Target Description

Type Detail
Target ID T02IOG
Protein Name Cyclin-dependent kinase inhibitor 1B
Uniprot ID P46527
Protein Name Alias Cyclin-dependent kinase inhibitor p27;  p27Kip1
Gene ID 1027
Gene Symbol CDKN1B
Gene Alias KIP1
TTD T14006: Research target
Pfam PF02234
GO
0030332:cyclin binding

0010942:positive regulation of cell death

0033673:negative regulation of kinase activity

0006977:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

0051087:chaperone binding

0019903:protein phosphatase binding

0045732:positive regulation of protein catabolic process

0048102:autophagic cell death

0004861:cyclin-dependent protein serine/threonine kinase inhibitor activity

0007507:heart development

1904706:negative regulation of vascular associated smooth muscle cell proliferation

0005829:cytosol

0031464:Cul4A-RING E3 ubiquitin ligase complex

0007050:cell cycle arrest

0030308:negative regulation of cell growth

0044877:protein-containing complex binding

1902806:regulation of cell cycle G1/S phase transition

0004860:protein kinase inhibitor activity

0005768:endosome

0005654:nucleoplasm

0045786:negative regulation of cell cycle

0005737:cytoplasm

0000079:regulation of cyclin-dependent protein serine/threonine kinase activity

0042326:negative regulation of phosphorylation

0071285:cellular response to lithium ion

0005634:nucleus

0019901:protein kinase binding

0019221:cytokine-mediated signaling pathway

1905179:negative regulation of cardiac muscle tissue regeneration

0045787:positive regulation of cell cycle

0045736:negative regulation of cyclin-dependent protein serine/threonine kinase activity

0045930:negative regulation of mitotic cell cycle

0045892:negative regulation of transcription, DNA-templated

1904030:negative regulation of cyclin-dependent protein kinase activity

0043231:intracellular membrane-bounded organelle

0000082:G1/S transition of mitotic cell cycle

0071850:mitotic cell cycle arrest

0008285:negative regulation of cell population proliferation

PDB 6P8E ; 2AST ; 6P8G ; 6P8F ; 6ATH ; 1H27 ; 5UQ3 ; 1JSU
Drugbank NA
KEGG hsa:1027

Related Compounds  (Total: 12)

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C0026
Name: Diosmetin
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C0325
Name: Progesterone
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C0385
Name: Salvianolic Acid A
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C0425
Name: Tangeretin
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C0482
Name: Vitamin E


Related Herbs  (Total: 211)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0351 Quan Shen拳参 BistortPolygonum bistorta
H0785 Ze Xi Huang Lian择细黄连 Coptis deltoideaCoptis chinensis
H0296 Niu Teng牛藤 twotooth achyranthes rootAchyranthes bidentata
H0088 Ju He橘核 Tangerine seedCitrus reticulata
H1227 Huai Zhi槐枝 NASophora japonica
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0029 Jiang Huang Lian姜黄连 Coptis deltoideaCoptis chinensis
H0651 Xiang Yuan香橼 Wilson citronCitrus medica
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H1128 Bai Jiang败酱 Whiteflower patriniaPatrinia villosa
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H1217 Bai Mei Hua白梅花 Japanese apricot flowerPrunus mume
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0201 Ma Huang Jin Gao麻黄浸膏 Chinese ephedraEphedra sinica
H0200 Ma Huang Gen麻黄根 Chinese ephedra rootEphedra sinica
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H0479 Shu Qu Cao鼠曲草 CudweedGnaphalium affine
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0819 Zhi Zi Jin Gao栀子浸膏 Cape jasmine fruitGardenia jasminoides
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0126 Lai Fu Zi莱菔子 Garden radish seedRaphanus sativus
H0676 Xin Yi Hua Jin Gao Fen辛夷花浸膏粉 MagnoliaMagnolia liliflora
H0153 Ling Zhi(1)灵芝 Lucid ganodermaGanoderma lucidum
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H0539 Tian Hua Fen天花粉 Mongolian snakegourd rootTrichosanthes kirilowii
H1111 Gua Lou Gen栝楼根 NATrichosanthes kirilowii
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H0383 San Qi Jing Ye三七茎叶 SanchiPanax notoginseng
H0667 Xiao Qing Pi小青皮 Green tangerine peelPericarpium citri reticulatae viride
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H0802 Zhi Geng枳梗 NACitrus aurantium
H0702 Yan Bai Cai岩白菜 Purple bergeniaBergenia purpurascens
H0551 Cang Zhu苍术 Swordlike atractylodesAtractylodes lancea
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H1105 Gua Lou Pi瓜蒌皮 NATrichosanthes kirilowii
H0357 Ren Shen人参 GinsengPanax ginseng
H0960 Dang Shen Qing Gao党参清膏 Root of hairy asiabellCodonopsis pilosula
H0709 Chang Shan常山 Antifebrile dichroaDichroa febrifuga
H0805 Zhi Ke Gan Jin Gao枳壳干浸膏 Seville ora nge unripe fruitCitrus aurantium
H0758 Cheng Pi橙皮 Bitter orangeCitrus aurantium
H1192 Hou Er Huan猴耳环 NAPithecellobium clypearia
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H0663 Xiao Ji小蓟 Setose thistleCirsium setosum
H0332 Qiao Mai荞麦 Common buckwheatFagopyrum esculentum
H0466 Cai Fu Zi菜菔子 Semen raphaniRaphanus sativus
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H0072 Jing Jie荆芥 Fineleaf schizonepetaSchizonepeta tenuifolia
H0155 Ban Xia半夏 Ternate pinelliaPinellia ternata
H0872 Chuan Huang Lian川黄连 rhizome of chinese goldthreadCoptis chinensis
H0297 Niu Xi牛膝 Twotooth achyranthesAchyranthes bidentata
H0433 She Ma Zi蛇麻子 Common cnidium fruitCnidium monnieri
H0887 Chuan Xin Lian Gan Jin Gao穿心莲干浸膏 Common andrographisAndrographis paniculata
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0082 Jiu Huang Lian酒黄连 Coptis deltoideaCoptis chinensis
H0891 Chuan Xin Lian Ye穿心莲叶 Powder of green chiretta leavesAndrographis herba
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H0682 Xiong Huang Lian雄黄连 Coptis deltoideaCoptis chinensis
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H0519 Suo Yang锁阳 Songaria cynomoriumCynomorium songaricum
H0370 Ru Xiang乳香 OlibanumBoswellia carterii
H0104 Bai Zhu白术 Largehead atractylodesAtractylodes macrocephala
H0273 Mu Tong木通 Fiveleaf akebiaAkebia quinata
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H0977 Bai Bu百部 Tuber stemonaStemona tuberosa
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0134 Li Zhi He荔枝核 Lychee seedLitchi chinensis
H0962 Dao Dou刀豆 Sword jackbeanCanavalia gladiata
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H1104 Gua Lou瓜蒌 NATrichosanthes kirilowii
H0347 Qing Pi青皮 Green tangerine peelPericarpium citri reticulatae viride
H0674 Xin Yi辛夷 Lily magnolia budsMagnolia liliflora
H0792 Zhang Yu章鱼 Common atlantic octopusOctopus vulgaris
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H0782 Zao Xiu蚤休 NAParis polyphylla
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H0979 Di Yu地榆 Garden burnetSanguisorba officinalis
H0818 Zhi Zi栀子 Cape jasmine fruitGardenia jasminoides
H0384 San Qi Ye三七叶 Folium panax notoginsengPanax notoginseng
H0527 Tao PeachPrunus persica
H0889 Chuan Xin Lian Jin Gao穿心莲浸膏 Common andrographisAndrographis paniculata
H0967 Di Er Cao地耳草 Japanese stJohn’swortHypericum japonicum
H0678 Xin Yi Ren辛夷仁 MagnoliaMagnolia liliflora
H0318 Pu Tao(1)蒲桃 SyzygiumSyzygium jambos
H1170 He Zi诃子 Medicine terminaliaTerminalia chebula
H0046 Jin Gan金柑 Japanese kumquatFortunella japonica
H0381 San Qi Gao Fen三七膏粉 SanchiPanax notoginseng
H1208 Hu Ma Ren胡麻仁 white seed of oriental sesameSesamum indicum
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H0675 Xin Yi Hua辛夷花 MagnoliaMagnolia liliflora
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H1241 Huang Lian黄连 Coptis deltoideaCoptis chinensis
H0416 Shan Shen山参 NAPanax ginseng
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0113 Ban Bian Lian半边莲 Chinese lobeliaLobelia chinensis
H0714 Yan Tai Chai Hu烟台柴胡 Chinese thorowaxBupleurum chinense
H0256 Ming Dang Shen明党参 Medicinal changiumChangium smyrnioides
H0159 Ban Xia Qu半夏曲 Pinellia tuber leavenPinellia ternata
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0604 Wu Wei Teng五味藤 NASecuridaca inappendiculata
H0424 Shan Zhi山栀 Cape jasmineGardenia jasminoides
H0602 Wu Mei Rou乌梅肉 EbonyPrunus mume
H0744 Yin Chai Hu银柴胡 Lanceolate starwortStellaria dichotoma var. lanceolata
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0052 Jin Ju金橘 Oval kumquatFortunella margarita
H0650 Chai Hu柴胡 Chinese thorowaxBupleurum chinense
H0930 Da Ji Gen大蓟根 NAHerba cirsii japonici
H1004 Bai Cha白茶 White teaCamellia sinensis
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H0659 Chai Hu Jin Gao柴胡浸膏 Chinese thorowaxBupleurum chinense
H0385 San Qi Ye Jing三七叶茎 SanchiPanax notoginseng
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H1247 Huang Qi黄芪 Membranous milkvetchAstragalus membranaceus
H0920 Da Ban Bian Lian大半边莲 Asian lobeliaLobelia chinensis
H0982 Bai Bu Gan Gao百部干膏 Tuber stemonaStemona tuberosa
H0382 San Qi Hua三七花 SanchiPanax notoginseng
H0976 Di Qing Pi地青皮 NAPericarpium citri reticulatae viride
H0958 Dang Shen党参 Pilose asiabellCodonopsis pilosula
H0991 Bai Bu Liu Jin Gao百部流浸膏 Tuber stemonaStemona tuberosa
H0043 Jie Zi芥子 India mustard seedBrassica juncea
H0886 Chuan Xin Lian穿心莲 Common andrographisAndrographis paniculata
H0760 Yu Huang Lian萸黄连 Coptis deltoideaCoptis chinensis
H1106 Gua Lou Ren瓜蒌仁 NATrichosanthes kirilowii
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H0198 Ma Huang Gao麻黄膏 Chinese ephedraEphedra sinica
H0933 Da Ji(1)大蓟 NAHerba cirsii japonici
H0719 Chen Pi陈皮 Dried tangerine peelPericarpium citri reticulatae
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H1112 Gua Lou Ren(1)栝楼仁 NATrichosanthes kirilowii
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H1090 Gao Ben藁本 Chinese ligusticumLigusticum sinense
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H1108 Gua Lou Shi栝蒌实 NATrichosanthes kirilowii
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0093 Ju Pi橘皮 Tangerine pericarpCitrus reticulata
H0665 Chai Hu Shao柴胡梢 Chinese thorowaxBupleurum chinense
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0565 Tu Bie Chong土鳖虫 CockroachEupolyphaga sinensis
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H1030 Fang Feng防风 Divaricate saposhnikoviaSaposhnikovia divaricata
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0601 Wu Mei乌梅 Japanese apricotPrunus mume
H1232 Huang Cao Wu黄草乌 NAAconitum vilmorinianum
H0980 Di Yu Tan地榆炭 Garden burnetSanguisorba officinalis
H0239 Bei Sha Shen北沙参 Coastal glehniaGlehnia littoralis
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0652 Xiang Yuan Pi香橼皮 Wilson citronCitrus medica
H1203 Hu Ji Sheng槲寄生 Colored mistletoeViscum coloratum
H1225 Huai Mi槐米 NASophora japonica
H0890 Chuan Xin Lian Nong Suo Ye穿心莲浓缩液 Common andrographisAndrographis paniculata
H1250 Huang Qi Ti Qu Ye黄芪提取液 Membranous milkvetchAstragalus membranaceus
H0338 Qing Ban Xia清半夏 Ternate pinelliaPinellia ternata
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0242 Bei Sha Shen Liu Jin Gao北沙参流浸膏 Glehnia littoralisGlehnia littoralis
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0729 Ye Ju Hua野菊花 Indian wild chrysanthemum flowerChrysanthemum indicum
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H1181 Hei Zhi Ma黑芝麻 Oriental sesameSesamum indicum
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H0987 Bai Bu Jin Gao百部浸膏 Tuber stemonaStemona tuberosa
H0125 Lai Fu莱菔 Garden radishRaphanus sativus
H0258 Mo Han Lian墨旱莲 YerbadetajoEclipta prostrata
H1194 Hou Er Huan Jin Gao猴耳环浸膏 NAPithecellobium clypearia
H1243 Huang Lian Xu黄连须 Coptis deltoideaCoptis chinensis
H0430 She Chuang Zi蛇床子 Common cnidiumCnidium monnieri
H1193 Hou Er Huan Gan Jin Gao猴耳环干浸膏 NAPithecellobium clypearia
H0801 Chong Bai La虫白蜡 Cera chinensis waxEricerus pela
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0233 Mao Liang Mian Zhen毛两面针 NAZanthoxylum nitidum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0197 Ma Huang麻黄 Chinese ephedraEphedra sinica
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H0439 Sheng Ban Xia生半夏 Ternate pinelliaPinellia ternata
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H1110 Gua Lou Zi瓜蒌子 mongolian snakegourd seedTrichosanthes kirilowii maxim
H1171 He Zi Rou诃子肉 Medicine terminaliaTerminalia chebula
H0074 Jing Jie Tan荆芥炭 NASchizonepetae herba
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0322 Qi Ye Yi Zhi Hua七叶一枝花 rhizome of verticillate parisParis polyphylla
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0547 Cang Qing Guo藏青果 MyrobalanTerminalia chebula
H1054 Fu Ling Pi茯苓皮 Indian bread peelExodermis poria
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0380 San Qi Gan Jin Gao三七干浸膏 SanchiPanax notoginseng
H1249 Huang Qi Jin Gao黄芪浸膏 Membranous milkvetchAstragalus membranaceus
H0931 Da Ji Gen Jin Gao大蓟根浸膏 NAHerba cirsii japonici
H0246 Mi Ma Huang蜜麻黄 Ephedra equisetinEphedra sinica
H1107 Gua Lou Ren Shuang瓜蒌仁霜 NATrichosanthes kirilowii
H0679 Xing Ren杏仁 Apricot seedPrunus armeniaca
H1248 Huang Qi Gan Jin Gao黄芪干浸膏 Membranous milkvetchAstragalus membranaceus
H1242 Huang Lian Gan Jin Gao黄连干浸膏 Coptis deltoideaCoptis chinensis
H1207 Hu Ma胡麻 white seed of oriental sesameSesamum indicum
H0152 Ling Zhi Jin Gao灵芝浸膏 NAGanoderma lucidum
H0813 Zhi Shi枳实 Seville orange young fruitCitrus aurantium