Target Description

Type Detail
Target ID T49A2A
Protein Name Sodium/hydrogen exchanger 1
Uniprot ID P19634
Protein Name Alias APNH;  Na(+)/H(+) antiporter, amiloride-sensitive;  Na(+)/H(+) exchanger 1;  NHE-1;  Solute carrier family 9 member 1
Gene ID 6548
Gene Symbol SLC9A1
Gene Alias APNH1;  NHE1
TTD T82028: Clinical Trial target
Pfam PF00999 ; PF16644
GO
0070062:extracellular exosome

0030011:maintenance of cell polarity

0014704:intercalated disc

0005789:endoplasmic reticulum membrane

0009986:cell surface

0016021:integral component of membrane

0071805:potassium ion transmembrane transport

0010613:positive regulation of cardiac muscle hypertrophy

0010447:response to acidic pH

0070417:cellular response to cold

0043066:negative regulation of apoptotic process

0071236:cellular response to antibiotic

0016477:cell migration

0035994:response to muscle stretch

0015386:potassium:proton antiporter activity

0071257:cellular response to electrical stimulus

0071872:cellular response to epinephrine stimulus

0071260:cellular response to mechanical stimulus

0051893:regulation of focal adhesion assembly

0005925:focal adhesion

0006885:regulation of pH

0043065:positive regulation of apoptotic process

0071456:cellular response to hypoxia

0006883:cellular sodium ion homeostasis

0005516:calmodulin binding

0030674:protein-macromolecule adaptor activity

0030307:positive regulation of cell growth

0006811:ion transport

0086092:regulation of the force of heart contraction by cardiac conduction

0070886:positive regulation of calcineurin-NFAT signaling cascade

0015299:solute:proton antiporter activity

0005886:plasma membrane

0010882:regulation of cardiac muscle contraction by calcium ion signaling

0051453:regulation of intracellular pH

0030315:T-tubule

0098735:positive regulation of the force of heart contraction

0005654:nucleoplasm

0015385:sodium:proton antiporter activity

1902600:proton transmembrane transport

0005887:integral component of plasma membrane

0051259:protein complex oligomerization

0005737:cytoplasm

0086003:cardiac muscle cell contraction

0036376:sodium ion export across plasma membrane

0048471:perinuclear region of cytoplasm

0005783:endoplasmic reticulum

0051492:regulation of stress fiber assembly

0030346:protein phosphatase 2B binding

0045760:positive regulation of action potential

0005739:mitochondrion

0032869:cellular response to insulin stimulus

0045944:positive regulation of transcription by RNA polymerase II

0048306:calcium-dependent protein binding

0016323:basolateral plasma membrane

1903281:positive regulation of calcium:sodium antiporter activity

0051930:regulation of sensory perception of pain

0086036:regulation of cardiac muscle cell membrane potential

0060090:molecular adaptor activity

0098719:sodium ion import across plasma membrane

0045121:membrane raft

0090533:cation-transporting ATPase complex

0070997:neuron death

0055007:cardiac muscle cell differentiation

0035794:positive regulation of mitochondrial membrane permeability

0086040:sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential

0005546:phosphatidylinositol-4,5-bisphosphate binding

0030214:hyaluronan catabolic process

0016324:apical plasma membrane

0071468:cellular response to acidic pH

0030027:lamellipodium

PDB 1Y4E ; 2MDF ; 6NUU ; 2E30 ; 2HTG ; 6NUF ; 6BJF ; 2BEC ; 2YGG ; 6NUC ; 2KBV ; 2L0E
Drugbank DB01043 ; DB02624 ; DB00594 ; DB06468
KEGG hsa:6548

Related Compounds  (Total: 2)

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C0101
Name: Genistein
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C0977
Name: urogastrone


Related Herbs  (Total: 45)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1227 Huai Zhi槐枝 NASophora japonica
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H0852 Zi Tan紫檀 Burmacoast padaukPterocarpus indicus
H0995 Dong Chong Xia Cao冬虫夏草 AwetoCordyceps sinensis
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H0980 Di Yu Tan地榆炭 Garden burnetSanguisorba officinalis
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0026 Jiang Soybean pasteGlycine max
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0129 Le Xian Cai勒苋菜 NAAmaranthus spinosus
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0979 Di Yu地榆 Garden burnetSanguisorba officinalis
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0792 Zhang Yu章鱼 Common atlantic octopusOctopus vulgaris
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0906 Ci Wan刺苋 spiny amaranthAmaranthus spinosus
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1225 Huai Mi槐米 NASophora japonica
H1007 Dou You豆油 Soybean oilGlycine max
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis