HIT-result

Type	Detail
Target ID	T25UYT
Protein Name	Dual specificity mitogen-activated protein kinase kinase 4
Uniprot ID	P45985
Protein Name Alias	MAP kinase kinase 4; MAPKK 4; EC 2.7.12.2; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKK
Gene ID	6416
Gene Symbol	MAP2K4
Gene Alias	JNKK1; MEK4; MKK4; PRKMK4; SEK1; SERK1; SKK1
TTD	NA
Pfam	PF00069
GO	0030424:axon 0005524:ATP binding 0072709:cellular response to sorbitol 0045740:positive regulation of DNA replication 0106311:protein threonine kinase activity 0071260:cellular response to mechanical stimulus 0038095:Fc-epsilon receptor signaling pathway 0031435:mitogen-activated protein kinase kinase kinase binding 0005829:cytosol 0009611:response to wounding 2000672:negative regulation of motor neuron apoptotic process 0061049:cell growth involved in cardiac muscle cell development 0006915:apoptotic process 0051770:positive regulation of nitric-oxide synthase biosynthetic process 0043204:perikaryon 0007257:activation of JUN kinase activity 0004708:MAP kinase kinase activity 0043525:positive regulation of neuron apoptotic process 0034393:positive regulation of smooth muscle cell apoptotic process 0004672:protein kinase activity 0005634:nucleus 0007254:JNK cascade 0106310:protein serine kinase activity 0000187:activation of MAPK activity 0007165:signal transduction 0004714:transmembrane receptor protein tyrosine kinase activity 0008545:JUN kinase kinase activity 0032839:dendrite cytoplasm
PDB	3ALN ; 3VUT ; 3ALO
Drugbank	NA
KEGG	hsa:6416

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0789	Zhang Shu Gen	樟树根	Camphor tree	Cinnamomum camphora
H0614	Wu Zhao Long	五爪龙	Cairo morningglory	Ipomoea cairica
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0366	Rou Gui	肉桂	Cassiabarktree	Cinnamomum cassia
H0787	Zhang Nao	樟脑	Camphorar	Cinnamomum camphora
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H0222	Man Tuo Luo	曼陀罗	Jimsonweed	Datura stramonium
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0852	Zi Tan	紫檀	Burmacoast padauk	Pterocarpus indicus
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max
H0408	Bing Lang	槟榔	Betenutpalm	Areca catechu
H1212	Hu Ye Gan Jin Gao	槲叶干浸膏	NA	Quercus dentata
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0925	Da Fu Zi	大腹子	Areca palm	Areca catechu
H0941	Da Zao	大枣	Chinese date	Ziziphus jujuba
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0181	Luo Bu Ma	罗布麻	Dogbane	Apocynum venetum
H0035	Bai Su Zi	白苏子	Common perilla fruit	Perilla frutescens
H0790	Zhang Shu Zi	樟树子	Camphor tree	Cinnamomum camphora
H0519	Suo Yang	锁阳	Songaria cynomorium	Cynomorium songaricum
H1041	Feng Qie Hua	枫茄花	Jimsonweed	Datura stramonium
H1164	He Geng	荷梗	Hindu lotus petiole	Nelumbo nucifera
H0226	Man Yue Mei	蔓越莓	Cranberry	Vaccinium oxycoccos
H0056	Jin Qiao Mai	金荞麦	Wild buckwheat rhizome	Rhizoma fagopyri cymosi
H0788	Zhang Nao Zi	樟脑子	Camphorar	Cinnamomum camphora
H0141	Lian Zi Xin	莲子心	Hindu lotus plumule	Nelumbo nucifera
H1094	Ge Gen	葛根	Lobed kudzuvine root	Pueraria lobata
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0575	Tu Ku Shen	土苦参	all-grass of hooker winghead	Sophora flavescens
H1139	Gui Zhi	桂枝	Cassiabarktree twig	Cinnamomum cassia
H0463	Shi Liu Pi	石榴皮	Pomegranate peel	Punica granatum
H0979	Di Yu	地榆	Garden burnet	Sanguisorba officinalis
H0615	Wu Zhi Mao Tao	五指毛桃	five-finger fig root	Ficus simplicissima
H1099	Gou Teng	钩藤	Sharpleaf gambirplant	Uncaria rhynchophylla
H1095	Ge Gen Gan Jin Gao	葛根干浸膏	Lobed kudzuvine root	Pueraria lobata
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0304	Ou Pian	藕片	Hindu lotus large rhizome	Nelumbo nucifera
H0533	Teng Ku Shen	藤苦参	NA	Sophora flavescens
H0422	Shan Zha Tan	山楂炭	Chinese hawthorn	Crataegus pinnatifida
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0792	Zhang Yu	章鱼	Common atlantic octopus	Octopus vulgaris
H0515	Suan Shi Liu	酸石榴	Pomegranate	Punica granatum
H1114	Guan Gui	官桂	Cassiabarktree	Cinnamomum cassia
H0478	Shu Lang	薯莨	NA	Dioscorea cirrhosa
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0215	Mai Ya	麦芽	Barley germinating fruit	Hordeum vulgare
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H0786	Zhang Mu	樟木	Ligum cinmamomi camphorae	Cinnamomum camphora
H0967	Di Er Cao	地耳草	Japanese stJohn’swort	Hypericum japonicum
H1096	Ge Hua	葛花	flower bud of lobed kudzuvine	Pueraria lobata
H1225	Huai Mi	槐米	NA	Sophora japonica
H0476	Can E	蚕蛾	Silkworm	Bombyx mori
H0462	Shi Liu	石榴	Pomegranate fruit	Punica granatum
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0223	Man Tuo Luo Jin Gao	曼陀罗浸膏	Jimsonweed	Datura stramonium
H0420	Shan Zha Chou Gao	山楂稠膏	Chinese hawthorn	Crataegus pinnatifida
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0301	Ou	藕	Hindu lotus large rhizome	Nelumbo nucifera
H1169	He Ye	荷叶	Hindu lotus leaf	Nelumbo nucifera
H0060	Jin Si Ku Lian	金丝苦楝	NA	Cardiospermum halicacabum
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H1127	Guang Shan Zha	广山楂	Chinese hawthorn	Crataegus pinnatifida
H1124	Guang Jin Qian Cao	广金钱草	Snowbellleaf tickclover	Desmodium styracifolium
H1080	Gan Ge	干葛	Lobed kudzuvine root	Pueraria lobata
H0626	Xi Nan Huang Qin	西南黄芩	Yunnan skullcap	Scutellaria amoena
H0464	Shi Liu Zi	石榴子	NA	Punica granatum
H0980	Di Yu Tan	地榆炭	Garden burnet	Sanguisorba officinalis
H0906	Ci Wan	刺苋	spiny amaranth	Amaranthus spinosus
H1137	Gui Yuan	桂圆	NA	Dimocarpus longan
H0308	Pi Ba Ren	枇杷仁	NA	Eriobotrya japonica
H0368	Rou Gui Zi	肉桂子	Cassiabarktree	Cinnamomum cassia
H1007	Dou You	豆油	Soybean oil	Glycine max
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H0302	Ou Fen	藕粉	Hindu lotus large rhizome	Nelumbo nucifera
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H0419	Shan Zha	山楂	Chinese hawthorn	Crataegus pinnatifida
H0863	Zui Xian Tao	醉仙桃	jimsonweed	Datura stramonium
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H0120	Ban Bian Qi	半边旗	pinnated brake herb	Pteris semipinnata
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0111	Ku Shen	苦参	Lightyellow sophora	Sophora flavescens
H0421	Shan Zha Qing Gao	山楂清膏	Chinese hawthorn	Crataegus pinnatifida
H0140	Lian Zi	莲子	Hindu lotus seed	Nelumbo nucifera
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H0129	Le Xian Cai	勒苋菜	NA	Amaranthus spinosus
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0995	Dong Chong Xia Cao	冬虫夏草	Aweto	Cordyceps sinensis
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H0764	Yu Xing Cao	鱼腥草	Heartleaf houttuynia	Houttuynia cordata
H0026	Jiang	姜	Soybean paste	Glycine max
H0733	Ye Shan Zha	野山楂	nippon bawthorn	Crataegus pinnatifida

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 103)