Target Description

Type Detail
Target ID T94HUW
Protein Name Pituitary adenylate cyclase-activating polypeptide
Uniprot ID P18509
Protein Name Alias PACAP
Gene ID 116
Gene Symbol ADCYAP1
Gene Alias NA
TTD T07045: Clinical Trial target
Pfam PF00123
GO
0060253:negative regulation of glial cell proliferation

0043267:negative regulation of potassium ion transport

0005615:extracellular space

0120162:positive regulation of cold-induced thermogenesis

0090274:positive regulation of somatostatin secretion

0032755:positive regulation of interleukin-6 production

0007204:positive regulation of cytosolic calcium ion concentration

0002862:negative regulation of inflammatory response to antigenic stimulus

0051428:peptide hormone receptor binding

0031858:pituitary adenylate cyclase-activating polypeptide receptor binding

0046034:ATP metabolic process

0070445:regulation of oligodendrocyte progenitor proliferation

0007186:G protein-coupled receptor signaling pathway

0043547:positive regulation of GTPase activity

0060078:regulation of postsynaptic membrane potential

0005102:signaling receptor binding

0042594:response to starvation

0043195:terminal bouton

0031175:neuron projection development

0001821:histamine secretion

0002865:negative regulation of acute inflammatory response to antigenic stimulus

0030073:insulin secretion

0007267:cell-cell signaling

0001662:behavioral fear response

0043204:perikaryon

0043005:neuron projection

0051968:positive regulation of synaptic transmission, glutamatergic

0043950:positive regulation of cAMP-mediated signaling

0021983:pituitary gland development

0019933:cAMP-mediated signaling

0010656:negative regulation of muscle cell apoptotic process

0007218:neuropeptide signaling pathway

0001541:ovarian follicle development

0060124:positive regulation of growth hormone secretion

0071385:cellular response to glucocorticoid stimulus

0034260:negative regulation of GTPase activity

0045944:positive regulation of transcription by RNA polymerase II

0008277:regulation of G protein-coupled receptor signaling pathway

0002878:negative regulation of acute inflammatory response to non-antigenic stimulus

0008284:positive regulation of cell population proliferation

0071651:positive regulation of chemokine (C-C motif) ligand 5 production

0019233:sensory perception of pain

0070374:positive regulation of ERK1 and ERK2 cascade

0010976:positive regulation of neuron projection development

0016521:pituitary adenylate cyclase activating polypeptide activity

0005576:extracellular region

0045471:response to ethanol

0007190:activation of adenylate cyclase activity

0005184:neuropeptide hormone activity

0045860:positive regulation of protein kinase activity

0007189:adenylate cyclase-activating G protein-coupled receptor signaling pathway

0007565:female pregnancy

0032880:regulation of protein localization

PDB 2D2P ; 6LPB ; 6VN7 ; 6M1I ; 1GEA ; 2JOD ; 6P9Y
Drugbank DB03988
KEGG hsa:116

Related Compounds  (Total: 2)

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C0305
Name: Phorbol Myristate Acetate
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C0325
Name: Progesterone


Related Herbs  (Total: 17)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H1168 He Tao Ren核桃仁 English walnut seedSemen juglandis
H0574 Cao Dou Kou草豆蔻 Katsumada galangalAlpinia katsumadai
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H0888 Ba Dou Ye巴豆叶 Pu rging crotonCroton tiglium
H0370 Ru Xiang乳香 OlibanumBoswellia carterii
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1167 He Tao核桃 English walnut seedSemen juglandis
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0878 Ba Dou Shuang巴豆霜 Defatted croton seed powderCroton tiglium
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H0582 Cao Dou Kou Ren草豆蔻仁 Katsumada galangalAlpinia katsumadai
H0869 Ba Dou巴豆 Pu rging crotonCroton tiglium