HIT-result

Type	Detail
Target ID	T33JGV
Protein Name	Tumor suppressor ARF;Cyclin-dependent kinase inhibitor 2A
Uniprot ID	Q8N726 ; P42771
Protein Name Alias	NA
Gene ID	1029
Gene Symbol	CDKN2A
Gene Alias	NA
TTD	T16452: Research target
Pfam	PF07392
GO	0006469:negative regulation of protein kinase activity 0035985:senescence-associated heterochromatin focus 0051882:mitochondrial depolarization 1903214:regulation of protein targeting to mitochondrion 0010389:regulation of G2/M transition of mitotic cell cycle 0008637:apoptotic mitochondrial changes 0005829:cytosol 1903051:negative regulation of proteolysis involved in cellular protein catabolic process 0042326:negative regulation of phosphorylation 0033235:positive regulation of protein sumoylation 0030889:negative regulation of B cell proliferation 0006364:rRNA processing 0048103:somatic stem cell division 0055105:ubiquitin-protein transferase inhibitor activity 1990000:amyloid fibril formation 0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process 0005654:nucleoplasm 0090398:cellular senescence 1904667:negative regulation of ubiquitin protein ligase activity 0031648:protein destabilization 0033088:negative regulation of immature T cell proliferation in thymus 2000111:positive regulation of macrophage apoptotic process 0019789:SUMO transferase activity 0043517:positive regulation of DNA damage response, signal transduction by p53 class mediator 0000082:G1/S transition of mitotic cell cycle 0003723:RNA binding 0035986:senescence-associated heterochromatin focus assembly 0097193:intrinsic apoptotic signaling pathway 0005759:mitochondrial matrix 0005829:cytosol 0005737:cytoplasm 2000435:negative regulation of protein neddylation 0060260:regulation of transcription initiation from RNA polymerase II promoter 0071158:positive regulation of cell cycle arrest 0030308:negative regulation of cell growth 0046825:regulation of protein export from nucleus 0045736:negative regulation of cyclin-dependent protein serine/threonine kinase activity 0032991:protein-containing complex 0097371:MDM2/MDM4 family protein binding 0045944:positive regulation of transcription by RNA polymerase II 1990948:ubiquitin ligase inhibitor activity 0097718:disordered domain specific binding 0070534:protein K63-linked ubiquitination 0043065:positive regulation of apoptotic process 0032088:negative regulation of NF-kappaB transcription factor activity 1901798:positive regulation of signal transduction by p53 class mediator 0051059:NF-kappaB binding 0090399:replicative senescence 1902510:regulation of apoptotic DNA fragmentation 1901796:regulation of signal transduction by p53 class mediator 2000134:negative regulation of G1/S transition of mitotic cell cycle 0005730:nucleolus 0001953:negative regulation of cell-matrix adhesion 0008285:negative regulation of cell population proliferation 1900182:positive regulation of protein localization to nucleus 0004861:cyclin-dependent protein serine/threonine kinase inhibitor activity 2000774:positive regulation of cellular senescence 0045893:positive regulation of transcription, DNA-templated 0050821:protein stabilization 0005634:nucleus 0002039:p53 binding 0031647:regulation of protein stability 0034393:positive regulation of smooth muscle cell apoptotic process 0019901:protein kinase binding 0010628:positive regulation of gene expression 0005739:mitochondrion 0007265:Ras protein signal transduction 0008134:transcription factor binding 0000422:autophagy of mitochondrion 2000059:negative regulation of ubiquitin-dependent protein catabolic process 0003677:DNA binding 0000209:protein polyubiquitination 0051444:negative regulation of ubiquitin-protein transferase activity 0045892:negative regulation of transcription, DNA-templated 0007050:cell cycle arrest
PDB	1BI7 ; 1A5E ; 1DC2 ; 2A5E
Drugbank	NA
KEGG	hsa:1029

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Name: Pidolic Acid

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Name: Vitamin E

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Name: Matrine

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Name: Atorvastatin

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Name: Curcumin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0351	Quan Shen	拳参	Bistort	Polygonum bistorta
H1203	Hu Ji Sheng	槲寄生	Colored mistletoe	Viscum coloratum
H0296	Niu Teng	牛藤	twotooth achyranthes root	Achyranthes bidentata
H0515	Suan Shi Liu	酸石榴	Pomegranate	Punica granatum
H0332	Qiao Mai	荞麦	Common buckwheat	Fagopyrum esculentum
H0466	Cai Fu Zi	菜菔子	Semen raphani	Raphanus sativus
H0256	Ming Dang Shen	明党参	Medicinal changium	Changium smyrnioides
H0111	Ku Shen	苦参	Lightyellow sophora	Sophora flavescens
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0937	Da Qing Ye	大青叶	Indigo-coloured woad leaf	Isatis indigotica
H0297	Niu Xi	牛膝	Twotooth achyranthes	Achyranthes bidentata
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1152	Bai Jie Zi	白芥子	White mustard seed	Sinapis alba
H1181	Hei Zhi Ma	黑芝麻	Oriental sesame	Sesamum indicum
H0137	Ban Lan Gen	板蓝根	Indigowoad root	Isatis indigotica
H1183	Hong Dou	红豆	Hosie ormosia	Ormosia hosiei
H0987	Bai Bu Jin Gao	百部浸膏	Tuber stemona	Stemona tuberosa
H0125	Lai Fu	莱菔	Garden radish	Raphanus sativus
H0314	Pu Gong Ying	蒲公英	Mongolian dandelion	Taraxacum mongolicum
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H0265	Mu Da Qing Ye	木大青叶	Indigo-coloured woad leaf equivalent	Isatis indigotica
H0982	Bai Bu Gan Gao	百部干膏	Tuber stemona	Stemona tuberosa
H0958	Dang Shen	党参	Pilose asiabell	Codonopsis pilosula
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0991	Bai Bu Liu Jin Gao	百部流浸膏	Tuber stemona	Stemona tuberosa
H0043	Jie Zi	芥子	India mustard seed	Brassica juncea
H0464	Shi Liu Zi	石榴子	NA	Punica granatum
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0126	Lai Fu Zi	莱菔子	Garden radish seed	Raphanus sativus
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0131	Ban Lan	板蓝	Indigowoad root	Isatis indigotica
H0977	Bai Bu	百部	Tuber stemona	Stemona tuberosa
H0263	Mu Ban Lan Gen	木板蓝根	Indigowoad root	Isatis indigotica
H0962	Dao Dou	刀豆	Sword jackbean	Canavalia gladiata
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H0396	Sang Ye	桑叶	White mulberry leaf	Morus alba
H0315	Pu Gong Ying Jin Gao	蒲公英浸膏	Mongolian dandelion	Taraxacum mongolicum
H0391	Sang Pi	桑皮	Prepared root-bark white mulberry	Morus alba
H1171	He Zi Rou	诃子肉	Medicine terminalia	Terminalia chebula
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0397	Sang Zhi	桑枝	White mulberry branch	Morus alba
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0547	Cang Qing Guo	藏青果	Myrobalan	Terminalia chebula
H0967	Di Er Cao	地耳草	Japanese stJohn’swort	Hypericum japonicum
H0463	Shi Liu Pi	石榴皮	Pomegranate peel	Punica granatum
H0318	Pu Tao(1)	蒲桃	Syzygium	Syzygium jambos
H0462	Shi Liu	石榴	Pomegranate fruit	Punica granatum
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0960	Dang Shen Qing Gao	党参清膏	Root of hairy asiabell	Codonopsis pilosula
H0709	Chang Shan	常山	Antifebrile dichroa	Dichroa febrifuga
H1170	He Zi	诃子	Medicine terminalia	Terminalia chebula
H1208	Hu Ma Ren	胡麻仁	white seed of oriental sesame	Sesamum indicum
H1244	Huang Miao	黄苗	NA	Taraxacum mongolicum
H0679	Xing Ren	杏仁	Apricot seed	Prunus armeniaca
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H1207	Hu Ma	胡麻	white seed of oriental sesame	Sesamum indicum
H0405	Shan Dou Gen	山豆根	Tonkin sophora root	Sophora subprostrata

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 62)