Herb Description

Herb ID:   H1228 Chinese Character:   黄柏
English Name:  Amur corktree Latin Name:  Phellodendron amurense
Chinese Pin Yin :  Huang Bai TCM-ID:  TCMH949
Therapeutic Function in Chinese :  清热 Therapeutic Function in English:  Heat clearence
Herb Function:  Clear heat and dry dampness, reduce fire and release toxins

Related Targets  (Total: 154)

Target idProtein NameGene SymbolUniprot IDNo.of Literature Evidence
T12PIB Lysosomal alpha-glucosidaseGAA P10253
1 Reference(s)
T83YZD AcetylcholinesteraseACHE P22303
3 Reference(s)
T91T8I Glucose-6-phosphatase catalytic subunit 1G6PC1 P35575
1 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
3 Reference(s)
T25Y64 CholinesteraseBCHE P06276
2 Reference(s)
T85AXP Cytochrome P450 3A4CYP3A4 P08684
3 Reference(s)
T28PHS Angiotensin-converting enzymeACE P12821
1 Reference(s)
T96OOK Signal transducer and activator of transcription 3STAT3 P40763
2 Reference(s)
T83P5X Inhibitor of nuclear factor kappa-B kinase subunit betaIKBKB O14920
1 Reference(s)
T81I4T 5'-AMP-activated protein kinase catalytic subunit alpha-1PRKAA1 Q13131
4 Reference(s)
T74QXI Serine/threonine-protein kinase mTORMTOR P42345
1 Reference(s)
T49ORJ Peroxisome proliferator-activated receptor alphaPPARA Q07869
7 Reference(s)
T70HTD Cytochrome P450 2E1CYP2E1 P05181
1 Reference(s)
T04H8Y Beta-secretase 1BACE1 P56817
1 Reference(s)
T33OSQ Sterol regulatory element-binding protein 1SREBF1 P36956
1 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
2 Reference(s)
T76SUY Solute carrier family 22 member 2SLC22A2 O15244
3 Reference(s)
T43N2D Epidermal growth factor receptorEGFR P00533
2 Reference(s)
T57FUN Beclin-1BECN1 Q14457
1 Reference(s)
T71BDH Mitogen-activated protein kinase 14MAPK14 Q16539
2 Reference(s)
T22OPB Nuclear factor erythroid 2-related factor 2NFE2L2 Q16236
3 Reference(s)
T85U8U Caspase-3CASP3 P42574
7 Reference(s)
T98RXH Focal adhesion kinase 1PTK2 Q05397
1 Reference(s)
T11ZYR Cytochrome P450 2D6CYP2D6 P10635
1 Reference(s)
T83ENN Solute carrier family 22 member 3SLC22A3 O75751
1 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
3 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
3 Reference(s)
T22H7B Neuronal acetylcholine receptor subunit alpha-4CHRNA4 P43681
1 Reference(s)
T20JZ2 Androgen receptorAR P10275
2 Reference(s)
T74QOR Tyrosine-protein kinase JAK3JAK3 P52333
1 Reference(s)
T74P7I G-protein coupled bile acid receptor 1GPBAR1 Q8TDU6
1 Reference(s)
T23P74 Caspase-9CASP9 P55211
3 Reference(s)
T50SJ8 5'-AMP-activated protein kinase catalytic subunit alpha-2PRKAA2 P54646
1 Reference(s)
T30VNV MyeloperoxidaseMPO P05164
1 Reference(s)
T62P0D Collagenase 3MMP13 P45452
2 Reference(s)
T74WWP Peroxisome proliferator-activated receptor deltaPPARD Q03181
1 Reference(s)
T14JSX PlasminogenPLG P00747
1 Reference(s)
T67LRH RNA-binding protein Musashi homolog 1MSI1 O43347
1 Reference(s)
T21DZX Amine oxidase [flavin-containing] AMAOA P21397
2 Reference(s)
T17E49 Cannabinoid receptor 1CNR1 P21554
1 Reference(s)
T95LIF Cannabinoid receptor 2CNR2 P34972
1 Reference(s)
T64BED 5-hydroxytryptamine receptor 2AHTR2A P28223
1 Reference(s)
T02QBS Cytochrome P450 1A2CYP1A2 P05177
2 Reference(s)
T69RXK Cytochrome P450 2C9CYP2C9 P11712
2 Reference(s)
T23TJV Tyrosine 3-monooxygenaseTH P07101
1 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
1 Reference(s)
T12OUN MyoglobinMB P02144
1 Reference(s)
T92P67 Vasodilator-stimulated phosphoproteinVASP P50552
2 Reference(s)
T67KTV Transient receptor potential cation channel subfamily V member 1TRPV1 Q8NER1
1 Reference(s)
T45XTW Retinoic acid receptor RXR-alphaRXRA P19793
1 Reference(s)
T52XO3 Cytochrome P450 2J2CYP2J2 P51589
1 Reference(s)
T54SZZ Endoplasmic reticulum chaperone BiPHSPA5 P11021
1 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
1 Reference(s)
T50V79 Interleukin-4IL4 P05112
1 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
2 Reference(s)
T06Q1R Amine oxidase [flavin-containing] BMAOB P27338
1 Reference(s)
T38T1U Caspase-8CASP8 Q14790
1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
5 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
2 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
1 Reference(s)
T39YFG Trypsin-1PRSS1 P07477
1 Reference(s)
T54WR0 Fatty acid-binding protein 5FABP5 Q01469
1 Reference(s)
T21Q0D 3-hydroxy-3-methylglutaryl-coenzyme A reductaseHMGCR P04035
1 Reference(s)
T12T4H Brain-derived neurotrophic factorBDNF P23560
1 Reference(s)
T07S0E BDNF/NT-3 growth factors receptorNTRK2 Q16620
1 Reference(s)
T90XYZ C-reactive proteinCRP P02741
1 Reference(s)
T51WGR Pancreas/duodenum homeobox protein 1PDX1 P52945
1 Reference(s)
T43NBB Solute carrier family 2, facilitated glucose transporter member 2SLC2A2 P11168
1 Reference(s)
T89L4V InsulinINS P01308
1 Reference(s)
T38WWN Serum paraoxonase/arylesterase 1PON1 P27169
2 Reference(s)
T23YZF Peptidyl-glycine alpha-amidating monooxygenasePAM P19021
1 Reference(s)
T77FOL NeuromodulinGAP43 P17677
1 Reference(s)
T93VFT Endothelin-1EDN1 P05305
2 Reference(s)
T36SOV Plasminogen activator inhibitor 1SERPINE1 P05121
1 Reference(s)
T02DEN Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptideGCG P01275
1 Reference(s)
T48UT8 Cholesteryl ester transfer proteinCETP P11597
1 Reference(s)
T32HPO Aspartyl aminopeptidaseDNPEP Q9ULA0
1 Reference(s)
T20H9F Stromelysin-1MMP3 P08254
3 Reference(s)
T02YLA Alpha-lactalbuminLALBA P00709
1 Reference(s)
T34DZ7 Interleukin-2IL2 P60568
1 Reference(s)
T44LWL Transcription factor p65RELA Q04206
1 Reference(s)
T75H3W Cyclin-dependent kinase 2CDK2 P24941
1 Reference(s)
T10S5F Cyclin-dependent kinase 4CDK4 P11802
1 Reference(s)
T64W2K Cyclin-dependent kinase inhibitor 1CDKN1A P38936
1 Reference(s)
T36YWU Kelch-like ECH-associated protein 1KEAP1 Q14145
1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
2 Reference(s)
T74LFK Neurogenic locus notch homolog protein 1NOTCH1 P46531
1 Reference(s)
T62ERY Interleukin-1 receptor-associated kinase 4IRAK4 Q9NWZ3
1 Reference(s)
T22NX4 Toll-like receptor 2TLR2 O60603
1 Reference(s)
T76AZQ Histidine decarboxylaseHDC P19113
1 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
1 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
3 Reference(s)
T32W5X Type-2 angiotensin II receptorAGTR2 P50052
1 Reference(s)
T32GWR Ephrin-B2EFNB2 P52799
3 Reference(s)
T95IYZ AdiponectinADIPOQ Q15848
1 Reference(s)
T38H79 Membrane protein MLC1MLC1 Q15049
1 Reference(s)
T62R6K Myosin light chain kinase 3MYLK3 Q32MK0
1 Reference(s)
T45G32 Proto-oncogene tyrosine-protein kinase SrcSRC P12931
1 Reference(s)
T80OJF Interstitial collagenaseMMP1 P03956
3 Reference(s)
T78OTS APC membrane recruitment protein 1AMER1 Q5JTC6
1 Reference(s)
T27LA6 DNADNMT1 P26358
1 Reference(s)
T28HOM LeptinLEP P41159
1 Reference(s)
T28K6X Insulin receptor substrate 1IRS1 P35568
1 Reference(s)
T70VB4 CortistatinCORT O00230
1 Reference(s)
T20E5P Cytochrome b-245 heavy chainCYBB P04839
1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
2 Reference(s)
T09HVO Sodium/hydrogen exchanger 3SLC9A3 P48764
1 Reference(s)
T94H37 Cadherin-1CDH1 P12830
1 Reference(s)
T10ICM Oxidized low-density lipoprotein receptor 1OLR1 P78380
1 Reference(s)
T80XW6 Scavenger receptor class B member 1SCARB1 Q8WTV0
1 Reference(s)
T75PC7 NAMIR21 NA
2 Reference(s)
T38JCD DNA-binding protein inhibitor ID-1ID1 P41134
1 Reference(s)
T58K2N Calmodulin-3;Calmodulin-1;Calmodulin-2CALM3;CALM1;CALM2 P0DP25;P0DP23;P0DP24
1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
1 Reference(s)
T40W2M NAMIR93 NA
1 Reference(s)
T90HSB NAMIR373 NA
1 Reference(s)
T29C6N EzrinEZR P15311
1 Reference(s)
T92BZ2 Catenin beta-1CTNNB1 P35222
2 Reference(s)
T31P1D Metalloproteinase inhibitor 1TIMP1 P01033
1 Reference(s)
T67ZT3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN P60484
2 Reference(s)
T26CFB DNA damage-inducible transcript 3 proteinDDIT3 P35638;P0DPQ6
1 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
1 Reference(s)
T33BF9 DNADNMT3B Q9UBC3
1 Reference(s)
T34WFL Proto-oncogene tyrosine-protein kinase receptor RetRET P07949
1 Reference(s)
T25YP8 Aquaporin-4AQP4 P55087
1 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
2 Reference(s)
T29C64 Calcitonin gene-related peptide 1CALCA P06881;P01258
1 Reference(s)
T76B0A Gap junction alpha-1 proteinGJA1 P17302
1 Reference(s)
T14ENF Microtubule-associated protein 2MAP2 P11137
1 Reference(s)
T78ZF2 Protein kinase C alpha typePRKCA P17252
1 Reference(s)
T67RBZ Mitochondrial uncoupling protein 2UCP2 P55851
1 Reference(s)
T67HYX Mitochondrial uncoupling protein 3UCP3 P55916
1 Reference(s)
T19EKF CholecystokininCCK P06307
1 Reference(s)
T19XSL Fatty acid-binding protein, liverFABP1 P07148
1 Reference(s)
T23APZ Retinol-binding protein 2RBP2 P50120
1 Reference(s)
T38K2W Receptor tyrosine-protein kinase erbB-2ERBB2 P04626
1 Reference(s)
T03NWF Sterol O-acyltransferase 1SOAT1 P35610
1 Reference(s)
T48YPL Aquaporin-3AQP3 Q92482
1 Reference(s)
T53SLQ Aquaporin-9AQP9 O43315
1 Reference(s)
T75EH8 Glucagon-like peptide 1 receptorGLP1R P43220
1 Reference(s)
T52VL6 Signal transducer and activator of transcription 5ASTAT5A P42229
1 Reference(s)
T19K8W Signal transducer and activator of transcription 5BSTAT5B P51692
1 Reference(s)
T60UPF Parvalbumin alphaPVALB P20472
2 Reference(s)
T18CUI Neuron-specific calcium-binding protein hippocalcinHPCA P84074
1 Reference(s)
T54CIF Interleukin-8CXCL8 P10145
1 Reference(s)
T09BRP NAPKB_RS07820 NA
1 Reference(s)
T39RV3 Dual specificity mitogen-activated protein kinase kinase 1MAP2K1 Q02750
1 Reference(s)
T66S13 Dual specificity mitogen-activated protein kinase kinase 2MAP2K2 P36507
1 Reference(s)
T08SJX Astrocytic phosphoprotein PEA-15PEA15 Q15121
1 Reference(s)
T38OQ4 Peroxiredoxin-2PRDX2 P32119
1 Reference(s)
T38J3Y Gamma-enolaseENO2 P09104
1 Reference(s)
T41TXS Retinoblastoma-associated proteinRB1 P06400
1 Reference(s)
T70B7U Angiotensin-converting enzyme 2ACE2 Q9BYF1
1 Reference(s)

Related Compounds  (Total: 20)

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C1231
Name: Chlorogenic Acid
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C0187
Name: Limonin
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C0300
Name: Phenol
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C1171
Name: Berberine
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C0602
Name: 2,3,9,10-Tetramethoxy-6,8,13,13A-Tetrahydro-5H-Isoquinolino[2,1-B]Isoquinoline