Target Description

Type Detail
Target ID T64BED
Protein Name 5-hydroxytryptamine receptor 2A
Uniprot ID P28223
Protein Name Alias 5-HT-2;  5-HT-2A;  Serotonin receptor 2A
Gene ID 3356
Gene Symbol HTR2A
Gene Alias HTR2
TTD T32060: Successful target
Pfam PF00001
0098666:G protein-coupled serotonin receptor complex

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0043267:negative regulation of potassium ion transport

0014824:artery smooth muscle contraction

0042493:response to drug


0001965:G-protein alpha-subunit binding

0070852:cell body fiber

0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

0045600:positive regulation of fat cell differentiation


0051378:serotonin binding

0007268:chemical synaptic transmission

0001587:Gq/11-coupled serotonin receptor activity


0048148:behavioral response to cocaine

0051967:negative regulation of synaptic transmission, glutamatergic

0043025:neuronal cell body

0007186:G protein-coupled receptor signaling pathway

0098664:G protein-coupled serotonin receptor signaling pathway

0001659:temperature homeostasis

0051209:release of sequestered calcium ion into cytosol

0071886:1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding


0008219:cell death

0001618:virus receptor activity

0004993:G protein-coupled serotonin receptor activity

0042802:identical protein binding

0050965:detection of temperature stimulus involved in sensory perception of pain

0044877:protein-containing complex binding

0044380:protein localization to cytoskeleton

0005886:plasma membrane

0014832:urinary bladder smooth muscle contraction

2000300:regulation of synaptic vesicle exocytosis

0030594:neurotransmitter receptor activity

0098978:glutamatergic synapse

0005887:integral component of plasma membrane

0010513:positive regulation of phosphatidylinositol biosynthetic process

0045907:positive regulation of vasoconstriction

0007208:phospholipase C-activating serotonin receptor signaling pathway

0014059:regulation of dopamine secretion

0007210:serotonin receptor signaling pathway

0014065:phosphatidylinositol 3-kinase signaling


0008284:positive regulation of cell population proliferation

0006874:cellular calcium ion homeostasis


0070374:positive regulation of ERK1 and ERK2 cascade

0099056:integral component of presynaptic membrane

0007200:phospholipase C-activating G protein-coupled receptor signaling pathway

0045821:positive regulation of glycolytic process

0043406:positive regulation of MAP kinase activity

0099055:integral component of postsynaptic membrane


0031410:cytoplasmic vesicle

0007202:activation of phospholipase C activity

0050966:detection of mechanical stimulus involved in sensory perception of pain

0043198:dendritic shaft

PDB 6WH4 ; 6WHA ; 6A93 ; 6A94 ; 6WGT
Drugbank DB00656 ; DB00734 ; DB12163 ; DB09194 ; DB00502 ; DB01200 ; DB00458 ; DB00589 ; DB00623 ; DB00408 ; DB00555 ; DB01049 ; DB09225 ; DB09128 ; DB01537 ; DB00321 ; DB01149 ; DB00875 ; DB00805 ; DB13345 ; DB00696 ; DB00777 ; DB05316 ; DB12141 ; DB00679 ; DB05227 ; DB01488 ; DB08810 ; DB00934 ; DB09167 ; DB01239 ; DB09304 ; DB14010 ; DB00751 ; DB00843 ; DB14011 ; DB01623 ; DB00574 ; DB12465 ; DB04599 ; DB14009 ; DB01454 ; DB01221 ; DB08922 ; DB06512 ; DB01079 ; DB06077 ; DB01267 ; DB06446 ; DB00714 ; DB06148 ; DB05492 ; DB06153 ; DB09061 ; DB12693 ; DB00420 ; DB01618 ; DB09223 ; DB01614 ; DB00543 ; DB00409 ; DB09286 ; DB00363 ; DB04946 ; DB05079 ; DB06288 ; DB06216 ; DB05687 ; DB00540 ; DB11273 ; DB08927 ; DB01242 ; DB04908 ; DB04842 ; DB13948 ; DB06144 ; DB00924 ; DB01403 ; DB00715 ; DB00434 ; DB09195 ; DB00247 ; DB01238 ; DB06229 ; DB01186 ; DB01175 ; DB01622 ; DB09016 ; DB00933 ; DB01621 ; DB06109 ; DB13940 ; DB00477 ; DB12177 ; DB01624 ; DB08815 ; DB06678 ; DB00315 ; DB01151 ; DB01142 ; DB14185 ; DB00726 ; DB12555 ; DB08839 ; DB06016 ; DB00370 ; DB00334 ; DB13025 ; DB01392 ; DB00248 ; DB01224 ; DB00604 ; DB01442 ; DB00246
KEGG hsa:3356

Related Compounds  (Total: 6)

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Name: Dopamine
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Name: Phenethylamine
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Name: Serotonin
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Name: Tmpea
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Name: Isocorynoxeine

Related Herbs  (Total: 21)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0365 Rou Dou Kou肉豆蔻 Common nutmegMyristica fragrans
H1078 Gan Chan干蟾 NABufo melanostictus
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0246 Mi Ma Huang蜜麻黄 Ephedra equisetinEphedra sinica
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0200 Ma Huang Gen麻黄根 Chinese ephedra rootEphedra sinica
H0704 Yan Guan Huang Bai盐关黄柏 Amur cork treePhellodendron amurense
H0197 Ma Huang麻黄 Chinese ephedraEphedra sinica
H1228 Huang Bai黄柏 Amur corktreePhellodendron amurense
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H0201 Ma Huang Jin Gao麻黄浸膏 Chinese ephedraEphedra sinica
H0198 Ma Huang Gao麻黄膏 Chinese ephedraEphedra sinica
H1230 Huang Bai Fen黄柏粉 Amur corktreePhellodendron amurense
H1099 Gou Teng钩藤 Sharpleaf gambirplantUncaria rhynchophylla
H1226 Huai Shan Yao淮山药 rhizome of biglcaf yamRhizoma dioscoreae
H1231 Huang Bai Tan黄柏炭 Amur corktreePhellodendron amurense
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0677 Chan Chu蟾蜍 ToadBufo melanostictus
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H1115 Guan Huang Bai关黄柏 Amur cork treePhellodendron amurense