Target Description

Type Detail
Target ID T39M81
Protein Name DNA-(apurinic or apyrimidinic site) endonuclease
Uniprot ID P27695
Protein Name Alias EC 3.1.-.-;  APEX nuclease;  APEN;  Apurinic-apyrimidinic endonuclease 1;  AP endonuclease 1;  APE-1;  REF-1;  Redox factor-1
Gene ID 328
Gene Symbol APEX1
Gene Alias APE;  APE1;  APEX;  APX;  HAP1;  REF1
TTD T13348: Clinical Trial target
Pfam PF03372
GO
0005813:centrosome

0000781:chromosome, telomeric region

0005667:transcription regulator complex

0003684:damaged DNA binding

0004844:uracil DNA N-glycosylase activity

0042493:response to drug

0004519:endonuclease activity

0070301:cellular response to hydrogen peroxide

0005730:nucleolus

0014912:negative regulation of smooth muscle cell migration

0071375:cellular response to peptide hormone stimulus

0003713:transcription coactivator activity

0008081:phosphoric diester hydrolase activity

0045454:cell redox homeostasis

0046872:metal ion binding

0042981:regulation of apoptotic process

0008408:3'-5' exonuclease activity

0044877:protein-containing complex binding

1900087:positive regulation of G1/S transition of mitotic cell cycle

0003691:double-stranded telomeric DNA binding

0051059:NF-kappaB binding

0031490:chromatin DNA binding

0071320:cellular response to cAMP

0003714:transcription corepressor activity

0005654:nucleoplasm

0003906:DNA-(apurinic or apyrimidinic site) endonuclease activity

0004520:endodeoxyribonuclease activity

0005737:cytoplasm

0003677:DNA binding

0006286:base-excision repair, base-free sugar-phosphate removal

0048471:perinuclear region of cytoplasm

0005783:endoplasmic reticulum

0006287:base-excision repair, gap-filling

0003723:RNA binding

0080111:DNA demethylation

0005840:ribosome

0008311:double-stranded DNA 3'-5' exodeoxyribonuclease activity

0005739:mitochondrion

0016607:nuclear speck

0016491:oxidoreductase activity

0045944:positive regulation of transcription by RNA polymerase II

0005634:nucleus

0006281:DNA repair

0006310:DNA recombination

0004523:RNA-DNA hybrid ribonuclease activity

0000723:telomere maintenance

0097698:telomere maintenance via base-excision repair

0006284:base-excision repair

0007568:aging

0016890:site-specific endodeoxyribonuclease activity, specific for altered base

0008309:double-stranded DNA exodeoxyribonuclease activity

0004528:phosphodiesterase I activity

0043488:regulation of mRNA stability

PDB 6BOW ; 1DE9 ; 5DFF ; 1DEW ; 6W3L ; 1CQG ; 4QHE ; 6MKK ; 6W0Q ; 5WN5 ; 6W2P ; 5DFH ; 4IEM ; 6W3N ; 6W4T ; 4QHD ; 5WN3 ; 5DG0 ; 6MK3 ; 1BIX ; 4LND ; 6W4I ; 1CQH ; 6BOS ; 6P93 ; 6BOQ ; 6BOT ; 6W3Q ; 1E9N ; 4QH9 ; 5WN2 ; 5WN1 ; 5WN4 ; 6MKM ; 2ISI ; 6BOV ; 5DFI ; 6W43 ; 6BOU ; 1DE8 ; 6W3U ; 2O3H ; 3U8U ; 5DFJ ; 5WN0 ; 6MKO ; 1HD7 ; 6BOR ; 6P94 ; 5CFG
Drugbank DB04967
KEGG hsa:328

Related Compounds  (Total: 5)

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C0101
Name: Genistein
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C0112
Name: Gossypol
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C0363
Name: Resveratrol
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C0929
Name: Oxymatrine
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C1265
Name: Curcumin


Related Herbs  (Total: 79)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0693 Xue Xie血蝎 Dragon's bloodDaemonorops draco
H1227 Huai Zhi槐枝 NASophora japonica
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0226 Man Yue Mei蔓越莓 CranberryVaccinium oxycoccos
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0357 Ren Shen人参 GinsengPanax ginseng
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1007 Dou You豆油 Soybean oilGlycine max
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H0617 Qian Cao Teng茜草藤 NARubia cordifolia
H0792 Zhang Yu章鱼 Common atlantic octopusOctopus vulgaris
H0979 Di Yu地榆 Garden burnetSanguisorba officinalis
H0129 Le Xian Cai勒苋菜 NAAmaranthus spinosus
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H0416 Shan Shen山参 NAPanax ginseng
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0026 Jiang Soybean pasteGlycine max
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0995 Dong Chong Xia Cao冬虫夏草 AwetoCordyceps sinensis
H0434 She Pu Tao蛇葡萄 AmpelopsisAmpelopsis brevipedunculata
H0852 Zi Tan紫檀 Burmacoast padaukPterocarpus indicus
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0432 She Gan射干 BlackberrylilyBelamcanda chinensis
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0980 Di Yu Tan地榆炭 Garden burnetSanguisorba officinalis
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H1225 Huai Mi槐米 NASophora japonica
H0472 Shu Da Huang熟大黄 NARheum palmatum
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H0626 Xi Nan Huang Qin西南黄芩 Yunnan skullcapScutellaria amoena
H0883 Chuan She Gan川射干 BlackberrylilyBelamcanda chinensis
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0142 Liang Jiang良姜 NAAlpinia officinarum
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0765 Chi Dou赤豆 Assuki beanVigna angularis
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H0253 Mian Hua Gen棉花根 Levant cotton rootGossypium herbaceum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H1117 Guan Zhong贯众 Male fern rhizomeDryopteris crassirhizoma
H0906 Ci Wan刺苋 spiny amaranthAmaranthus spinosus
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0405 Shan Dou Gen山豆根 Tonkin sophora rootSophora subprostrata