Target Description

Type Detail
Target ID T33JS5
Protein Name CCN family member 2
Uniprot ID P29279
Protein Name Alias Cellular communication network factor 2;  Connective tissue growth factor;  Hypertrophic chondrocyte-specific protein 24;  Insulin-like growth factor-binding protein 8;  IBP-8;  IGF-binding protein 8;  IGFBP-8
Gene ID 1490
Gene Symbol CCN2
Gene Alias CTGF;  HCS24;  IGFBP8
TTD T29036: Clinical Trial target
Pfam PF00093 ; PF19035 ; PF00007 ; PF00219
GO
0060401:cytosolic calcium ion transport

0005178:integrin binding

0010942:positive regulation of cell death

0050867:positive regulation of cell activation

0060452:positive regulation of cardiac muscle contraction

0035556:intracellular signal transduction

0070542:response to fatty acid

0031012:extracellular matrix

0010629:negative regulation of gene expression

0045597:positive regulation of cell differentiation

0005615:extracellular space

0005801:cis-Golgi network

0001502:cartilage condensation

0070278:extracellular matrix constituent secretion

0001968:fibronectin binding

0007229:integrin-mediated signaling pathway

0043200:response to amino acid

0016477:cell migration

0071897:DNA biosynthetic process

0008022:protein C-terminus binding

0001934:positive regulation of protein phosphorylation

0001525:angiogenesis

0005829:cytosol

0032330:regulation of chondrocyte differentiation

0009611:response to wounding

0043434:response to peptide hormone

0005576:extracellular region

0030154:cell differentiation

0008083:growth factor activity

0051496:positive regulation of stress fiber assembly

0035988:chondrocyte proliferation

0034059:response to anoxia

0005886:plasma membrane

0007160:cell-matrix adhesion

0001894:tissue homeostasis

0030324:lung development

0046330:positive regulation of JNK cascade

0032355:response to estradiol

0048471:perinuclear region of cytoplasm

0005938:cell cortex

0072593:reactive oxygen species metabolic process

0060548:negative regulation of cell death

0008284:positive regulation of cell population proliferation

0032967:positive regulation of collagen biosynthetic process

0009749:response to glucose

0043280:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

0070374:positive regulation of ERK1 and ERK2 cascade

0001503:ossification

0006367:transcription initiation from RNA polymerase II promoter

0010628:positive regulation of gene expression

0008543:fibroblast growth factor receptor signaling pathway

0051385:response to mineralocorticoid

0007155:cell adhesion

0008544:epidermis development

0007165:signal transduction

0008201:heparin binding

0007568:aging

0070318:positive regulation of G0 to G1 transition

0005520:insulin-like growth factor binding

PDB NA
Drugbank NA
KEGG hsa:1490

Related Compounds  (Total: 12)

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C0101
Name: Genistein
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C0224
Name: Monocrotaline
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C0247
Name: Nicotine
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C0305
Name: Phorbol Myristate Acetate
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C0371
Name: Riboflavin


Related Herbs  (Total: 134)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0888 Ba Dou Ye巴豆叶 Pu rging crotonCroton tiglium
H1227 Huai Zhi槐枝 NASophora japonica
H0111 Ku Shen苦参 Lightyellow sophoraSophora flavescens
H0500 Can Yong蚕蛹 Silkworm chrysalisBombyx mori
H1174 Hei Da Dou黑大豆 Black soyabeanGlycine max
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H1168 He Tao Ren核桃仁 English walnut seedSemen juglandis
H0395 Sang Shen Qing Gao桑葚清膏 MulberryMorus alba
H1033 Fang Ji防己 Fourstamen stephaniaStephania tetrandra
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0429 Shao Yao芍药 Red peony rootPaeonia obovata
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H1133 Gui Jian Yu鬼箭羽 Winged euonymusEuonymus alatus
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H1094 Ge Gen葛根 Lobed kudzuvine rootPueraria lobata
H1080 Gan Ge干葛 Lobed kudzuvine rootPueraria lobata
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H0394 Sang Shen Jin Gao桑葚浸膏 MulberryMorus alba
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H0357 Ren Shen人参 GinsengPanax ginseng
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H0965 Deng Zhan Xi Xin灯盏细辛 Shortscape fleabaneErigeron breviscapus
H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1007 Dou You豆油 Soybean oilGlycine max
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0878 Ba Dou Shuang巴豆霜 Defatted croton seed powderCroton tiglium
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0574 Cao Dou Kou草豆蔻 Katsumada galangalAlpinia katsumadai
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1029 Fang Er Cha方儿茶 khair in hindiSenegalia catechu
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H0615 Wu Zhi Mao Tao五指毛桃 five-finger fig rootFicus simplicissima
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H1095 Ge Gen Gan Jin Gao葛根干浸膏 Lobed kudzuvine rootPueraria lobata
H1176 Hei Hu Jiao黑胡椒 Black pepperPiper nigrum
H0792 Zhang Yu章鱼 Common atlantic octopusOctopus vulgaris
H0423 Shan Zha Ye山楂叶 NACrataegi folium
H0979 Di Yu地榆 Garden burnetSanguisorba officinalis
H0190 Lv Dou绿豆 Common sainfoinOnobrychis viciifolia
H0527 Tao PeachPrunus persica
H0129 Le Xian Cai勒苋菜 NAAmaranthus spinosus
H0476 Can E蚕蛾 SilkwormBombyx mori
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H0327 Qian Li Guang千里光 Climbing groundselSenecio scandens
H1208 Hu Ma Ren胡麻仁 white seed of oriental sesameSesamum indicum
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0031 Jiang Tan姜炭 Soybean pasteGlycine max
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0416 Shan Shen山参 NAPanax ginseng
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0714 Yan Tai Chai Hu烟台柴胡 Chinese thorowaxBupleurum chinense
H0026 Jiang Soybean pasteGlycine max
H0256 Ming Dang Shen明党参 Medicinal changiumChangium smyrnioides
H0095 Gou Qi Zi枸杞子 Chinese wolfberry fruitLycium chinense
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0533 Teng Ku Shen藤苦参 NASophora flavescens
H0172 Lu Gen芦根 Common reed rhizomePhragmites communis
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H0094 Gou Qi枸杞 Chinese wolfberry fruitLycium chinense
H0659 Chai Hu Jin Gao柴胡浸膏 Chinese thorowaxBupleurum chinense
H0650 Chai Hu柴胡 Chinese thorowaxBupleurum chinense
H1004 Bai Cha白茶 White teaCamellia sinensis
H0582 Cao Dou Kou Ren草豆蔻仁 Katsumada galangalAlpinia katsumadai
H0995 Dong Chong Xia Cao冬虫夏草 AwetoCordyceps sinensis
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H0852 Zi Tan紫檀 Burmacoast padaukPterocarpus indicus
H0784 Chi Shao赤芍 Red peony rootPaeonia obovata
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0132 Li Lu藜芦 Black falsehelleboreVeratrum nigrum
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H0952 Dan Xiang Chi淡香豉 NAGlycine max
H0775 Yun Zhi云芝 Coriolus versicolorPolysaccharidum versicolor
H0358 Ren Shen Ye人参叶 Ginseng leafPanax ginseng
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0665 Chai Hu Shao柴胡梢 Chinese thorowaxBupleurum chinense
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0075 Jing Mi粳米 RiceOryza sativa
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0330 Qian Shi芡实 seed of gordon euryaleSemen euryales
H0341 Qing Feng Teng青风藤 OrientvineSinomenium acutum
H0980 Di Yu Tan地榆炭 Garden burnetSanguisorba officinalis
H0575 Tu Ku Shen土苦参 all-grass of hooker wingheadSophora flavescens
H0393 Sang Shen桑葚 MulberryMorus alba
H1204 Hu Jiao胡椒 Black pepperPiper nigrum
H0087 Ju Gu Ye枸骨叶 FOLIUM iLICIS cORNUTAEIlex cornuta
H1167 He Tao核桃 English walnut seedSemen juglandis
H1225 Huai Mi槐米 NASophora japonica
H0869 Ba Dou巴豆 Pu rging crotonCroton tiglium
H0472 Shu Da Huang熟大黄 NARheum palmatum
H1212 Hu Ye Gan Jin Gao槲叶干浸膏 NAQuercus dentata
H1096 Ge Hua葛花 flower bud of lobed kudzuvinePueraria lobata
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H1181 Hei Zhi Ma黑芝麻 Oriental sesameSesamum indicum
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H0027 Jiang Gao姜膏 Soybean pasteGlycine max
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0142 Liang Jiang良姜 NAAlpinia officinarum
H1077 Bai Hu Jiao白胡椒 white pepperPiper nigrum
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0737 Yi Tang饴糖 moltoseSaccharum granorum
H0603 Wu Tong Ye Jin Gao梧桐叶浸膏 Parasol treesFirmiana simplex
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0168 Long Yan Rou龙眼肉 Longan arilArillus longan
H0906 Ci Wan刺苋 spiny amaranthAmaranthus spinosus
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H0560 Cao Bei Mu草贝母 Indian iphigeniaIphigenia indica
H1207 Hu Ma胡麻 white seed of oriental sesameSesamum indicum
H0944 Dan Dou Gu淡豆鼓 NAGlycine max
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis