Home
Search
Target-mining
My-Target curation
Browse
Help

Compound Description

ID:   C1171 Common name:   Berberine
IUPAC:  NA CAS:  CAS:2086-83-1
Chembl ID:   CHEMBL295124 Pubchem ID:   CID:2353
Formula:  C20H18NO4 TCM-ID:  TCMC784
Smiles:  COc1c(OC)ccc2c1c[n+]1CCc3c(c1c2)cc1c(c3)OCO1
Alias:

Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-;

Umbellatine;

5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium;

Berbericine;

Berberin;

Berberine;

Berberone;

Majarine;

Thalsine;

Umbellatin
Structure:

Related Targets  (Total: 66)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T83P5X Inhibitor of nuclear factor kappa-B kinase subunit betaIKBKB O14920
 A 1 Reference(s)
T81I4T 5'-AMP-activated protein kinase catalytic subunit alpha-1PRKAA1 Q13131
 A 3 Reference(s)
T74QXI Serine/threonine-protein kinase mTORMTOR P42345
 A 1 Reference(s)
T49ORJ Peroxisome proliferator-activated receptor alphaPPARA Q07869
 A 3 Reference(s)
T70HTD Cytochrome P450 2E1CYP2E1 P05181
 A 1 Reference(s)
T04H8Y Beta-secretase 1BACE1 P56817
 A 1 Reference(s)
T33OSQ Sterol regulatory element-binding protein 1SREBF1 P36956
 A 1 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
 A 2 Reference(s)
T76SUY Solute carrier family 22 member 2SLC22A2 O15244
 A 2 Reference(s)
T43N2D Epidermal growth factor receptorEGFR P00533
 A 2 Reference(s)
T57FUN Beclin-1BECN1 Q14457
 A 1 Reference(s)
T71BDH Mitogen-activated protein kinase 14MAPK14 Q16539
 A 2 Reference(s)
T22OPB Nuclear factor erythroid 2-related factor 2NFE2L2 Q16236
 A 1 Reference(s)
T85U8U Caspase-3CASP3 P42574
 A 1 Reference(s)
T83YZD AcetylcholinesteraseACHE P22303
 A 1 Reference(s)
T98RXH Focal adhesion kinase 1PTK2 Q05397
 A 1 Reference(s)
T11ZYR Cytochrome P450 2D6CYP2D6 P10635
 A 1 Reference(s)
T83ENN Solute carrier family 22 member 3SLC22A3 O75751
 A 1 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
 A 1 Reference(s)
T96OOK Signal transducer and activator of transcription 3STAT3 P40763
 B 1 Reference(s)
T92P67 Vasodilator-stimulated phosphoproteinVASP P50552
 B 2 Reference(s)
T67KTV Transient receptor potential cation channel subfamily V member 1TRPV1 Q8NER1
 B 1 Reference(s)
T45XTW Retinoic acid receptor RXR-alphaRXRA P19793
 B 1 Reference(s)
T52XO3 Cytochrome P450 2J2CYP2J2 P51589
 B 1 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
 B 1 Reference(s)
T54SZZ Endoplasmic reticulum chaperone BiPHSPA5 P11021
 B 1 Reference(s)
T20JZ2 Androgen receptorAR P10275
 C 1 Reference(s)
T32GWR Ephrin-B2EFNB2 P52799
 C 3 Reference(s)
T95IYZ AdiponectinADIPOQ Q15848
 C 1 Reference(s)
T38H79 Membrane protein MLC1MLC1 Q15049
 C 1 Reference(s)
T62R6K Myosin light chain kinase 3MYLK3 Q32MK0
 C 1 Reference(s)
T45G32 Proto-oncogene tyrosine-protein kinase SrcSRC P12931
 C 1 Reference(s)
T80OJF Interstitial collagenaseMMP1 P03956
 C 2 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
 C 1 Reference(s)
T78OTS APC membrane recruitment protein 1AMER1 Q5JTC6
 C 1 Reference(s)
T27LA6 DNADNMT1 P26358
 C 1 Reference(s)
T28HOM LeptinLEP P41159
 C 1 Reference(s)
T38WWN Serum paraoxonase/arylesterase 1PON1 P27169
 C 1 Reference(s)
T28K6X Insulin receptor substrate 1IRS1 P35568
 C 1 Reference(s)
T70VB4 CortistatinCORT O00230
 C 1 Reference(s)
T20E5P Cytochrome b-245 heavy chainCYBB P04839
 C 1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
 C 1 Reference(s)
T09HVO Sodium/hydrogen exchanger 3SLC9A3 P48764
 C 1 Reference(s)
T94H37 Cadherin-1CDH1 P12830
 C 1 Reference(s)
T10ICM Oxidized low-density lipoprotein receptor 1OLR1 P78380
 C 1 Reference(s)
T80XW6 Scavenger receptor class B member 1SCARB1 Q8WTV0
 C 1 Reference(s)
T75PC7 NAMIR21 NA
 C 2 Reference(s)
T38JCD DNA-binding protein inhibitor ID-1ID1 P41134
 C 1 Reference(s)
T58K2N Calmodulin-3;Calmodulin-1;Calmodulin-2CALM3;CALM1;CALM2 P0DP25;P0DP23;P0DP24
 C 1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
 C 1 Reference(s)
T40W2M NAMIR93 NA
 C 1 Reference(s)
T90HSB NAMIR373 NA
 C 1 Reference(s)
T29C6N EzrinEZR P15311
 C 1 Reference(s)
T92BZ2 Catenin beta-1CTNNB1 P35222
 C 1 Reference(s)
T31P1D Metalloproteinase inhibitor 1TIMP1 P01033
 C 1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
 C 1 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
 C 2 Reference(s)
T20H9F Stromelysin-1MMP3 P08254
 C 1 Reference(s)
T62P0D Collagenase 3MMP13 P45452
 C 1 Reference(s)
T67ZT3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN P60484
 C 2 Reference(s)
T26CFB DNA damage-inducible transcript 3 proteinDDIT3 P35638;P0DPQ6
 C 1 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
 C 1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
 C 1 Reference(s)
T33BF9 DNADNMT3B Q9UBC3
 C 1 Reference(s)
T34WFL Proto-oncogene tyrosine-protein kinase receptor RetRET P07949
 C 1 Reference(s)
T25YP8 Aquaporin-4AQP4 P55087
 C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 24)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1242 Huang Lian Gan Jin Gao黄连干浸膏 Coptis deltoideaCoptis chinensis
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1115 Guan Huang Bai关黄柏 Amur cork treePhellodendron amurense
H1061 Bai He百合 LilyLilium brownii
H0006 Bai Qu Cai白屈菜 Greater celandineChelidonium majus
H0706 Yan Hu Suo延胡索 YanhusuoCorydalis yanhusuo
H1230 Huang Bai Fen黄柏粉 Amur corktreePhellodendron amurense
H0651 Xiang Yuan香橼 Wilson citronCitrus medica
H0029 Jiang Huang Lian姜黄连 Coptis deltoideaCoptis chinensis
H0704 Yan Guan Huang Bai盐关黄柏 Amur cork treePhellodendron amurense
H0827 Zhu Hong Jun竹红菌 Bambusa hypocrella*Hypocrella bambusae
H0760 Yu Huang Lian萸黄连 Coptis deltoideaCoptis chinensis
H0682 Xiong Huang Lian雄黄连 Coptis deltoideaCoptis chinensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0785 Ze Xi Huang Lian择细黄连 Coptis deltoideaCoptis chinensis
H1228 Huang Bai黄柏 Amur corktreePhellodendron amurense
H0872 Chuan Huang Lian川黄连 rhizome of chinese goldthreadCoptis chinensis
H1068 Bai He Liu Jin Gao百合流浸膏 LilyLilium brownii
H1243 Huang Lian Xu黄连须 Coptis deltoideaCoptis chinensis
H0652 Xiang Yuan Pi香橼皮 Wilson citronCitrus medica
H1241 Huang Lian黄连 Coptis deltoideaCoptis chinensis
H0633 Xia Tian Wu夏天无 Decumbent corydalisCorydalis decumbens
H1231 Huang Bai Tan黄柏炭 Amur corktreePhellodendron amurense
H0082 Jiu Huang Lian酒黄连 Coptis deltoideaCoptis chinensis

Ckey description of the interaction between compound and target


Site Map Contact Us Terms and Conditions Privacy Policy