Compound Description

ID:   C1265 Common name:   Curcumin
IUPAC:  (1E,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one CAS:  CAS:458-37-7
Chembl ID:   CHEMBL116438 Pubchem ID:   CID:5281767
Formula:  C21H20O6 TCM-ID:  TCMC962
Smiles:  COc1cc(/C=C/C(=C/C(=O)/C=C/c2ccc(c(c2)OC)O)/O)ccc1O
Alias:

1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)-;

Curcumin;

(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione;

(E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione;

(E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione;

BR 213;

Biocurcumax;

C Yellow 15;

C.I. 75300;

C.I. Natural Yellow 3;

Colorant E 100;

Curcuma;

Curcumax;

Curcumin I;

Curcumin W;

Curcumine;

Cureit;

Diferuloylmethane;

E 100;

E 100 (dye);

Haidr;

Halad;

Haldar;

Halud;

INS 100i;

Indian Saffron;

Jianghuangsu;

Kacha Haldi;

Kiriyasu Oil Yellow U;

Lipocurc;

Longvida;

Merita Earth;

NSC 32982;

NanoCurc;

Natural Yellow 3;

Natxtra;

San-Ei Curcumine AL;

San-Ei Gen Curcumine AL;

Souchet;

Terra Merita;

Theracurmin;

Theracurmin CR 011L;

Turmeric;

Turmeric (dye);

Turmeric yellow;

Ukon;

Ukon (dye);

Vacurin;

Yellow Ginger;

Yellow Root;

Yo-Kin;

trans,trans-Curcumin
Structure:

Related Targets  (Total: 155)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T47HTN Prostaglandin E synthasePTGES O14684
A 1 Reference(s)
T96OOK Signal transducer and activator of transcription 3STAT3 P40763
A 3 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
A 5 Reference(s)
T06RMZ Nuclear factor NF-kappa-B p105 subunitNFKB1 P19838
A 12 Reference(s)
T39M81 DNA-(apurinic or apyrimidinic site) endonucleaseAPEX1 P27695
A 1 Reference(s)
T47VCA Glutathione S-transferase Mu 5GSTM5 P46439
A 1 Reference(s)
T83BVT Mitochondrial 2-oxodicarboxylate carrierSLC25A21 Q9BQT8
A 3 Reference(s)
T75HEW DNA polymerase lambdaPOLL Q9UGP5
A 1 Reference(s)
T27IAF Lactoylglutathione lyaseGLO1 Q04760
A 2 Reference(s)
T69HP8 P2X purinoceptor 3P2RX3 P56373
A 1 Reference(s)
T01E8J Amyloid-beta precursor proteinAPP P05067
A 1 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
A 3 Reference(s)
T20RA0 Adenosine deaminaseADA P00813
A 2 Reference(s)
T01JSX Carbonyl reductase [NADPH] 1CBR1 P16152
A 2 Reference(s)
T23VMI Tumor necrosis factorTNF P01375
A 6 Reference(s)
T74QXI Serine/threonine-protein kinase mTORMTOR P42345
A 3 Reference(s)
T22OPB Nuclear factor erythroid 2-related factor 2NFE2L2 Q16236
A 4 Reference(s)
T40DIM Corticosteroid 11-beta-dehydrogenase isozyme 1HSD11B1 P28845
A 2 Reference(s)
T96JGO Solute carrier organic anion transporter family member 1B1SLCO1B1 Q9Y6L6
A 1 Reference(s)
T70SFS Superoxide dismutase [Mn], mitochondrialSOD2 P04179
A 1 Reference(s)
T16MRU NACHT, LRR and PYD domains-containing protein 3NLRP3 Q96P20
A 1 Reference(s)
T79QBE Multidrug resistance-associated protein 5ABCC5 O15440
A 1 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
A 3 Reference(s)
T66GX9 Proline-rich transmembrane protein 2PRRT2 Q7Z6L0
A 2 Reference(s)
T29MD1 Mitogen-activated protein kinase 8MAPK8 P45983
A 2 Reference(s)
T62JK9 NAUGT1A NA
A 1 Reference(s)
T60IL5 Flap endonuclease 1FEN1 P39748
A 1 Reference(s)
T41SFE Histone acetyltransferase p300EP300 Q09472
A 1 Reference(s)
T54SB3 Retrotransposon-derived protein PEG10PEG10 Q86TG7
A 1 Reference(s)
T57HGP Tumor necrosis factor receptor superfamily member 6FAS P25445
A 1 Reference(s)
T06Q1R Amine oxidase [flavin-containing] BMAOB P27338
A 1 Reference(s)
T65S3S Tyrosine-protein kinase JAK2JAK2 O60674
A 1 Reference(s)
T92BZ2 Catenin beta-1CTNNB1 P35222
A 2 Reference(s)
T78T4E Hematopoietic prostaglandin D synthaseHPGDS O60760
A 1 Reference(s)
T40JZG GPI-anchor transamidasePIGK Q92643
A 1 Reference(s)
T27LA6 DNADNMT1 P26358
A 2 Reference(s)
T38OH4 Caspase-1CASP1 P29466
A 1 Reference(s)
T30VNV MyeloperoxidaseMPO P05164
A 1 Reference(s)
T26CFB DNA damage-inducible transcript 3 proteinDDIT3 P35638;P0DPQ6
A 1 Reference(s)
T75IW3 Matrix metalloproteinase-14MMP14 P50281
A 1 Reference(s)
T17YBS Transmembrane protease serine 11DTMPRSS11D O60235
A 1 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
A 1 Reference(s)
T44LWL Transcription factor p65RELA Q04206
A 1 Reference(s)
T20C6X Kinesin-like protein KIF11KIF11 P52732
B 2 Reference(s)
T68OIU CREB-regulated transcription coactivator 1CRTC1 Q6UUV9
B 2 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
B 5 Reference(s)
T93WZG G1/S-specific cyclin-D1CCND1 P24385
B 5 Reference(s)
T38EQ6 NAD(P)H dehydrogenase [quinone] 1NQO1 P15559
B 2 Reference(s)
T33JGV Tumor suppressor ARF;Cyclin-dependent kinase inhibitor 2ACDKN2A Q8N726;P42771
B 1 Reference(s)
T10KMJ Insulin-like growth factor IIIGF2 P01344
B 1 Reference(s)
T47H3O Heat shock protein HSP 90-alphaHSP90AA1 P07900
B 1 Reference(s)
T18YXD AlbuminALB P02768
B 1 Reference(s)
T05SMP Folate receptor betaFOLR2 P14207
B 1 Reference(s)
T34WFL Proto-oncogene tyrosine-protein kinase receptor RetRET P07949
B 1 Reference(s)
T42PUG Solute carrier family 2, facilitated glucose transporter member 1SLC2A1 P11166
B 1 Reference(s)
T12T4H Brain-derived neurotrophic factorBDNF P23560
B 3 Reference(s)
T84FV7 Zinc finger protein SNAI2SNAI2 O43623
B 1 Reference(s)
T84OOM Transcription factor EBTFEB P19484
B 1 Reference(s)
T04PM9 TransthyretinTTR P02766
B 1 Reference(s)
T92HNO High mobility group protein B1HMGB1 P09429
C 2 Reference(s)
T58XLK Tyrosine-protein phosphatase non-receptor type 1PTPN1 P18031
C 2 Reference(s)
T75WT1 Transcription factor 21TCF21 O43680
C 1 Reference(s)
T34N64 NAMIR29B1 NA
C 1 Reference(s)
T33JS5 CCN family member 2CCN2 P29279
C 4 Reference(s)
T88WHQ B-lymphocyte antigen CD19CD19 P15391
C 1 Reference(s)
T13YN2 Bcl-2-like protein 1Bcl2l1 Q64373
C 2 Reference(s)
T77QE6 Thrombospondin-4THBS4 P35443
C 2 Reference(s)
T94H37 Cadherin-1CDH1 P12830
C 1 Reference(s)
T06SWE Hematopoietic progenitor cell antigen CD34CD34 P28906
C 1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
C 2 Reference(s)
T53Z7Y Transcriptional coactivator YAP1YAP1 P46937
C 1 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
C 5 Reference(s)
T46K2X Heat shock 70 kDa protein 4HSPA4 P34932
C 2 Reference(s)
T40FOE NAMIR7-1 NA
C 2 Reference(s)
T84RJ0 NAMIR7-2 NA
C 2 Reference(s)
T31NKI NAMIR7-3 NA
C 2 Reference(s)
T27M4K Rho GTPase-activating protein 7DLC1 Q96QB1
C 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
C 3 Reference(s)
T81X6W EndoplasminHSP90B1 P14625
C 1 Reference(s)
T10ICM Oxidized low-density lipoprotein receptor 1OLR1 P78380
C 1 Reference(s)
T86ROZ Heme oxygenase 1HMOX1 P09601
C 2 Reference(s)
T89GNB FascinFSCN1 Q16658
C 1 Reference(s)
T28HOM LeptinLEP P41159
C 1 Reference(s)
T57L0X Oxysterols receptor LXR-alphaNR1H3 Q13133
C 1 Reference(s)
T17A6S VIP peptides [Cleaved into: Intestinal peptide PHV-42VIP P01282
C 1 Reference(s)
T04UTZ G1/S-specific cyclin-E1CCNE1 P24864
C 1 Reference(s)
T38JCD DNA-binding protein inhibitor ID-1ID1 P41134
C 2 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
C 1 Reference(s)
T77W6N Thioredoxin reductase 1, cytoplasmicTXNRD1 Q16881
C 1 Reference(s)
T16T9T Krueppel-like factor 15KLF15 Q9UIH9
C 1 Reference(s)
T28K6X Insulin receptor substrate 1IRS1 P35568
C 1 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
C 3 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
C 3 Reference(s)
T36Q35 Tumor-associated calcium signal transducer 2TACSTD2 P09758
C 3 Reference(s)
T02QZI NADPH oxidase 5NOX5 Q96PH1
C 1 Reference(s)
T85K8L Forkhead box protein O1FOXO1 Q12778
C 1 Reference(s)
T28HCY Presenilin-1PSEN1 P49768
C 2 Reference(s)
T44JTS Zinc finger and BTB domain-containing protein 7AZBTB7A O95365
C 2 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
C 2 Reference(s)
T54CIF Interleukin-8CXCL8 P10145
C 2 Reference(s)
T02DKV Gastrin [Cleaved into: Gastrin-71GAST P01350
C 1 Reference(s)
T15JRW Interferon alpha-inducible protein 27, mitochondrialIFI27 P40305
C 1 Reference(s)
T95DSF TuberinTSC2 P49815
C 1 Reference(s)
T19AGJ Tumor necrosis factor ligand superfamily member 13BTNFSF13B Q9Y275
C 1 Reference(s)
T71BDH Mitogen-activated protein kinase 14MAPK14 Q16539
C 1 Reference(s)
T85U8U Caspase-3CASP3 P42574
C 4 Reference(s)
T67ZT3 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN P60484
C 1 Reference(s)
T84FSA Forkhead box protein O3FOXO3 O43524
C 1 Reference(s)
T23RWU Type-1 angiotensin II receptorAGTR1 P30556
C 1 Reference(s)
T82ALJ Glycogen synthase kinase-3 betaGSK3B P49841
C 2 Reference(s)
T20JZ2 Androgen receptorAR P10275
C 2 Reference(s)
T17UP9 C-C motif chemokine 2CCL2 P13500
C 1 Reference(s)
T70VMI Nitric oxide synthase, brainNOS1 P29475
C 1 Reference(s)
T20MBF SerotransferrinTF P02787
C 1 Reference(s)
T52ARL Suppressor of cytokine signaling 3SOCS3 O14543
C 1 Reference(s)
T24UPH NAMIR206 NA
C 1 Reference(s)
T33OSQ Sterol regulatory element-binding protein 1SREBF1 P36956
C 1 Reference(s)
T10HL8 Intercellular adhesion molecule 1ICAM1 P05362
C 1 Reference(s)
T69NG6 Interleukin-10IL10 P22301
C 1 Reference(s)
T20E5P Cytochrome b-245 heavy chainCYBB P04839
C 1 Reference(s)
T50VJF OsteopontinSPP1 P10451
C 1 Reference(s)
T78MPR SynaptophysinSYP P08247
C 1 Reference(s)
T33VZN Retinoic acid receptor betaRARB P10826
C 1 Reference(s)
T30C8X Peripheral myelin protein 22PMP22 Q01453
C 1 Reference(s)
T00CXT Prostaglandin G/H synthase 1PTGS1 P23219
C 1 Reference(s)
T79KQO NF-kappa-B inhibitor alphaNFKBIA P25963
C 1 Reference(s)
T95IYZ AdiponectinADIPOQ Q15848
C 1 Reference(s)
T64BTV Interleukin-1 betaIL1B P01584
C 1 Reference(s)
T41BJ0 NAMIR130A NA
C 1 Reference(s)
T98PLL Reversion-inducing cysteine-rich protein with Kazal motifsRECK O95980
C 1 Reference(s)
T37PX5 Zinc finger protein GLI1GLI1 P08151
C 1 Reference(s)
T44Z3T Metastasis-associated protein MTA1MTA1 Q13330
C 1 Reference(s)
T53AOE Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptideTGFB1 P01137
C 1 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
C 1 Reference(s)
T60I6V E3 SUMO-protein ligase PIAS3PIAS3 Q9Y6X2
C 1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
C 1 Reference(s)
T38ILG Zinc finger protein PLAGL1PLAGL1 Q9UM63
C 1 Reference(s)
T49UAP Ras-specific guanine nucleotide-releasing factor 1RASGRF1 Q13972
C 1 Reference(s)
T43BVC BasiginBSG P35613
C 1 Reference(s)
T75CHS NAMIR15A NA
C 1 Reference(s)
T49PL1 Low-density lipoprotein receptorLDLR P01130
C 1 Reference(s)
T33OPP Interleukin-6IL6 P05231
C 2 Reference(s)
T15URL Cathelicidin antimicrobial peptideCAMP P49913
C 1 Reference(s)
T68XO1 Indoleamine 2,3-dioxygenase 1IDO1 P14902
C 1 Reference(s)
T18UDY Synapsin-1SYN1 P17600
C 1 Reference(s)
T95Z7B Polycomb complex protein BMI-1BMI1 P35226
C 1 Reference(s)
T74D4Y CASP8 and FADD-like apoptosis regulatorCFLAR O15519
C 1 Reference(s)
T09KPZ VimentinVIM P08670
C 1 Reference(s)
T06URY Transcription factor Sp1SP1 P08047
C 1 Reference(s)
T11N8F NAMIR7641-1 NA
C 1 Reference(s)
T91MKC Runt-related transcription factor 2RUNX2 Q13950
C 1 Reference(s)
T32IXS Integrin alpha-MITGAM P11215
C 1 Reference(s)
T83YZD AcetylcholinesteraseACHE P22303
C 1 Reference(s)
T05WYT CDGSH iron-sulfur domain-containing protein 2CISD2 Q8N5K1
C 1 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 7)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H0142 Liang Jiang良姜 NAAlpinia officinarum
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0028 Jiang Huang姜黄 Common turmericCurcuma longa