HIT-result

Type	Detail
Target ID	T49A2A
Protein Name	Sodium/hydrogen exchanger 1
Uniprot ID	P19634
Protein Name Alias	APNH; Na(+)/H(+) antiporter, amiloride-sensitive; Na(+)/H(+) exchanger 1; NHE-1; Solute carrier family 9 member 1
Gene ID	6548
Gene Symbol	SLC9A1
Gene Alias	APNH1; NHE1
TTD	T82028: Clinical Trial target
Pfam	PF00999 ; PF16644
GO	0070062:extracellular exosome 0030011:maintenance of cell polarity 0014704:intercalated disc 0005789:endoplasmic reticulum membrane 0009986:cell surface 0016021:integral component of membrane 0071805:potassium ion transmembrane transport 0010613:positive regulation of cardiac muscle hypertrophy 0010447:response to acidic pH 0070417:cellular response to cold 0043066:negative regulation of apoptotic process 0071236:cellular response to antibiotic 0016477:cell migration 0035994:response to muscle stretch 0015386:potassium:proton antiporter activity 0071257:cellular response to electrical stimulus 0071872:cellular response to epinephrine stimulus 0071260:cellular response to mechanical stimulus 0051893:regulation of focal adhesion assembly 0005925:focal adhesion 0006885:regulation of pH 0043065:positive regulation of apoptotic process 0071456:cellular response to hypoxia 0006883:cellular sodium ion homeostasis 0005516:calmodulin binding 0030674:protein-macromolecule adaptor activity 0030307:positive regulation of cell growth 0006811:ion transport 0086092:regulation of the force of heart contraction by cardiac conduction 0070886:positive regulation of calcineurin-NFAT signaling cascade 0015299:solute:proton antiporter activity 0005886:plasma membrane 0010882:regulation of cardiac muscle contraction by calcium ion signaling 0051453:regulation of intracellular pH 0030315:T-tubule 0098735:positive regulation of the force of heart contraction 0005654:nucleoplasm 0015385:sodium:proton antiporter activity 1902600:proton transmembrane transport 0005887:integral component of plasma membrane 0051259:protein complex oligomerization 0005737:cytoplasm 0086003:cardiac muscle cell contraction 0036376:sodium ion export across plasma membrane 0048471:perinuclear region of cytoplasm 0005783:endoplasmic reticulum 0051492:regulation of stress fiber assembly 0030346:protein phosphatase 2B binding 0045760:positive regulation of action potential 0005739:mitochondrion 0032869:cellular response to insulin stimulus 0045944:positive regulation of transcription by RNA polymerase II 0048306:calcium-dependent protein binding 0016323:basolateral plasma membrane 1903281:positive regulation of calcium:sodium antiporter activity 0051930:regulation of sensory perception of pain 0086036:regulation of cardiac muscle cell membrane potential 0060090:molecular adaptor activity 0098719:sodium ion import across plasma membrane 0045121:membrane raft 0090533:cation-transporting ATPase complex 0070997:neuron death 0055007:cardiac muscle cell differentiation 0035794:positive regulation of mitochondrial membrane permeability 0086040:sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential 0005546:phosphatidylinositol-4,5-bisphosphate binding 0030214:hyaluronan catabolic process 0016324:apical plasma membrane 0071468:cellular response to acidic pH 0030027:lamellipodium
PDB	1Y4E ; 2MDF ; 6NUU ; 2E30 ; 2HTG ; 6NUF ; 6BJF ; 2BEC ; 2YGG ; 6NUC ; 2KBV ; 2L0E
Drugbank	DB01043 ; DB02624 ; DB00594 ; DB06468
KEGG	hsa:6548

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Name: urogastrone

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0111	Ku Shen	苦参	Lightyellow sophora	Sophora flavescens
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1080	Gan Ge	干葛	Lobed kudzuvine root	Pueraria lobata
H0852	Zi Tan	紫檀	Burmacoast padauk	Pterocarpus indicus
H0995	Dong Chong Xia Cao	冬虫夏草	Aweto	Cordyceps sinensis
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H0980	Di Yu Tan	地榆炭	Garden burnet	Sanguisorba officinalis
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1124	Guang Jin Qian Cao	广金钱草	Snowbellleaf tickclover	Desmodium styracifolium
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0026	Jiang	姜	Soybean paste	Glycine max
H1095	Ge Gen Gan Jin Gao	葛根干浸膏	Lobed kudzuvine root	Pueraria lobata
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0575	Tu Ku Shen	土苦参	all-grass of hooker winghead	Sophora flavescens
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H0129	Le Xian Cai	勒苋菜	NA	Amaranthus spinosus
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0979	Di Yu	地榆	Garden burnet	Sanguisorba officinalis
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0792	Zhang Yu	章鱼	Common atlantic octopus	Octopus vulgaris
H1094	Ge Gen	葛根	Lobed kudzuvine root	Pueraria lobata
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0906	Ci Wan	刺苋	spiny amaranth	Amaranthus spinosus
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1096	Ge Hua	葛花	flower bud of lobed kudzuvine	Pueraria lobata
H0533	Teng Ku Shen	藤苦参	NA	Sophora flavescens
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1225	Huai Mi	槐米	NA	Sophora japonica
H1007	Dou You	豆油	Soybean oil	Glycine max
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 45)