Compound Description

ID:   C0397 Common name:   Serotonin
IUPAC:  3-(2-aminoethyl)-1H-indol-5-ol CAS:  CAS:50-67-9
Chembl ID:   CHEMBL39 Pubchem ID:   CID:5202
Formula:  C10H12N2O TCM-ID:  TCMC2063
Smiles:  NCCc1c[nH]c2c1cc(O)cc2
Alias:

Indol-5-ol, 3-(2-aminoethyl)-;

3-(2-Aminoethyl)-1H-indol-5-ol;

3-(2-Aminoethyl)indol-5-ol;

3-(β-Aminoethyl)-5-hydroxyindole;

5-HT;

5-HTA;

5-Hydroxy-3-(β-aminoethyl)indole;

5-Hydroxyltryptamine;

5-Hydroxytriptamine;

5-Hydroxytryptamine;

DS substance;

Enteramin;

Enteramine;

Serotonin;

Substance DS;

Thrombocytin;

Thrombotonin;

Tryptamine, 5-hydroxy-
Structure:

Related Targets  (Total: 49)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T11ZYR Cytochrome P450 2D6CYP2D6 P10635
A 2 Reference(s)
T58J2Y Peroxisome proliferator-activated receptor gammaPPARG P37231
A 3 Reference(s)
T24OK4 Rho-associated protein kinase 2Rock2 Q62868
A 1 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
A 2 Reference(s)
T25NSJ Mitogen-activated protein kinase 3MAPK3 P27361
A 2 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
A 1 Reference(s)
T25Y64 CholinesteraseBCHE P06276
A 1 Reference(s)
T76C5R Parathyroid hormone-related proteinPTHLH P12272
A 1 Reference(s)
T77WRE Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylaseCMAHP Q9Y471
A 1 Reference(s)
T13KGH TyrosinaseTYR P14679
A 1 Reference(s)
T83COK 5-hydroxytryptamine receptor 2CHTR2C P28335
A 1 Reference(s)
T39T57 Tryptophan 5-hydroxylase 1TPH1 P17752
A 1 Reference(s)
T61NZN Progonadoliberin-1GNRH1 P01148
A 1 Reference(s)
T29B10 Interleukin-17AIL17A Q16552
A 1 Reference(s)
T13HNJ NATERC NA
A 1 Reference(s)
T84YTJ Glutamate receptor 4GRIA4 P48058
A 1 Reference(s)
T03GNH Alpha-2B adrenergic receptorADRA2B P18089
A 1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
A 1 Reference(s)
T39GNZ 5-hydroxytryptamine receptor 3AHTR3A P46098
A 1 Reference(s)
T97ZTQ 5-hydroxytryptamine receptor 1BHTR1B P28222
A 1 Reference(s)
T86YQL ProlactinPRL P01236
A 1 Reference(s)
T48ZIG D(2) dopamine receptorDRD2 P14416
A 1 Reference(s)
T36O3K Beta-adrenergic receptor kinase 1GRK2 P25098
A 1 Reference(s)
T31QEZ 5-hydroxytryptamine receptor 1AHTR1A P08908
A 1 Reference(s)
T84W8G Aryl hydrocarbon receptorAHR P35869
A 1 Reference(s)
T64BED 5-hydroxytryptamine receptor 2AHTR2A P28223
A 1 Reference(s)
T25RHJ Sodium-dependent serotonin transporterSLC6A4 P31645
B 1 Reference(s)
T78BSU 5-hydroxytryptamine receptor 2BHTR2B P41595
B 1 Reference(s)
T04MBA Vascular endothelial growth factor receptor 2KDR P35968
B 1 Reference(s)
T17UP9 C-C motif chemokine 2CCL2 P13500
C 1 Reference(s)
T53Z7Y Transcriptional coactivator YAP1YAP1 P46937
C 2 Reference(s)
T69XVX Cytochrome P450 1B1CYP1B1 Q16678
C 2 Reference(s)
T91MKC Runt-related transcription factor 2RUNX2 Q13950
C 1 Reference(s)
T94H37 Cadherin-1CDH1 P12830
C 1 Reference(s)
T73ZPO Beta-caseinCSN2 P05814
C 1 Reference(s)
T54CIF Interleukin-8CXCL8 P10145
C 1 Reference(s)
T10HL8 Intercellular adhesion molecule 1ICAM1 P05362
C 1 Reference(s)
T52VL6 Signal transducer and activator of transcription 5ASTAT5A P42229
C 1 Reference(s)
T19K8W Signal transducer and activator of transcription 5BSTAT5B P51692
C 1 Reference(s)
T15URL Cathelicidin antimicrobial peptideCAMP P49913
C 1 Reference(s)
T21DZX Amine oxidase [flavin-containing] AMAOA P21397
C 1 Reference(s)
T76TED Pro-opiomelanocortinPOMC P01189
C 1 Reference(s)
T20E5P Cytochrome b-245 heavy chainCYBB P04839
C 1 Reference(s)
T67HXL Glial cell line-derived neurotrophic factorGDNF P39905
C 1 Reference(s)
T91MWA Disintegrin and metalloproteinase domain-containing protein 17ADAM17 P78536
C 1 Reference(s)
T53TBQ Elongation factor 2EEF2 P13639
C 1 Reference(s)
T13M0G Protein S100-BS100B P04271
C 1 Reference(s)
T01QLH Estrogen receptorESR1 P03372
C 1 Reference(s)
T34ZZ0 Potassium channel subfamily K member 2KCNK2 O95069
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 7)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0677 Chan Chu蟾蜍 ToadBufo melanostictus
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1078 Gan Chan干蟾 NABufo melanostictus
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale