Target Description

Type Detail
Target ID T26UZV
Protein Name Dual specificity mitogen-activated protein kinase kinase 5
Uniprot ID Q13163
Protein Name Alias MAP kinase kinase 5;  MAPKK 5;  EC 2.7.12.2;  MAPK/ERK kinase 5;  MEK 5
Gene ID 5607
Gene Symbol MAP2K5
Gene Alias MEK5;  MKK5;  PRKMK5
TTD T17143: Research target
Pfam PF00069 ; PF00564
GO
0030307:positive regulation of cell growth

0000187:activation of MAPK activity

0034115:negative regulation of heterotypic cell-cell adhesion

0071363:cellular response to growth factor stimulus

0046872:metal ion binding

0051247:positive regulation of protein metabolic process

0004714:transmembrane receptor protein tyrosine kinase activity

0032088:negative regulation of NF-kappaB transcription factor activity

0106310:protein serine kinase activity

2000342:negative regulation of chemokine (C-X-C motif) ligand 2 production

0000122:negative regulation of transcription by RNA polymerase II

0106311:protein threonine kinase activity

0004672:protein kinase activity

2001240:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

0005524:ATP binding

0005634:nucleus

0005829:cytosol

0007507:heart development

0007165:signal transduction

0032717:negative regulation of interleukin-8 production

0090051:negative regulation of cell migration involved in sprouting angiogenesis

0004708:MAP kinase kinase activity

0060761:negative regulation of response to cytokine stimulus

0005819:spindle

0050679:positive regulation of epithelial cell proliferation

0071499:cellular response to laminar fluid shear stress

0045944:positive regulation of transcription by RNA polymerase II

0070375:ERK5 cascade

0043154:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

PDB 2O2V ; 4IC7 ; 2NPT
Drugbank DB12010
KEGG hsa:5607

Related Compounds  (Total: 2)

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C0101
Name: Genistein
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C1188
Name: Biochanin


Related Herbs  (Total: 62)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0277 Nan Ban Lan Gen南板蓝根 Indigowoad rootBaphicacanthus cusia
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H0246 Mi Ma Huang蜜麻黄 Ephedra equisetinEphedra sinica
H0152 Ling Zhi Jin Gao灵芝浸膏 NAGanoderma lucidum
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H1227 Huai Zhi槐枝 NASophora japonica
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0198 Ma Huang Gao麻黄膏 Chinese ephedraEphedra sinica
H1247 Huang Qi黄芪 Membranous milkvetchAstragalus membranaceus
H0197 Ma Huang麻黄 Chinese ephedraEphedra sinica
H1248 Huang Qi Gan Jin Gao黄芪干浸膏 Membranous milkvetchAstragalus membranaceus
H1007 Dou You豆油 Soybean oilGlycine max
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0826 Chu Mu Dan臭牡丹 rose glorybowerClerodendrum bungei
H0957 Dang Gui Teng当归藤 NAEmbelia parviflora
H0555 Tie Xian Cai铁苋菜 Copperleaf herbHerba acalyphae
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0705 Yan Hu Lu Ba盐胡芦巴 FenugreekTrigonella foenum-graecum
H1250 Huang Qi Ti Qu Ye黄芪提取液 Membranous milkvetchAstragalus membranaceus
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0200 Ma Huang Gen麻黄根 Chinese ephedra rootEphedra sinica
H0995 Dong Chong Xia Cao冬虫夏草 AwetoCordyceps sinensis
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0852 Zi Tan紫檀 Burmacoast padaukPterocarpus indicus
H0153 Ling Zhi(1)灵芝 Lucid ganodermaGanoderma lucidum
H0026 Jiang Soybean pasteGlycine max
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H0201 Ma Huang Jin Gao麻黄浸膏 Chinese ephedraEphedra sinica
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0979 Di Yu地榆 Garden burnetSanguisorba officinalis
H0906 Ci Wan刺苋 spiny amaranthAmaranthus spinosus
H1249 Huang Qi Jin Gao黄芪浸膏 Membranous milkvetchAstragalus membranaceus
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0792 Zhang Yu章鱼 Common atlantic octopusOctopus vulgaris
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0129 Le Xian Cai勒苋菜 NAAmaranthus spinosus
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1225 Huai Mi槐米 NASophora japonica
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H0278 Nan Ban Lan Gen Jin Gao Fen南板蓝根浸膏粉 Indigowoad rootBaphicacanthus cusia
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0980 Di Yu Tan地榆炭 Garden burnetSanguisorba officinalis
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis