HIT-result

Type	Detail
Target ID	T26CFB
Protein Name	DNA damage-inducible transcript 3 protein
Uniprot ID	P35638 ; P0DPQ6
Protein Name Alias	NA
Gene ID	1649
Gene Symbol	DDIT3
Gene Alias	NA
TTD	NA
Pfam	NA
GO	0003677:DNA binding 0008134:transcription factor binding 0005634:nucleus 0045454:cell redox homeostasis 1990442:intrinsic apoptotic signaling pathway in response to nitrosative stress 2001244:positive regulation of intrinsic apoptotic signaling pathway 0034976:response to endoplasmic reticulum stress 0008140:cAMP response element binding protein binding 0005770:late endosome 0007050:cell cycle arrest 2000016:negative regulation of determination of dorsal identity 0032713:negative regulation of interleukin-4 production 0005829:cytosol 0006355:regulation of transcription, DNA-templated 0032689:negative regulation of interferon-gamma production 0006986:response to unfolded protein 0120163:negative regulation of cold-induced thermogenesis 0009948:anterior/posterior axis specification 0051209:release of sequestered calcium ion into cytosol 0043525:positive regulation of neuron apoptotic process 0032792:negative regulation of CREB transcription factor activity 1990622:CHOP-ATF3 complex 0045892:negative regulation of transcription, DNA-templated 0140416:transcription regulator inhibitor activity 0005737:cytoplasm 0043161:proteasome-mediated ubiquitin-dependent protein catabolic process 1902237:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 0001228:DNA-binding transcription activator activity, RNA polymerase II-specific 0043522:leucine zipper domain binding 0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0051898:negative regulation of protein kinase B signaling 1990617:CHOP-ATF4 complex 0007605:sensory perception of sound 0045662:negative regulation of myoblast differentiation 0016055:Wnt signaling pathway 0000785:chromatin 0000976:transcription regulatory region sequence-specific DNA binding 0072655:establishment of protein localization to mitochondrion 1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 0036500:ATF6-mediated unfolded protein response 0006983:ER overload response 0032088:negative regulation of NF-kappaB transcription factor activity 0030968:endoplasmic reticulum unfolded protein response 0005667:transcription regulator complex 0036488:CHOP-C/EBP complex 0036499:PERK-mediated unfolded protein response 0032757:positive regulation of interleukin-8 production 0000981:DNA-binding transcription factor activity, RNA polymerase II-specific 0045893:positive regulation of transcription, DNA-templated 0051091:positive regulation of DNA-binding transcription factor activity 0000122:negative regulation of transcription by RNA polymerase II 0043433:negative regulation of DNA-binding transcription factor activity 0003700:DNA-binding transcription factor activity 0042803:protein homodimerization activity 0032700:negative regulation of interleukin-17 production 1903026:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding 0006357:regulation of transcription by RNA polymerase II 0046982:protein heterodimerization activity 0090090:negative regulation of canonical Wnt signaling pathway 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0043618:regulation of transcription from RNA polymerase II promoter in response to stress 0001955:blood vessel maturation 0010506:regulation of autophagy 0045599:negative regulation of fat cell differentiation 0045944:positive regulation of transcription by RNA polymerase II 0042594:response to starvation 0032993:protein-DNA complex 0006974:cellular response to DNA damage stimulus
PDB	NA
Drugbank	NA
KEGG	hsa:1649

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Name: Berberine

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Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0785	Ze Xi Huang Lian	择细黄连	Coptis deltoidea	Coptis chinensis
H0774	Yun Xiang Jin Gao	芸香浸膏	Ruta	Ruta graveolens
H0029	Jiang Huang Lian	姜黄连	Coptis deltoidea	Coptis chinensis
H0651	Xiang Yuan	香橼	Wilson citron	Citrus medica
H0500	Can Yong	蚕蛹	Silkworm chrysalis	Bombyx mori
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1183	Hong Dou	红豆	Hosie ormosia	Ormosia hosiei
H0648	Xiang Si Teng	相思藤	Coralhead plant vine	Abrus precatorius
H0490	Can Jian	蚕茧	Silk cocoon	Bombyx mori
H0697	Ya Ma Zi	亚麻子	Common flax seed	Linum usitatissimum
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H1068	Bai He Liu Jin Gao	百合流浸膏	Lily	Lilium brownii
H0056	Jin Qiao Mai	金荞麦	Wild buckwheat rhizome	Rhizoma fagopyri cymosi
H0450	Shi Chang Pu	石菖蒲	Grassleaved sweetflag	Acorus tatarinowii
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H1026	Fan Hun Cao	返魂草	Tatarian aster	Aster tataricus
H1073	Gan Cao Jie	甘草节	Glycyrrhiza uralensis fisch	Glycyrrhiza uralensis
H1235	Huang Hao	黄蒿	Virg ate wormwood	Artemisia scoparia
H0016	Ji Xue Cao	积雪草	Asiatic pennywort	Centella asiatica
H1184	Bai Lian	白蔹	Japanese ampelopsis	Ampelopsis japonica
H1134	Bai Jiang Can	白僵蚕	Silkworm larva	Bombyx mori
H0240	Mi Gan Cao	蜜甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1061	Bai He	百合	Lily	Lilium brownii
H0632	Xia Ku Cao	夏枯草	Common selfheal	Prunella vulgaris
H0872	Chuan Huang Lian	川黄连	rhizome of chinese goldthread	Coptis chinensis
H0853	Zi Wan	紫菀	Tatarion aster	Aster tataricus
H0082	Jiu Huang Lian	酒黄连	Coptis deltoidea	Coptis chinensis
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0682	Xiong Huang Lian	雄黄连	Coptis deltoidea	Coptis chinensis
H1166	He Shou Wu	何首乌	Tuber fleeceflower	Polygonum multiflorum
H0704	Yan Guan Huang Bai	盐关黄柏	Amur cork tree	Phellodendron amurense
H0574	Cao Dou Kou	草豆蔻	Katsumada galangal	Alpinia katsumadai
H0571	Tu Gan Cao	土甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0452	Shi Chang Pu Qing Gao	石菖蒲清膏	Grassleaved sweetflag	Acorus tatarinowii
H1140	Guo Gang Long	过岗龙	NA	Entada phaseoloides
H1075	Gan Cao Liu Jin Gao	甘草流浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1072	Gan Cao Gao	甘草膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0606	Wu Wei Zi Chun Jin Gao	五味子醇浸膏	Five-flavor berry	Schisandra chinensis
H0827	Zhu Hong Jun	竹红菌	Bambusa hypocrella*	Hypocrella bambusae
H0476	Can E	蚕蛾	Silkworm	Bombyx mori
H0608	Wu Wei Zi Jin Gao	五味子浸膏	Five-flavor berry	Schisandra chinensis
H1100	Gu Jing Cao	谷精草	Pipewart	Eriocaulon buergerianum
H0735	Yi Bei Mu	伊贝母	Siberian fritillary equivalent plant: fritillaria walujewii	Fritillaria pallidiflora
H1241	Huang Lian	黄连	Coptis deltoidea	Coptis chinensis
H1066	Gan Cao	甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis
H1230	Huang Bai Fen	黄柏粉	Amur corktree	Phellodendron amurense
H1067	Gan Cao Fen	甘草粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0685	Xuan Cao Gen	萱草根	Orange daylily	Hemerocallis fulva
H0110	Ku Mu	苦木	Indian quassiawood	Picrasma quassioides
H0092	Ju Hua	菊花	Florists chrysanthemum flower	Chrysanthemum morifolium
H0173	Lu Hui	芦荟	Kulaso aloe dried juice	Aloe vera
H0287	Nao Yang Hua	闹羊花	Chinese azalea	Rhododendron molle
H0582	Cao Dou Kou Ren	草豆蔻仁	Katsumada galangal	Alpinia katsumadai
H0605	Wu Wei Zi	五味子	Chinese magnoliavine	Schisandra chinensis
H0649	Xiang Si Zi	相思子	Coralhead plant	Abrus precatorius
H0227	Mang Guo Ye	芒果叶	Mango leaf	Mangifera indica
H0495	Can Sha	蚕砂	Silkworm excrement	Bombyx mori
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H1223	Huai Hun Cao	还魂草	NA	Aster tataricus
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0809	Zhi Mu	知母	Common anemarrhena	Anemarrhena asphodeloides
H1000	Dong Gua Zi	冬瓜子	Chinese waxgourd seed	Benincasa hispida
H1161	Hang Ju	杭菊	Chrysanthemum flower	Chrysanthemum morifolium
H1074	Gan Cao Jin Gao	甘草浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0998	Dong Gua Pi	冬瓜皮	Chinese waxgourd peel	Benincasa hispida
H1070	Gan Cao Gan Gao Fen	甘草干膏粉	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0451	Shi Chang Pu Jin Gao	石菖蒲浸膏	Grassleaved sweetflag	Acorus tatarinowii
H0689	Xue Feng Teng	血风藤	NA	Ventilago leiocarpa
H0219	Man Shan Hong	满山红	Dahurian rhododendron	Rhododendron dauricum
H0652	Xiang Yuan Pi	香橼皮	Wilson citron	Citrus medica
H1213	Hu Zhang	虎杖	Japanese fleeceflower	Polygonum cuspidatum
H0006	Bai Qu Cai	白屈菜	Greater celandine	Chelidonium majus
H0706	Yan Hu Suo	延胡索	Yanhusuo	Corydalis yanhusuo
H0053	Jin Lian Hua	金莲花	Chinese globeflower	Trollius chinensis
H0607	Wu Wei Zi Jin Chu Wu	五味子浸出物	Five-flavor berry	Schisandra chinensis
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H1011	Bai Chou	白丑	Pharbitis seed	Semen pharbitidis
H1069	Gan Cao Gan Gao	甘草干膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H1243	Huang Lian Xu	黄连须	Coptis deltoidea	Coptis chinensis
H0570	Tu Fu Ling	土茯苓	Glabrous greenbrier	Smilax glabra
H0609	Wu Wei Zi Liu Jin Gao	五味子流浸膏	Five-flavor berry	Schisandra chinensis
H1226	Huai Shan Yao	淮山药	rhizome of biglcaf yam	Rhizoma dioscoreae
H0102	Jue Ming Zi	决明子	Sickle senna seed	Cassia tora
H0540	Tian Ji Huang	田基黄	all - grass of japanese st. johnswort	Grangea maderaspatana
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1231	Huang Bai Tan	黄柏炭	Amur corktree	Phellodendron amurense
H1141	Guo Gang Long Jin Gao	过岗龙浸膏	NA	Entada phaseoloides
H1228	Huang Bai	黄柏	Amur corktree	Phellodendron amurense
H1071	Gan Cao Gan Jin Gao	甘草干浸膏	Glycyrrhiza inflata	Glycyrrhiza uralensis
H0387	San Ya Ku	三桠苦	Common rue	Ruta graveolens
H1173	Hei Chou	黑丑	Pharbitis seed	Semen pharbitidis
H0457	Shi Er	石耳	Rock-Ears	Umbilicaria esculenta
H1115	Guan Huang Bai	关黄柏	Amur cork tree	Phellodendron amurense
H0298	Niu Xi Xi	牛西西	Patience dock	Rumex patientia
H0633	Xia Tian Wu	夏天无	Decumbent corydalis	Corydalis decumbens
H0250	Mi Zi Wan	蜜紫菀	Tatarian aster	Aster tataricus
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H1242	Huang Lian Gan Jin Gao	黄连干浸膏	Coptis deltoidea	Coptis chinensis
H0760	Yu Huang Lian	萸黄连	Coptis deltoidea	Coptis chinensis
H0444	Sheng Gan Cao	生甘草	Glycyrrhiza inflata	Glycyrrhiza uralensis

Target Description

Related Compounds (Total: 7)

Related Herbs (Total: 106)