HIT-result

Target Description

Type	Detail
Target ID	T53Z7Y
Protein Name	Transcriptional coactivator YAP1
Uniprot ID	P46937
Protein Name Alias	Yes-associated protein 1; Protein yorkie homolog; Yes-associated protein YAP65 homolog
Gene ID	10413
Gene Symbol	YAP1
Gene Alias	YAP65
TTD	T94048: Research target
Pfam	PF00397
GO	0003682:chromatin binding 0030216:keratinocyte differentiation 0035019:somatic stem cell population maintenance 0003015:heart process 0006367:transcription initiation from RNA polymerase II promoter 0045599:negative regulation of fat cell differentiation 0050767:regulation of neurogenesis 0001829:trophectodermal cell differentiation 0010629:negative regulation of gene expression 0001674:female germ cell nucleus 0000902:cell morphogenesis 0072307:regulation of metanephric nephron tubule epithelial cell differentiation 0003714:transcription corepressor activity 0050679:positive regulation of epithelial cell proliferation 0003713:transcription coactivator activity 0042060:wound healing 1902018:negative regulation of cilium assembly 0005654:nucleoplasm 1902036:regulation of hematopoietic stem cell differentiation 0060045:positive regulation of cardiac muscle cell proliferation 1904036:negative regulation of epithelial cell apoptotic process 0016020:membrane 0071480:cellular response to gamma radiation 0045747:positive regulation of Notch signaling pathway 0008283:cell population proliferation 2001237:negative regulation of extrinsic apoptotic signaling pathway 0005829:cytosol 0030903:notochord development 0005737:cytoplasm 0070064:proline-rich region binding 0032570:response to progesterone 0006974:cellular response to DNA damage stimulus 0030857:negative regulation of epithelial cell differentiation 0045944:positive regulation of transcription by RNA polymerase II 0061026:cardiac muscle tissue regeneration 0070102:interleukin-6-mediated signaling pathway 0071300:cellular response to retinoic acid 0060576:intestinal epithelial cell development 0033148:positive regulation of intracellular estrogen receptor signaling pathway 0050847:progesterone receptor signaling pathway 0048368:lateral mesoderm development 0001570:vasculogenesis 0048339:paraxial mesoderm development 0001894:tissue homeostasis 0140552:TEAD-YAP complex 0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding 0065003:protein-containing complex assembly 0140297:DNA-binding transcription factor binding 0072091:regulation of stem cell proliferation 0010837:regulation of keratinocyte proliferation 1900182:positive regulation of protein localization to nucleus 2000737:negative regulation of stem cell differentiation 0000976:transcription regulatory region sequence-specific DNA binding 0090263:positive regulation of canonical Wnt signaling pathway 1902459:positive regulation of stem cell population maintenance 0045893:positive regulation of transcription, DNA-templated 0005634:nucleus 0035329:hippo signaling 0010628:positive regulation of gene expression 0060242:contact inhibition 0000122:negative regulation of transcription by RNA polymerase II 0060487:lung epithelial cell differentiation 0045669:positive regulation of osteoblast differentiation 0008022:protein C-terminus binding 0003143:embryonic heart tube morphogenesis 0060449:bud elongation involved in lung branching 0007399:nervous system development
PDB	6GEE ; 1K5R ; 6GEK ; 6GE6 ; 6G8K ; 6Q2X ; 6G8L ; 6GEI ; 6GEG ; 6G8J ; 2LAW ; 5OAQ ; 6GEC ; 6HIK ; 1K9R ; 6G8P ; 4RE1 ; 1K9Q ; 6HIL ; 6G6X ; 6G8I ; 4REX ; 3MHR ; 3KYS ; 5YDX ; 2LAX ; 5YDY ; 6GE5 ; 6GE4 ; 2LAY ; 6G8Q ; 6GE3 ; 1JMQ ; 2LTV ; 2LTW
Drugbank	NA
KEGG	hsa:10413

Type

Detail

Target ID

T53Z7Y

Protein Name

Transcriptional coactivator YAP1

Uniprot ID

P46937

Protein Name Alias

Yes-associated protein 1; Protein yorkie homolog; Yes-associated protein YAP65 homolog

Gene ID

10413

Gene Symbol

YAP1

Gene Alias

YAP65

TTD

T94048: Research target

Pfam

PF00397

0003682:chromatin binding

0030216:keratinocyte differentiation

0035019:somatic stem cell population maintenance

0003015:heart process

0006367:transcription initiation from RNA polymerase II promoter

0045599:negative regulation of fat cell differentiation

0050767:regulation of neurogenesis

0001829:trophectodermal cell differentiation

0010629:negative regulation of gene expression

0001674:female germ cell nucleus

0000902:cell morphogenesis

0072307:regulation of metanephric nephron tubule epithelial cell differentiation

0003714:transcription corepressor activity

0050679:positive regulation of epithelial cell proliferation

0003713:transcription coactivator activity

0042060:wound healing

1902018:negative regulation of cilium assembly

0005654:nucleoplasm

1902036:regulation of hematopoietic stem cell differentiation

0060045:positive regulation of cardiac muscle cell proliferation

1904036:negative regulation of epithelial cell apoptotic process

0016020:membrane

0071480:cellular response to gamma radiation

0045747:positive regulation of Notch signaling pathway

0008283:cell population proliferation

2001237:negative regulation of extrinsic apoptotic signaling pathway

0005829:cytosol

0030903:notochord development

0005737:cytoplasm

0070064:proline-rich region binding

0032570:response to progesterone

0006974:cellular response to DNA damage stimulus

0030857:negative regulation of epithelial cell differentiation

0045944:positive regulation of transcription by RNA polymerase II

0061026:cardiac muscle tissue regeneration

0070102:interleukin-6-mediated signaling pathway

0071300:cellular response to retinoic acid

0060576:intestinal epithelial cell development

0033148:positive regulation of intracellular estrogen receptor signaling pathway

0050847:progesterone receptor signaling pathway

0048368:lateral mesoderm development

0001570:vasculogenesis

0048339:paraxial mesoderm development

0001894:tissue homeostasis

0140552:TEAD-YAP complex

0000978:RNA polymerase II cis-regulatory region sequence-specific DNA binding

0065003:protein-containing complex assembly

0140297:DNA-binding transcription factor binding

0072091:regulation of stem cell proliferation

0010837:regulation of keratinocyte proliferation

1900182:positive regulation of protein localization to nucleus

2000737:negative regulation of stem cell differentiation

0000976:transcription regulatory region sequence-specific DNA binding

0090263:positive regulation of canonical Wnt signaling pathway

1902459:positive regulation of stem cell population maintenance

0045893:positive regulation of transcription, DNA-templated

0005634:nucleus

0035329:hippo signaling

0010628:positive regulation of gene expression

0060242:contact inhibition

0000122:negative regulation of transcription by RNA polymerase II

0060487:lung epithelial cell differentiation

0045669:positive regulation of osteoblast differentiation

0008022:protein C-terminus binding

0003143:embryonic heart tube morphogenesis

0060449:bud elongation involved in lung branching

0007399:nervous system development

PDB

6GEE ; 1K5R ; 6GEK ; 6GE6 ; 6G8K ; 6Q2X ; 6G8L ; 6GEI ; 6GEG ; 6G8J ; 2LAW ; 5OAQ ; 6GEC ; 6HIK ; 1K9R ; 6G8P ; 4RE1 ; 1K9Q ; 6HIL ; 6G6X ; 6G8I ; 4REX ; 3MHR ; 3KYS ; 5YDX ; 2LAX ; 5YDY ; 6GE5 ; 6GE4 ; 2LAY ; 6G8Q ; 6GE3 ; 1JMQ ; 2LTV ; 2LTW

Drugbank

KEGG

hsa:10413

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0677	Chan Chu	蟾蜍	Toad	Bufo melanostictus
H1093	Gao Liang Jiang You	高良姜油	Lesser galangal	Alpinia officinarum
H0258	Mo Han Lian	墨旱莲	Yerbadetajo	Eclipta prostrata
H0142	Liang Jiang	良姜	NA	Alpinia officinarum
H0532	Teng Huang	藤黄	Gamboge tree resin	Garcinia morella
H0114	Ku Xuan Shen	苦玄参	Common bitterfigwort	Picria felterrae
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H1078	Gan Chan	干蟾	NA	Bufo melanostictus
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H1092	Gao Liang Jiang	高良姜	Lesser galangal	Alpinia officinarum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0160	Liu Zhi	柳枝	Babylon weeping willow branch	Salix babylonica
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa

Target Description

Related Compounds (Total: 5)

Related Herbs (Total: 18)