Target Description

Type Detail
Target ID T11R4S
Protein Name Tumor necrosis factor receptor superfamily member 5
Uniprot ID P25942
Protein Name Alias B-cell surface antigen CD40;  Bp50;  CD40L receptor;  CDw40;  CD antigen CD40
Gene ID 958
Gene Symbol CD40
Gene Alias TNFRSF5
TTD T45758: Clinical Trial target
Pfam PF00020
GO
0023035:CD40 signaling pathway

0045766:positive regulation of angiogenesis

0043406:positive regulation of MAP kinase activity

0002768:immune response-regulating cell surface receptor signaling pathway

0001934:positive regulation of protein phosphorylation

0043536:positive regulation of blood vessel endothelial cell migration

0031625:ubiquitin protein ligase binding

0048304:positive regulation of isotype switching to IgG isotypes

0035666:TRIF-dependent toll-like receptor signaling pathway

0006954:inflammatory response

0036018:cellular response to erythropoietin

0009897:external side of plasma membrane

0043231:intracellular membrane-bounded organelle

0051607:defense response to virus

0065003:protein-containing complex assembly

0019899:enzyme binding

1901652:response to peptide

0045944:positive regulation of transcription by RNA polymerase II

0042113:B cell activation

0009986:cell surface

0070062:extracellular exosome

0050776:regulation of immune response

0090037:positive regulation of protein kinase C signaling

0006874:cellular calcium ion homeostasis

0042832:defense response to protozoan

0071356:cellular response to tumor necrosis factor

0032735:positive regulation of interleukin-12 production

0034341:response to interferon-gamma

0030168:platelet activation

2000353:positive regulation of endothelial cell apoptotic process

0071222:cellular response to lipopolysaccharide

0043196:varicosity

0042100:B cell proliferation

0035631:CD40 receptor complex

0005886:plasma membrane

0043025:neuronal cell body

0043547:positive regulation of GTPase activity

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0051092:positive regulation of NF-kappaB transcription factor activity

0038023:signaling receptor activity

0019904:protein domain specific binding

0005887:integral component of plasma membrane

0071347:cellular response to interleukin-1

0071260:cellular response to mechanical stimulus

0033209:tumor necrosis factor-mediated signaling pathway

0043491:protein kinase B signaling

0042531:positive regulation of tyrosine phosphorylation of STAT protein

0033590:response to cobalamin

0030890:positive regulation of B cell proliferation

0005737:cytoplasm

0003823:antigen binding

PDB 1FLL ; 6FAX ; 1CZZ ; 5DMI ; 1D00 ; 6PE8 ; 5DMJ ; 5IHL ; 1LB6 ; 6PE9 ; 1CDF ; 3QD6
Drugbank DB12589 ; DB06360
KEGG hsa:958

Related Compounds  (Total: 6)

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C0255
Name: Norepinephrine
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C0461
Name: Triptolide
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C0482
Name: Vitamin E
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C1025
Name: emetine
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C1073
Name: sorbitol


Related Herbs  (Total: 59)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0256 Ming Dang Shen明党参 Medicinal changiumChangium smyrnioides
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0732 Ye Mu Dan野牡丹 Common melastomaMelastoma candidum
H0332 Qiao Mai荞麦 Common buckwheatFagopyrum esculentum
H0987 Bai Bu Jin Gao百部浸膏 Tuber stemonaStemona tuberosa
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0466 Cai Fu Zi菜菔子 Semen raphaniRaphanus sativus
H0446 Sheng Jiang生姜 Fresh common gingerZingiber officinale
H0043 Jie Zi芥子 India mustard seedBrassica juncea
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H1170 He Zi诃子 Medicine terminaliaTerminalia chebula
H1203 Hu Ji Sheng槲寄生 Colored mistletoeViscum coloratum
H0488 Shui Niu Jiao Gan Jin Gao水牛角干浸膏 Buffalo hornBubalus bubalis
H0962 Dao Dou刀豆 Sword jackbeanCanavalia gladiata
H1181 Hei Zhi Ma黑芝麻 Oriental sesameSesamum indicum
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0292 Niu Jiao Jian Fen牛角尖粉 Buffalo hornBubalus bubalis
H0351 Quan Shen拳参 BistortPolygonum bistorta
H0296 Niu Teng牛藤 twotooth achyranthes rootAchyranthes bidentata
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0126 Lai Fu Zi莱菔子 Garden radish seedRaphanus sativus
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0643 Xiang Jiao橡胶 RubberMusa paradisiaca var. sapientum
H0967 Di Er Cao地耳草 Japanese stJohn’swortHypericum japonicum
H0982 Bai Bu Gan Gao百部干膏 Tuber stemonaStemona tuberosa
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H1208 Hu Ma Ren胡麻仁 white seed of oriental sesameSesamum indicum
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0977 Bai Bu百部 Tuber stemonaStemona tuberosa
H0958 Dang Shen党参 Pilose asiabellCodonopsis pilosula
H0960 Dang Shen Qing Gao党参清膏 Root of hairy asiabellCodonopsis pilosula
H0125 Lai Fu莱菔 Garden radishRaphanus sativus
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H0489 Shui Niu Jiao Nong Suo Fen水牛角浓缩粉 Buffalo hornBubalus bubalis
H0487 Shui Niu Jiao水牛角 Buffalo hornBubalus bubalis
H0709 Chang Shan常山 Antifebrile dichroaDichroa febrifuga
H0679 Xing Ren杏仁 Apricot seedPrunus armeniaca
H0991 Bai Bu Liu Jin Gao百部流浸膏 Tuber stemonaStemona tuberosa
H0297 Niu Xi牛膝 Twotooth achyranthesAchyranthes bidentata
H1171 He Zi Rou诃子肉 Medicine terminaliaTerminalia chebula
H0318 Pu Tao(1)蒲桃 SyzygiumSyzygium jambos
H0293 Niu Jiao Tan牛角炭 Buffalo hornBubalus bubalis
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0118 Kun Ming Shan Hai Tang昆明山海棠 Glaucousback threewingnutTripterygium hypoglaucum
H1207 Hu Ma胡麻 white seed of oriental sesameSesamum indicum
H0547 Cang Qing Guo藏青果 MyrobalanTerminalia chebula
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0291 Niu Jiao Fen牛角粉 Buffalo hornBubalus bubalis
H0214 Bei He Huan北合欢 AlbiziaAlbizia julibrissin