Compound Description
| ID: C0397 | Common name: Serotonin |
| IUPAC: 3-(2-aminoethyl)-1H-indol-5-ol | CAS: CAS:50-67-9 |
| Chembl ID: CHEMBL39 | Pubchem ID: CID:5202 |
| Formula: C10H12N2O | TCM-ID: TCMC2063 |
| Smiles: NCCc1c[nH]c2c1cc(O)cc2 | |
| Alias:
Indol-5-ol, 3-(2-aminoethyl)-;
3-(2-Aminoethyl)-1H-indol-5-ol; 3-(2-Aminoethyl)indol-5-ol; 3-(β-Aminoethyl)-5-hydroxyindole; 5-HT; 5-HTA; 5-Hydroxy-3-(β-aminoethyl)indole; 5-Hydroxyltryptamine; 5-Hydroxytriptamine; 5-Hydroxytryptamine; DS substance; Enteramin; Enteramine; Serotonin; Substance DS; Thrombocytin; Thrombotonin; Tryptamine, 5-hydroxy- |
Structure:
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Related Targets (Total: 49)
| Target id | Protein Name | Gene Symbol | Uniprot ID | Target Level | No.of Literature Evidence |
|---|---|---|---|---|---|
| T11ZYR | Cytochrome P450 2D6 | CYP2D6 |
P10635 |
A | 2 Reference(s) |
| T58J2Y | Peroxisome proliferator-activated receptor gamma | PPARG |
P37231 |
A | 3 Reference(s) |
| T24OK4 | Rho-associated protein kinase 2 | Rock2 |
Q62868 |
A | 1 Reference(s) |
| T79WXA | Mitogen-activated protein kinase 1 | MAPK1 |
P28482 |
A | 2 Reference(s) |
| T25NSJ | Mitogen-activated protein kinase 3 | MAPK3 |
P27361 |
A | 2 Reference(s) |
| T88TDZ | RAC-alpha serine/threonine-protein kinase | AKT1 |
P31749 |
A | 1 Reference(s) |
| T25Y64 | Cholinesterase | BCHE |
P06276 |
A | 1 Reference(s) |
| T76C5R | Parathyroid hormone-related protein | PTHLH |
P12272 |
A | 1 Reference(s) |
| T77WRE | Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase | CMAHP |
Q9Y471 |
A | 1 Reference(s) |
| T13KGH | Tyrosinase | TYR |
P14679 |
A | 1 Reference(s) |
| T83COK | 5-hydroxytryptamine receptor 2C | HTR2C |
P28335 |
A | 1 Reference(s) |
| T39T57 | Tryptophan 5-hydroxylase 1 | TPH1 |
P17752 |
A | 1 Reference(s) |
| T61NZN | Progonadoliberin-1 | GNRH1 |
P01148 |
A | 1 Reference(s) |
| T29B10 | Interleukin-17A | IL17A |
Q16552 |
A | 1 Reference(s) |
| T13HNJ | NA | TERC |
NA |
A | 1 Reference(s) |
| T84YTJ | Glutamate receptor 4 | GRIA4 |
P48058 |
A | 1 Reference(s) |
| T03GNH | Alpha-2B adrenergic receptor | ADRA2B |
P18089 |
A | 1 Reference(s) |
| T08Q7W | Prostaglandin G/H synthase 2 | PTGS2 |
P35354 |
A | 1 Reference(s) |
| T39GNZ | 5-hydroxytryptamine receptor 3A | HTR3A |
P46098 |
A | 1 Reference(s) |
| T97ZTQ | 5-hydroxytryptamine receptor 1B | HTR1B |
P28222 |
A | 1 Reference(s) |
| T86YQL | Prolactin | PRL |
P01236 |
A | 1 Reference(s) |
| T48ZIG | D(2) dopamine receptor | DRD2 |
P14416 |
A | 1 Reference(s) |
| T36O3K | Beta-adrenergic receptor kinase 1 | GRK2 |
P25098 |
A | 1 Reference(s) |
| T31QEZ | 5-hydroxytryptamine receptor 1A | HTR1A |
P08908 |
A | 1 Reference(s) |
| T84W8G | Aryl hydrocarbon receptor | AHR |
P35869 |
A | 1 Reference(s) |
| T64BED | 5-hydroxytryptamine receptor 2A | HTR2A |
P28223 |
A | 1 Reference(s) |
| T25RHJ | Sodium-dependent serotonin transporter | SLC6A4 |
P31645 |
B | 1 Reference(s) |
| T78BSU | 5-hydroxytryptamine receptor 2B | HTR2B |
P41595 |
B | 1 Reference(s) |
| T04MBA | Vascular endothelial growth factor receptor 2 | KDR |
P35968 |
B | 1 Reference(s) |
| T17UP9 | C-C motif chemokine 2 | CCL2 |
P13500 |
C | 1 Reference(s) |
| T53Z7Y | Transcriptional coactivator YAP1 | YAP1 |
P46937 |
C | 2 Reference(s) |
| T69XVX | Cytochrome P450 1B1 | CYP1B1 |
Q16678 |
C | 2 Reference(s) |
| T91MKC | Runt-related transcription factor 2 | RUNX2 |
Q13950 |
C | 1 Reference(s) |
| T94H37 | Cadherin-1 | CDH1 |
P12830 |
C | 1 Reference(s) |
| T73ZPO | Beta-casein | CSN2 |
P05814 |
C | 1 Reference(s) |
| T54CIF | Interleukin-8 | CXCL8 |
P10145 |
C | 1 Reference(s) |
| T10HL8 | Intercellular adhesion molecule 1 | ICAM1 |
P05362 |
C | 1 Reference(s) |
| T52VL6 | Signal transducer and activator of transcription 5A | STAT5A |
P42229 |
C | 1 Reference(s) |
| T19K8W | Signal transducer and activator of transcription 5B | STAT5B |
P51692 |
C | 1 Reference(s) |
| T15URL | Cathelicidin antimicrobial peptide | CAMP |
P49913 |
C | 1 Reference(s) |
| T21DZX | Amine oxidase [flavin-containing] A | MAOA |
P21397 |
C | 1 Reference(s) |
| T76TED | Pro-opiomelanocortin | POMC |
P01189 |
C | 1 Reference(s) |
| T20E5P | Cytochrome b-245 heavy chain | CYBB |
P04839 |
C | 1 Reference(s) |
| T67HXL | Glial cell line-derived neurotrophic factor | GDNF |
P39905 |
C | 1 Reference(s) |
| T91MWA | Disintegrin and metalloproteinase domain-containing protein 17 | ADAM17 |
P78536 |
C | 1 Reference(s) |
| T53TBQ | Elongation factor 2 | EEF2 |
P13639 |
C | 1 Reference(s) |
| T13M0G | Protein S100-B | S100B |
P04271 |
C | 1 Reference(s) |
| T01QLH | Estrogen receptor | ESR1 |
P03372 |
C | 1 Reference(s) |
| T34ZZ0 | Potassium channel subfamily K member 2 | KCNK2 |
O95069 |
C | 1 Reference(s) |
*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".
Related Herbs (Total: 7)
| Herb id | Chinese Pin Yin | Chinese Character | English Name | Latin Name |
|---|---|---|---|---|
| H0677 | Chan Chu | 蟾蜍 | Toad | Bufo melanostictus |
| H0928 | Da Huang Liu Jin Gao | 大黄流浸膏 | Medicinal rhubarb | Rheum officinale |
| H0847 | Zi He Che | 紫河车 | Human placenta | Homo sapiens |
| H0926 | Da Huang | 大黄 | Medicinal rhubarb | Rheum officinale |
| H0927 | Da Huang Jin Gao | 大黄浸膏 | Medicinal rhubarb | Rheum officinale |
| H1078 | Gan Chan | 干蟾 | NA | Bufo melanostictus |
| H0360 | Ren Zhong Bai | 人中白 | Human urine sediment | Homo sapiens |
Ckey description of the interaction between compound and target