Target Description

Type Detail
Target ID T34ZZ0
Protein Name Potassium channel subfamily K member 2
Uniprot ID O95069
Protein Name Alias Outward rectifying potassium channel protein TREK-1;  TREK-1 K(+) channel subunit;  Two pore domain potassium channel TREK-1;  Two pore potassium channel TPKC1
Gene ID 3776
Gene Symbol KCNK2
Gene Alias TREK;  TREK1
TTD NA
Pfam PF07885
GO
0005634:nucleus

0060044:negative regulation of cardiac muscle cell proliferation

0097449:astrocyte projection

0044305:calyx of Held

0030322:stabilization of membrane potential

0071805:potassium ion transmembrane transport

0071456:cellular response to hypoxia

0005789:endoplasmic reticulum membrane

0005783:endoplasmic reticulum

0009986:cell surface

0003231:cardiac ventricle development

2000279:negative regulation of DNA biosynthetic process

0019870:potassium channel inhibitor activity

0009612:response to mechanical stimulus

0048678:response to axon injury

0015271:outward rectifier potassium channel activity

0007613:memory

0043025:neuronal cell body

1900039:positive regulation of cellular response to hypoxia

0005886:plasma membrane

0016324:apical plasma membrane

0007186:G protein-coupled receptor signaling pathway

0010942:positive regulation of cell death

0005887:integral component of plasma membrane

0090102:cochlea development

0008076:voltage-gated potassium channel complex

0022841:potassium ion leak channel activity

PDB 4TWK
Drugbank DB04855 ; DB00204
KEGG hsa:3776

Related Compounds  (Total: 4)

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C0080
Name: Fluoxetine
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C0397
Name: Serotonin
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C0898
Name: Anandamide
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C0917
Name: Arachidonic Acid


Related Herbs  (Total: 22)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0919 Cui Yun Cao翠云草 Hooked spikemossSelaginella uncinata
H0951 Dan Shen Jin Gao丹参浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0461 Shi Jun Zi Ren使君子仁 NACombretum indicum
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0204 Ma Ren麻仁 NACannabis sativa
H0677 Chan Chu蟾蜍 ToadBufo melanostictus
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0736 Yi Dian Hong一点红 Sowthistle tasselflowerEmilia sonchifolia
H0950 Dan Shen Gan Jin Gao丹参干浸膏 The root of red-rooted salviaSalvia miltiorrhiza
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0003 Huo Ma Ren火麻仁 Hemp fimble seedCannabis sativa
H0949 Dan Shen丹参 The root of red-rooted salviaSalvia miltiorrhiza
H0849 Zi Su Geng紫苏梗 Common perilla stemPerilla frutescens var. arguta
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0484 Shui Fei Ji水飞蓟 St marysSilybum marianum
H0943 Dan Cai淡菜 MusselMytilus edulis
H0850 Zi Su Ye紫苏叶 Common perilla leafPerilla frutescens var. arguta
H1078 Gan Chan干蟾 NABufo melanostictus