HIT-result

Target Description

Type	Detail
Target ID	T34WFL
Protein Name	Proto-oncogene tyrosine-protein kinase receptor Ret
Uniprot ID	P07949
Protein Name Alias	EC 2.7.10.1; Cadherin family member 12; Proto-oncogene c-Ret
Gene ID	5979
Gene Symbol	RET
Gene Alias	CDHF12; CDHR16; PTC; RET51
TTD	T60631: Successful target
Pfam	PF17756 ; PF07714 ; PF00028 ; PF17812 ; PF17813
GO	0045793:positive regulation of cell size 0007497:posterior midgut development 0071300:cellular response to retinoic acid 0004713:protein tyrosine kinase activity 0043410:positive regulation of MAPK cascade 0000165:MAPK cascade 0042493:response to drug 0030424:axon 0005524:ATP binding 0030425:dendrite 0006468:protein phosphorylation 0038023:signaling receptor activity 0007169:transmembrane receptor protein tyrosine kinase signaling pathway 0043025:neuronal cell body 0007156:homophilic cell adhesion via plasma membrane adhesion molecules 0033619:membrane protein proteolysis 2001241:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 0007275:multicellular organism development 0030155:regulation of cell adhesion 0007158:neuron cell-cell adhesion 0001657:ureteric bud development 0072300:positive regulation of metanephric glomerulus development 0050770:regulation of axonogenesis 0048265:response to pain 0060041:retina development in camera-type eye 0033141:positive regulation of peptidyl-serine phosphorylation of STAT protein 0005886:plasma membrane 0033674:positive regulation of kinase activity 0060384:innervation 0005887:integral component of plasma membrane 0045893:positive regulation of transcription, DNA-templated 0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process 0097021:lymphocyte migration into lymphoid organs 0030335:positive regulation of cell migration 0043235:receptor complex 0048484:enteric nervous system development 0010008:endosome membrane 0035799:ureter maturation 0001755:neural crest cell migration 0045121:membrane raft 0098797:plasma membrane protein complex 0005509:calcium ion binding 0007411:axon guidance 0033630:positive regulation of cell adhesion mediated by integrin 0001838:embryonic epithelial tube formation 0005769:early endosome 0035860:glial cell-derived neurotrophic factor receptor signaling pathway 0014042:positive regulation of neuron maturation 0010976:positive regulation of neuron projection development 0061146:Peyer's patch morphogenesis 0000187:activation of MAPK activity 0007165:signal transduction 0051897:positive regulation of protein kinase B signaling 0004714:transmembrane receptor protein tyrosine kinase activity 0042551:neuron maturation
PDB	6Q2N ; 2IVV ; 6FEK ; 2X2U ; 4CKJ ; 6Q2J ; 7JU5 ; 4CKI ; 6Q2O ; 6Q2S ; 6I83 ; 6NJA ; 2IVU ; 2X2M ; 6NE7 ; 6VHG ; 5AMN ; 6NEC ; 4UX8 ; 2IVS ; 7JU6 ; 5FM3 ; 6I82 ; 2X2L ; 2IVT ; 6GL7 ; 1XPD ; 2X2K ; 6Q2R ; 5FM2
Drugbank	DB15685 ; DB12742 ; DB08901 ; DB08875 ; DB08896 ; DB00398 ; DB09078 ; DB12010 ; DB05294 ; DB01809 ; DB15822
KEGG	hsa:5979

Type

Detail

Target ID

T34WFL

Protein Name

Proto-oncogene tyrosine-protein kinase receptor Ret

Uniprot ID

P07949

Protein Name Alias

EC 2.7.10.1; Cadherin family member 12; Proto-oncogene c-Ret

Gene ID

5979

Gene Symbol

RET

Gene Alias

CDHF12; CDHR16; PTC; RET51

TTD

T60631: Successful target

Pfam

PF17756 ; PF07714 ; PF00028 ; PF17812 ; PF17813

0045793:positive regulation of cell size

0007497:posterior midgut development

0071300:cellular response to retinoic acid

0004713:protein tyrosine kinase activity

0043410:positive regulation of MAPK cascade

0000165:MAPK cascade

0042493:response to drug

0030424:axon

0005524:ATP binding

0030425:dendrite

0006468:protein phosphorylation

0038023:signaling receptor activity

0007169:transmembrane receptor protein tyrosine kinase signaling pathway

0043025:neuronal cell body

0007156:homophilic cell adhesion via plasma membrane adhesion molecules

0033619:membrane protein proteolysis

2001241:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

0007275:multicellular organism development

0030155:regulation of cell adhesion

0007158:neuron cell-cell adhesion

0001657:ureteric bud development

0072300:positive regulation of metanephric glomerulus development

0050770:regulation of axonogenesis

0048265:response to pain

0060041:retina development in camera-type eye

0033141:positive regulation of peptidyl-serine phosphorylation of STAT protein

0005886:plasma membrane

0033674:positive regulation of kinase activity

0060384:innervation

0005887:integral component of plasma membrane

0045893:positive regulation of transcription, DNA-templated

0006919:activation of cysteine-type endopeptidase activity involved in apoptotic process

0097021:lymphocyte migration into lymphoid organs

0030335:positive regulation of cell migration

0043235:receptor complex

0048484:enteric nervous system development

0010008:endosome membrane

0035799:ureter maturation

0001755:neural crest cell migration

0045121:membrane raft

0098797:plasma membrane protein complex

0005509:calcium ion binding

0007411:axon guidance

0033630:positive regulation of cell adhesion mediated by integrin

0001838:embryonic epithelial tube formation

0005769:early endosome

0035860:glial cell-derived neurotrophic factor receptor signaling pathway

0014042:positive regulation of neuron maturation

0010976:positive regulation of neuron projection development

0061146:Peyer's patch morphogenesis

0000187:activation of MAPK activity

0007165:signal transduction

0051897:positive regulation of protein kinase B signaling

0004714:transmembrane receptor protein tyrosine kinase activity

0042551:neuron maturation

PDB

6Q2N ; 2IVV ; 6FEK ; 2X2U ; 4CKJ ; 6Q2J ; 7JU5 ; 4CKI ; 6Q2O ; 6Q2S ; 6I83 ; 6NJA ; 2IVU ; 2X2M ; 6NE7 ; 6VHG ; 5AMN ; 6NEC ; 4UX8 ; 2IVS ; 7JU6 ; 5FM3 ; 6I82 ; 2X2L ; 2IVT ; 6GL7 ; 1XPD ; 2X2K ; 6Q2R ; 5FM2

Drugbank

DB15685 ; DB12742 ; DB08901 ; DB08875 ; DB08896 ; DB00398 ; DB09078 ; DB12010 ; DB05294 ; DB01809 ; DB15822

KEGG

hsa:5979

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0652	Xiang Yuan Pi	香橼皮	Wilson citron	Citrus medica
H0006	Bai Qu Cai	白屈菜	Greater celandine	Chelidonium majus
H0785	Ze Xi Huang Lian	择细黄连	Coptis deltoidea	Coptis chinensis
H1230	Huang Bai Fen	黄柏粉	Amur corktree	Phellodendron amurense
H0706	Yan Hu Suo	延胡索	Yanhusuo	Corydalis yanhusuo
H0029	Jiang Huang Lian	姜黄连	Coptis deltoidea	Coptis chinensis
H0651	Xiang Yuan	香橼	Wilson citron	Citrus medica
H1061	Bai He	百合	Lily	Lilium brownii
H0872	Chuan Huang Lian	川黄连	rhizome of chinese goldthread	Coptis chinensis
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0082	Jiu Huang Lian	酒黄连	Coptis deltoidea	Coptis chinensis
H0682	Xiong Huang Lian	雄黄连	Coptis deltoidea	Coptis chinensis
H0704	Yan Guan Huang Bai	盐关黄柏	Amur cork tree	Phellodendron amurense
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H1243	Huang Lian Xu	黄连须	Coptis deltoidea	Coptis chinensis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H1231	Huang Bai Tan	黄柏炭	Amur corktree	Phellodendron amurense
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H1228	Huang Bai	黄柏	Amur corktree	Phellodendron amurense
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H1068	Bai He Liu Jin Gao	百合流浸膏	Lily	Lilium brownii
H1115	Guan Huang Bai	关黄柏	Amur cork tree	Phellodendron amurense
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa
H0827	Zhu Hong Jun	竹红菌	Bambusa hypocrella*	Hypocrella bambusae
H0633	Xia Tian Wu	夏天无	Decumbent corydalis	Corydalis decumbens
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H1242	Huang Lian Gan Jin Gao	黄连干浸膏	Coptis deltoidea	Coptis chinensis
H1241	Huang Lian	黄连	Coptis deltoidea	Coptis chinensis
H0760	Yu Huang Lian	萸黄连	Coptis deltoidea	Coptis chinensis

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 31)