HIT-result

Target Description

Type	Detail
Target ID	T78BSU
Protein Name	5-hydroxytryptamine receptor 2B
Uniprot ID	P41595
Protein Name Alias	5-HT-2B; 5-HT2B; Serotonin receptor 2B
Gene ID	3357
Gene Symbol	HTR2B
Gene Alias	NA
TTD	T31204: Successful target
Pfam	PF00001
GO	0051378:serotonin binding 0003300:cardiac muscle hypertrophy 0010507:negative regulation of autophagy 0030425:dendrite 0007202:activation of phospholipase C activity 0007268:chemical synaptic transmission 0001938:positive regulation of endothelial cell proliferation 0019934:cGMP-mediated signaling 0003007:heart morphogenesis 0051209:release of sequestered calcium ion into cytosol 0008284:positive regulation of cell population proliferation 0010513:positive regulation of phosphatidylinositol biosynthetic process 0060548:negative regulation of cell death 0051781:positive regulation of cell division 0004993:G protein-coupled serotonin receptor activity 0014033:neural crest cell differentiation 0007208:phospholipase C-activating serotonin receptor signaling pathway 0007205:protein kinase C-activating G protein-coupled receptor signaling pathway 0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 0001587:Gq/11-coupled serotonin receptor activity 0007200:phospholipase C-activating G protein-coupled receptor signaling pathway 0007610:behavior 0070528:protein kinase C signaling 0042310:vasoconstriction 0005887:integral component of plasma membrane 0006874:cellular calcium ion homeostasis 0051000:positive regulation of nitric-oxide synthase activity 0050795:regulation of behavior 0001965:G-protein alpha-subunit binding 0005886:plasma membrane 0048598:embryonic morphogenesis 0002031:G protein-coupled receptor internalization 0070371:ERK1 and ERK2 cascade 0042493:response to drug 0030594:neurotransmitter receptor activity 0045202:synapse 0070374:positive regulation of ERK1 and ERK2 cascade 0005096:GTPase activator activity 0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling 0001819:positive regulation of cytokine production 0014827:intestine smooth muscle contraction 0098666:G protein-coupled serotonin receptor complex 0098664:G protein-coupled serotonin receptor signaling pathway 0014065:phosphatidylinositol 3-kinase signaling 0001755:neural crest cell migration 0043406:positive regulation of MAP kinase activity 0005737:cytoplasm 0016310:phosphorylation 0007186:G protein-coupled receptor signaling pathway 0019722:calcium-mediated signaling 0005654:nucleoplasm 0071502:cellular response to temperature stimulus 0043066:negative regulation of apoptotic process
PDB	4NC3 ; 4IB4 ; 5TVN ; 5TUD ; 6DRX ; 6DRY ; 6DRZ ; 6DS0
Drugbank	DB01242 ; DB01079 ; DB13345 ; DB01454 ; DB01049 ; DB11273 ; DB00353 ; DB06016 ; DB09286 ; DB01142 ; DB04829 ; DB00248 ; DB01186 ; DB01200 ; DB00715 ; DB05607 ; DB06229 ; DB09304 ; DB01221 ; DB00508 ; DB00543 ; DB00320 ; DB05492 ; DB00714 ; DB06153 ; DB13025 ; DB00805 ; DB01238 ; DB12141 ; DB00315 ; DB00247 ; DB01392 ; DB06678 ; DB06148 ; DB00574 ; DB00924 ; DB01239 ; DB00477 ; DB05461 ; DB06216 ; DB00696 ; DB00589
KEGG	hsa:3357

Type

Detail

Target ID

T78BSU

Protein Name

5-hydroxytryptamine receptor 2B

Uniprot ID

P41595

Protein Name Alias

5-HT-2B; 5-HT2B; Serotonin receptor 2B

Gene ID

3357

Gene Symbol

HTR2B

Gene Alias

TTD

T31204: Successful target

Pfam

PF00001

0051378:serotonin binding

0003300:cardiac muscle hypertrophy

0010507:negative regulation of autophagy

0030425:dendrite

0007202:activation of phospholipase C activity

0007268:chemical synaptic transmission

0001938:positive regulation of endothelial cell proliferation

0019934:cGMP-mediated signaling

0003007:heart morphogenesis

0051209:release of sequestered calcium ion into cytosol

0008284:positive regulation of cell population proliferation

0010513:positive regulation of phosphatidylinositol biosynthetic process

0060548:negative regulation of cell death

0051781:positive regulation of cell division

0004993:G protein-coupled serotonin receptor activity

0014033:neural crest cell differentiation

0007208:phospholipase C-activating serotonin receptor signaling pathway

0007205:protein kinase C-activating G protein-coupled receptor signaling pathway

0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

0001587:Gq/11-coupled serotonin receptor activity

0007200:phospholipase C-activating G protein-coupled receptor signaling pathway

0007610:behavior

0070528:protein kinase C signaling

0042310:vasoconstriction

0005887:integral component of plasma membrane

0006874:cellular calcium ion homeostasis

0051000:positive regulation of nitric-oxide synthase activity

0050795:regulation of behavior

0001965:G-protein alpha-subunit binding

0005886:plasma membrane

0048598:embryonic morphogenesis

0002031:G protein-coupled receptor internalization

0070371:ERK1 and ERK2 cascade

0042493:response to drug

0030594:neurotransmitter receptor activity

0045202:synapse

0070374:positive regulation of ERK1 and ERK2 cascade

0005096:GTPase activator activity

0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling

0001819:positive regulation of cytokine production

0014827:intestine smooth muscle contraction

0098666:G protein-coupled serotonin receptor complex

0098664:G protein-coupled serotonin receptor signaling pathway

0014065:phosphatidylinositol 3-kinase signaling

0001755:neural crest cell migration

0043406:positive regulation of MAP kinase activity

0005737:cytoplasm

0016310:phosphorylation

0007186:G protein-coupled receptor signaling pathway

0019722:calcium-mediated signaling

0005654:nucleoplasm

0071502:cellular response to temperature stimulus

0043066:negative regulation of apoptotic process

PDB

4NC3 ; 4IB4 ; 5TVN ; 5TUD ; 6DRX ; 6DRY ; 6DRZ ; 6DS0

Drugbank

DB01242 ; DB01079 ; DB13345 ; DB01454 ; DB01049 ; DB11273 ; DB00353 ; DB06016 ; DB09286 ; DB01142 ; DB04829 ; DB00248 ; DB01186 ; DB01200 ; DB00715 ; DB05607 ; DB06229 ; DB09304 ; DB01221 ; DB00508 ; DB00543 ; DB00320 ; DB05492 ; DB00714 ; DB06153 ; DB13025 ; DB00805 ; DB01238 ; DB12141 ; DB00315 ; DB00247 ; DB01392 ; DB06678 ; DB06148 ; DB00574 ; DB00924 ; DB01239 ; DB00477 ; DB05461 ; DB06216 ; DB00696 ; DB00589

KEGG

hsa:3357

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H1078	Gan Chan	干蟾	NA	Bufo melanostictus
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0677	Chan Chu	蟾蜍	Toad	Bufo melanostictus

Target Description

Related Compounds (Total: 2)

Related Herbs (Total: 10)