HIT-result

Target Description

Type	Detail
Target ID	T64BED
Protein Name	5-hydroxytryptamine receptor 2A
Uniprot ID	P28223
Protein Name Alias	5-HT-2; 5-HT-2A; Serotonin receptor 2A
Gene ID	3356
Gene Symbol	HTR2A
Gene Alias	HTR2
TTD	T32060: Successful target
Pfam	PF00001
GO	0098666:G protein-coupled serotonin receptor complex 0050731:positive regulation of peptidyl-tyrosine phosphorylation 0043267:negative regulation of potassium ion transport 0014824:artery smooth muscle contraction 0042493:response to drug 0030424:axon 0001965:G-protein alpha-subunit binding 0070852:cell body fiber 0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 0045600:positive regulation of fat cell differentiation 0030425:dendrite 0051378:serotonin binding 0007268:chemical synaptic transmission 0001587:Gq/11-coupled serotonin receptor activity 0030431:sleep 0048148:behavioral response to cocaine 0051967:negative regulation of synaptic transmission, glutamatergic 0043025:neuronal cell body 0007186:G protein-coupled receptor signaling pathway 0098664:G protein-coupled serotonin receptor signaling pathway 0001659:temperature homeostasis 0051209:release of sequestered calcium ion into cytosol 0071886:1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding 0005829:cytosol 0008219:cell death 0001618:virus receptor activity 0004993:G protein-coupled serotonin receptor activity 0042802:identical protein binding 0050965:detection of temperature stimulus involved in sensory perception of pain 0044877:protein-containing complex binding 0044380:protein localization to cytoskeleton 0005886:plasma membrane 0014832:urinary bladder smooth muscle contraction 2000300:regulation of synaptic vesicle exocytosis 0030594:neurotransmitter receptor activity 0098978:glutamatergic synapse 0005887:integral component of plasma membrane 0010513:positive regulation of phosphatidylinositol biosynthetic process 0045907:positive regulation of vasoconstriction 0007208:phospholipase C-activating serotonin receptor signaling pathway 0014059:regulation of dopamine secretion 0007210:serotonin receptor signaling pathway 0014065:phosphatidylinositol 3-kinase signaling 0007613:memory 0008284:positive regulation of cell population proliferation 0006874:cellular calcium ion homeostasis 0005901:caveola 0070374:positive regulation of ERK1 and ERK2 cascade 0099056:integral component of presynaptic membrane 0007200:phospholipase C-activating G protein-coupled receptor signaling pathway 0045821:positive regulation of glycolytic process 0043406:positive regulation of MAP kinase activity 0099055:integral component of postsynaptic membrane 0007568:aging 0031410:cytoplasmic vesicle 0007202:activation of phospholipase C activity 0050966:detection of mechanical stimulus involved in sensory perception of pain 0043198:dendritic shaft
PDB	6WH4 ; 6WHA ; 6A93 ; 6A94 ; 6WGT
Drugbank	DB00656 ; DB00734 ; DB12163 ; DB09194 ; DB00502 ; DB01200 ; DB00458 ; DB00589 ; DB00623 ; DB00408 ; DB00555 ; DB01049 ; DB09225 ; DB09128 ; DB01537 ; DB00321 ; DB01149 ; DB00875 ; DB00805 ; DB13345 ; DB00696 ; DB00777 ; DB05316 ; DB12141 ; DB00679 ; DB05227 ; DB01488 ; DB08810 ; DB00934 ; DB09167 ; DB01239 ; DB09304 ; DB14010 ; DB00751 ; DB00843 ; DB14011 ; DB01623 ; DB00574 ; DB12465 ; DB04599 ; DB14009 ; DB01454 ; DB01221 ; DB08922 ; DB06512 ; DB01079 ; DB06077 ; DB01267 ; DB06446 ; DB00714 ; DB06148 ; DB05492 ; DB06153 ; DB09061 ; DB12693 ; DB00420 ; DB01618 ; DB09223 ; DB01614 ; DB00543 ; DB00409 ; DB09286 ; DB00363 ; DB04946 ; DB05079 ; DB06288 ; DB06216 ; DB05687 ; DB00540 ; DB11273 ; DB08927 ; DB01242 ; DB04908 ; DB04842 ; DB13948 ; DB06144 ; DB00924 ; DB01403 ; DB00715 ; DB00434 ; DB09195 ; DB00247 ; DB01238 ; DB06229 ; DB01186 ; DB01175 ; DB01622 ; DB09016 ; DB00933 ; DB01621 ; DB06109 ; DB13940 ; DB00477 ; DB12177 ; DB01624 ; DB08815 ; DB06678 ; DB00315 ; DB01151 ; DB01142 ; DB14185 ; DB00726 ; DB12555 ; DB08839 ; DB06016 ; DB00370 ; DB00334 ; DB13025 ; DB01392 ; DB00248 ; DB01224 ; DB00604 ; DB01442 ; DB00246
KEGG	hsa:3356

Type

Detail

Target ID

T64BED

Protein Name

5-hydroxytryptamine receptor 2A

Uniprot ID

P28223

Protein Name Alias

5-HT-2; 5-HT-2A; Serotonin receptor 2A

Gene ID

3356

Gene Symbol

HTR2A

Gene Alias

HTR2

TTD

T32060: Successful target

Pfam

PF00001

0098666:G protein-coupled serotonin receptor complex

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0043267:negative regulation of potassium ion transport

0014824:artery smooth muscle contraction

0042493:response to drug

0030424:axon

0001965:G-protein alpha-subunit binding

0070852:cell body fiber

0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

0045600:positive regulation of fat cell differentiation

0030425:dendrite

0051378:serotonin binding

0007268:chemical synaptic transmission

0001587:Gq/11-coupled serotonin receptor activity

0030431:sleep

0048148:behavioral response to cocaine

0051967:negative regulation of synaptic transmission, glutamatergic

0043025:neuronal cell body

0007186:G protein-coupled receptor signaling pathway

0098664:G protein-coupled serotonin receptor signaling pathway

0001659:temperature homeostasis

0051209:release of sequestered calcium ion into cytosol

0071886:1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding

0005829:cytosol

0008219:cell death

0001618:virus receptor activity

0004993:G protein-coupled serotonin receptor activity

0042802:identical protein binding

0050965:detection of temperature stimulus involved in sensory perception of pain

0044877:protein-containing complex binding

0044380:protein localization to cytoskeleton

0005886:plasma membrane

0014832:urinary bladder smooth muscle contraction

2000300:regulation of synaptic vesicle exocytosis

0030594:neurotransmitter receptor activity

0098978:glutamatergic synapse

0005887:integral component of plasma membrane

0010513:positive regulation of phosphatidylinositol biosynthetic process

0045907:positive regulation of vasoconstriction

0007208:phospholipase C-activating serotonin receptor signaling pathway

0014059:regulation of dopamine secretion

0007210:serotonin receptor signaling pathway

0014065:phosphatidylinositol 3-kinase signaling

0007613:memory

0008284:positive regulation of cell population proliferation

0006874:cellular calcium ion homeostasis

0005901:caveola

0070374:positive regulation of ERK1 and ERK2 cascade

0099056:integral component of presynaptic membrane

0007200:phospholipase C-activating G protein-coupled receptor signaling pathway

0045821:positive regulation of glycolytic process

0043406:positive regulation of MAP kinase activity

0099055:integral component of postsynaptic membrane

0007568:aging

0031410:cytoplasmic vesicle

0007202:activation of phospholipase C activity

0050966:detection of mechanical stimulus involved in sensory perception of pain

0043198:dendritic shaft

PDB

6WH4 ; 6WHA ; 6A93 ; 6A94 ; 6WGT

Drugbank

DB00656 ; DB00734 ; DB12163 ; DB09194 ; DB00502 ; DB01200 ; DB00458 ; DB00589 ; DB00623 ; DB00408 ; DB00555 ; DB01049 ; DB09225 ; DB09128 ; DB01537 ; DB00321 ; DB01149 ; DB00875 ; DB00805 ; DB13345 ; DB00696 ; DB00777 ; DB05316 ; DB12141 ; DB00679 ; DB05227 ; DB01488 ; DB08810 ; DB00934 ; DB09167 ; DB01239 ; DB09304 ; DB14010 ; DB00751 ; DB00843 ; DB14011 ; DB01623 ; DB00574 ; DB12465 ; DB04599 ; DB14009 ; DB01454 ; DB01221 ; DB08922 ; DB06512 ; DB01079 ; DB06077 ; DB01267 ; DB06446 ; DB00714 ; DB06148 ; DB05492 ; DB06153 ; DB09061 ; DB12693 ; DB00420 ; DB01618 ; DB09223 ; DB01614 ; DB00543 ; DB00409 ; DB09286 ; DB00363 ; DB04946 ; DB05079 ; DB06288 ; DB06216 ; DB05687 ; DB00540 ; DB11273 ; DB08927 ; DB01242 ; DB04908 ; DB04842 ; DB13948 ; DB06144 ; DB00924 ; DB01403 ; DB00715 ; DB00434 ; DB09195 ; DB00247 ; DB01238 ; DB06229 ; DB01186 ; DB01175 ; DB01622 ; DB09016 ; DB00933 ; DB01621 ; DB06109 ; DB13940 ; DB00477 ; DB12177 ; DB01624 ; DB08815 ; DB06678 ; DB00315 ; DB01151 ; DB01142 ; DB14185 ; DB00726 ; DB12555 ; DB08839 ; DB06016 ; DB00370 ; DB00334 ; DB13025 ; DB01392 ; DB00248 ; DB01224 ; DB00604 ; DB01442 ; DB00246

KEGG

hsa:3356

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0677	Chan Chu	蟾蜍	Toad	Bufo melanostictus
H0195	Ma Chi Xian	马齿苋	Purslane	Portulaca oleracea
H1228	Huang Bai	黄柏	Amur corktree	Phellodendron amurense
H0198	Ma Huang Gao	麻黄膏	Chinese ephedra	Ephedra sinica
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H1230	Huang Bai Fen	黄柏粉	Amur corktree	Phellodendron amurense
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0365	Rou Dou Kou	肉豆蔻	Common nutmeg	Myristica fragrans
H1099	Gou Teng	钩藤	Sharpleaf gambirplant	Uncaria rhynchophylla
H0197	Ma Huang	麻黄	Chinese ephedra	Ephedra sinica
H1231	Huang Bai Tan	黄柏炭	Amur corktree	Phellodendron amurense
H0200	Ma Huang Gen	麻黄根	Chinese ephedra root	Ephedra sinica
H1226	Huai Shan Yao	淮山药	rhizome of biglcaf yam	Rhizoma dioscoreae
H1078	Gan Chan	干蟾	NA	Bufo melanostictus
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0704	Yan Guan Huang Bai	盐关黄柏	Amur cork tree	Phellodendron amurense
H1115	Guan Huang Bai	关黄柏	Amur cork tree	Phellodendron amurense
H0201	Ma Huang Jin Gao	麻黄浸膏	Chinese ephedra	Ephedra sinica
H0246	Mi Ma Huang	蜜麻黄	Ephedra equisetin	Ephedra sinica

Target Description

Related Compounds (Total: 6)

Related Herbs (Total: 21)