Herb Description
| Herb ID: H0297 | Chinese Character: 牛膝 |
| English Name: Twotooth achyranthes | Latin Name: Achyranthes bidentata |
| Chinese Pin Yin : Niu Xi | TCM-ID: TCMH1588 |
| Therapeutic Function in Chinese : 活血化淤 | Therapeutic Function in English: Blood activation and stasis removal |
| Herb Function: Replenish the liver and the kidney, strengthen the tendons and bones, eliminate blood stasis and stimulate menstrual discharge, and lead the blood flow downward | |
Related Targets (Total: 116)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
1 Reference(s) |
| T06MXL | Neprilysin | MME |
P08473 |
1 Reference(s) |
| T40LTN | Phospholipase A2, membrane associated | PLA2G2A |
P14555 |
1 Reference(s) |
| T02WMA | Ornithine decarboxylase | ODC1 |
P11926 |
1 Reference(s) |
| T25H22 | Protein kinase C beta type | PRKCB |
P05771 |
1 Reference(s) |
| T56TXY | Polyunsaturated fatty acid 5-lipoxygenase | ALOX5 |
P09917 |
1 Reference(s) |
| T64F54 | Mineralocorticoid receptor | NR3C2 |
P08235 |
1 Reference(s) |
| T24G2P | Serum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) | PON3 |
Q15166 |
1 Reference(s) |
| T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
1 Reference(s) |
| T89GFN | Macrophage migration inhibitory factor | MIF |
P14174 |
1 Reference(s) |
| T22NX4 | Toll-like receptor 2 | TLR2 |
O60603 |
1 Reference(s) |
| T76QBQ | CREB-regulated transcription coactivator 2 | CRTC2 |
Q53ET0 |
1 Reference(s) |
| T43XD8 | Carbonic anhydrase 2 | CA2 |
P00918 |
1 Reference(s) |
| T29MD1 | Mitogen-activated protein kinase 8 | MAPK8 |
P45983 |
1 Reference(s) |
| T33OSQ | Sterol regulatory element-binding protein 1 | SREBF1 |
P36956 |
2 Reference(s) |
| T37VLU | Interferon gamma | IFNG |
P01579 |
2 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
3 Reference(s) |
| T26EZU | Myc proto-oncogene protein | MYC |
P01106 |
2 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
10 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
1 Reference(s) |
| T05PKX | Steroid 17-alpha-hydroxylase/17,20 lyase | CYP17A1 |
P05093 |
1 Reference(s) |
| T85S9Z | Cholesterol side-chain cleavage enzyme, mitochondrial | CYP11A1 |
P05108 |
1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
1 Reference(s) |
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
2 Reference(s) |
| T20JZ2 | Androgen receptor | AR |
P10275 |
1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
3 Reference(s) |
| T53G91 | Nischarin | NISCH |
Q9Y2I1 |
1 Reference(s) |
| T23P74 | Caspase-9 | CASP9 |
P55211 |
5 Reference(s) |
| T50SJ8 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | PRKAA2 |
P54646 |
1 Reference(s) |
| T67KTV | Transient receptor potential cation channel subfamily V member 1 | TRPV1 |
Q8NER1 |
3 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
2 Reference(s) |
| T68SE0 | Solute carrier family 2, facilitated glucose transporter member 4 | SLC2A4 |
P14672 |
1 Reference(s) |
| T41INV | Nuclear receptor subfamily 1 group I member 3 | NR1I3 |
Q14994 |
1 Reference(s) |
| T42K6K | M-phase inducer phosphatase 3 | CDC25C |
P30307 |
1 Reference(s) |
| T04A2Q | Serine/threonine-protein kinase PLK1 | PLK1 |
P53350 |
1 Reference(s) |
| T07TMB | Cyclin-dependent kinase 1 | CDK1 |
P06493 |
1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
5 Reference(s) |
| T38T1U | Caspase-8 | CASP8 |
Q14790 |
1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
4 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
1 Reference(s) |
| T53AOE | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide | TGFB1 |
P01137 |
2 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
2 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
2 Reference(s) |
| T32ECR | Collagen alpha-2(I) chain | COL1A2 |
P08123 |
1 Reference(s) |
| T50E9D | Metallothionein-3 | MT3 |
P25713 |
1 Reference(s) |
| T24U57 | E-selectin | SELE |
P16581 |
1 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
1 Reference(s) |
| T82ALJ | Glycogen synthase kinase-3 beta | GSK3B |
P49841 |
1 Reference(s) |
| T79KQO | NF-kappa-B inhibitor alpha | NFKBIA |
P25963 |
1 Reference(s) |
| T17CNB | Thioredoxin | TXN |
P10599 |
1 Reference(s) |
| T21T2E | Extracellular superoxide dismutase [Cu-Zn] | SOD3 |
P08294 |
1 Reference(s) |
| T70SFS | Superoxide dismutase [Mn], mitochondrial | SOD2 |
P04179 |
1 Reference(s) |
| T16A2X | Catalase | CAT |
P04040 |
1 Reference(s) |
| T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
1 Reference(s) |
| T56MD7 | Glutathione hydrolase 5 proenzyme | GGT5 |
P36269 |
1 Reference(s) |
| T87CV3 | Guanylate cyclase soluble subunit beta-1 | GUCY1B1 |
Q02153 |
1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
2 Reference(s) |
| T21Q0D | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR |
P04035 |
1 Reference(s) |
| T02QBS | Cytochrome P450 1A2 | CYP1A2 |
P05177 |
1 Reference(s) |
| T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
1 Reference(s) |
| T70HTD | Cytochrome P450 2E1 | CYP2E1 |
P05181 |
1 Reference(s) |
| T11R4S | Tumor necrosis factor receptor superfamily member 5 | CD40 |
P25942 |
1 Reference(s) |
| T47MPW | T-lymphocyte activation antigen CD86 | CD86 |
P42081 |
1 Reference(s) |
| T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
1 Reference(s) |
| T30KQB | Alanine aminotransferase 1 | GPT |
P24298 |
1 Reference(s) |
| T42XY2 | Insulin-like growth factor 1 receptor | IGF1R |
P08069 |
1 Reference(s) |
| T30D9G | Superoxide dismutase [Cu-Zn] | SOD1 |
P00441 |
2 Reference(s) |
| T02OOS | C-C chemokine receptor type 5 | CCR5 |
P51681 |
1 Reference(s) |
| T26TBJ | Calpain-1 catalytic subunit | CAPN1 |
P07384 |
1 Reference(s) |
| T32EIL | F-box only protein 32 | FBXO32 |
Q969P5 |
1 Reference(s) |
| T92LEW | Inactive caspase-12 | CASP12 |
Q6UXS9 |
1 Reference(s) |
| T96ABY | E3 ubiquitin-protein ligase TRIM63 | TRIM63 |
Q969Q1 |
1 Reference(s) |
| T50V79 | Interleukin-4 | IL4 |
P05112 |
1 Reference(s) |
| T83YZD | Acetylcholinesterase | ACHE |
P22303 |
1 Reference(s) |
| T02IOG | Cyclin-dependent kinase inhibitor 1B | CDKN1B |
P46527 |
1 Reference(s) |
| T71B0A | Cytosolic phospholipase A2 | PLA2G4A |
P47712 |
1 Reference(s) |
| T93SFQ | NAD-dependent protein deacetylase sirtuin-1 | SIRT1 |
Q96EB6 |
2 Reference(s) |
| T33JGV | Tumor suppressor ARF;Cyclin-dependent kinase inhibitor 2A | CDKN2A |
Q8N726;P42771 |
1 Reference(s) |
| T94H37 | Cadherin-1 | CDH1 |
P12830 |
1 Reference(s) |
| T78ZF2 | Protein kinase C alpha type | PRKCA |
P17252 |
2 Reference(s) |
| T28HOM | Leptin | LEP |
P41159 |
1 Reference(s) |
| T36SOV | Plasminogen activator inhibitor 1 | SERPINE1 |
P05121 |
1 Reference(s) |
| T17CZC | Tissue factor | F3 |
P13726 |
1 Reference(s) |
| T40JZG | GPI-anchor transamidase | PIGK |
Q92643 |
1 Reference(s) |
| T69NG6 | Interleukin-10 | IL10 |
P22301 |
1 Reference(s) |
| T51EKP | Apolipoprotein M | APOM |
O95445 |
1 Reference(s) |
| T07VV7 | Guanylin | GUCA2A |
Q02747 |
1 Reference(s) |
| T67ZT3 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN |
P60484 |
1 Reference(s) |
| T80WPU | Protein ABHD15 | ABHD15 |
Q6UXT9 |
1 Reference(s) |
| T56OUM | 14-3-3 protein zeta/delta | YWHAZ |
P63104 |
1 Reference(s) |
| T24YWQ | Insulin-degrading enzyme | IDE |
P14735 |
1 Reference(s) |
| T34HYH | Interleukin-1 alpha | IL1A |
P01583 |
1 Reference(s) |
| T54B00 | P2X purinoceptor 7 | P2RX7 |
Q99572 |
1 Reference(s) |
| T20H9F | Stromelysin-1 | MMP3 |
P08254 |
1 Reference(s) |
| T89L4V | Insulin | INS |
P01308 |
1 Reference(s) |
| T88AJI | Hypoxia-inducible factor 1-alpha | HIF1A |
Q16665 |
1 Reference(s) |
| T42HHN | Follicle-stimulating hormone receptor | FSHR |
P23945 |
1 Reference(s) |
| T43NBB | Solute carrier family 2, facilitated glucose transporter member 2 | SLC2A2 |
P11168 |
1 Reference(s) |
| T90ADC | BH3-interacting domain death agonist | BID |
P55957 |
1 Reference(s) |
| T05O6O | Estrogen receptor beta | ESR2 |
Q92731 |
1 Reference(s) |
| T09KPZ | Vimentin | VIM |
P08670 |
1 Reference(s) |
| T84W8G | Aryl hydrocarbon receptor | AHR |
P35869 |
1 Reference(s) |
| T69X4A | 14-3-3 protein sigma | SFN |
P31947 |
1 Reference(s) |
| T58H37 | Perforin-1 | PRF1 |
P14222 |
1 Reference(s) |
| T16CFE | Lysosome-associated membrane glycoprotein 1 | LAMP1 |
P11279 |
1 Reference(s) |
| T14ENF | Microtubule-associated protein 2 | MAP2 |
P11137 |
1 Reference(s) |
| T93VFT | Endothelin-1 | EDN1 |
P05305 |
1 Reference(s) |
| T94AGC | [F-actin]-monooxygenase MICAL1 | MICAL1 |
Q8TDZ2 |
1 Reference(s) |
| T48K08 | Procathepsin L | CTSL |
P07711 |
1 Reference(s) |
| T38BR0 | G1/S-specific cyclin-D2 | CCND2 |
P30279 |
1 Reference(s) |
| T57L0X | Oxysterols receptor LXR-alpha | NR1H3 |
Q13133 |
1 Reference(s) |
| T34Y8V | Oxysterols receptor LXR-beta | NR1H2 |
P55055 |
1 Reference(s) |
| T86ROZ | Heme oxygenase 1 | HMOX1 |
P09601 |
1 Reference(s) |
| T38EQ6 | NAD(P)H dehydrogenase [quinone] 1 | NQO1 |
P15559 |
1 Reference(s) |
Related Compounds (Total: 13)
C0482
Name: Vitamin E
C0285
Name: Palmitic Acid
C1240
Name: Chrysophanol
C0922
Name: Arjunolic Acid
C1179
Name: Betulin
key description of the interaction between compound and target