HIT-result

Type	Detail
Target ID	T36O3K
Protein Name	Beta-adrenergic receptor kinase 1
Uniprot ID	P25098
Protein Name Alias	Beta-ARK-1; EC 2.7.11.15; G-protein coupled receptor kinase 2
Gene ID	156
Gene Symbol	GRK2
Gene Alias	ADRBK1; BARK; BARK1
TTD	T62548: Patented target
Pfam	PF00069 ; PF00615 ; PF00169
GO	0005524:ATP binding 0004672:protein kinase activity 0007507:heart development 0031623:receptor internalization 0045202:synapse 0007186:G protein-coupled receptor signaling pathway 0018107:peptidyl-threonine phosphorylation 0003108:negative regulation of the force of heart contraction by chemical signal 0033605:positive regulation of catecholamine secretion 0047696:beta-adrenergic receptor kinase activity 0016020:membrane 1901081:negative regulation of relaxation of smooth muscle 0005829:cytosol 0060048:cardiac muscle contraction 0018105:peptidyl-serine phosphorylation 0046718:viral entry into host cell 0031694:alpha-2A adrenergic receptor binding 0019079:viral genome replication 0007213:G protein-coupled acetylcholine receptor signaling pathway 0031755:Edg-2 lysophosphatidic acid receptor binding 0005886:plasma membrane 0002029:desensitization of G protein-coupled receptor signaling pathway 0005929:cilium 0005737:cytoplasm 0007217:tachykinin receptor signaling pathway 0045988:negative regulation of striated muscle contraction 0004703:G protein-coupled receptor kinase activity
PDB	3V5W ; 6C2Y ; 4PNK ; 5WG5 ; 5WG4 ; 3CIK ; 5HE1 ; 6U7C ; 5UKL ; 1BAK ; 5UKK ; 5WG3 ; 4MK0 ; 3KRW ; 3KRX ; 5UVC ; 5UUU ; 7K7Z ; 7K7L
Drugbank	DB00171
KEGG	hsa:156

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Name: Metoprolol

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Name: Serotonin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0677	Chan Chu	蟾蜍	Toad	Bufo melanostictus
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1078	Gan Chan	干蟾	NA	Bufo melanostictus
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale