Compound Description

ID:   C0739 Common name:   (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione
IUPAC:  (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione CAS:  NA
Chembl ID:   CHEMBL140 Pubchem ID:   CID:969516
Formula:  C21H20O6 TCM-ID:  TCMC43
Smiles:  COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
Alias:

NA
Structure:

Related Targets  (Total: 161)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T30D9G Superoxide dismutase [Cu-Zn]SOD1 P00441
A 1 Reference(s)
T58XLK Tyrosine-protein phosphatase non-receptor type 1PTPN1 P18031
A 1 Reference(s)
T27LA6 DNADNMT1 P26358
A 1 Reference(s)
T10ICM Oxidized low-density lipoprotein receptor 1OLR1 P78380
A 1 Reference(s)
T75F65 Interleukin-2 receptor subunit alphaIL2RA P01589
A 1 Reference(s)
T38T1U Caspase-8CASP8 Q14790
A 1 Reference(s)
T77UWH CCAAT/enhancer-binding protein betaCEBPB P17676
A 1 Reference(s)
T28I32 Nuclear receptor subfamily 2 group C member 2NR2C2 P49116
A 1 Reference(s)
T82S6C Hexokinase-4GCK P35557
A 1 Reference(s)
T41SFE Histone acetyltransferase p300EP300 Q09472
A 1 Reference(s)
T83YZD AcetylcholinesteraseACHE P22303
A 1 Reference(s)
T80OJF Interstitial collagenaseMMP1 P03956
A 1 Reference(s)
T56IUI Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPIK3CA P42336
A 1 Reference(s)
T62N3I Frizzled-1FZD1 Q9UP38
A 1 Reference(s)
T60I6V E3 SUMO-protein ligase PIAS3PIAS3 Q9Y6X2
A 1 Reference(s)
T02WMA Ornithine decarboxylaseODC1 P11926
A 1 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
A 1 Reference(s)
T00RT4 Inosine-5'-monophosphate dehydrogenase 1IMPDH1 P20839
A 1 Reference(s)
T42E30 DNA fragmentation factor subunit betaDFFB O76075
A 1 Reference(s)
T84W8G Aryl hydrocarbon receptorAHR P35869
A 1 Reference(s)
T58N83 Serine/threonine-protein kinase STK11STK11 Q15831
A 1 Reference(s)
T63BQU Cytochrome P450 1A1CYP1A1 P04798
A 1 Reference(s)
T85AXP Cytochrome P450 3A4CYP3A4 P08684
A 1 Reference(s)
T38EQ6 NAD(P)H dehydrogenase [quinone] 1NQO1 P15559
A 1 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
A 1 Reference(s)
T17YBS Transmembrane protease serine 11DTMPRSS11D O60235
A 1 Reference(s)
T87DEX Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenaseXDH P47989
A 1 Reference(s)
T11TKN Leucine-rich repeat serine/threonine-protein kinase 2LRRK2 Q5S007
A 1 Reference(s)
T37WY2 Phosphoenolpyruvate carboxykinase, cytosolic [GTP]PCK1 P35558
A 1 Reference(s)
T91T8I Glucose-6-phosphatase catalytic subunit 1G6PC1 P35575
A 1 Reference(s)
T08DG3 Histone acetyltransferase type B catalytic subunitHAT1 O14929
A 1 Reference(s)
T48XM4 Glutathione S-transferase Mu 2GSTM2 P28161
A 1 Reference(s)
T62F1Y Glutathione S-transferase A2GSTA2 P09210
A 1 Reference(s)
T76EHP Glutathione S-transferase A1GSTA1 P08263
A 1 Reference(s)
T87WYU Glutathione S-transferase Mu 1GSTM1 P09488
A 1 Reference(s)
T46AQJ Glutathione S-transferase PGSTP1 P09211
A 1 Reference(s)
T09DI4 Lysine-specific histone demethylase 1AKDM1A O60341
A 1 Reference(s)
T74LFK Neurogenic locus notch homolog protein 1NOTCH1 P46531
A 1 Reference(s)
T96OOK Signal transducer and activator of transcription 3STAT3 P40763
A 1 Reference(s)
T69XEM Tyrosine-protein kinase SYKSYK P43405
A 2 Reference(s)
T45WTI UDP-glucuronosyltransferase 1A4 (UGT1A4) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 2) (hUG-BR2) (UDP-glucuronosyltransferase 1-4) (UDPGT 1-4) (UGT1*4) (UGT1-04) (UGT1.4) (UDP-glucuronosyltransferase 1-D) (UGT-1D) (UGT1D)UGT1A4 P22310
A 1 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
A 2 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
A 2 Reference(s)
T21EGX Multidrug resistance-associated protein 1ABCC1 P33527
A 1 Reference(s)
T42D4V Histone deacetylase 1HDAC1 Q13547
A 1 Reference(s)
T30VNV MyeloperoxidaseMPO P05164
B 1 Reference(s)
T06Q1R Amine oxidase [flavin-containing] BMAOB P27338
B 1 Reference(s)
T21DZX Amine oxidase [flavin-containing] AMAOA P21397
B 1 Reference(s)
T80PUR Caspase-7CASP7 P55210
B 1 Reference(s)
T23P74 Caspase-9CASP9 P55211
B 1 Reference(s)
T90ORW Bcl2-associated agonist of cell deathBAD Q92934
B 1 Reference(s)
T07TMB Cyclin-dependent kinase 1CDK1 P06493
B 1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
B 1 Reference(s)
T98RXH Focal adhesion kinase 1PTK2 Q05397
B 1 Reference(s)
T49PL1 Low-density lipoprotein receptorLDLR P01130
B 1 Reference(s)
T43N2D Epidermal growth factor receptorEGFR P00533
B 1 Reference(s)
T85U8U Caspase-3CASP3 P42574
B 1 Reference(s)
T04PM9 TransthyretinTTR P02766
B 1 Reference(s)
T29BIB Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8)MAPK15 Q8TD08
B 1 Reference(s)
T05RAA Inhibitor of nuclear factor kappa-B kinase subunit alphaCHUK O15111
B 2 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
C 1 Reference(s)
T20JZ2 Androgen receptorAR P10275
C 1 Reference(s)
T37ADS Early growth response protein 1EGR1 P18146
C 1 Reference(s)
T09KQF Proliferating cell nuclear antigenPCNA P12004
C 1 Reference(s)
T01JSX Carbonyl reductase [NADPH] 1CBR1 P16152
C 1 Reference(s)
T68O49 Prostaglandin E2 receptor EP4 subtypePTGER4 P35408
C 1 Reference(s)
T26EZU Myc proto-oncogene proteinMYC P01106
C 1 Reference(s)
T97FEF Broad substrate specificity ATP-binding cassette transporter ABCG2ABCG2 Q9UNQ0
C 1 Reference(s)
T33OPP Interleukin-6IL6 P05231
C 1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
C 1 Reference(s)
T07NML P-selectinSELP P16109
C 1 Reference(s)
T24U57 E-selectinSELE P16581
C 1 Reference(s)
T84TJB Homeobox protein Nkx-3.1NKX3-1 Q99801
C 1 Reference(s)
T83P5X Inhibitor of nuclear factor kappa-B kinase subunit betaIKBKB O14920
C 1 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
C 1 Reference(s)
T17UP9 C-C motif chemokine 2CCL2 P13500
C 1 Reference(s)
T51DHZ Protein C-ets-1ETS1 P14921
C 1 Reference(s)
T73LPO Poly [ADP-ribose] polymerase 1PARP1 P09874
C 1 Reference(s)
T31P1D Metalloproteinase inhibitor 1TIMP1 P01033
C 1 Reference(s)
T88QQE Fibroblast growth factor 2FGF2 P09038
C 1 Reference(s)
T23OTN T-lymphocyte activation antigen CD80CD80 P33681
C 1 Reference(s)
T90QGN T-cell-specific surface glycoprotein CD28CD28 P10747
C 1 Reference(s)
T74I49 Bcl-2-like protein 1BCL2L1 Q07817
C 1 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
C 1 Reference(s)
T74QXI Serine/threonine-protein kinase mTORMTOR P42345
C 1 Reference(s)
T63YAO Caveolin-1CAV1 Q03135
C 1 Reference(s)
T63GUB Proto-oncogene c-FosFOS P01100
C 1 Reference(s)
T33OSQ Sterol regulatory element-binding protein 1SREBF1 P36956
C 1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
C 1 Reference(s)
T20H9F Stromelysin-1MMP3 P08254
C 1 Reference(s)
T71KM2 TGF-beta receptor type-1TGFBR1 P36897
C 1 Reference(s)
T94S85 Collagen alpha-1(I) chainCOL1A1 P02452
C 1 Reference(s)
T24LXT G2/mitotic-specific cyclin-B1CCNB1 P14635
C 1 Reference(s)
T64W2K Cyclin-dependent kinase inhibitor 1CDKN1A P38936
C 1 Reference(s)
T44LWL Transcription factor p65RELA Q04206
C 1 Reference(s)
T25H22 Protein kinase C beta typePRKCB P05771
C 1 Reference(s)
T40MAR Cadherin-11CDH11 P55287
C 1 Reference(s)
T84P70 Urokinase-type plasminogen activatorPLAU P00749
C 1 Reference(s)
T86ROZ Heme oxygenase 1HMOX1 P09601
C 1 Reference(s)
T65S3S Tyrosine-protein kinase JAK2JAK2 O60674
C 1 Reference(s)
T14LSK E3 ubiquitin-protein ligase XIAPXIAP P98170
C 1 Reference(s)
T74JJN Fatty acid synthaseFASN P49327
C 1 Reference(s)
T34VFO Platelet-derived growth factor receptor betaPDGFRB P09619
C 1 Reference(s)
T36SOV Plasminogen activator inhibitor 1SERPINE1 P05121
C 1 Reference(s)
T12T4H Brain-derived neurotrophic factorBDNF P23560
C 1 Reference(s)
T75IW3 Matrix metalloproteinase-14MMP14 P50281
C 1 Reference(s)
T34X07 CCAAT/enhancer-binding protein alphaCEBPA P49715
C 1 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
C 1 Reference(s)
T06PVX E3 ubiquitin-protein ligase Mdm2MDM2 Q00987
C 1 Reference(s)
T54CIF Interleukin-8CXCL8 P10145
C 1 Reference(s)
T19AGJ Tumor necrosis factor ligand superfamily member 13BTNFSF13B Q9Y275
C 1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
C 1 Reference(s)
T30L86 Tumor necrosis factor receptor superfamily member 10BTNFRSF10B O14763
C 1 Reference(s)
T62USB Tumor necrosis factor receptor superfamily member 10ATNFRSF10A O00220
C 1 Reference(s)
T31VDH Myeloid differentiation primary response protein MyD88MYD88 Q99836
C 1 Reference(s)
T17CZC Tissue factorF3 P13726
C 1 Reference(s)
T88BCB Glycerol-3-phosphate phosphatasePGP A6NDG6
C 1 Reference(s)
T75U40 Cytotoxic T-lymphocyte protein 4CTLA4 P16410
C 1 Reference(s)
T06URY Transcription factor Sp1SP1 P08047
C 1 Reference(s)
T73ATB Toll-like receptor 9TLR9 Q9NR96
C 1 Reference(s)
T11BI7 Toll-like receptor 4TLR4 O00206
C 1 Reference(s)
T28BLO Cyclic AMP-responsive element-binding protein 3-like protein 3CREB3L3 Q68CJ9
C 1 Reference(s)
T59IKQ Vascular cell adhesion protein 1VCAM1 P19320
C 1 Reference(s)
T75HMM Induced myeloid leukemia cell differentiation protein Mcl-1MCL1 Q07820
C 1 Reference(s)
T37PX5 Zinc finger protein GLI1GLI1 P08151
C 1 Reference(s)
T79KKF Protein patched homolog 1PTCH1 Q13635
C 1 Reference(s)
T10HL8 Intercellular adhesion molecule 1ICAM1 P05362
C 1 Reference(s)
T42XY2 Insulin-like growth factor 1 receptorIGF1R P08069
C 1 Reference(s)
T62IRH Inhibitor of growth protein 4ING4 Q9UNL4
C 1 Reference(s)
T50MQN NPC1-like intracellular cholesterol transporter 1NPC1L1 Q9UHC9
C 1 Reference(s)
T04MBA Vascular endothelial growth factor receptor 2KDR P35968
C 1 Reference(s)
T54D6L Angiopoietin-1ANGPT1 Q15389
C 1 Reference(s)
T72BXP Platelet endothelial cell adhesion moleculePECAM1 P16284
C 1 Reference(s)
T36K5T DnaJ homolog subfamily B member 4DNAJB4 Q9UDY4
C 1 Reference(s)
T71UHA Transcription factor jun-DJUND P17535
C 1 Reference(s)
T05CWL Arylamine N-acetyltransferase 1NAT1 P18440
C 1 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
C 1 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
C 1 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
C 1 Reference(s)
T95QJ9 G1/S-specific cyclin-D3CCND3 P30281
C 1 Reference(s)
T51TPZ Protein delta homolog 1DLK1 P80370
C 1 Reference(s)
T28V82 Wilms tumor proteinWT1 P19544
C 1 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
C 2 Reference(s)
T34DZ7 Interleukin-2IL2 P60568
C 1 Reference(s)
T44JTS Zinc finger and BTB domain-containing protein 7AZBTB7A O95365
C 1 Reference(s)
T06HS2 Tumor necrosis factor receptor superfamily member 11ATNFRSF11A Q9Y6Q6
C 1 Reference(s)
T16UHV Nuclear factor of activated T-cells, cytoplasmic 1NFATC1 O95644
C 1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
C 1 Reference(s)
T06MQM Heat shock protein beta-1HSPB1 P04792
C 1 Reference(s)
T18YXD AlbuminALB P02768
C 1 Reference(s)
T04R1T Major vault proteinMVP Q14764
C 1 Reference(s)
T55VKP CD9 antigenCD9 P21926
C 1 Reference(s)
T93WZG G1/S-specific cyclin-D1CCND1 P24385
C 1 Reference(s)
T62MI4 Extracellular matrix protein 1ECM1 Q16610
C 1 Reference(s)
T92BZ2 Catenin beta-1CTNNB1 P35222
C 1 Reference(s)
T83QHM Beta-nerve growth factorNGF P01138
C 1 Reference(s)
T87QUW Actin, aortic smooth muscleACTA2 P62736
C 1 Reference(s)
T14JSQ Baculoviral IAP repeat-containing protein 2BIRC2 Q13490
C 1 Reference(s)
T20PAH Ferritin heavy chain (Ferritin H subunit) (EC 1.16.3.1) (Cell proliferation-inducing gene 15 protein) [Cleaved into: Ferritin heavy chain, N-terminally processed]FTH1 P02794
C 1 Reference(s)
T02IOG Cyclin-dependent kinase inhibitor 1BCDKN1B P46527
C 1 Reference(s)
T03TCQ Receptor protein-tyrosine kinase (EC 2.7.10.1)EGFR Q504U8
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

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