Herb Description

Herb ID:   H0297 Chinese Character:   牛膝
English Name:  Twotooth achyranthes Latin Name:  Achyranthes bidentata
Chinese Pin Yin :  Niu Xi TCM-ID:  TCMH1588
Therapeutic Function in Chinese :  活血化淤 Therapeutic Function in English:  Blood activation and stasis removal
Herb Function:  Replenish the liver and the kidney, strengthen the tendons and bones, eliminate blood stasis and stimulate menstrual discharge, and lead the blood flow downward

Related Targets  (Total: 116)

Target idProtein NameGene SymbolUniprot IDNo.of Literature Evidence
T44LWL Transcription factor p65RELA Q04206
1 Reference(s)
T06MXL NeprilysinMME P08473
1 Reference(s)
T40LTN Phospholipase A2, membrane associatedPLA2G2A P14555
1 Reference(s)
T02WMA Ornithine decarboxylaseODC1 P11926
1 Reference(s)
T25H22 Protein kinase C beta typePRKCB P05771
1 Reference(s)
T56TXY Polyunsaturated fatty acid 5-lipoxygenaseALOX5 P09917
1 Reference(s)
T64F54 Mineralocorticoid receptorNR3C2 P08235
1 Reference(s)
T24G2P Serum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1)PON3 Q15166
1 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
1 Reference(s)
T89GFN Macrophage migration inhibitory factorMIF P14174
1 Reference(s)
T22NX4 Toll-like receptor 2TLR2 O60603
1 Reference(s)
T76QBQ CREB-regulated transcription coactivator 2CRTC2 Q53ET0
1 Reference(s)
T43XD8 Carbonic anhydrase 2CA2 P00918
1 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
1 Reference(s)
T33OSQ Sterol regulatory element-binding protein 1SREBF1 P36956
2 Reference(s)
T37VLU Interferon gammaIFNG P01579
2 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
3 Reference(s)
T26EZU Myc proto-oncogene proteinMYC P01106
2 Reference(s)
T85U8U Caspase-3CASP3 P42574
10 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
1 Reference(s)
T05PKX Steroid 17-alpha-hydroxylase/17,20 lyaseCYP17A1 P05093
1 Reference(s)
T85S9Z Cholesterol side-chain cleavage enzyme, mitochondrialCYP11A1 P05108
1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
1 Reference(s)
T43N2D Epidermal growth factor receptorEGFR P00533
2 Reference(s)
T20JZ2 Androgen receptorAR P10275
1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
3 Reference(s)
T53G91 NischarinNISCH Q9Y2I1
1 Reference(s)
T23P74 Caspase-9CASP9 P55211
5 Reference(s)
T50SJ8 5'-AMP-activated protein kinase catalytic subunit alpha-2PRKAA2 P54646
1 Reference(s)
T67KTV Transient receptor potential cation channel subfamily V member 1TRPV1 Q8NER1
3 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
2 Reference(s)
T68SE0 Solute carrier family 2, facilitated glucose transporter member 4SLC2A4 P14672
1 Reference(s)
T41INV Nuclear receptor subfamily 1 group I member 3NR1I3 Q14994
1 Reference(s)
T42K6K M-phase inducer phosphatase 3CDC25C P30307
1 Reference(s)
T04A2Q Serine/threonine-protein kinase PLK1PLK1 P53350
1 Reference(s)
T07TMB Cyclin-dependent kinase 1CDK1 P06493
1 Reference(s)
T01QLH Estrogen receptorESR1 P03372
5 Reference(s)
T38T1U Caspase-8CASP8 Q14790
1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
4 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
1 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
2 Reference(s)
T10HL8 Intercellular adhesion molecule 1ICAM1 P05362
2 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
1 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
2 Reference(s)
T32ECR Collagen alpha-2(I) chainCOL1A2 P08123
1 Reference(s)
T50E9D Metallothionein-3MT3 P25713
1 Reference(s)
T24U57 E-selectinSELE P16581
1 Reference(s)
T63GUB Proto-oncogene c-FosFOS P01100
1 Reference(s)
T82ALJ Glycogen synthase kinase-3 betaGSK3B P49841
1 Reference(s)
T79KQO NF-kappa-B inhibitor alphaNFKBIA P25963
1 Reference(s)
T17CNB ThioredoxinTXN P10599
1 Reference(s)
T21T2E Extracellular superoxide dismutase [Cu-Zn]SOD3 P08294
1 Reference(s)
T70SFS Superoxide dismutase [Mn], mitochondrialSOD2 P04179
1 Reference(s)
T16A2X CatalaseCAT P04040
1 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
1 Reference(s)
T56MD7 Glutathione hydrolase 5 proenzymeGGT5 P36269
1 Reference(s)
T87CV3 Guanylate cyclase soluble subunit beta-1GUCY1B1 Q02153
1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
2 Reference(s)
T21Q0D 3-hydroxy-3-methylglutaryl-coenzyme A reductaseHMGCR P04035
1 Reference(s)
T02QBS Cytochrome P450 1A2CYP1A2 P05177
1 Reference(s)
T63BQU Cytochrome P450 1A1CYP1A1 P04798
1 Reference(s)
T70HTD Cytochrome P450 2E1CYP2E1 P05181
1 Reference(s)
T11R4S Tumor necrosis factor receptor superfamily member 5CD40 P25942
1 Reference(s)
T47MPW T-lymphocyte activation antigen CD86CD86 P42081
1 Reference(s)
T59IKQ Vascular cell adhesion protein 1VCAM1 P19320
1 Reference(s)
T30KQB Alanine aminotransferase 1GPT P24298
1 Reference(s)
T42XY2 Insulin-like growth factor 1 receptorIGF1R P08069
1 Reference(s)
T30D9G Superoxide dismutase [Cu-Zn]SOD1 P00441
2 Reference(s)
T02OOS C-C chemokine receptor type 5CCR5 P51681
1 Reference(s)
T26TBJ Calpain-1 catalytic subunitCAPN1 P07384
1 Reference(s)
T32EIL F-box only protein 32FBXO32 Q969P5
1 Reference(s)
T92LEW Inactive caspase-12CASP12 Q6UXS9
1 Reference(s)
T96ABY E3 ubiquitin-protein ligase TRIM63TRIM63 Q969Q1
1 Reference(s)
T50V79 Interleukin-4IL4 P05112
1 Reference(s)
T83YZD AcetylcholinesteraseACHE P22303
1 Reference(s)
T02IOG Cyclin-dependent kinase inhibitor 1BCDKN1B P46527
1 Reference(s)
T71B0A Cytosolic phospholipase A2PLA2G4A P47712
1 Reference(s)
T93SFQ NAD-dependent protein deacetylase sirtuin-1SIRT1 Q96EB6
2 Reference(s)
T33JGV Tumor suppressor ARF;Cyclin-dependent kinase inhibitor 2ACDKN2A Q8N726;P42771
1 Reference(s)
T94H37 Cadherin-1CDH1 P12830
1 Reference(s)
T78ZF2 Protein kinase C alpha typePRKCA P17252
2 Reference(s)
T28HOM LeptinLEP P41159
1 Reference(s)
T36SOV Plasminogen activator inhibitor 1SERPINE1 P05121
1 Reference(s)
T17CZC Tissue factorF3 P13726
1 Reference(s)
T40JZG GPI-anchor transamidasePIGK Q92643
1 Reference(s)
T69NG6 Interleukin-10IL10 P22301
1 Reference(s)
T51EKP Apolipoprotein MAPOM O95445
1 Reference(s)
T07VV7 GuanylinGUCA2A Q02747
1 Reference(s)
T67ZT3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN P60484
1 Reference(s)
T80WPU Protein ABHD15ABHD15 Q6UXT9
1 Reference(s)
T56OUM 14-3-3 protein zeta/deltaYWHAZ P63104
1 Reference(s)
T24YWQ Insulin-degrading enzymeIDE P14735
1 Reference(s)
T34HYH Interleukin-1 alphaIL1A P01583
1 Reference(s)
T54B00 P2X purinoceptor 7P2RX7 Q99572
1 Reference(s)
T20H9F Stromelysin-1MMP3 P08254
1 Reference(s)
T89L4V InsulinINS P01308
1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
1 Reference(s)
T42HHN Follicle-stimulating hormone receptorFSHR P23945
1 Reference(s)
T43NBB Solute carrier family 2, facilitated glucose transporter member 2SLC2A2 P11168
1 Reference(s)
T90ADC BH3-interacting domain death agonistBID P55957
1 Reference(s)
T05O6O Estrogen receptor betaESR2 Q92731
1 Reference(s)
T09KPZ VimentinVIM P08670
1 Reference(s)
T84W8G Aryl hydrocarbon receptorAHR P35869
1 Reference(s)
T69X4A 14-3-3 protein sigmaSFN P31947
1 Reference(s)
T58H37 Perforin-1PRF1 P14222
1 Reference(s)
T16CFE Lysosome-associated membrane glycoprotein 1LAMP1 P11279
1 Reference(s)
T14ENF Microtubule-associated protein 2MAP2 P11137
1 Reference(s)
T93VFT Endothelin-1EDN1 P05305
1 Reference(s)
T94AGC [F-actin]-monooxygenase MICAL1MICAL1 Q8TDZ2
1 Reference(s)
T48K08 Procathepsin LCTSL P07711
1 Reference(s)
T38BR0 G1/S-specific cyclin-D2CCND2 P30279
1 Reference(s)
T57L0X Oxysterols receptor LXR-alphaNR1H3 Q13133
1 Reference(s)
T34Y8V Oxysterols receptor LXR-betaNR1H2 P55055
1 Reference(s)
T86ROZ Heme oxygenase 1HMOX1 P09601
1 Reference(s)
T38EQ6 NAD(P)H dehydrogenase [quinone] 1NQO1 P15559
1 Reference(s)

Related Compounds  (Total: 13)

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C0482
Name: Vitamin E
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C0285
Name: Palmitic Acid
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C1240
Name: Chrysophanol
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C0922
Name: Arjunolic Acid
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C1179
Name: Betulin