Herb Description
| Herb ID: H0405 | Chinese Character: 山豆根 |
| English Name: Tonkin sophora root | Latin Name: Sophora subprostrata |
| Chinese Pin Yin : Shan Dou Gen | TCM-ID: TCMH1814 |
| Therapeutic Function in Chinese : 清热 | Therapeutic Function in English: Heat clearence |
| Herb Function: Remove toxic heat, promote the subsidence of swelling, and soothe the sore throat | |
Related Targets (Total: 93)
| Target id | Protein Name | Gene Symbol | Uniprot ID | No.of Literature Evidence |
|---|---|---|---|---|
| T91W8B | All-trans-retinol dehydrogenase [NAD(+)] ADH4 | ADH4 |
P08319 |
1 Reference(s) |
| T03VS9 | Protein-tyrosine kinase 2-beta | PTK2B |
Q14289 |
1 Reference(s) |
| T44WZO | Alcohol dehydrogenase 1C | ADH1C |
P00326 |
1 Reference(s) |
| T12T4H | Brain-derived neurotrophic factor | BDNF |
P23560 |
1 Reference(s) |
| T50SX0 | Nuclear receptor subfamily 1 group I member 2 | NR1I2 |
O75469 |
1 Reference(s) |
| T85U8U | Caspase-3 | CASP3 |
P42574 |
3 Reference(s) |
| T63YAO | Caveolin-1 | CAV1 |
Q03135 |
2 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
5 Reference(s) |
| T12PIB | Lysosomal alpha-glucosidase | GAA |
P10253 |
1 Reference(s) |
| T32OC4 | Aldehyde dehydrogenase, mitochondrial | ALDH2 |
P05091 |
1 Reference(s) |
| T54G8J | Protein kinase C delta type | PRKCD |
Q05655 |
1 Reference(s) |
| T22MME | Quinone oxidoreductase | CRYZ |
Q08257 |
1 Reference(s) |
| T25M2J | Anoctamin-1 | ANO1 |
Q5XXA6 |
2 Reference(s) |
| T53KY7 | Cystic fibrosis transmembrane conductance regulator | CFTR |
P13569 |
1 Reference(s) |
| T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
3 Reference(s) |
| T45X9Z | Hepatocyte growth factor | HGF |
P14210 |
1 Reference(s) |
| T39M81 | DNA-(apurinic or apyrimidinic site) endonuclease | APEX1 |
P27695 |
1 Reference(s) |
| T85AXP | Cytochrome P450 3A4 | CYP3A4 |
P08684 |
3 Reference(s) |
| T69RXK | Cytochrome P450 2C9 | CYP2C9 |
P11712 |
1 Reference(s) |
| T04AHN | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 | HSD3B2 |
P26439 |
1 Reference(s) |
| T84W8G | Aryl hydrocarbon receptor | AHR |
P35869 |
1 Reference(s) |
| T23K1O | Calmodulin | CALM3;CALML2;CAM3;CAMC;CAMIII |
P62158 |
1 Reference(s) |
| T44LWL | Transcription factor p65 | RELA |
Q04206 |
2 Reference(s) |
| T09TS5 | Gamma-aminobutyric acid type B receptor subunit 1 | GABBR1 |
Q9UBS5 |
1 Reference(s) |
| T74ETU | Steroid 21-hydroxylase | CYP21A2 |
P08686 |
1 Reference(s) |
| T50WUM | Leucine--tRNA ligase, cytoplasmic | LARS1 |
Q9P2J5 |
1 Reference(s) |
| T05O6O | Estrogen receptor beta | ESR2 |
Q92731 |
5 Reference(s) |
| T30V3R | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 | HSD3B1 |
P14060 |
2 Reference(s) |
| T09H2Z | Nitric oxide synthase, inducible | NOS2 |
P35228 |
2 Reference(s) |
| T67HAF | Signal transducer and activator of transcription 1-alpha/beta | STAT1 |
P42224 |
1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
1 Reference(s) |
| T29GH0 | Trefoil factor 1 | TFF1 |
P04155 |
2 Reference(s) |
| T98JPP | Carnitine O-palmitoyltransferase 1, liver isoform | CPT1A |
P50416 |
1 Reference(s) |
| T42EAZ | Vascular endothelial growth factor A | VEGFA |
P15692 |
2 Reference(s) |
| T50V79 | Interleukin-4 | IL4 |
P05112 |
1 Reference(s) |
| T26KIE | Transcription factor AP-1 | JUN |
P05412 |
2 Reference(s) |
| T64UH1 | Nitric oxide synthase, endothelial | NOS3 |
P29474 |
1 Reference(s) |
| T73S71 | Apolipoprotein B-100 | APOB |
P04114 |
1 Reference(s) |
| T49PL1 | Low-density lipoprotein receptor | LDLR |
P01130 |
1 Reference(s) |
| T12EWD | Cytochrome b-c1 complex subunit 7 | UQCRB |
P14927 |
1 Reference(s) |
| T23VMI | Tumor necrosis factor | TNF |
P01375 |
2 Reference(s) |
| T33OPP | Interleukin-6 | IL6 |
P05231 |
3 Reference(s) |
| T07NZK | Low affinity immunoglobulin epsilon Fc receptor | FCER2 |
P06734 |
1 Reference(s) |
| T11GHO | Transforming protein RhoA | RHOA |
P61586 |
1 Reference(s) |
| T34AYH | Solute carrier family 52, riboflavin transporter, member 1 | SLC52A1 |
Q9NWF4 |
1 Reference(s) |
| T36I66 | Metallothionein-2 | MT2A |
P02795 |
1 Reference(s) |
| T90ZS8 | Endothelin-converting enzyme 1 | ECE1 |
P42892 |
1 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
1 Reference(s) |
| T59IKQ | Vascular cell adhesion protein 1 | VCAM1 |
P19320 |
1 Reference(s) |
| T42XY2 | Insulin-like growth factor 1 receptor | IGF1R |
P08069 |
1 Reference(s) |
| T16IWB | Growth arrest and DNA damage-inducible protein GADD45 alpha | GADD45A |
P24522 |
1 Reference(s) |
| T29CYD | BRCA1-associated RING domain protein 1 | BARD1 |
Q99728 |
1 Reference(s) |
| T41SFE | Histone acetyltransferase p300 | EP300 |
Q09472 |
1 Reference(s) |
| T57R3V | Proliferation marker protein Ki-67 | MKI67 |
P46013 |
1 Reference(s) |
| T64W2K | Cyclin-dependent kinase inhibitor 1 | CDKN1A |
P38936 |
1 Reference(s) |
| T82I76 | Ubiquitin carboxyl-terminal hydrolase BAP1 | BAP1 |
Q92560 |
1 Reference(s) |
| T82JWE | Cellular tumor antigen p53 | TP53 |
P04637 |
1 Reference(s) |
| T82S9G | DNA repair protein RAD51 homolog 1 | RAD51 |
Q06609 |
1 Reference(s) |
| T53QOD | ATP synthase subunit beta, mitochondrial | ATP5F1B |
P06576 |
1 Reference(s) |
| T63SUZ | NADH-ubiquinone oxidoreductase chain 6 | MT-ND6 |
P03923 |
1 Reference(s) |
| T63GUB | Proto-oncogene c-Fos | FOS |
P01100 |
1 Reference(s) |
| T46HRF | Growth hormone receptor | GHR |
P10912 |
1 Reference(s) |
| T35FQV | Microsomal triglyceride transfer protein large subunit | MTTP |
P55157 |
1 Reference(s) |
| T16A2X | Catalase | CAT |
P04040 |
1 Reference(s) |
| T70SFS | Superoxide dismutase [Mn], mitochondrial | SOD2 |
P04179 |
1 Reference(s) |
| T80TUC | Apoptosis regulator BAX | BAX |
Q07812 |
2 Reference(s) |
| T28B0B | Monocarboxylate transporter 8 | SLC16A2 |
P36021 |
1 Reference(s) |
| T53GFX | Arginase-1 | ARG1 |
P05089 |
1 Reference(s) |
| T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
2 Reference(s) |
| T35QZO | Cytochrome c | CYCS |
P99999 |
1 Reference(s) |
| T63BQU | Cytochrome P450 1A1 | CYP1A1 |
P04798 |
1 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
1 Reference(s) |
| T93WZG | G1/S-specific cyclin-D1 | CCND1 |
P24385 |
3 Reference(s) |
| T53AOE | Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide | TGFB1 |
P01137 |
1 Reference(s) |
| T43HES | Paired box protein Pax-2 | PAX2 |
Q02962 |
2 Reference(s) |
| T87FX7 | Receptor-interacting serine/threonine-protein kinase 3 | RIPK3 |
Q9Y572 |
1 Reference(s) |
| T67ZT3 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | PTEN |
P60484 |
2 Reference(s) |
| T40JZG | GPI-anchor transamidase | PIGK |
Q92643 |
1 Reference(s) |
| T15JRW | Interferon alpha-inducible protein 27, mitochondrial | IFI27 |
P40305 |
1 Reference(s) |
| T33JGV | Tumor suppressor ARF;Cyclin-dependent kinase inhibitor 2A | CDKN2A |
Q8N726;P42771 |
1 Reference(s) |
| T96OOK | Signal transducer and activator of transcription 3 | STAT3 |
P40763 |
1 Reference(s) |
| T21EGX | Multidrug resistance-associated protein 1 | ABCC1 |
P33527 |
1 Reference(s) |
| T64BTV | Interleukin-1 beta | IL1B |
P01584 |
1 Reference(s) |
| T29MD1 | Mitogen-activated protein kinase 8 | MAPK8 |
P45983 |
1 Reference(s) |
| T57HGP | Tumor necrosis factor receptor superfamily member 6 | FAS |
P25445 |
1 Reference(s) |
| T71K92 | Apoptosis regulator Bcl-2 | BCL2 |
P10415 |
2 Reference(s) |
| T43N2D | Epidermal growth factor receptor | EGFR |
P00533 |
2 Reference(s) |
| T88IXL | Histone H2AX | H2AX |
P16104 |
1 Reference(s) |
| T73LPO | Poly [ADP-ribose] polymerase 1 | PARP1 |
P09874 |
1 Reference(s) |
| T67CB6 | Transcriptional regulator ERG | ERG |
P11308 |
1 Reference(s) |
| T09KPZ | Vimentin | VIM |
P08670 |
1 Reference(s) |
| T95IYZ | Adiponectin | ADIPOQ |
Q15848 |
1 Reference(s) |
| T28HOM | Leptin | LEP |
P41159 |
1 Reference(s) |
Related Compounds (Total: 4)
key description of the interaction between compound and target