Target Description

Type Detail
Target ID T26CFB
Protein Name DNA damage-inducible transcript 3 protein
Uniprot ID P35638
; P0DPQ6
Protein Name Alias NA
Gene ID 1649
Gene Symbol DDIT3
Gene Alias NA
TTD NA
Pfam NA
GO
0003677:DNA binding

0008134:transcription factor binding

0005634:nucleus

0045454:cell redox homeostasis

1990442:intrinsic apoptotic signaling pathway in response to nitrosative stress

2001244:positive regulation of intrinsic apoptotic signaling pathway

0034976:response to endoplasmic reticulum stress

0008140:cAMP response element binding protein binding

0005770:late endosome

0007050:cell cycle arrest

2000016:negative regulation of determination of dorsal identity

0032713:negative regulation of interleukin-4 production

0005829:cytosol

0006355:regulation of transcription, DNA-templated

0032689:negative regulation of interferon-gamma production

0006986:response to unfolded protein

0120163:negative regulation of cold-induced thermogenesis

0009948:anterior/posterior axis specification

0051209:release of sequestered calcium ion into cytosol

0043525:positive regulation of neuron apoptotic process

0032792:negative regulation of CREB transcription factor activity

1990622:CHOP-ATF3 complex

0045892:negative regulation of transcription, DNA-templated

0140416:transcription regulator inhibitor activity

0005737:cytoplasm

0043161:proteasome-mediated ubiquitin-dependent protein catabolic process

1902237:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

0001228:DNA-binding transcription activator activity, RNA polymerase II-specific

0043522:leucine zipper domain binding

0070059:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

0051898:negative regulation of protein kinase B signaling

1990617:CHOP-ATF4 complex

0007605:sensory perception of sound

0045662:negative regulation of myoblast differentiation

0016055:Wnt signaling pathway

0000785:chromatin

0000976:transcription regulatory region sequence-specific DNA binding

0072655:establishment of protein localization to mitochondrion

1990440:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

0036500:ATF6-mediated unfolded protein response

0006983:ER overload response

0032088:negative regulation of NF-kappaB transcription factor activity

0030968:endoplasmic reticulum unfolded protein response

0005667:transcription regulator complex

0036488:CHOP-C/EBP complex

0036499:PERK-mediated unfolded protein response

0032757:positive regulation of interleukin-8 production

0000981:DNA-binding transcription factor activity, RNA polymerase II-specific

0045893:positive regulation of transcription, DNA-templated

0051091:positive regulation of DNA-binding transcription factor activity

0000122:negative regulation of transcription by RNA polymerase II

0043433:negative regulation of DNA-binding transcription factor activity

0003700:DNA-binding transcription factor activity

0042803:protein homodimerization activity

0032700:negative regulation of interleukin-17 production

1903026:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding

0006357:regulation of transcription by RNA polymerase II

0046982:protein heterodimerization activity

0090090:negative regulation of canonical Wnt signaling pathway

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0043618:regulation of transcription from RNA polymerase II promoter in response to stress

0001955:blood vessel maturation

0010506:regulation of autophagy

0045599:negative regulation of fat cell differentiation

0045944:positive regulation of transcription by RNA polymerase II

0042594:response to starvation

0032993:protein-DNA complex

0006974:cellular response to DNA damage stimulus

PDB NA
Drugbank NA
KEGG hsa:1649

Related Compounds  (Total: 7)

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C0041
Name: Emodin
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C0089
Name: Galangin
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C0369
Name: Rhein
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C0456
Name: Tretinoin
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C1171
Name: Berberine


Related Herbs  (Total: 106)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0809 Zhi Mu知母 Common anemarrhenaAnemarrhena asphodeloides
H0609 Wu Wei Zi Liu Jin Gao五味子流浸膏 Five-flavor berrySchisandra chinensis
H0648 Xiang Si Teng相思藤 Coralhead plant vineAbrus precatorius
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0605 Wu Wei Zi五味子 Chinese magnoliavineSchisandra chinensis
H1026 Fan Hun Cao返魂草 Tatarian asterAster tataricus
H0853 Zi Wan紫菀 Tatarion asterAster tataricus
H1061 Bai He百合 LilyLilium brownii
H1226 Huai Shan Yao淮山药 rhizome of biglcaf yamRhizoma dioscoreae
H1223 Huai Hun Cao还魂草 NAAster tataricus
H0457 Shi Er石耳 Rock-EarsUmbilicaria esculenta
H0029 Jiang Huang Lian姜黄连 Coptis deltoideaCoptis chinensis
H1072 Gan Cao Gao甘草膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0142 Liang Jiang良姜 NAAlpinia officinarum
H1075 Gan Cao Liu Jin Gao甘草流浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H0092 Ju Hua菊花 Florists chrysanthemum flowerChrysanthemum morifolium
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H1073 Gan Cao Jie甘草节 Glycyrrhiza uralensis fischGlycyrrhiza uralensis
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0250 Mi Zi Wan蜜紫菀 Tatarian asterAster tataricus
H0570 Tu Fu Ling土茯苓 Glabrous greenbrierSmilax glabra
H1068 Bai He Liu Jin Gao百合流浸膏 LilyLilium brownii
H0607 Wu Wei Zi Jin Chu Wu五味子浸出物 Five-flavor berrySchisandra chinensis
H0298 Niu Xi Xi牛西西 Patience dockRumex patientia
H0387 San Ya Ku三桠苦 Common rueRuta graveolens
H0998 Dong Gua Pi冬瓜皮 Chinese waxgourd peelBenincasa hispida
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0540 Tian Ji Huang田基黄 all - grass of japanese st. johnswortGrangea maderaspatana
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H1070 Gan Cao Gan Gao Fen甘草干膏粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H1161 Hang Ju杭菊 Chrysanthemum flowerChrysanthemum morifolium
H0500 Can Yong蚕蛹 Silkworm chrysalisBombyx mori
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0110 Ku Mu苦木 Indian quassiawoodPicrasma quassioides
H0574 Cao Dou Kou草豆蔻 Katsumada galangalAlpinia katsumadai
H0450 Shi Chang Pu石菖蒲 Grassleaved sweetflagAcorus tatarinowii
H1166 He Shou Wu何首乌 Tuber fleeceflowerPolygonum multiflorum
H1100 Gu Jing Cao谷精草 PipewartEriocaulon buergerianum
H1235 Huang Hao黄蒿 Virg ate wormwoodArtemisia scoparia
H0785 Ze Xi Huang Lian择细黄连 Coptis deltoideaCoptis chinensis
H1067 Gan Cao Fen甘草粉 Glycyrrhiza inflataGlycyrrhiza uralensis
H0689 Xue Feng Teng血风藤 NAVentilago leiocarpa
H0173 Lu Hui芦荟 Kulaso aloe dried juiceAloe vera
H0652 Xiang Yuan Pi香橼皮 Wilson citronCitrus medica
H1213 Hu Zhang虎杖 Japanese fleeceflowerPolygonum cuspidatum
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H1231 Huang Bai Tan黄柏炭 Amur corktreePhellodendron amurense
H1242 Huang Lian Gan Jin Gao黄连干浸膏 Coptis deltoideaCoptis chinensis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0706 Yan Hu Suo延胡索 YanhusuoCorydalis yanhusuo
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H1074 Gan Cao Jin Gao甘草浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H1184 Bai Lian白蔹 Japanese ampelopsisAmpelopsis japonica
H1183 Hong Dou红豆 Hosie ormosiaOrmosia hosiei
H1069 Gan Cao Gan Gao甘草干膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0827 Zhu Hong Jun竹红菌 Bambusa hypocrella*Hypocrella bambusae
H0760 Yu Huang Lian萸黄连 Coptis deltoideaCoptis chinensis
H0735 Yi Bei Mu伊贝母 Siberian fritillary equivalent plant: fritillaria walujewiiFritillaria pallidiflora
H1240 Huang Jing Zi黄荆子 NAVitex negundo
H0102 Jue Ming Zi决明子 Sickle senna seedCassia tora
H0632 Xia Ku Cao夏枯草 Common selfhealPrunella vulgaris
H0682 Xiong Huang Lian雄黄连 Coptis deltoideaCoptis chinensis
H0872 Chuan Huang Lian川黄连 rhizome of chinese goldthreadCoptis chinensis
H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H1243 Huang Lian Xu黄连须 Coptis deltoideaCoptis chinensis
H0697 Ya Ma Zi亚麻子 Common flax seedLinum usitatissimum
H1000 Dong Gua Zi冬瓜子 Chinese waxgourd seedBenincasa hispida
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H1241 Huang Lian黄连 Coptis deltoideaCoptis chinensis
H0082 Jiu Huang Lian酒黄连 Coptis deltoideaCoptis chinensis
H0240 Mi Gan Cao蜜甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0287 Nao Yang Hua闹羊花 Chinese azaleaRhododendron molle
H1066 Gan Cao甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1115 Guan Huang Bai关黄柏 Amur cork treePhellodendron amurense
H0606 Wu Wei Zi Chun Jin Gao五味子醇浸膏 Five-flavor berrySchisandra chinensis
H0006 Bai Qu Cai白屈菜 Greater celandineChelidonium majus
H1230 Huang Bai Fen黄柏粉 Amur corktreePhellodendron amurense
H0685 Xuan Cao Gen萱草根 Orange daylilyHemerocallis fulva
H0608 Wu Wei Zi Jin Gao五味子浸膏 Five-flavor berrySchisandra chinensis
H0651 Xiang Yuan香橼 Wilson citronCitrus medica
H0704 Yan Guan Huang Bai盐关黄柏 Amur cork treePhellodendron amurense
H0444 Sheng Gan Cao生甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H0774 Yun Xiang Jin Gao芸香浸膏 RutaRuta graveolens
H0053 Jin Lian Hua金莲花 Chinese globeflowerTrollius chinensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H1228 Huang Bai黄柏 Amur corktreePhellodendron amurense
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H0582 Cao Dou Kou Ren草豆蔻仁 Katsumada galangalAlpinia katsumadai
H0451 Shi Chang Pu Jin Gao石菖蒲浸膏 Grassleaved sweetflagAcorus tatarinowii
H1141 Guo Gang Long Jin Gao过岗龙浸膏 NAEntada phaseoloides
H1140 Guo Gang Long过岗龙 NAEntada phaseoloides
H0452 Shi Chang Pu Qing Gao石菖蒲清膏 Grassleaved sweetflagAcorus tatarinowii
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H1011 Bai Chou白丑 Pharbitis seedSemen pharbitidis
H0476 Can E蚕蛾 SilkwormBombyx mori
H0056 Jin Qiao Mai金荞麦 Wild buckwheat rhizomeRhizoma fagopyri cymosi
H0571 Tu Gan Cao土甘草 Glycyrrhiza inflataGlycyrrhiza uralensis
H1071 Gan Cao Gan Jin Gao甘草干浸膏 Glycyrrhiza inflataGlycyrrhiza uralensis
H0649 Xiang Si Zi相思子 Coralhead plantAbrus precatorius
H0633 Xia Tian Wu夏天无 Decumbent corydalisCorydalis decumbens
H1173 Hei Chou黑丑 Pharbitis seedSemen pharbitidis