
C | 1 Reference(s) |
| T73LPO | Poly [ADP-ribose] polymerase 1 | PARP1 |
P09874 |
C | 1 Reference(s) |
| T31P1D | Metalloproteinase inhibitor 1 | TIMP1 |
P01033 |
C | 1 Reference(s) |
| T88QQE | Fibroblast growth factor 2 | FGF2 |
P09038 |
C | 1 Reference(s) |
| T23OTN | T-lymphocyte activation antigen CD80 | CD80 |
P33681 |
C | 1 Reference(s) |
| T90QGN | T-cell-specific surface glycoprotein CD28 | CD28 |
P10747 |
C | 1 Reference(s) |
| T74I49 | Bcl-2-like protein 1 | BCL2L1 |
Q07817 |
C | 1 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
C | 1 Reference(s) |
| T74QXI | Serine/threonine-protein kinase mTOR | MTOR |
P42345 |
C | 1 Reference(s) |
| T63YAO | Caveolin-1 | CAV1 |
Q03135 |
C | 1 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
C | 1 Reference(s) |
| T33OSQ | Sterol regulatory element-binding protein 1 | SREBF1 |
P36956 |
C | 1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
C | 1 Reference(s) |
| T20H9F | Stromelysin-1 | MMP3 |
P08254 |
C | 1 Reference(s) |
| T71KM2 | TGF-beta receptor type-1 | TGFBR1 |
P36897 |
C | 1 Reference(s) |
| T94S85 | Collagen alpha-1(I) chain | COL1A1 |
P02452 |
C | 1 Reference(s) |
| T24LXT | G2/mitotic-specific cyclin-B1 | CCNB1 |
P14635 |
C | 1 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
C | 1 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
C | 1 Reference(s) |
| T25H22 | Protein kinase C beta type | PRKCB |
P05771 |
C | 1 Reference(s) |
| T40MAR | Cadherin-11 | CDH11 |
P55287 |
C | 1 Reference(s) |
| T84P70 | Urokinase-type plasminogen activator | PLAU |
P00749 |
C | 1 Reference(s) |
| T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
C | 1 Reference(s) |
| T65S3S | Tyrosine-protein kinase JAK2 | JAK2 |
O60674 |
C | 1 Reference(s) |
| T14LSK | E3 ubiquitin-protein ligase XIAP | XIAP |
P98170 |
C | 1 Reference(s) |
| T74JJN | Fatty acid synthase | FASN |
P49327 |
C | 1 Reference(s) |
| T34VFO | Platelet-derived growth factor receptor beta | PDGFRB |
P09619 |
C | 1 Reference(s) |
| T36SOV | Plasminogen activator inhibitor 1 | SERPINE1 |
P05121 |
C | 1 Reference(s) |
| T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
C | 1 Reference(s) |
| T75IW3 | Matrix metalloproteinase-14 | MMP14 |
P50281 |
C | 1 Reference(s) |
| T34X07 | CCAAT/enhancer-binding protein alpha | CEBPA |
P49715 |
C | 1 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
C | 1 Reference(s) |
| T06PVX | E3 ubiquitin-protein ligase Mdm2 | MDM2 |
Q00987 |
C | 1 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
C | 1 Reference(s) |
| T19AGJ | Tumor necrosis factor ligand superfamily member 13B | TNFSF13B |
Q9Y275 |
C | 1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
C | 1 Reference(s) |
| T30L86 | Tumor necrosis factor receptor superfamily member 10B | TNFRSF10B |
O14763 |
C | 1 Reference(s) |
| T62USB | Tumor necrosis factor receptor superfamily member 10A | TNFRSF10A |
O00220 |
C | 1 Reference(s) |
| T31VDH | Myeloid differentiation primary response protein MyD88 | MYD88 |
Q99836 |
C | 1 Reference(s) |
| T17CZC | Tissue factor | F3 |
P13726 |
C | 1 Reference(s) |
| T88BCB | Glycerol-3-phosphate phosphatase | PGP |
A6NDG6 |
C | 1 Reference(s) |
| T75U40 | Cytotoxic T-lymphocyte protein 4 | CTLA4 |
P16410 |
C | 1 Reference(s) |
| T06URY | Transcription factor Sp1 | SP1 |
P08047 |
C | 1 Reference(s) |
| T73ATB | Toll-like receptor 9 | TLR9 |
Q9NR96 |
C | 1 Reference(s) |
| T11BI7 | Toll-like receptor 4 | TLR4 |
O00206 |
C | 1 Reference(s) |
| T28BLO | Cyclic AMP-responsive element-binding protein 3-like protein 3 | CREB3L3 |
Q68CJ9 |
C | 1 Reference(s) |
| T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
C | 1 Reference(s) |
| T75HMM | Induced myeloid leukemia cell differentiation protein Mcl-1 | MCL1 |
Q07820 |
C | 1 Reference(s) |
| T37PX5 | Zinc finger protein GLI1 | GLI1 |
P08151 |
C | 1 Reference(s) |
| T79KKF | Protein patched homolog 1 | PTCH1 |
Q13635 |
C | 1 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
C | 1 Reference(s) |
| T42XY2 | Insulin-like growth factor 1 receptor | IGF1R |
P08069 |
C | 1 Reference(s) |
| T62IRH | Inhibitor of growth protein 4 | ING4 |
Q9UNL4 |
C | 1 Reference(s) |
| T50MQN | NPC1-like intracellular cholesterol transporter 1 | NPC1L1 |
Q9UHC9 |
C | 1 Reference(s) |
| T04MBA | Vascular endothelial growth factor receptor 2 | KDR |
P35968 |
C | 1 Reference(s) |
| T54D6L | Angiopoietin-1 | ANGPT1 |
Q15389 |
C | 1 Reference(s) |
| T72BXP | Platelet endothelial cell adhesion molecule | PECAM1 |
P16284 |
C | 1 Reference(s) |
| T36K5T | DnaJ homolog subfamily B member 4 | DNAJB4 |
Q9UDY4 |
C | 1 Reference(s) |
| T71UHA | Transcription factor jun-D | JUND |
P17535 |
C | 1 Reference(s) |
| T05CWL | Arylamine N-acetyltransferase 1 | NAT1 |
P18440 |
C | 1 Reference(s) |
| T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
C | 1 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
C | 1 Reference(s) |
| T53AOE | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide | TGFB1 |
P01137 |
C | 1 Reference(s) |
| T95QJ9 | G1/S-specific cyclin-D3 | CCND3 |
P30281 |
C | 1 Reference(s) |
| T51TPZ | Protein delta homolog 1 | DLK1 |
P80370 |
C | 1 Reference(s) |
| T28V82 | Wilms tumor protein | WT1 |
P19544 |
C | 1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
C | 2 Reference(s) |
| T34DZ7 | Interleukin-2 | IL2 |
P60568 |
C | 1 Reference(s) |
| T44JTS | Zinc finger and BTB domain-containing protein 7A | ZBTB7A |
O95365 |
C | 1 Reference(s) |
| T06HS2 | Tumor necrosis factor receptor superfamily member 11A | TNFRSF11A |
Q9Y6Q6 |
C | 1 Reference(s) |
| T16UHV | Nuclear factor of activated T-cells, cytoplasmic 1 | NFATC1 |
O95644 |
C | 1 Reference(s) |
| T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
C | 1 Reference(s) |
| T06MQM | Heat shock protein beta-1 | HSPB1 |
P04792 |
C | 1 Reference(s) |
| T18YXD | Albumin | ALB |
P02768 |
C | 1 Reference(s) |
| T04R1T | Major vault protein | MVP |
Q14764 |
C | 1 Reference(s) |
| T55VKP | CD9 antigen | CD9 |
P21926 |
C | 1 Reference(s) |
| T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
C | 1 Reference(s) |
| T62MI4 | Extracellular matrix protein 1 | ECM1 |
Q16610 |
C | 1 Reference(s) |
| T92BZ2 | Catenin beta-1 | CTNNB1 |
P35222 |
C | 1 Reference(s) |
| T83QHM | Beta-nerve growth factor | NGF |
P01138 |
C | 1 Reference(s) |
| T87QUW | Actin, aortic smooth muscle | ACTA2 |
P62736 |
C | 1 Reference(s) |
| T14JSQ | Baculoviral IAP repeat-containing protein 2 | BIRC2 |
Q13490 |
C | 1 Reference(s) |
| T20PAH | Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed] | FTH1 |
P02794 |
C | 1 Reference(s) |
| T02IOG | Cyclin-dependent kinase inhibitor 1B | CDKN1B |
P46527 |
C | 1 Reference(s) |
| T03TCQ | Receptor protein-tyrosine kinase (EC 2.7.10.1) | EGFR |
Q504U8 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 7)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H0446 | Sheng Jiang | 生姜 | Fresh common ginger | Zingiber officinale |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
| H0761 | Yu Jin | 郁金 | AromaticTurmeric | Curcuma aromatica |
| H0556 | Tie Xian Cao | 铁线草 | NA | Adiantum capillus-veneris |
| H0895 | Chuan Yu Jin | 川郁金 | Turmeric | Curcuma longa |
| H0028 | Jiang Huang | 姜黄 | Common turmeric | Curcuma longa |
Ckey description of the interaction between compound and target