ID: C0305 | Common name: Phorbol Myristate Acetate |
IUPAC: NA | CAS: CAS:16561-29-8 |
Chembl ID: CHEMBL279115 | Pubchem ID: CID:27924 |
Formula: C36H56O8 | TCM-ID: TCMC1881 |
Smiles: CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@H]([C@H]3[C@]1(OC(=O)C)C3(C)C)C=C(C[C@]1([C@H]2C=C(C1=O)C)O)CO | |
Alias:
Myristic acid, 9-ester with 1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9a-acetate, (+)-;
Tetradecanoic acid, 9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester, [1aR-(1aα,1bβ,4aβ,7aα,7bα,8α,9β,9aα)]-; 1H-Cyclopropa[3,4]benz[1,2-e]azulene, tetradecanoic acid deriv.; 12-O-Tetradecanoylphorbol 13-acetate; 12-Tetradecanoylphorbol 13-acetate; 12-Tetradecanoylphorbol 13-monoacetate; 13-O-Acetylphorbol 12-myristate; 4β-Phorbol 12-myristate 13-acetate; Factor A1; Factor A1 (croton oil); NSC 262244; PD 616; PMA; PMA (tumor promoter); Phorbol 12-myristate 13-acetate; Phorbol 12-tetradecanoate 13-acetate; Phorbol myristate acetate; TPA; TPA (phorbol derivative); Tetradecanoylphorbol acetate; β-Phorbol 12-myristate 13-acetate |
Structure:
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Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
---|---|---|---|---|---|
T36SOV | Plasminogen activator inhibitor 1 | SERPINE1 |
P05121 |
A | 3 Reference(s) |
T66GX9 | Proline-rich transmembrane protein 2 | PRRT2 |
Q7Z6L0 |
A | 10 Reference(s) |
T91MWA | Disintegrin and metalloproteinase domain-containing protein 17 | ADAM17 |
P78536 |
A | 2 Reference(s) |
T98DNG | Natriuretic peptides A | NPPA |
P01160 |
A | 1 Reference(s) |
T06RMZ | Nuclear factor NF-kappa-B p105 subunit | NFKB1 |
P19838 |
A | 3 Reference(s) |
T46YMA | Ras-related C3 botulinum toxin substrate 1 | RAC1 |
P63000 |
A | 2 Reference(s) |
T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
A | 3 Reference(s) |
T49TDM | Matrix metalloproteinase-9 | MMP9 |
P14780 |
A | 5 Reference(s) |
T95Y0K | Sphingosine kinase 1 | SPHK1 |
Q9NYA1 |
A | 2 Reference(s) |
T50WOV | ATP-dependent translocase ABCB1 | ABCB1 |
P08183 |
A | 1 Reference(s) |
T41PB6 | Serine/threonine-protein kinase D3 | PRKD3 |
O94806 |
A | 1 Reference(s) |
T78ZF2 | Protein kinase C alpha type | PRKCA |
P17252 |
A | 1 Reference(s) |
T44LWL | Transcription factor p65 | RELA |
Q04206 |
A | 1 Reference(s) |
T84Z2I | SHC-transforming protein 1 | SHC1 |
P29353 |
A | 1 Reference(s) |
T27ZME | Myosin light chain kinase, smooth muscle | MYLK |
Q15746 |
A | 1 Reference(s) |
T25YP8 | Aquaporin-4 | AQP4 |
P55087 |
A | 1 Reference(s) |
T93VFT | Endothelin-1 | EDN1 |
P05305 |
A | 1 Reference(s) |
T84P70 | Urokinase-type plasminogen activator | PLAU |
P00749 |
A | 1 Reference(s) |
T68EEP | Phospholipase D1 | PLD1 |
Q13393 |
A | 1 Reference(s) |
T97KFC | Transcription factor jun-B | JUNB |
P17275 |
A | 1 Reference(s) |
T82ALJ | Glycogen synthase kinase-3 beta | GSK3B |
P49841 |
B | 1 Reference(s) |
T62Y4H | Protein kinase C epsilon type | PRKCE |
Q02156 |
B | 2 Reference(s) |
T23VMI | Tumor necrosis factor | TNF |
P01375 |
B | 1 Reference(s) |
T63W5U | Ski-like protein | SKIL |
P12757 |
B | 1 Reference(s) |
T71GRQ | Hexokinase-2 | HK2 |
P52789 |
C | 1 Reference(s) |
T31P1D | Metalloproteinase inhibitor 1 | TIMP1 |
P01033 |
C | 1 Reference(s) |
T80GUN | 72 kDa type IV collagenase | MMP2 |
P08253 |
C | 1 Reference(s) |
T50JP5 | Chorion-specific transcription factor GCMa | GCM1 |
Q9NP62 |
C | 1 Reference(s) |
T33JS5 | CCN family member 2 | CCN2 |
P29279 |
C | 1 Reference(s) |
T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
C | 1 Reference(s) |
T97FEF | Broad substrate specificity ATP-binding cassette transporter ABCG2 | ABCG2 |
Q9UNQ0 |
C | 1 Reference(s) |
T43BVC | Basigin | BSG |
P35613 |
C | 1 Reference(s) |
T63YAO | Caveolin-1 | CAV1 |
Q03135 |
C | 1 Reference(s) |
T12CH9 | Sphingosine 1-phosphate receptor 1 | S1PR1 |
P21453 |
C | 1 Reference(s) |
T83RFH | Protein S100-A9 | S100A9 |
P06702 |
C | 1 Reference(s) |
T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
C | 1 Reference(s) |
T45RI0 | G protein-coupled receptor kinase 5 | GRK5 |
P34947 |
C | 1 Reference(s) |
T91OUC | Mucin-5AC | MUC5AC |
P98088 |
C | 2 Reference(s) |
T94HUW | Pituitary adenylate cyclase-activating polypeptide | ADCYAP1 |
P18509 |
C | 1 Reference(s) |
T34WJB | Netrin-1 | NTN1 |
O95631 |
C | 1 Reference(s) |
T08OEP | Monocyte differentiation antigen CD14 | CD14 |
P08571 |
C | 1 Reference(s) |
T46PRA | Excitatory amino acid transporter 3 | SLC1A1 |
P43005 |
C | 1 Reference(s) |
T63EMC | Interleukin-18 | IL18 |
Q14116 |
C | 1 Reference(s) |
T05M8H | Ras-related protein Rab-9A | RAB9A |
P51151 |
C | 1 Reference(s) |
T80OJF | Interstitial collagenase | MMP1 |
P03956 |
C | 1 Reference(s) |
T90ZS8 | Endothelin-converting enzyme 1 | ECE1 |
P42892 |
C | 1 Reference(s) |
T53YWQ | Pro-neuropeptide Y [Cleaved into: Neuropeptide Y | NPY |
P01303 |
C | 1 Reference(s) |
T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
C | 1 Reference(s) |
T41BXR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | SIRT3 |
Q9NTG7 |
C | 1 Reference(s) |
T07EU4 | Transcription factor Sp3 | SP3 |
Q02447 |
C | 1 Reference(s) |
T74KF7 | RE1-silencing transcription factor | REST |
Q13127 |
C | 1 Reference(s) |
T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
C | 1 Reference(s) |
Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
---|---|---|---|---|
H0888 | Ba Dou Ye | 巴豆叶 | Pu rging croton | Croton tiglium |
H1167 | He Tao | 核桃 | English walnut seed | Semen juglandis |
H0269 | Mu Gua | 木瓜 | Chinese floweringquince | Chaenomeles sinensis |
H1168 | He Tao Ren | 核桃仁 | English walnut seed | Semen juglandis |
H0582 | Cao Dou Kou Ren | 草豆蔻仁 | Katsumada galangal | Alpinia katsumadai |
H0484 | Shui Fei Ji | 水飞蓟 | St marys | Silybum marianum |
H0878 | Ba Dou Shuang | 巴豆霜 | Defatted croton seed powder | Croton tiglium |
H0869 | Ba Dou | 巴豆 | Pu rging croton | Croton tiglium |
H0574 | Cao Dou Kou | 草豆蔻 | Katsumada galangal | Alpinia katsumadai |