HIT-result

Type	Detail
Target ID	T25RHJ
Protein Name	Sodium-dependent serotonin transporter
Uniprot ID	P31645
Protein Name Alias	SERT; 5HT transporter; 5HTT; Solute carrier family 6 member 4
Gene ID	6532
Gene Symbol	SLC6A4
Gene Alias	HTT; SERT
TTD	T27812: Successful target
Pfam	PF00209 ; PF03491
GO	0071300:cellular response to retinoic acid 0009636:response to toxic substance 0015844:monoamine transport 0042493:response to drug 0019811:cocaine binding 0090067:regulation of thalamus size 0042713:sperm ejaculation 0051610:serotonin uptake 0001666:response to hypoxia 0007584:response to nutrient 0005925:focal adhesion 0046872:metal ion binding 0051015:actin filament binding 0042136:neurotransmitter biosynthetic process 0042802:identical protein binding 0008504:monoamine transmembrane transporter activity 0048854:brain morphogenesis 0099055:integral component of postsynaptic membrane 0045202:synapse 0005886:plasma membrane 0071321:cellular response to cGMP 0046621:negative regulation of organ growth 0050998:nitric-oxide synthase binding 0032227:negative regulation of synaptic transmission, dopaminergic 0043005:neuron projection 0042310:vasoconstriction 0005887:integral component of plasma membrane 0005335:serotonin:sodium symporter activity 0006836:neurotransmitter transport 0032355:response to estradiol 0012505:endomembrane system 0007613:memory 0010008:endosome membrane 0017075:syntaxin-1 binding 0035176:social behavior 0035725:sodium ion transmembrane transport 0045121:membrane raft 0005326:neurotransmitter transmembrane transporter activity 0021941:negative regulation of cerebellar granule cell precursor proliferation 0099056:integral component of presynaptic membrane 0045787:positive regulation of cell cycle 0010628:positive regulation of gene expression 0007623:circadian rhythm 0051378:serotonin binding 0045665:negative regulation of neuron differentiation 0014064:positive regulation of serotonin secretion 0099154:serotonergic synapse
PDB	6VRH ; 6DZY ; 6DZV ; 5I6X ; 6VRL ; 6VRK ; 5I71 ; 5I6Z ; 5I75 ; 6W2B ; 5I74 ; 6AWQ ; 5I73 ; 6AWP ; 6AWN ; 6W2C ; 6AWO ; 6DZZ ; 6DZW
Drugbank	DB00215 ; DB00656 ; DB01175 ; DB06148 ; DB00285 ; DB09194 ; DB01363 ; DB00176 ; DB01577 ; DB09016 ; DB04889 ; DB09068 ; DB00514 ; DB12305 ; DB00458 ; DB00543 ; DB01442 ; DB00344 ; DB05964 ; DB09167 ; DB09186 ; DB00193 ; DB04832 ; DB01104 ; DB00408 ; DB04896 ; DB00182 ; DB05688 ; DB01191 ; DB06156 ; DB06701 ; DB01151 ; DB00852 ; DB09225 ; DB01142 ; DB08918 ; DB00289 ; DB05422 ; DB00540 ; DB00321 ; DB00988 ; DB08839 ; DB06204 ; DB00574 ; DB00726 ; DB00370 ; DB00191 ; DB00472 ; DB00661 ; DB00907 ; DB06684 ; DB01242 ; DB01105 ; DB01454 ; DB01149 ; DB00476 ; DB00579 ; DB00805 ; DB00924 ; DB04821 ; DB00715 ; DB00454 ; DB00721 ; DB00245 ; DB01114 ; DB04836 ; DB09195 ; DB01079 ; DB01238 ; DB06077 ; DB01472 ; DB06700
KEGG	hsa:6532

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Name: Escitalopram

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Name: Evodiamine

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Name: Fluoxetine

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Name: Monocrotaline

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Name: Serotonin

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Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0616	Wu Zhu Yu	吴茱萸	Medicinal evodia	Evodia rutaecarpa
H0327	Qian Li Guang	千里光	Climbing groundsel	Senecio scandens
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H1078	Gan Chan	干蟾	NA	Bufo melanostictus
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0677	Chan Chu	蟾蜍	Toad	Bufo melanostictus