Compound Description

ID:   C0305 Common name:   Phorbol Myristate Acetate
IUPAC:  NA CAS:  CAS:16561-29-8
Chembl ID:   CHEMBL279115 Pubchem ID:   CID:27924
Formula:  C36H56O8 TCM-ID:  TCMC1881
Smiles:  CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@H]([C@H]3[C@]1(OC(=O)C)C3(C)C)C=C(C[C@]1([C@H]2C=C(C1=O)C)O)CO
Alias:

Myristic acid, 9-ester with 1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-decahydro-4aβ,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9a-acetate, (+)-;

Tetradecanoic acid, 9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester, [1aR-(1aα,1bβ,4aβ,7aα,7bα,8α,9β,9aα)]-;

1H-Cyclopropa[3,4]benz[1,2-e]azulene, tetradecanoic acid deriv.;

12-O-Tetradecanoylphorbol 13-acetate;

12-Tetradecanoylphorbol 13-acetate;

12-Tetradecanoylphorbol 13-monoacetate;

13-O-Acetylphorbol 12-myristate;

4β-Phorbol 12-myristate 13-acetate;

Factor A1;

Factor A1 (croton oil);

NSC 262244;

PD 616;

PMA;

PMA (tumor promoter);

Phorbol 12-myristate 13-acetate;

Phorbol 12-tetradecanoate 13-acetate;

Phorbol myristate acetate;

TPA;

TPA (phorbol derivative);

Tetradecanoylphorbol acetate;

β-Phorbol 12-myristate 13-acetate
Structure:

Related Targets  (Total: 52)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T36SOV Plasminogen activator inhibitor 1SERPINE1 P05121
A 3 Reference(s)
T66GX9 Proline-rich transmembrane protein 2PRRT2 Q7Z6L0
A 10 Reference(s)
T91MWA Disintegrin and metalloproteinase domain-containing protein 17ADAM17 P78536
A 2 Reference(s)
T98DNG Natriuretic peptides ANPPA P01160
A 1 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
A 3 Reference(s)
T46YMA Ras-related C3 botulinum toxin substrate 1RAC1 P63000
A 2 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
A 3 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
A 5 Reference(s)
T95Y0K Sphingosine kinase 1SPHK1 Q9NYA1
A 2 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
A 1 Reference(s)
T41PB6 Serine/threonine-protein kinase D3PRKD3 O94806
A 1 Reference(s)
T78ZF2 Protein kinase C alpha typePRKCA P17252
A 1 Reference(s)
T44LWL Transcription factor p65RELA Q04206
A 1 Reference(s)
T84Z2I SHC-transforming protein 1SHC1 P29353
A 1 Reference(s)
T27ZME Myosin light chain kinase, smooth muscleMYLK Q15746
A 1 Reference(s)
T25YP8 Aquaporin-4AQP4 P55087
A 1 Reference(s)
T93VFT Endothelin-1EDN1 P05305
A 1 Reference(s)
T84P70 Urokinase-type plasminogen activatorPLAU P00749
A 1 Reference(s)
T68EEP Phospholipase D1PLD1 Q13393
A 1 Reference(s)
T97KFC Transcription factor jun-BJUNB P17275
A 1 Reference(s)
T82ALJ Glycogen synthase kinase-3 betaGSK3B P49841
B 1 Reference(s)
T62Y4H Protein kinase C epsilon typePRKCE Q02156
B 2 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
B 1 Reference(s)
T63W5U Ski-like proteinSKIL P12757
B 1 Reference(s)
T71GRQ Hexokinase-2HK2 P52789
C 1 Reference(s)
T31P1D Metalloproteinase inhibitor 1TIMP1 P01033
C 1 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
C 1 Reference(s)
T50JP5 Chorion-specific transcription factor GCMaGCM1 Q9NP62
C 1 Reference(s)
T33JS5 CCN family member 2CCN2 P29279
C 1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
C 1 Reference(s)
T97FEF Broad substrate specificity ATP-binding cassette transporter ABCG2ABCG2 Q9UNQ0
C 1 Reference(s)
T43BVC BasiginBSG P35613
C 1 Reference(s)
T63YAO Caveolin-1CAV1 Q03135
C 1 Reference(s)
T12CH9 Sphingosine 1-phosphate receptor 1S1PR1 P21453
C 1 Reference(s)
T83RFH Protein S100-A9S100A9 P06702
C 1 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
C 1 Reference(s)
T45RI0 G protein-coupled receptor kinase 5GRK5 P34947
C 1 Reference(s)
T91OUC Mucin-5ACMUC5AC P98088
C 2 Reference(s)
T94HUW Pituitary adenylate cyclase-activating polypeptideADCYAP1 P18509
C 1 Reference(s)
T34WJB Netrin-1NTN1 O95631
C 1 Reference(s)
T08OEP Monocyte differentiation antigen CD14CD14 P08571
C 1 Reference(s)
T46PRA Excitatory amino acid transporter 3SLC1A1 P43005
C 1 Reference(s)
T63EMC Interleukin-18IL18 Q14116
C 1 Reference(s)
T05M8H Ras-related protein Rab-9ARAB9A P51151
C 1 Reference(s)
T80OJF Interstitial collagenaseMMP1 P03956
C 1 Reference(s)
T90ZS8 Endothelin-converting enzyme 1ECE1 P42892
C 1 Reference(s)
T53YWQ Pro-neuropeptide Y [Cleaved into: Neuropeptide YNPY P01303
C 1 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
C 1 Reference(s)
T41BXR NAD-dependent protein deacetylase sirtuin-3, mitochondrialSIRT3 Q9NTG7
C 1 Reference(s)
T07EU4 Transcription factor Sp3SP3 Q02447
C 1 Reference(s)
T74KF7 RE1-silencing transcription factorREST Q13127
C 1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 9)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0888 Ba Dou Ye巴豆叶 Pu rging crotonCroton tiglium
H1167 He Tao核桃 English walnut seedSemen juglandis
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H1168 He Tao Ren核桃仁 English walnut seedSemen juglandis
H0582 Cao Dou Kou Ren草豆蔻仁 Katsumada galangalAlpinia katsumadai
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0878 Ba Dou Shuang巴豆霜 Defatted croton seed powderCroton tiglium
H0869 Ba Dou巴豆 Pu rging crotonCroton tiglium
H0574 Cao Dou Kou草豆蔻 Katsumada galangalAlpinia katsumadai