HIT-result

Type	Detail
Target ID	T26UZV
Protein Name	Dual specificity mitogen-activated protein kinase kinase 5
Uniprot ID	Q13163
Protein Name Alias	MAP kinase kinase 5; MAPKK 5; EC 2.7.12.2; MAPK/ERK kinase 5; MEK 5
Gene ID	5607
Gene Symbol	MAP2K5
Gene Alias	MEK5; MKK5; PRKMK5
TTD	T17143: Research target
Pfam	PF00069 ; PF00564
GO	0030307:positive regulation of cell growth 0000187:activation of MAPK activity 0034115:negative regulation of heterotypic cell-cell adhesion 0071363:cellular response to growth factor stimulus 0046872:metal ion binding 0051247:positive regulation of protein metabolic process 0004714:transmembrane receptor protein tyrosine kinase activity 0032088:negative regulation of NF-kappaB transcription factor activity 0106310:protein serine kinase activity 2000342:negative regulation of chemokine (C-X-C motif) ligand 2 production 0000122:negative regulation of transcription by RNA polymerase II 0106311:protein threonine kinase activity 0004672:protein kinase activity 2001240:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 0005524:ATP binding 0005634:nucleus 0005829:cytosol 0007507:heart development 0007165:signal transduction 0032717:negative regulation of interleukin-8 production 0090051:negative regulation of cell migration involved in sprouting angiogenesis 0004708:MAP kinase kinase activity 0060761:negative regulation of response to cytokine stimulus 0005819:spindle 0050679:positive regulation of epithelial cell proliferation 0071499:cellular response to laminar fluid shear stress 0045944:positive regulation of transcription by RNA polymerase II 0070375:ERK5 cascade 0043154:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
PDB	2O2V ; 4IC7 ; 2NPT
Drugbank	DB12010
KEGG	hsa:5607

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1248	Huang Qi Gan Jin Gao	黄芪干浸膏	Membranous milkvetch	Astragalus membranaceus
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0198	Ma Huang Gao	麻黄膏	Chinese ephedra	Ephedra sinica
H0111	Ku Shen	苦参	Lightyellow sophora	Sophora flavescens
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1080	Gan Ge	干葛	Lobed kudzuvine root	Pueraria lobata
H0852	Zi Tan	紫檀	Burmacoast padauk	Pterocarpus indicus
H0995	Dong Chong Xia Cao	冬虫夏草	Aweto	Cordyceps sinensis
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0278	Nan Ban Lan Gen Jin Gao Fen	南板蓝根浸膏粉	Indigowoad root	Baphicacanthus cusia
H1174	Hei Da Dou	黑大豆	Black soyabean	Glycine max
H0980	Di Yu Tan	地榆炭	Garden burnet	Sanguisorba officinalis
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1124	Guang Jin Qian Cao	广金钱草	Snowbellleaf tickclover	Desmodium styracifolium
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H0705	Yan Hu Lu Ba	盐胡芦巴	Fenugreek	Trigonella foenum-graecum
H0152	Ling Zhi Jin Gao	灵芝浸膏	NA	Ganoderma lucidum
H0197	Ma Huang	麻黄	Chinese ephedra	Ephedra sinica
H0952	Dan Xiang Chi	淡香豉	NA	Glycine max
H0200	Ma Huang Gen	麻黄根	Chinese ephedra root	Ephedra sinica
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0026	Jiang	姜	Soybean paste	Glycine max
H1250	Huang Qi Ti Qu Ye	黄芪提取液	Membranous milkvetch	Astragalus membranaceus
H1095	Ge Gen Gan Jin Gao	葛根干浸膏	Lobed kudzuvine root	Pueraria lobata
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0575	Tu Ku Shen	土苦参	all-grass of hooker winghead	Sophora flavescens
H0084	Jiu Li Xiang	九里香	Common jasminorange	Murraya paniculata
H0129	Le Xian Cai	勒苋菜	NA	Amaranthus spinosus
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0979	Di Yu	地榆	Garden burnet	Sanguisorba officinalis
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0792	Zhang Yu	章鱼	Common atlantic octopus	Octopus vulgaris
H1094	Ge Gen	葛根	Lobed kudzuvine root	Pueraria lobata
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0906	Ci Wan	刺苋	spiny amaranth	Amaranthus spinosus
H0944	Dan Dou Gu	淡豆鼓	NA	Glycine max
H0027	Jiang Gao	姜膏	Soybean paste	Glycine max
H0031	Jiang Tan	姜炭	Soybean paste	Glycine max
H0555	Tie Xian Cai	铁苋菜	Copperleaf herb	Herba acalyphae
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H1249	Huang Qi Jin Gao	黄芪浸膏	Membranous milkvetch	Astragalus membranaceus
H0153	Ling Zhi(1)	灵芝	Lucid ganoderma	Ganoderma lucidum
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1096	Ge Hua	葛花	flower bud of lobed kudzuvine	Pueraria lobata
H0533	Teng Ku Shen	藤苦参	NA	Sophora flavescens
H0277	Nan Ban Lan Gen	南板蓝根	Indigowoad root	Baphicacanthus cusia
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0201	Ma Huang Jin Gao	麻黄浸膏	Chinese ephedra	Ephedra sinica
H1247	Huang Qi	黄芪	Membranous milkvetch	Astragalus membranaceus
H0957	Dang Gui Teng	当归藤	NA	Embelia parviflora
H1225	Huai Mi	槐米	NA	Sophora japonica
H1007	Dou You	豆油	Soybean oil	Glycine max
H0246	Mi Ma Huang	蜜麻黄	Ephedra equisetin	Ephedra sinica
H0826	Chu Mu Dan	臭牡丹	rose glorybower	Clerodendrum bungei
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 62)