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Compound Description

ID:   C0101 Common name:   Genistein
IUPAC:  5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one CAS:  CAS:446-72-0
Chembl ID:   CHEMBL44 Pubchem ID:   CID:5280961
Formula:  C15H10O5 TCM-ID:  TCMC1236
Smiles:  C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O
Alias:

Genistein;

Isoflavone, 4',5,7-trihydroxy-;

5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;

4',5,7-Trihydroxyisoflavone;

5,7,4'-Trihydroxyisoflavone;

5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one;

BIO 300;

Baichanin A;

Bonistein;

C.I. 75610;

CSU 1999;

CSU-1999;

Climagen F;

FW 635I-2;

GeniVida;

Genisteol;

Genisterin;

Genistin aglycone;

NPI 031L;

NSC 36586;

Prunetol;

SIPI 807-1;

Sophoricol
Structure:

Related Targets  (Total: 109)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T74JJN Fatty acid synthaseFASN P49327
 A 1 Reference(s)
T01QLH Estrogen receptorESR1 P03372
 A 4 Reference(s)
T05O6O Estrogen receptor betaESR2 Q92731
 A 2 Reference(s)
T53KY7 Cystic fibrosis transmembrane conductance regulatorCFTR P13569
 A 2 Reference(s)
T69XEM Tyrosine-protein kinase SYKSYK P43405
 A 1 Reference(s)
T49ORJ Peroxisome proliferator-activated receptor alphaPPARA Q07869
 A 2 Reference(s)
T27LA6 DNADNMT1 P26358
 A 1 Reference(s)
T25UYT Dual specificity mitogen-activated protein kinase kinase 4MAP2K4 P45985
 A 1 Reference(s)
T43N2D Epidermal growth factor receptorEGFR P00533
 A 3 Reference(s)
T20JZ2 Androgen receptorAR P10275
 A 3 Reference(s)
T70NYW Fibroblast growth factor receptor 4FGFR4 P22455
 A 1 Reference(s)
T03VS9 Protein-tyrosine kinase 2-betaPTK2B Q14289
 A 2 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
 A 2 Reference(s)
T12BGL Cytochrome P450 2A6CYP2A6 P11509
 A 1 Reference(s)
T24VJT GDH/6PGL endoplasmic bifunctional protein [Includes: Hexose-6-phosphate dehydrogenaseH6PD O95479
 A 1 Reference(s)
T93YV8 Tumor necrosis factor receptor superfamily member 11BTNFRSF11B O00300
 A 3 Reference(s)
T07TRP Short transient receptor potential channel 5TRPC5 Q9UL62
 A 1 Reference(s)
T97FEF Broad substrate specificity ATP-binding cassette transporter ABCG2ABCG2 Q9UNQ0
 A 1 Reference(s)
T15RPU Kinesin-like protein KIF20AKIF20A O95235
 A 1 Reference(s)
T68DAN Histone deacetylase 9HDAC9 Q9UKV0
 A 1 Reference(s)
T49CBW Class E basic helix-loop-helix protein 40BHLHE40 O14503
 A 1 Reference(s)
T40DIM Corticosteroid 11-beta-dehydrogenase isozyme 1HSD11B1 P28845
 A 1 Reference(s)
T61OY3 UDP-glucuronosyltransferase 1A1UGT1A1 P22309
 B 1 Reference(s)
T19JEU Beta-galactosidaseGLB1 P16278
 B 1 Reference(s)
T67HAF Signal transducer and activator of transcription 1-alpha/betaSTAT1 P42224
 B 1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
 B 1 Reference(s)
T42XY2 Insulin-like growth factor 1 receptorIGF1R P08069
 B 1 Reference(s)
T67ZT3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN P60484
 B 1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
 B 3 Reference(s)
T44LWL Transcription factor p65RELA Q04206
 B 4 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
 B 1 Reference(s)
T07TMB Cyclin-dependent kinase 1CDK1 P06493
 B 3 Reference(s)
T78VUO RAF proto-oncogene serine/threonine-protein kinaseRAF1 P04049
 B 2 Reference(s)
T64W2K Cyclin-dependent kinase inhibitor 1CDKN1A P38936
 B 5 Reference(s)
T24LXT G2/mitotic-specific cyclin-B1CCNB1 P14635
 B 4 Reference(s)
T20NCI Serine-protein kinase ATMATM Q13315
 B 1 Reference(s)
T28EY5 Serine/threonine-protein kinase Chk2CHEK2 O96017
 B 2 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
 B 1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
 B 1 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
 B 1 Reference(s)
T17UP9 C-C motif chemokine 2CCL2 P13500
 B 1 Reference(s)
T54CIF Interleukin-8CXCL8 P10145
 B 1 Reference(s)
T10HL8 Intercellular adhesion molecule 1ICAM1 P05362
 B 1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
 B 3 Reference(s)
T59IKQ Vascular cell adhesion protein 1VCAM1 P19320
 B 2 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
 B 2 Reference(s)
T86UXL Cyclin-A2CCNA2 P20248
 B 1 Reference(s)
T68NCI Aldo-keto reductase family 1 member B1AKR1B1 P15121
 B 1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
 B 2 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
 B 2 Reference(s)
T63GUB Proto-oncogene c-FosFOS P01100
 B 2 Reference(s)
T77PFO Histone deacetylase 6HDAC6 Q9UBN7
 B 1 Reference(s)
T26UZV Dual specificity mitogen-activated protein kinase kinase 5MAP2K5 Q13163
 B 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
 B 3 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
 B 3 Reference(s)
T85U8U Caspase-3CASP3 P42574
 B 2 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
 B 3 Reference(s)
T44S1A Apolipoprotein A-IAPOA1 P02647
 B 1 Reference(s)
T54VQA Cyclin-dependent kinase inhibitor 2ACDKN2A P42771
 B 1 Reference(s)
T64UH1 Nitric oxide synthase, endothelialNOS3 P29474
 B 1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
 B 1 Reference(s)
T96OOK Signal transducer and activator of transcription 3STAT3 P40763
 B 1 Reference(s)
T38K2W Receptor tyrosine-protein kinase erbB-2ERBB2 P04626
 B 2 Reference(s)
T23P74 Caspase-9CASP9 P55211
 B 1 Reference(s)
T79A7K Protein PMLPML P29590
 B 1 Reference(s)
T19Z2N Nuclear receptor corepressor 1NCOR1 O75376
 B 1 Reference(s)
T68BGR Glial fibrillary acidic proteinGFAP P14136
 B 1 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
 B 1 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
 B 1 Reference(s)
T31P1D Metalloproteinase inhibitor 1TIMP1 P01033
 B 2 Reference(s)
T24U57 E-selectinSELE P16581
 B 1 Reference(s)
T39M81 DNA-(apurinic or apyrimidinic site) endonucleaseAPEX1 P27695
 B 1 Reference(s)
T05WU9 Serine/threonine-protein phosphatase 2A activatorPTPA Q15257
 B 1 Reference(s)
T98QOA DNA-dependent protein kinase catalytic subunitPRKDC P78527
 B 1 Reference(s)
T38N69 Lymphokine-activated killer T-cell-originated protein kinasePBK Q96KB5
 C 1 Reference(s)
T06PVX E3 ubiquitin-protein ligase Mdm2MDM2 Q00987
 C 1 Reference(s)
T42K6K M-phase inducer phosphatase 3CDC25C P30307
 C 1 Reference(s)
T89VFL Alpha-crystallin B chainCRYAB P02511
 C 1 Reference(s)
T04A2Q Serine/threonine-protein kinase PLK1PLK1 P53350
 C 1 Reference(s)
T82S6C Hexokinase-4GCK P35557
 C 1 Reference(s)
T00F43 Mediator of DNA damage checkpoint protein 1MDC1 Q14676
 C 1 Reference(s)
T21YK3 Cell division cycle protein 20 homologCDC20 Q12834
 C 1 Reference(s)
T75I26 Mitotic checkpoint serine/threonine-protein kinase BUB1BUB1 O43683
 C 1 Reference(s)
T49PL1 Low-density lipoprotein receptorLDLR P01130
 C 2 Reference(s)
T21Q0D 3-hydroxy-3-methylglutaryl-coenzyme A reductaseHMGCR P04035
 C 2 Reference(s)
T13I7C Transforming growth factor beta-2 proproteinTGFB2 P61812
 C 1 Reference(s)
T04WT7 FibronectinFN1 P02751
 C 1 Reference(s)
T03G09 Tumor necrosis factor ligand superfamily member 11TNFSF11 O14788
 C 2 Reference(s)
T34N64 NAMIR29B1 NA
 C 1 Reference(s)
T30NJL Electrogenic sodium bicarbonate cotransporter 1SLC4A4 Q9Y6R1
 C 1 Reference(s)
T33JS5 CCN family member 2CCN2 P29279
 C 2 Reference(s)
T88MR0 Solute carrier family 26 member 6SLC26A6 Q9BXS9
 C 1 Reference(s)
T91MKC Runt-related transcription factor 2RUNX2 Q13950
 C 1 Reference(s)
T31SX8 Bone morphogenetic protein 2BMP2 P12643
 C 1 Reference(s)
T17X6I DNA fragmentation factor subunit alphaDFFA O00273
 C 1 Reference(s)
T16S8T Baculoviral IAP repeat-containing protein 7BIRC7 Q96CA5
 C 1 Reference(s)
T46AQJ Glutathione S-transferase PGSTP1 P09211
 C 1 Reference(s)
T49A2A Sodium/hydrogen exchanger 1SLC9A1 P19634
 C 1 Reference(s)
T25SPW Sodium/hydrogen exchanger 2SLC9A2 Q9UBY0
 C 1 Reference(s)
T09HVO Sodium/hydrogen exchanger 3SLC9A3 P48764
 C 1 Reference(s)
T33BF9 DNADNMT3B Q9UBC3
 C 1 Reference(s)
T76B0A Gap junction alpha-1 proteinGJA1 P17302
 C 1 Reference(s)
T74V1Z Dual specificity mitogen-activated protein kinase kinase 7MAP2K7 O14733
 C 1 Reference(s)
T45G32 Proto-oncogene tyrosine-protein kinase SrcSRC P12931
 C 1 Reference(s)
T72BXP Platelet endothelial cell adhesion moleculePECAM1 P16284
 C 1 Reference(s)
T24LWC Sodium-dependent dopamine transporterSLC6A3 Q01959
 C 1 Reference(s)
T35QZO Cytochrome cCYCS P99999
 C 1 Reference(s)
T89SY7 Zinc finger and BTB domain-containing protein 16ZBTB16 Q05516
 C 1 Reference(s)
T02QBS Cytochrome P450 1A2CYP1A2 P05177
 C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 45)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1227 Huai Zhi槐枝 NASophora japonica
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H0852 Zi Tan紫檀 Burmacoast padaukPterocarpus indicus
H0995 Dong Chong Xia Cao冬虫夏草 AwetoCordyceps sinensis
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H0980 Di Yu Tan地榆炭 Garden burnetSanguisorba officinalis
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0026 Jiang姜 Soybean pasteGlycine max
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0129 Le Xian Cai勒苋菜 NAAmaranthus spinosus
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0979 Di Yu地榆 Garden burnetSanguisorba officinalis
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0792 Zhang Yu章鱼 Common atlantic octopusOctopus vulgaris
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0906 Ci Wan刺苋 spiny amaranthAmaranthus spinosus
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1225 Huai Mi槐米 NASophora japonica
H1007 Dou You豆油 Soybean oilGlycine max
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis

Ckey description of the interaction between compound and target


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