HIT-result

Target Description

Type	Detail
Target ID	T27ZME
Protein Name	Myosin light chain kinase, smooth muscle
Uniprot ID	Q15746
Protein Name Alias	MLCK; smMLCK; EC 2.7.11.18; Kinase-related protein; KRP; Telokin
Gene ID	4638
Gene Symbol	MYLK
Gene Alias	MLCK; MLCK1; MYLK1
TTD	T97141: Clinical Trial target
Pfam	PF00069 ; PF07679 ; PF00041
GO	0003779:actin binding 0004687:myosin light chain kinase activity 0004672:protein kinase activity 0030335:positive regulation of cell migration 0090303:positive regulation of wound healing 0005829:cytosol 0051928:positive regulation of calcium ion transport 0032060:bleb assembly 0071476:cellular hypotonic response 0060414:aorta smooth muscle tissue morphogenesis 0005737:cytoplasm 0006939:smooth muscle contraction 0005524:ATP binding 0005886:plasma membrane 0001725:stress fiber 0005516:calmodulin binding 0006468:protein phosphorylation 0032154:cleavage furrow 0030027:lamellipodium 0015629:actin cytoskeleton 0014820:tonic smooth muscle contraction 0046872:metal ion binding 0006936:muscle contraction
PDB	6C6M ; 2CQV ; 2YR3 ; 5JQA ; 2K0F ; 5JTH
Drugbank	DB12010
KEGG	hsa:4638

Type

Detail

Target ID

T27ZME

Protein Name

Myosin light chain kinase, smooth muscle

Uniprot ID

Q15746

Protein Name Alias

MLCK; smMLCK; EC 2.7.11.18; Kinase-related protein; KRP; Telokin

Gene ID

4638

Gene Symbol

MYLK

Gene Alias

MLCK; MLCK1; MYLK1

TTD

T97141: Clinical Trial target

Pfam

PF00069 ; PF07679 ; PF00041

0003779:actin binding

0004687:myosin light chain kinase activity

0004672:protein kinase activity

0030335:positive regulation of cell migration

0090303:positive regulation of wound healing

0005829:cytosol

0051928:positive regulation of calcium ion transport

0032060:bleb assembly

0071476:cellular hypotonic response

0060414:aorta smooth muscle tissue morphogenesis

0005737:cytoplasm

0006939:smooth muscle contraction

0005524:ATP binding

0005886:plasma membrane

0001725:stress fiber

0005516:calmodulin binding

0006468:protein phosphorylation

0032154:cleavage furrow

0030027:lamellipodium

0015629:actin cytoskeleton

0014820:tonic smooth muscle contraction

0046872:metal ion binding

0006936:muscle contraction

PDB

6C6M ; 2CQV ; 2YR3 ; 5JQA ; 2K0F ; 5JTH

Drugbank

DB12010

KEGG

hsa:4638

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0888	Ba Dou Ye	巴豆叶	Pu rging croton	Croton tiglium
H1167	He Tao	核桃	English walnut seed	Semen juglandis
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H1168	He Tao Ren	核桃仁	English walnut seed	Semen juglandis
H0582	Cao Dou Kou Ren	草豆蔻仁	Katsumada galangal	Alpinia katsumadai
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0878	Ba Dou Shuang	巴豆霜	Defatted croton seed powder	Croton tiglium
H0869	Ba Dou	巴豆	Pu rging croton	Croton tiglium
H0574	Cao Dou Kou	草豆蔻	Katsumada galangal	Alpinia katsumadai

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 9)