Herb Description

Herb ID:   H0878 Chinese Character:   巴豆霜
English Name:  Defatted croton seed powder Latin Name:  Croton tiglium
Chinese Pin Yin :  Ba Dou Shuang TCM-ID:  TCMH29
Therapeutic Function in Chinese :  泻下 Therapeutic Function in English:  Purging
Herb Function:  Cause drastic purgation, relieve edema, soothe the throat

Related Targets  (Total: 138)

Target idProtein NameGene SymbolUniprot IDNo.of Literature Evidence
T36SOV Plasminogen activator inhibitor 1SERPINE1 P05121
4 Reference(s)
T66GX9 Proline-rich transmembrane protein 2PRRT2 Q7Z6L0
12 Reference(s)
T91MWA Disintegrin and metalloproteinase domain-containing protein 17ADAM17 P78536
2 Reference(s)
T98DNG Natriuretic peptides ANPPA P01160
2 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
6 Reference(s)
T46YMA Ras-related C3 botulinum toxin substrate 1RAC1 P63000
2 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
5 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
5 Reference(s)
T95Y0K Sphingosine kinase 1SPHK1 Q9NYA1
2 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
2 Reference(s)
T41PB6 Serine/threonine-protein kinase D3PRKD3 O94806
1 Reference(s)
T78ZF2 Protein kinase C alpha typePRKCA P17252
3 Reference(s)
T44LWL Transcription factor p65RELA Q04206
1 Reference(s)
T84Z2I SHC-transforming protein 1SHC1 P29353
1 Reference(s)
T27ZME Myosin light chain kinase, smooth muscleMYLK Q15746
1 Reference(s)
T25YP8 Aquaporin-4AQP4 P55087
1 Reference(s)
T93VFT Endothelin-1EDN1 P05305
2 Reference(s)
T84P70 Urokinase-type plasminogen activatorPLAU P00749
1 Reference(s)
T68EEP Phospholipase D1PLD1 Q13393
1 Reference(s)
T97KFC Transcription factor jun-BJUNB P17275
1 Reference(s)
T58XLK Tyrosine-protein phosphatase non-receptor type 1PTPN1 P18031
2 Reference(s)
T77PFO Histone deacetylase 6HDAC6 Q9UBN7
2 Reference(s)
T22NX4 Toll-like receptor 2TLR2 O60603
2 Reference(s)
T76QBQ CREB-regulated transcription coactivator 2CRTC2 Q53ET0
1 Reference(s)
T12PIB Lysosomal alpha-glucosidaseGAA P10253
1 Reference(s)
T83YZD AcetylcholinesteraseACHE P22303
2 Reference(s)
T91T8I Glucose-6-phosphatase catalytic subunit 1G6PC1 P35575
1 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
3 Reference(s)
T25Y64 CholinesteraseBCHE P06276
1 Reference(s)
T30VNV MyeloperoxidaseMPO P05164
1 Reference(s)
T62P0D Collagenase 3MMP13 P45452
1 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
2 Reference(s)
T74WWP Peroxisome proliferator-activated receptor deltaPPARD Q03181
1 Reference(s)
T14JSX PlasminogenPLG P00747
1 Reference(s)
T49ORJ Peroxisome proliferator-activated receptor alphaPPARA Q07869
3 Reference(s)
T67LRH RNA-binding protein Musashi homolog 1MSI1 O43347
1 Reference(s)
T37G49 Platelet-activating factor acetylhydrolasePLA2G7 Q13093
1 Reference(s)
T68HNO Glutathione S-transferase omega-1GSTO1 P78417
1 Reference(s)
T61LV9 Free fatty acid receptor 3FFAR3 O14843
1 Reference(s)
T76MVQ Free fatty acid receptor 4FFAR4 Q5NUL3
1 Reference(s)
T08U92 Mitochondrial brown fat uncoupling protein 1UCP1 P25874
1 Reference(s)
T91AIW Receptor-type tyrosine-protein kinase FLT3FLT3 P36888
1 Reference(s)
T17E95 Protein kinase C gamma typePRKCG P05129
1 Reference(s)
T82ALJ Glycogen synthase kinase-3 betaGSK3B P49841
1 Reference(s)
T62Y4H Protein kinase C epsilon typePRKCE Q02156
2 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
2 Reference(s)
T63W5U Ski-like proteinSKIL P12757
1 Reference(s)
T85U8U Caspase-3CASP3 P42574
1 Reference(s)
T80XW6 Scavenger receptor class B member 1SCARB1 Q8WTV0
1 Reference(s)
T02DEN Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptideGCG P01275
2 Reference(s)
T74JJN Fatty acid synthaseFASN P49327
1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
2 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
1 Reference(s)
T39YFG Trypsin-1PRSS1 P07477
1 Reference(s)
T54WR0 Fatty acid-binding protein 5FABP5 Q01469
1 Reference(s)
T21Q0D 3-hydroxy-3-methylglutaryl-coenzyme A reductaseHMGCR P04035
1 Reference(s)
T12T4H Brain-derived neurotrophic factorBDNF P23560
1 Reference(s)
T07S0E BDNF/NT-3 growth factors receptorNTRK2 Q16620
1 Reference(s)
T90XYZ C-reactive proteinCRP P02741
1 Reference(s)
T51WGR Pancreas/duodenum homeobox protein 1PDX1 P52945
1 Reference(s)
T43NBB Solute carrier family 2, facilitated glucose transporter member 2SLC2A2 P11168
1 Reference(s)
T89L4V InsulinINS P01308
1 Reference(s)
T38WWN Serum paraoxonase/arylesterase 1PON1 P27169
1 Reference(s)
T23YZF Peptidyl-glycine alpha-amidating monooxygenasePAM P19021
1 Reference(s)
T77FOL NeuromodulinGAP43 P17677
1 Reference(s)
T48UT8 Cholesteryl ester transfer proteinCETP P11597
1 Reference(s)
T32HPO Aspartyl aminopeptidaseDNPEP Q9ULA0
1 Reference(s)
T20H9F Stromelysin-1MMP3 P08254
1 Reference(s)
T02YLA Alpha-lactalbuminLALBA P00709
1 Reference(s)
T76TED Pro-opiomelanocortinPOMC P01189
1 Reference(s)
T37JN5 Neutrophil gelatinase-associated lipocalinLCN2 P80188
1 Reference(s)
T17UP9 C-C motif chemokine 2CCL2 P13500
1 Reference(s)
T71GRQ Hexokinase-2HK2 P52789
1 Reference(s)
T31P1D Metalloproteinase inhibitor 1TIMP1 P01033
1 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
1 Reference(s)
T50JP5 Chorion-specific transcription factor GCMaGCM1 Q9NP62
1 Reference(s)
T33JS5 CCN family member 2CCN2 P29279
1 Reference(s)
T97FEF Broad substrate specificity ATP-binding cassette transporter ABCG2ABCG2 Q9UNQ0
1 Reference(s)
T43BVC BasiginBSG P35613
1 Reference(s)
T63YAO Caveolin-1CAV1 Q03135
1 Reference(s)
T12CH9 Sphingosine 1-phosphate receptor 1S1PR1 P21453
1 Reference(s)
T83RFH Protein S100-A9S100A9 P06702
1 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
1 Reference(s)
T45RI0 G protein-coupled receptor kinase 5GRK5 P34947
1 Reference(s)
T91OUC Mucin-5ACMUC5AC P98088
2 Reference(s)
T94HUW Pituitary adenylate cyclase-activating polypeptideADCYAP1 P18509
1 Reference(s)
T34WJB Netrin-1NTN1 O95631
1 Reference(s)
T08OEP Monocyte differentiation antigen CD14CD14 P08571
1 Reference(s)
T46PRA Excitatory amino acid transporter 3SLC1A1 P43005
1 Reference(s)
T63EMC Interleukin-18IL18 Q14116
1 Reference(s)
T05M8H Ras-related protein Rab-9ARAB9A P51151
1 Reference(s)
T80OJF Interstitial collagenaseMMP1 P03956
1 Reference(s)
T90ZS8 Endothelin-converting enzyme 1ECE1 P42892
1 Reference(s)
T53YWQ Pro-neuropeptide Y [Cleaved into: Neuropeptide YNPY P01303
1 Reference(s)
T41BXR NAD-dependent protein deacetylase sirtuin-3, mitochondrialSIRT3 Q9NTG7
1 Reference(s)
T07EU4 Transcription factor Sp3SP3 Q02447
1 Reference(s)
T74KF7 RE1-silencing transcription factorREST Q13127
1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
1 Reference(s)
T04V7K Ectonucleotide pyrophosphatase/phosphodiesterase family member 7ENPP7 Q6UWV6
1 Reference(s)
T51U9M Carnitine O-palmitoyltransferase 1, muscle isoformCPT1B Q92523
1 Reference(s)
T07TMB Cyclin-dependent kinase 1CDK1 P06493
1 Reference(s)
T69NG6 Interleukin-10IL10 P22301
1 Reference(s)
T51EKP Apolipoprotein MAPOM O95445
1 Reference(s)
T07VV7 GuanylinGUCA2A Q02747
1 Reference(s)
T67ZT3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN P60484
1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
4 Reference(s)
T80WPU Protein ABHD15ABHD15 Q6UXT9
1 Reference(s)
T56OUM 14-3-3 protein zeta/deltaYWHAZ P63104
1 Reference(s)
T24YWQ Insulin-degrading enzymeIDE P14735
1 Reference(s)
T34HYH Interleukin-1 alphaIL1A P01583
1 Reference(s)
T70HC9 Hepatocyte nuclear factor 1-alphaHNF1A P20823
1 Reference(s)
T49J7I Hepatocyte nuclear factor 4-alphaHNF4A P41235
1 Reference(s)
T67RBZ Mitochondrial uncoupling protein 2UCP2 P55851
2 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
1 Reference(s)
T74LFK Neurogenic locus notch homolog protein 1NOTCH1 P46531
1 Reference(s)
T62ERY Interleukin-1 receptor-associated kinase 4IRAK4 Q9NWZ3
1 Reference(s)
T76AZQ Histidine decarboxylaseHDC P19113
1 Reference(s)
T67HYX Mitochondrial uncoupling protein 3UCP3 P55916
1 Reference(s)
T19EKF CholecystokininCCK P06307
1 Reference(s)
T19XSL Fatty acid-binding protein, liverFABP1 P07148
1 Reference(s)
T23APZ Retinol-binding protein 2RBP2 P50120
1 Reference(s)
T38K2W Receptor tyrosine-protein kinase erbB-2ERBB2 P04626
1 Reference(s)
T03NWF Sterol O-acyltransferase 1SOAT1 P35610
1 Reference(s)
T48YPL Aquaporin-3AQP3 Q92482
1 Reference(s)
T53SLQ Aquaporin-9AQP9 O43315
1 Reference(s)
T75EH8 Glucagon-like peptide 1 receptorGLP1R P43220
1 Reference(s)
T52VL6 Signal transducer and activator of transcription 5ASTAT5A P42229
1 Reference(s)
T19K8W Signal transducer and activator of transcription 5BSTAT5B P51692
1 Reference(s)
T10HL8 Intercellular adhesion molecule 1ICAM1 P05362
1 Reference(s)
T78ILO Stearoyl-CoA desaturaseSCD O00767
1 Reference(s)
T63GUB Proto-oncogene c-FosFOS P01100
1 Reference(s)
T68IZC Natriuretic peptides BNPPB P16860
1 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
1 Reference(s)
T02H9U Nuclear factor of activated T-cells, cytoplasmic 4NFATC4 Q14934
1 Reference(s)
T38AWT Histone deacetylase 3HDAC3 O15379
1 Reference(s)
T69ZIZ DNA dC->dU-editing enzyme APOBEC-3AAPOBEC3A P31941
1 Reference(s)
T19Y64 DNA dC->dU-editing enzyme APOBEC-3BAPOBEC3B Q9UH17
1 Reference(s)
T39PME G protein-coupled receptor kinase 4GRK4 P32298
1 Reference(s)

Related Compounds  (Total: 11)

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C0305
Name: Phorbol Myristate Acetate
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C0416
Name: Stearic Acid
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C0285
Name: Palmitic Acid
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C0190
Name: Linolenic Acid
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C1231
Name: Chlorogenic Acid