Target Description

Type Detail
Target ID T74V1Z
Protein Name Dual specificity mitogen-activated protein kinase kinase 7
Uniprot ID O14733
Protein Name Alias MAP kinase kinase 7;  MAPKK 7;  EC 2.7.12.2;  JNK-activating kinase 2;  MAPK/ERK kinase 7;  MEK 7;  Stress-activated protein kinase kinase 4;  SAPK kinase 4;  SAPKK-4;  SAPKK4;  c-Jun N-terminal kinase kinase 2;  JNK kinase 2;  JNKK 2
Gene ID 5609
Gene Symbol MAP2K7
Gene Alias JNKK2;  MEK7;  MKK7;  PRKMK7;  SKK4
TTD T53159: Research target
Pfam PF00069
GO
0005634:nucleus

0007257:activation of JUN kinase activity

0004708:MAP kinase kinase activity

0106311:protein threonine kinase activity

0051973:positive regulation of telomerase activity

0005829:cytosol

0000187:activation of MAPK activity

0034612:response to tumor necrosis factor

0032212:positive regulation of telomere maintenance via telomerase

0007254:JNK cascade

0008545:JUN kinase kinase activity

0051403:stress-activated MAPK cascade

0019899:enzyme binding

0045893:positive regulation of transcription, DNA-templated

0106310:protein serine kinase activity

0009411:response to UV

0007165:signal transduction

0004714:transmembrane receptor protein tyrosine kinase activity

0005524:ATP binding

0006915:apoptotic process

0019903:protein phosphatase binding

0070374:positive regulation of ERK1 and ERK2 cascade

0038095:Fc-epsilon receptor signaling pathway

0019901:protein kinase binding

0006970:response to osmotic stress

0009408:response to heat

0005737:cytoplasm

0000287:magnesium ion binding

1904355:positive regulation of telomere capping

PDB 6IB0 ; 5B2M ; 6YG1 ; 5Z1E ; 4UX9 ; 6YG5 ; 6QFT ; 6YG3 ; 2DYL ; 6QFL ; 6YG6 ; 6QG7 ; 5Y90 ; 6QG4 ; 3WZU ; 5Z1D ; 6IB2 ; 6QFR ; 6YG2 ; 6YZ4 ; 7CBX ; 5B2K ; 6QHO ; 6YG7 ; 5Y8U ; 6QHR ; 6YG4 ; 6YFZ ; 5B2L ; 6YG0
Drugbank NA
KEGG hsa:5609

Related Compounds  (Total: 10)

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C0048
Name: Epinephrine
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C0101
Name: Genistein
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C0157
Name: Isorhamnetin
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C0365
Name: Retinal
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C0512
Name: Indole-3-Acetic Acid


Related Herbs  (Total: 114)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0139 Lian Qiao连翘 Weeping forsythiaForsythia suspensa
H0214 Bei He Huan北合欢 AlbiziaAlbizia julibrissin
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H1250 Huang Qi Ti Qu Ye黄芪提取液 Membranous milkvetchAstragalus membranaceus
H0557 Ting Li Cao葶苈草 Descurainia sophiaLepidium apetalum
H0580 Tu Si Rou菟丝肉 Dodder seedCuscuta australis
H0416 Shan Shen山参 NAPanax ginseng
H0026 Jiang Soybean pasteGlycine max
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0425 Shan Zhi Ma山芝麻 Narrowleaf screwtreeHelicteres angustifolia
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H0423 Shan Zha Ye山楂叶 NACrataegi folium
H0729 Ye Ju Hua野菊花 Indian wild chrysanthemum flowerChrysanthemum indicum
H0792 Zhang Yu章鱼 Common atlantic octopusOctopus vulgaris
H0717 Yang Cong Tou洋葱头 Common onionAllium cepa
H0067 Jin Ying Zi金樱子 Cherokee rose seedRosa laevigata
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H0906 Ci Wan刺苋 spiny amaranthAmaranthus spinosus
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0418 Shan Yin Chen山茵陈 Capillary wormwoodArtemisia capillaris
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0357 Ren Shen人参 GinsengPanax ginseng
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H0746 Yin Chen Hao Gan Jin Gao茵陈蒿干浸膏 Capillary wormwoodArtemisia capillaris
H0980 Di Yu Tan地榆炭 Garden burnetSanguisorba officinalis
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0365 Rou Dou Kou肉豆蔻 Common nutmegMyristica fragrans
H1141 Guo Gang Long Jin Gao过岗龙浸膏 NAEntada phaseoloides
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0763 Yu Mi Xu玉米须 Maize styleZea mays
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H0222 Man Tuo Luo曼陀罗 JimsonweedDatura stramonium
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H1225 Huai Mi槐米 NASophora japonica
H0524 Tan Xiang檀香 SandalwoodSantalum album
H1152 Bai Jie Zi白芥子 White mustard seedSinapis alba
H1007 Dou You豆油 Soybean oilGlycine max
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H0215 Mai Ya麦芽 Barley germinating fruitHordeum vulgare
H0745 Yin Chen Hao茵陈蒿 Capillary wormwoodArtemisia capillaris
H1041 Feng Qie Hua枫茄花 JimsonweedDatura stramonium
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0581 Tu Si Zi菟丝子 Dodder seedCuscuta australis
H1140 Guo Gang Long过岗龙 NAEntada phaseoloides
H1227 Huai Zhi槐枝 NASophora japonica
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H0129 Le Xian Cai勒苋菜 NAAmaranthus spinosus
H0010 Ji Guan Hua鸡冠花 Common cockscomb flowerCelosia cristata
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H0583 Tu Si Zi Teng菟丝子藤 Dodder seedCuscuta australis
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0426 Shan Zhi Ma Gan Jin Gao山芝麻干浸膏 Narrowleaf screwtreeHelicteres angustifolia
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0995 Dong Chong Xia Cao冬虫夏草 AwetoCordyceps sinensis
H0476 Can E蚕蛾 SilkwormBombyx mori
H0585 Tu Yin Chen Hao土茵陈蒿 Capillary wormwoodArtemisia capillaris
H0979 Di Yu地榆 Garden burnetSanguisorba officinalis
H0056 Jin Qiao Mai金荞麦 Wild buckwheat rhizomeRhizoma fagopyri cymosi
H0193 Ma Bian Cao马鞭草 European verbenaVerbena officinalis
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0558 Ting Li Zi葶苈子 Descurainia sophiaLepidium apetalum
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H0500 Can Yong蚕蛹 Silkworm chrysalisBombyx mori
H0249 Bei Ting Li Zi北葶苈子 Descurainia sophiaLepidium apetalum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1247 Huang Qi黄芪 Membranous milkvetchAstragalus membranaceus
H0068 Jin Ying Zi Rou金樱子肉 Cherokee rose seedRosa laevigata
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H1248 Huang Qi Gan Jin Gao黄芪干浸膏 Membranous milkvetchAstragalus membranaceus
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1021 E Da Xia莪大夏 NAOxytropis falcata
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H1249 Huang Qi Jin Gao黄芪浸膏 Membranous milkvetchAstragalus membranaceus
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0379 Bian Xu萹蓄 Common knotgrassPolygonum aviculare
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H0045 Jin Fei Cao金沸草 Japanese inulaInula japonica
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H0002 Hui Xiang茴香 Fennel fruitFoeniculum vulgare
H0852 Zi Tan紫檀 Burmacoast padaukPterocarpus indicus
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0223 Man Tuo Luo Jin Gao曼陀罗浸膏 JimsonweedDatura stramonium
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0069 Jin Ying Zi Ti Qu Ye金樱子提取液 Cherokee rose seedRosa laevigata
H0863 Zui Xian Tao醉仙桃 jimsonweedDatura stramonium
H0716 Yang Cong洋葱 Common onionAllium cepa
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0457 Shi Er石耳 Rock-EarsUmbilicaria esculenta