HIT-result

Target Description

Type	Detail
Target ID	T48ZIG
Protein Name	D(2) dopamine receptor
Uniprot ID	P14416
Protein Name Alias	Dopamine D2 receptor
Gene ID	1813
Gene Symbol	DRD2
Gene Alias	NA
TTD	T67162: Successful target
Pfam	PF00001
GO	0060170:ciliary membrane 0098982:GABA-ergic synapse 0032147:activation of protein kinase activity 0030336:negative regulation of cell migration 0060134:prepulse inhibition 0045745:positive regulation of G protein-coupled receptor signaling pathway 0043473:pigmentation 0030139:endocytic vesicle 0004930:G protein-coupled receptor activity 0035240:dopamine binding 0050482:arachidonic acid secretion 2000300:regulation of synaptic vesicle exocytosis 0098978:glutamatergic synapse 0060160:negative regulation of dopamine receptor signaling pathway 0021769:orbitofrontal cortex development 0014854:response to inactivity 0014059:regulation of dopamine secretion 0060124:positive regulation of growth hormone secretion 0031223:auditory behavior 0060548:negative regulation of cell death 0043679:axon terminus 0036126:sperm flagellum 0006874:cellular calcium ion homeostasis 1900168:positive regulation of glial cell-derived neurotrophic factor production 0002092:positive regulation of receptor internalization 0042756:drinking behavior 0035810:positive regulation of urine volume 0001933:negative regulation of protein phosphorylation 0008306:associative learning 0001976:nervous system process involved in regulation of systemic arterial blood pressure 0060079:excitatory postsynaptic potential 0035556:intracellular signal transduction 0042321:negative regulation of circadian sleep/wake cycle, sleep 0007626:locomotory behavior 0030425:dendrite 0006914:autophagy 0060158:phospholipase C-activating dopamine receptor signaling pathway 0001666:response to hypoxia 0050709:negative regulation of protein secretion 0043666:regulation of phosphoprotein phosphatase activity 0007409:axonogenesis 0001659:temperature homeostasis 0048149:behavioral response to ethanol 0043266:regulation of potassium ion transport 0002028:regulation of sodium ion transport 0051823:regulation of synapse structural plasticity 0046717:acid secretion 1900273:positive regulation of long-term synaptic potentiation 0016055:Wnt signaling pathway 0042802:identical protein binding 0046676:negative regulation of insulin secretion 0035255:ionotropic glutamate receptor binding 0071880:adenylate cyclase-activating adrenergic receptor signaling pathway 0048678:response to axon injury 0030432:peristalsis 0032467:positive regulation of cytokinesis 0014069:postsynaptic density 0030424:axon 0010039:response to iron ion 0008542:visual learning 0015459:potassium channel regulator activity 0051898:negative regulation of protein kinase B signaling 0021756:striatum development 0042417:dopamine metabolic process 0042493:response to drug 0035815:positive regulation of renal sodium excretion 0035094:response to nicotine 0043197:dendritic spine 0001669:acrosomal vesicle 0007270:neuron-neuron synaptic transmission 0007625:grooming behavior 0007194:negative regulation of adenylate cyclase activity 0045202:synapse 0007628:adult walking behavior 0005929:cilium 0005886:plasma membrane 0090325:regulation of locomotion involved in locomotory behavior 0002027:regulation of heart rate 0002052:positive regulation of neuroblast proliferation 0007416:synapse assembly 0008104:protein localization 0007616:long-term memory 0045944:positive regulation of transcription by RNA polymerase II 0009416:response to light stimulus 0051481:negative regulation of cytosolic calcium ion concentration 0007195:adenylate cyclase-inhibiting dopamine receptor signaling pathway 0033602:negative regulation of dopamine secretion 0032922:circadian regulation of gene expression 0002031:G protein-coupled receptor internalization 0045776:negative regulation of blood pressure 0008285:negative regulation of cell population proliferation 0051967:negative regulation of synaptic transmission, glutamatergic 0016328:lateral plasma membrane 1990384:hyaloid vascular plexus regression 0051584:regulation of dopamine uptake involved in synaptic transmission 0048169:regulation of long-term neuronal synaptic plasticity 0009636:response to toxic substance 0043278:response to morphine 0048755:branching morphogenesis of a nerve 0001591:dopamine neurotransmitter receptor activity, coupled via Gi/Go 1901386:negative regulation of voltage-gated calcium channel activity 0051482:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 0040018:positive regulation of multicellular organism growth 0021984:adenohypophysis development 0042220:response to cocaine 0051209:release of sequestered calcium ion into cytosol 0044877:protein-containing complex binding 0099055:integral component of postsynaptic membrane 0043204:perikaryon 0005887:integral component of plasma membrane 0021853:cerebral cortex GABAergic interneuron migration 0030672:synaptic vesicle membrane 0045824:negative regulation of innate immune response 0051586:positive regulation of dopamine uptake involved in synaptic transmission 0001975:response to amphetamine 0098691:dopaminergic synapse 0070374:positive regulation of ERK1 and ERK2 cascade 0099056:integral component of presynaptic membrane 0007608:sensory perception of smell 0097730:non-motile cilium 0034776:response to histamine 0000139:Golgi membrane 0099170:postsynaptic modulation of chemical synaptic transmission 0032228:regulation of synaptic transmission, GABAergic 0048148:behavioral response to cocaine
PDB	6CM4 ; 6LUQ ; 5AER ; 6VMS ; 1I15
Drugbank	DB00734 ; DB09194 ; DB09207 ; DB04889 ; DB00502 ; DB00391 ; DB01200 ; DB01038 ; DB00458 ; DB00589 ; DB00623 ; DB01100 ; DB00408 ; DB00555 ; DB01049 ; DB09225 ; DB09128 ; DB01184 ; DB00875 ; DB00805 ; DB13345 ; DB00696 ; DB04857 ; DB00777 ; DB01235 ; DB05316 ; DB05766 ; DB00679 ; DB12478 ; DB05271 ; DB12579 ; DB06477 ; DB00934 ; DB09018 ; DB01069 ; DB00433 ; DB01239 ; DB01043 ; DB00508 ; DB01623 ; DB11274 ; DB04599 ; DB00372 ; DB01221 ; DB08922 ; DB06077 ; DB01267 ; DB00714 ; DB06148 ; DB01063 ; DB01233 ; DB00420 ; DB09097 ; DB01618 ; DB09223 ; DB01614 ; DB00543 ; DB04844 ; DB05964 ; DB00409 ; DB09286 ; DB00363 ; DB04946 ; DB00182 ; DB06288 ; DB01425 ; DB06216 ; DB05687 ; DB00568 ; DB01549 ; DB00850 ; DB00540 ; DB04842 ; DB06144 ; DB12518 ; DB01403 ; DB00450 ; DB00715 ; DB01238 ; DB00490 ; DB06229 ; DB01186 ; DB06454 ; DB01175 ; DB01622 ; DB00831 ; DB00933 ; DB11275 ; DB01621 ; DB06109 ; DB00413 ; DB00477 ; DB00915 ; DB01624 ; DB08815 ; DB09224 ; DB00268 ; DB12093 ; DB01151 ; DB12061 ; DB14185 ; DB00726 ; DB00988 ; DB06016 ; DB00334 ; DB13025 ; DB01392 ; DB00248 ; DB01224 ; DB04888 ; DB04924 ; DB00246
KEGG	hsa:1813

Type

Detail

Target ID

T48ZIG

Protein Name

D(2) dopamine receptor

Uniprot ID

P14416

Protein Name Alias

Dopamine D2 receptor

Gene ID

1813

Gene Symbol

DRD2

Gene Alias

TTD

T67162: Successful target

Pfam

PF00001

0060170:ciliary membrane

0098982:GABA-ergic synapse

0032147:activation of protein kinase activity

0030336:negative regulation of cell migration

0060134:prepulse inhibition

0045745:positive regulation of G protein-coupled receptor signaling pathway

0043473:pigmentation

0030139:endocytic vesicle

0004930:G protein-coupled receptor activity

0035240:dopamine binding

0050482:arachidonic acid secretion

2000300:regulation of synaptic vesicle exocytosis

0098978:glutamatergic synapse

0060160:negative regulation of dopamine receptor signaling pathway

0021769:orbitofrontal cortex development

0014854:response to inactivity

0014059:regulation of dopamine secretion

0060124:positive regulation of growth hormone secretion

0031223:auditory behavior

0060548:negative regulation of cell death

0043679:axon terminus

0036126:sperm flagellum

0006874:cellular calcium ion homeostasis

1900168:positive regulation of glial cell-derived neurotrophic factor production

0002092:positive regulation of receptor internalization

0042756:drinking behavior

0035810:positive regulation of urine volume

0001933:negative regulation of protein phosphorylation

0008306:associative learning

0001976:nervous system process involved in regulation of systemic arterial blood pressure

0060079:excitatory postsynaptic potential

0035556:intracellular signal transduction

0042321:negative regulation of circadian sleep/wake cycle, sleep

0007626:locomotory behavior

0030425:dendrite

0006914:autophagy

0060158:phospholipase C-activating dopamine receptor signaling pathway

0001666:response to hypoxia

0050709:negative regulation of protein secretion

0043666:regulation of phosphoprotein phosphatase activity

0007409:axonogenesis

0001659:temperature homeostasis

0048149:behavioral response to ethanol

0043266:regulation of potassium ion transport

0002028:regulation of sodium ion transport

0051823:regulation of synapse structural plasticity

0046717:acid secretion

1900273:positive regulation of long-term synaptic potentiation

0016055:Wnt signaling pathway

0042802:identical protein binding

0046676:negative regulation of insulin secretion

0035255:ionotropic glutamate receptor binding

0071880:adenylate cyclase-activating adrenergic receptor signaling pathway

0048678:response to axon injury

0030432:peristalsis

0032467:positive regulation of cytokinesis

0014069:postsynaptic density

0030424:axon

0010039:response to iron ion

0008542:visual learning

0015459:potassium channel regulator activity

0051898:negative regulation of protein kinase B signaling

0021756:striatum development

0042417:dopamine metabolic process

0042493:response to drug

0035815:positive regulation of renal sodium excretion

0035094:response to nicotine

0043197:dendritic spine

0001669:acrosomal vesicle

0007270:neuron-neuron synaptic transmission

0007625:grooming behavior

0007194:negative regulation of adenylate cyclase activity

0045202:synapse

0007628:adult walking behavior

0005929:cilium

0005886:plasma membrane

0090325:regulation of locomotion involved in locomotory behavior

0002027:regulation of heart rate

0002052:positive regulation of neuroblast proliferation

0007416:synapse assembly

0008104:protein localization

0007616:long-term memory

0045944:positive regulation of transcription by RNA polymerase II

0009416:response to light stimulus

0051481:negative regulation of cytosolic calcium ion concentration

0007195:adenylate cyclase-inhibiting dopamine receptor signaling pathway

0033602:negative regulation of dopamine secretion

0032922:circadian regulation of gene expression

0002031:G protein-coupled receptor internalization

0045776:negative regulation of blood pressure

0008285:negative regulation of cell population proliferation

0051967:negative regulation of synaptic transmission, glutamatergic

0016328:lateral plasma membrane

1990384:hyaloid vascular plexus regression

0051584:regulation of dopamine uptake involved in synaptic transmission

0048169:regulation of long-term neuronal synaptic plasticity

0009636:response to toxic substance

0043278:response to morphine

0048755:branching morphogenesis of a nerve

0001591:dopamine neurotransmitter receptor activity, coupled via Gi/Go

1901386:negative regulation of voltage-gated calcium channel activity

0051482:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

0040018:positive regulation of multicellular organism growth

0021984:adenohypophysis development

0042220:response to cocaine

0051209:release of sequestered calcium ion into cytosol

0044877:protein-containing complex binding

0099055:integral component of postsynaptic membrane

0043204:perikaryon

0005887:integral component of plasma membrane

0021853:cerebral cortex GABAergic interneuron migration

0030672:synaptic vesicle membrane

0045824:negative regulation of innate immune response

0051586:positive regulation of dopamine uptake involved in synaptic transmission

0001975:response to amphetamine

0098691:dopaminergic synapse

0070374:positive regulation of ERK1 and ERK2 cascade

0099056:integral component of presynaptic membrane

0007608:sensory perception of smell

0097730:non-motile cilium

0034776:response to histamine

0000139:Golgi membrane

0099170:postsynaptic modulation of chemical synaptic transmission

0032228:regulation of synaptic transmission, GABAergic

0048148:behavioral response to cocaine

PDB

6CM4 ; 6LUQ ; 5AER ; 6VMS ; 1I15

Drugbank

DB00734 ; DB09194 ; DB09207 ; DB04889 ; DB00502 ; DB00391 ; DB01200 ; DB01038 ; DB00458 ; DB00589 ; DB00623 ; DB01100 ; DB00408 ; DB00555 ; DB01049 ; DB09225 ; DB09128 ; DB01184 ; DB00875 ; DB00805 ; DB13345 ; DB00696 ; DB04857 ; DB00777 ; DB01235 ; DB05316 ; DB05766 ; DB00679 ; DB12478 ; DB05271 ; DB12579 ; DB06477 ; DB00934 ; DB09018 ; DB01069 ; DB00433 ; DB01239 ; DB01043 ; DB00508 ; DB01623 ; DB11274 ; DB04599 ; DB00372 ; DB01221 ; DB08922 ; DB06077 ; DB01267 ; DB00714 ; DB06148 ; DB01063 ; DB01233 ; DB00420 ; DB09097 ; DB01618 ; DB09223 ; DB01614 ; DB00543 ; DB04844 ; DB05964 ; DB00409 ; DB09286 ; DB00363 ; DB04946 ; DB00182 ; DB06288 ; DB01425 ; DB06216 ; DB05687 ; DB00568 ; DB01549 ; DB00850 ; DB00540 ; DB04842 ; DB06144 ; DB12518 ; DB01403 ; DB00450 ; DB00715 ; DB01238 ; DB00490 ; DB06229 ; DB01186 ; DB06454 ; DB01175 ; DB01622 ; DB00831 ; DB00933 ; DB11275 ; DB01621 ; DB06109 ; DB00413 ; DB00477 ; DB00915 ; DB01624 ; DB08815 ; DB09224 ; DB00268 ; DB12093 ; DB01151 ; DB12061 ; DB14185 ; DB00726 ; DB00988 ; DB06016 ; DB00334 ; DB13025 ; DB01392 ; DB00248 ; DB01224 ; DB04888 ; DB04924 ; DB00246

KEGG

hsa:1813

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0677	Chan Chu	蟾蜍	Toad	Bufo melanostictus
H0603	Wu Tong Ye Jin Gao	梧桐叶浸膏	Parasol trees	Firmiana simplex
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H1207	Hu Ma	胡麻	white seed of oriental sesame	Sesamum indicum
H1208	Hu Ma Ren	胡麻仁	white seed of oriental sesame	Sesamum indicum
H0341	Qing Feng Teng	青风藤	Orientvine	Sinomenium acutum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0003	Huo Ma Ren	火麻仁	Hemp fimble seed	Cannabis sativa
H0204	Ma Ren	麻仁	NA	Cannabis sativa
H1212	Hu Ye Gan Jin Gao	槲叶干浸膏	NA	Quercus dentata
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1033	Fang Ji	防己	Fourstamen stephania	Stephania tetrandra
H1240	Huang Jing Zi	黄荆子	NA	Vitex negundo
H0087	Ju Gu Ye	枸骨叶	FOLIUM iLICIS cORNUTAE	Ilex cornuta
H1226	Huai Shan Yao	淮山药	rhizome of biglcaf yam	Rhizoma dioscoreae
H1078	Gan Chan	干蟾	NA	Bufo melanostictus
H1029	Fang Er Cha	方儿茶	khair in hindi	Senegalia catechu
H0615	Wu Zhi Mao Tao	五指毛桃	five-finger fig root	Ficus simplicissima
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1181	Hei Zhi Ma	黑芝麻	Oriental sesame	Sesamum indicum
H1004	Bai Cha	白茶	White tea	Camellia sinensis
H0637	Cha Ye	茶叶	Common tea	Camellia sinensis
H0325	Qian Jin Zi	千金子	Caper euphorbia seed	Euphorbia lathyris

Target Description

Related Compounds (Total: 9)

Related Herbs (Total: 25)