Target Description

Type Detail
Target ID T62ERY
Protein Name Interleukin-1 receptor-associated kinase 4
Uniprot ID Q9NWZ3
Protein Name Alias IRAK-4;  EC 2.7.11.1;  Renal carcinoma antigen NY-REN-64
Gene ID 51135
Gene Symbol IRAK4
Gene Alias NA
TTD T55398: Clinical Trial target
Pfam PF07714
GO
0005634:nucleus

0034162:toll-like receptor 9 signaling pathway

0035556:intracellular signal transduction

0070498:interleukin-1-mediated signaling pathway

0106310:protein serine kinase activity

0005829:cytosol

0004674:protein serine/threonine kinase activity

0106311:protein threonine kinase activity

1990266:neutrophil migration

0010008:endosome membrane

0002446:neutrophil mediated immunity

0002224:toll-like receptor signaling pathway

0005615:extracellular space

0005524:ATP binding

0000287:magnesium ion binding

0005886:plasma membrane

0048661:positive regulation of smooth muscle cell proliferation

0007254:JNK cascade

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0005149:interleukin-1 receptor binding

0002755:MyD88-dependent toll-like receptor signaling pathway

0005737:cytoplasm

0019221:cytokine-mediated signaling pathway

0045087:innate immune response

PDB 4XS2 ; 4ZTM ; 5K72 ; 6F3E ; 6N8G ; 6TI8 ; 5W84 ; 6VQL ; 6MOM ; 6EG9 ; 6EGA ; 6THZ ; 2OIC ; 6TIA ; 4U9A ; 4ZTL ; 7C2W ; 3MOP ; 6THX ; 4YO6 ; 6O8U ; 4U97 ; 5T1T ; 6O95 ; 5T1S ; 6LXY ; 6F3D ; 5UIQ ; 4RMZ ; 6EGD ; 6EGE ; 5K7G ; 7C2V ; 5KX7 ; 6O94 ; 5UIT ; 4YP8 ; 5UIU ; 6RFJ ; 4Y73 ; 5K7I ; 6O9D ; 6UYA ; 5UIR ; 4ZTN ; 6RFI ; 2OIB ; 5W85 ; 5UIS ; 5K75 ; 2NRU ; 2NRY ; 5K76 ; 5KX8 ; 2O8Y ; 6F3G ; 6F3I ; 6THW ; 6EGF ; 2OID
Drugbank DB12010 ; DB08590
KEGG hsa:51135

Related Compounds  (Total: 1)

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C1231
Name: Chlorogenic Acid


Related Herbs  (Total: 197)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0760 Yu Huang Lian萸黄连 Coptis deltoideaCoptis chinensis
H0007 Huo Xue Teng活血藤 NASargentodoxa cuneata
H0308 Pi Ba Ren枇杷仁 NAEriobotrya japonica
H0764 Yu Xing Cao鱼腥草 Heartleaf houttuyniaHouttuynia cordata
H0605 Wu Wei Zi五味子 Chinese magnoliavineSchisandra chinensis
H0464 Shi Liu Zi石榴子 NAPunica granatum
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H0166 Long Kui龙葵 Black nightshadeSolanum nigrum
H1026 Fan Hun Cao返魂草 Tatarian asterAster tataricus
H1019 E Bu Shi Cao鹅不食草 Small centipedaCentipeda minima
H0965 Deng Zhan Xi Xin灯盏细辛 Shortscape fleabaneErigeron breviscapus
H0988 Ding Gong Teng丁公藤 Obtuseleaf Erycibe StemErycibe obtusifolia
H0609 Wu Wei Zi Liu Jin Gao五味子流浸膏 Five-flavor berrySchisandra chinensis
H1201 Hu Er Cao虎耳草 Creeping rockfoilSaxifraga stolonifera
H1055 Bai Guo Ren白果仁 ginkgoGinkgo biloba
H0202 Ma Qian Zi马钱子 Nut-vomitive poisonnutStrychnos nux-vomica
H0423 Shan Zha Ye山楂叶 NACrataegi folium
H0141 Lian Zi Xin莲子心 Hindu lotus plumuleNelumbo nucifera
H0422 Shan Zha Tan山楂炭 Chinese hawthornCrataegus pinnatifida
H0012 Ji Mu Ye Jin Gao继木叶浸膏 NALoropetalum chinense
H0817 Zhi Zhu Xiang蜘蛛香 Jatamans valerianaValeriana jatamansii
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H0250 Mi Zi Wan蜜紫菀 Tatarian asterAster tataricus
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0243 Mi Kuan Dong Hua蜜款冬花 Common coltsfootTussilago farfara
H0509 Cang Er苍耳 Siberian cockleburXanthium sibiricum
H0342 Qing Hao青蒿 sweet wormwoodArtemisia carvifolia
H1004 Bai Cha白茶 White teaCamellia sinensis
H0075 Jing Mi粳米 RiceOryza sativa
H1100 Gu Jing Cao谷精草 PipewartEriocaulon buergerianum
H1223 Huai Hun Cao还魂草 NAAster tataricus
H0005 Huo Xiang Ye藿香叶 PatchouliPogostemon cablin
H0613 Wu Yue Ai五月艾 ArtemisiaArtemisia princeps
H1212 Hu Ye Gan Jin Gao槲叶干浸膏 NAQuercus dentata
H0239 Bei Sha Shen北沙参 Coastal glehniaGlehnia littoralis
H0343 Qing Hao Zi青蒿子 sweet wormwoodArtemisia carvifolia
H0315 Pu Gong Ying Jin Gao蒲公英浸膏 Mongolian dandelionTaraxacum mongolicum
H1051 Bai Guo白果 Ginkgo nutGinkgo biloba
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0869 Ba Dou巴豆 Pu rging crotonCroton tiglium
H0607 Wu Wei Zi Jin Chu Wu五味子浸出物 Five-flavor berrySchisandra chinensis
H0546 Tian Shan Xue Lian Hua天山雪莲花 NASaussurea involucrata
H1115 Guan Huang Bai关黄柏 Amur cork treePhellodendron amurense
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H1099 Gou Teng钩藤 Sharpleaf gambirplantUncaria rhynchophylla
H0103 Ai Ye艾叶 Argy wormwood leafArtemisia argyi
H1068 Bai He Liu Jin Gao百合流浸膏 LilyLilium brownii
H0468 Shi Wei石韦 Japanese felt fern frondPyrrosia lingua
H0872 Chuan Huang Lian川黄连 rhizome of chinese goldthreadCoptis chinensis
H0730 Ye Ma Zhui野马追 NAEupatorium lindleyanum
H0424 Shan Zhi山栀 Cape jasmineGardenia jasminoides
H0888 Ba Dou Ye巴豆叶 Pu rging crotonCroton tiglium
H0868 Chuan Du Huo川独活 Doubleteeth pubescent angelicaAngelica pubescens
H0894 Chuan Xu Duan川续断 Himalayan teaselDipsacus asperoides
H0848 Zi Jin Niu紫金牛 Japanese ardisiaArdisia japonica
H0704 Yan Guan Huang Bai盐关黄柏 Amur cork treePhellodendron amurense
H0583 Tu Si Zi Teng菟丝子藤 Dodder seedCuscuta australis
H0615 Wu Zhi Mao Tao五指毛桃 five-finger fig rootFicus simplicissima
H0304 Ou Pian藕片 Hindu lotus large rhizomeNelumbo nucifera
H0302 Ou Fen藕粉 Hindu lotus large rhizomeNelumbo nucifera
H0029 Jiang Huang Lian姜黄连 Coptis deltoideaCoptis chinensis
H0741 Yi Zhi Hao一枝蒿 Alpine yarrow herbSolidago decurrens
H0608 Wu Wei Zi Jin Gao五味子浸膏 Five-flavor berrySchisandra chinensis
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0636 Xian Mao仙茅 Common cruculigoCurculigo orchioides
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0939 Da Xue Teng大血藤 SargentgloryvineSargentodoxa cuneata
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H1230 Huang Bai Fen黄柏粉 Amur corktreePhellodendron amurense
H0002 Hui Xiang茴香 Fennel fruitFoeniculum vulgare
H0115 Kuan Dong Hua款冬花 Common coltsfootTussilago farfara
H0889 Chuan Xin Lian Jin Gao穿心莲浸膏 Common andrographisAndrographis paniculata
H1089 Gang Ren Zi岗稔子 rose myrtleRhodomyrtus tomentosa
H0819 Zhi Zi Jin Gao栀子浸膏 Cape jasmine fruitGardenia jasminoides
H0602 Wu Mei Rou乌梅肉 EbonyPrunus mume
H0690 Xue Lian雪莲 Snow lotusSaussurea involucrata
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H0528 Tao Jin Niang Gen桃金娘根 Downy rosemyrtle rootRhodomyrtus tomentosa
H0572 Tu Huo Xiang土藿香 PatchouliPogostemon cablin
H0418 Shan Yin Chen山茵陈 Capillary wormwoodArtemisia capillaris
H0108 Ku Lian Pi苦楝皮 Chinaberry-tree barkMelia azedarach
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0083 Jiu Jie Cha九节茶 Glabrous sarcandraSarcandra glabra
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H1173 Hei Chou黑丑 Pharbitis seedSemen pharbitidis
H0891 Chuan Xin Lian Ye穿心莲叶 Powder of green chiretta leavesAndrographis herba
H0897 Chuan Lian川楝 ChinaberryMelia azedarach
H0237 Mei Gui Hua玫瑰花 Rugose rose flowerRosa rugosa
H0967 Di Er Cao地耳草 Japanese stJohn’swortHypericum japonicum
H0420 Shan Zha Chou Gao山楂稠膏 Chinese hawthornCrataegus pinnatifida
H0818 Zhi Zi栀子 Cape jasmine fruitGardenia jasminoides
H0601 Wu Mei乌梅 Japanese apricotPrunus mume
H0269 Mu Gua木瓜 Chinese floweringquinceChaenomeles sinensis
H0283 Nan Shan Zha南山楂 Chinese hawthornCrataegus cuneata
H0954 Dan Zhu Ye淡竹叶 Common lophatherumLophatherum gracile
H0035 Bai Su Zi白苏子 Common perilla fruitPerilla frutescens
H0289 Niu Bang Zi牛蒡子 Great burdock fruitArctium lappa
H0140 Lian Zi莲子 Hindu lotus seedNelumbo nucifera
H1010 Du Huo Xiang杜藿香 PatchouliPogostemon cablin
H1164 He Geng荷梗 Hindu lotus petioleNelumbo nucifera
H1127 Guang Shan Zha广山楂 Chinese hawthornCrataegus pinnatifida
H1061 Bai He百合 LilyLilium brownii
H0065 Jin Yin Hua Ti Qu Ye金银花提取液 Japanese honeysuckleLonicera japonica
H1235 Huang Hao黄蒿 Virg ate wormwoodArtemisia scoparia
H0612 Cao Shan Hu Jin Gao草珊瑚浸膏 NASarcandra glabra
H0258 Mo Han Lian墨旱莲 YerbadetajoEclipta prostrata
H1011 Bai Chou白丑 Pharbitis seedSemen pharbitidis
H0301 Ou Hindu lotus large rhizomeNelumbo nucifera
H0729 Ye Ju Hua野菊花 Indian wild chrysanthemum flowerChrysanthemum indicum
H0691 Xue Lian Hua雪莲花 Snow lotusSaussurea involucrata
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0733 Ye Shan Zha野山楂 nippon bawthornCrataegus pinnatifida
H0807 Zhi Ma Qian Zi炙马钱子 Nux vomicaStrychnos nux-vomica
H0932 Ba Qia菝葜 Chinaroot greenbrierSmilax china
H0746 Yin Chen Hao Gan Jin Gao茵陈蒿干浸膏 Capillary wormwoodArtemisia capillaris
H1217 Bai Mei Hua白梅花 Japanese apricot flowerPrunus mume
H1241 Huang Lian黄连 Coptis deltoideaCoptis chinensis
H0682 Xiong Huang Lian雄黄连 Coptis deltoideaCoptis chinensis
H0394 Sang Shen Jin Gao桑葚浸膏 MulberryMorus alba
H0663 Xiao Ji小蓟 Setose thistleCirsium setosum
H0870 Chuan Du Zhong川杜仲 Eucommia barkCortex eucommiae
H0548 Tian Ye Ju甜叶菊 Rebaud eupatorium*Eupatorium rebaudianum
H0004 Huo Xiang藿香 PatchouliPogostemon cablin
H0606 Wu Wei Zi Chun Jin Gao五味子醇浸膏 Five-flavor berrySchisandra chinensis
H0393 Sang Shen桑葚 MulberryMorus alba
H0064 Jin Yin Hua金银花 Japanese honeysuckleLonicera japonica
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H0892 Chuan Xiong川芎 cnidium officinaleCnidium officinale
H0750 Yin Xing Ye银杏叶 Folium ginkgoGinkgo biloba
H0514 Cang Er Cao苍耳草 Cocklebur grassXanthium sibiricum
H1242 Huang Lian Gan Jin Gao黄连干浸膏 Coptis deltoideaCoptis chinensis
H1020 E Bu Shi Cao Nong Suo Ye鹅不食草浓缩液 Small centipedaCentipeda minima
H0890 Chuan Xin Lian Nong Suo Ye穿心莲浓缩液 Common andrographisAndrographis paniculata
H1228 Huang Bai黄柏 Amur corktreePhellodendron amurense
H0139 Lian Qiao连翘 Weeping forsythiaForsythia suspensa
H0785 Ze Xi Huang Lian择细黄连 Coptis deltoideaCoptis chinensis
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H0314 Pu Gong Ying蒲公英 Mongolian dandelionTaraxacum mongolicum
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0082 Jiu Huang Lian酒黄连 Coptis deltoideaCoptis chinensis
H0379 Bian Xu萹蓄 Common knotgrassPolygonum aviculare
H0585 Tu Yin Chen Hao土茵陈蒿 Capillary wormwoodArtemisia capillaris
H0745 Yin Chen Hao茵陈蒿 Capillary wormwoodArtemisia capillaris
H0354 Ren Dong Teng忍冬藤 Japanese honeysuckle vineLonicera japonica
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0421 Shan Zha Qing Gao山楂清膏 Chinese hawthornCrataegus pinnatifida
H0203 Ma Qian Zi Fen马钱子粉 Nux vomica powderStrychnos nux-vomica
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H0887 Chuan Xin Lian Gan Jin Gao穿心莲干浸膏 Common andrographisAndrographis paniculata
H0772 Yue Ji Hua月季花 Chinese roseRosa chinensis
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0327 Qian Li Guang千里光 Climbing groundselSenecio scandens
H0154 Ai Ye You艾叶油 Argy wormwood leafArtemisia argyi
H0878 Ba Dou Shuang巴豆霜 Defatted croton seed powderCroton tiglium
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0632 Xia Ku Cao夏枯草 Common selfhealPrunella vulgaris
H0095 Gou Qi Zi枸杞子 Chinese wolfberry fruitLycium chinense
H0242 Bei Sha Shen Liu Jin Gao北沙参流浸膏 Glehnia littoralisGlehnia littoralis
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H1231 Huang Bai Tan黄柏炭 Amur corktreePhellodendron amurense
H1244 Huang Miao黄苗 NATaraxacum mongolicum
H0581 Tu Si Zi菟丝子 Dodder seedCuscuta australis
H0580 Tu Si Rou菟丝肉 Dodder seedCuscuta australis
H0871 Chuan Duan川断 TeaselsDipsacus asper
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H0853 Zi Wan紫菀 Tatarion asterAster tataricus
H0886 Chuan Xin Lian穿心莲 Common andrographisAndrographis paniculata
H0094 Gou Qi枸杞 Chinese wolfberry fruitLycium chinense
H0656 Xiao Bo Gen小檗根 Barberry rootBerberis julianae
H1243 Huang Lian Xu黄连须 Coptis deltoideaCoptis chinensis
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H0419 Shan Zha山楂 Chinese hawthornCrataegus pinnatifida
H0109 Ku Lian Zi苦楝子 NAMelia azedarach
H0576 Tu Mu Xiang土木香 Elecampane inulaInula helenium
H1169 He Ye荷叶 Hindu lotus leafNelumbo nucifera
H0190 Lv Dou绿豆 Common sainfoinOnobrychis viciifolia
H1090 Gao Ben藁本 Chinese ligusticumLigusticum sinense
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H1120 Guang Huo Xiang广藿香 PatchouliPogostemon cablin
H1009 Du Huo独活 Doubleteeth pubescent angelicaAngelica pubescens
H0273 Mu Tong木通 Fiveleaf akebiaAkebia quinata
H1124 Guang Jin Qian Cao广金钱草 Snowbellleaf tickcloverDesmodium styracifolium
H0045 Jin Fei Cao金沸草 Japanese inulaInula japonica
H0181 Luo Bu Ma罗布麻 DogbaneApocynum venetum
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis
H0395 Sang Shen Qing Gao桑葚清膏 MulberryMorus alba
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H0893 Chuan Xiong Jin Gao川芎浸膏 cnidium officinaleCnidium officinale
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum