Target Description

Type Detail
Target ID T89GFN
Protein Name Macrophage migration inhibitory factor
Uniprot ID P14174
Protein Name Alias MIF;  EC 5.3.2.1;  Glycosylation-inhibiting factor;  GIF;  L-dopachrome isomerase;  L-dopachrome tautomerase;  EC 5.3.3.12;  Phenylpyruvate tautomerase
Gene ID 4282
Gene Symbol MIF
Gene Alias GLIF;  MMIF
TTD T39977: Clinical Trial target
Pfam PF01187
GO
0071157:negative regulation of cell cycle arrest

0031982:vesicle

0005829:cytosol

0009986:cell surface

0030336:negative regulation of cell migration

0006954:inflammatory response

0090344:negative regulation of cell aging

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0043066:negative regulation of apoptotic process

0043518:negative regulation of DNA damage response, signal transduction by p53 class mediator

1904813:ficolin-1-rich granule lumen

0042802:identical protein binding

0005615:extracellular space

0005654:nucleoplasm

0005125:cytokine activity

0050178:phenylpyruvate tautomerase activity

0050900:leukocyte migration

0035722:interleukin-12-mediated signaling pathway

0010629:negative regulation of gene expression

0070062:extracellular exosome

0007166:cell surface receptor signaling pathway

0001819:positive regulation of cytokine production

0010739:positive regulation of protein kinase A signaling

1902166:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

0033138:positive regulation of peptidyl-serine phosphorylation

0042327:positive regulation of phosphorylation

0042056:chemoattractant activity

0043312:neutrophil degranulation

0005126:cytokine receptor binding

0070374:positive regulation of ERK1 and ERK2 cascade

0043030:regulation of macrophage activation

0032760:positive regulation of tumor necrosis factor production

0005576:extracellular region

0070207:protein homotrimerization

0045087:innate immune response

0010760:negative regulation of macrophage chemotaxis

0005886:plasma membrane

0034774:secretory granule lumen

0048146:positive regulation of fibroblast proliferation

0019752:carboxylic acid metabolic process

0030890:positive regulation of B cell proliferation

0005737:cytoplasm

0001516:prostaglandin biosynthetic process

0004167:dopachrome isomerase activity

PDB 5UMK ; 1P1G ; 5UZY ; 3B9S ; 6OYG ; 3SMB ; 4XX7 ; 4F2K ; 3U18 ; 5BSC ; 3L5V ; 1LJT ; 3L5U ; 3L5R ; 4EVG ; 3HOF ; 3SMC ; 6OY8 ; 4TRU ; 4GRU ; 3L5P ; 5V73 ; 4GRR ; 4Z1U ; 1CA7 ; 4PLU ; 5J7Q ; 3IJG ; 4Z1T ; 4K9G ; 4GRO ; 5HVT ; 4EUI ; 4WR8 ; 1GIF ; 2OOH ; 1MIF ; 4GRP ; 6CBG ; 5HVS ; 5B4O ; 5EIZ ; 5XEJ ; 5V70 ; 1GCZ ; 4ETG ; 6PEG ; 6BG7 ; 4P0H ; 6OYB ; 4PKK ; 4TRF ; 4Z15 ; 3IJJ ; 5UMJ ; 6CBF ; 4GUM ; 5BSJ ; 5J7P ; 4OYQ ; 2OOW ; 6FVH ; 6B1K ; 1CGQ ; 4OSF ; 6OYE ; 3L5S ; 3WNR ; 3L5T ; 3JSF ; 3CE4 ; 3DJI ; 6B1C ; 4GRN ; 4P01 ; 3JTU ; 4WRB ; 3WNT ; 3DJH ; 3JSG ; 6B2C ; 6CBH ; 1GD0 ; 5BSI ; 5BS9 ; 2OOZ ; 4XX8 ; 3WNS ; 6BG6 ; 4PKZ ; 5HVV ; 6FVE ; 6CB5 ; 4GRQ
Drugbank DB07888 ; DB01880 ; DB08335 ; DB08334 ; DB07718 ; DB08333 ; DB02728 ; DB08765
KEGG hsa:4282

Related Compounds  (Total: 7)

Go to browser
C0182
Name: Levothyroxine
Go to browser
C0358
Name: Quinoline
Go to browser
C0482
Name: Vitamin E
Go to browser
C1067
Name: hirudin
Go to browser
C1109
Name: trypsin


Related Herbs  (Total: 115)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H0023 Bai Shao Gan Jin Gao白芍干浸膏 Common peonyPaeonia lactiflora
H0043 Jie Zi芥子 India mustard seedBrassica juncea
H1203 Hu Ji Sheng槲寄生 Colored mistletoeViscum coloratum
H0918 Cu Yuan Hua醋芫花 Lilac daphneDaphne genkwa
H1036 Fen Dan Pi粉丹皮 Tree peony barkPaeonia suffruticosa
H0137 Ban Lan Gen板蓝根 Indigowoad rootIsatis indigotica
H0605 Wu Wei Zi五味子 Chinese magnoliavineSchisandra chinensis
H0297 Niu Xi牛膝 Twotooth achyranthesAchyranthes bidentata
H0606 Wu Wei Zi Chun Jin Gao五味子醇浸膏 Five-flavor berrySchisandra chinensis
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H0707 Yuan Hua芫花 Lilac daphneDaphne genkwa
H0547 Cang Qing Guo藏青果 MyrobalanTerminalia chebula
H0747 An Xi Xiang安息香 Sumatra snowbelStyrax benzoin
H0429 Shao Yao芍药 Red peony rootPaeonia obovata
H1181 Hei Zhi Ma黑芝麻 Oriental sesameSesamum indicum
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H0960 Dang Shen Qing Gao党参清膏 Root of hairy asiabellCodonopsis pilosula
H0973 Di Huang Tan地黄炭 RehmanniaeRehmannia glutinosa
H0708 Yuan Hua Gen芫花根 Lilac daphne rootDaphne genkwa
H0608 Wu Wei Zi Jin Gao五味子浸膏 Five-flavor berrySchisandra chinensis
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H0972 Di Huang地黄 RehmanniaeRehmannia glutinosa
H0296 Niu Teng牛藤 twotooth achyranthes rootAchyranthes bidentata
H1207 Hu Ma胡麻 white seed of oriental sesameSesamum indicum
H1208 Hu Ma Ren胡麻仁 white seed of oriental sesameSesamum indicum
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0607 Wu Wei Zi Jin Chu Wu五味子浸出物 Five-flavor berrySchisandra chinensis
H0709 Chang Shan常山 Antifebrile dichroaDichroa febrifuga
H0802 Zhi Geng枳梗 NACitrus aurantium
H0293 Niu Jiao Tan牛角炭 Buffalo hornBubalus bubalis
H1171 He Zi Rou诃子肉 Medicine terminaliaTerminalia chebula
H0500 Can Yong蚕蛹 Silkworm chrysalisBombyx mori
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H0461 Shi Jun Zi Ren使君子仁 NACombretum indicum
H0318 Pu Tao(1)蒲桃 SyzygiumSyzygium jambos
H0804 Zhi Ke枳壳 Seville ora nge unripe fruitCitrus aurantium
H0958 Dang Shen党参 Pilose asiabellCodonopsis pilosula
H0805 Zhi Ke Gan Jin Gao枳壳干浸膏 Seville ora nge unripe fruitCitrus aurantium
H0291 Niu Jiao Fen牛角粉 Buffalo hornBubalus bubalis
H0565 Tu Bie Chong土鳖虫 CockroachEupolyphaga sinensis
H0351 Quan Shen拳参 BistortPolygonum bistorta
H1079 Gan Di Huang干地黄 Adhesive rehmannia dried rootRehmannia glutinosa
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0710 Yuan Hua Tiao芫花条 stem of lilac daphneDaphne genkwa
H0263 Mu Ban Lan Gen木板蓝根 Indigowoad rootIsatis indigotica
H0332 Qiao Mai荞麦 Common buckwheatFagopyrum esculentum
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H0987 Bai Bu Jin Gao百部浸膏 Tuber stemonaStemona tuberosa
H1133 Gui Jian Yu鬼箭羽 Winged euonymusEuonymus alatus
H0024 Jia 蒟ye假蒟叶 Sarmentose pepperPiper sarmentosum
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0125 Lai Fu莱菔 Garden radishRaphanus sativus
H0476 Can E蚕蛾 SilkwormBombyx mori
H0498 Si Ji Cai四季菜 Ghostplant wormwoodArtemisia lactiflora
H0711 Yuan Hua Zhi Tiao芫花枝条 stem of lilac daphneDaphne genkwa
H0679 Xing Ren杏仁 Apricot seedPrunus armeniaca
H0250 Mi Zi Wan蜜紫菀 Tatarian asterAster tataricus
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0265 Mu Da Qing Ye木大青叶 Indigo-coloured woad leaf equivalentIsatis indigotica
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0292 Niu Jiao Jian Fen牛角尖粉 Buffalo hornBubalus bubalis
H1026 Fan Hun Cao返魂草 Tatarian asterAster tataricus
H0871 Chuan Duan川断 TeaselsDipsacus asper
H0768 Yuan Shen元参 Figwort rootScrophularia ningpoensis
H0131 Ban Lan板蓝 Indigowoad rootIsatis indigotica
H0967 Di Er Cao地耳草 Japanese stJohn’swortHypericum japonicum
H0758 Cheng Pi橙皮 Bitter orangeCitrus aurantium
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0076 Jing Tian San Qi景天三七 Chrusanthemum-like groundselGynura segetum
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0688 Xuan Shen玄参 Ningpo figwortScrophularia ningpoensis
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H1162 Hang Shao杭芍 White peony rootPaeonia albiflora
H0962 Dao Dou刀豆 Sword jackbeanCanavalia gladiata
H1170 He Zi诃子 Medicine terminaliaTerminalia chebula
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0013 Ji Shi Teng鸡矢藤 FevervinePaederia scandens
H0022 Jia Ju假蒟 Sarmentose pepperPiper sarmentosum
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H0256 Ming Dang Shen明党参 Medicinal changiumChangium smyrnioides
H0126 Lai Fu Zi莱菔子 Garden radish seedRaphanus sativus
H0784 Chi Shao赤芍 Red peony rootPaeonia obovata
H1156 Ai Di Huang矮地黄 RehmanniaeRehmannia glutinosa
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0473 Shu Di Huang熟地黄 Adhesive rehmannia cocked rootRehmannia glutinosa
H0696 Ya Jiao Ai鸭脚艾 Ghostplant wormwoodArtemisia lactiflora
H0578 Tu San Qi土三七 Chrusanthemum-like groundselGynura segetum
H0937 Da Qing Ye大青叶 Indigo-coloured woad leafIsatis indigotica
H0489 Shui Niu Jiao Nong Suo Fen水牛角浓缩粉 Buffalo hornBubalus bubalis
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H0982 Bai Bu Gan Gao百部干膏 Tuber stemonaStemona tuberosa
H0977 Bai Bu百部 Tuber stemonaStemona tuberosa
H0488 Shui Niu Jiao Gan Jin Gao水牛角干浸膏 Buffalo hornBubalus bubalis
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H0813 Zhi Shi枳实 Seville orange young fruitCitrus aurantium
H0139 Lian Qiao连翘 Weeping forsythiaForsythia suspensa
H0991 Bai Bu Liu Jin Gao百部流浸膏 Tuber stemonaStemona tuberosa
H0853 Zi Wan紫菀 Tatarion asterAster tataricus
H0609 Wu Wei Zi Liu Jin Gao五味子流浸膏 Five-flavor berrySchisandra chinensis
H0021 Bai Shao白芍 Common peonyPaeonia lactiflora
H0466 Cai Fu Zi菜菔子 Semen raphaniRaphanus sativus
H0487 Shui Niu Jiao水牛角 Buffalo hornBubalus bubalis
H0464 Shi Liu Zi石榴子 NAPunica granatum
H1223 Huai Hun Cao还魂草 NAAster tataricus