HIT-result

Type	Detail
Target ID	T97ZTQ
Protein Name	5-hydroxytryptamine receptor 1B
Uniprot ID	P28222
Protein Name Alias	5-HT-1B; 5-HT1B; S12; Serotonin 1D beta receptor; 5-HT-1D-beta; Serotonin receptor 1B
Gene ID	3351
Gene Symbol	HTR1B
Gene Alias	HTR1DB
TTD	T07806: Successful target
Pfam	PF00001
GO	0007187:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 0051378:serotonin binding 0030594:neurotransmitter receptor activity 0035690:cellular response to drug 1904707:positive regulation of vascular associated smooth muscle cell proliferation 0044305:calyx of Held 0032229:negative regulation of synaptic transmission, GABAergic 0030425:dendrite 0007205:protein kinase C-activating G protein-coupled receptor signaling pathway 0014059:regulation of dopamine secretion 0099171:presynaptic modulation of chemical synaptic transmission 0071312:cellular response to alkaloid 0007193:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 0099626:voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels 0046849:bone remodeling 0042310:vasoconstriction 0099056:integral component of presynaptic membrane 0014063:negative regulation of serotonin secretion 0008144:drug binding 0042756:drinking behavior 0071502:cellular response to temperature stimulus 2000300:regulation of synaptic vesicle exocytosis 0050795:regulation of behavior 0045471:response to ethanol 0002031:G protein-coupled receptor internalization 0042220:response to cocaine 0005886:plasma membrane 0099154:serotonergic synapse 0007186:G protein-coupled receptor signaling pathway 0005887:integral component of plasma membrane 0014053:negative regulation of gamma-aminobutyric acid secretion 0004993:G protein-coupled serotonin receptor activity 0007198:adenylate cyclase-inhibiting serotonin receptor signaling pathway 0005737:cytoplasm 0051385:response to mineralocorticoid 0098666:G protein-coupled serotonin receptor complex 0051967:negative regulation of synaptic transmission, glutamatergic 0007268:chemical synaptic transmission
PDB	5V54 ; 2G1X ; 4IAR ; 7C61 ; 6G79 ; 4IAQ
Drugbank	DB13345 ; DB06096 ; DB00589 ; DB00321 ; DB00248 ; DB00953 ; DB00363 ; DB12141 ; DB01392 ; DB01239 ; DB00918 ; DB01238 ; DB00571 ; DB08807 ; DB00952 ; DB01186 ; DB00246 ; DB00408 ; DB06216 ; DB00960 ; DB00315 ; DB06153 ; DB00216 ; DB14185 ; DB11273 ; DB00714 ; DB04884 ; DB01359 ; DB13025 ; DB01049 ; DB09304 ; DB00543 ; DB01200 ; DB00320 ; DB00696 ; DB00998 ; DB00669 ; DB00715 ; DB00247 ; DB00904 ; DB09068 ; DB00334 ; DB01221 ; DB01224
KEGG	hsa:3351

Go to browser

Name: Fluoxetine

Go to browser

Name: Serotonin

Go to browser

Name: Sertraline

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0949	Dan Shen	丹参	The root of red-rooted salvia	Salvia miltiorrhiza
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H1078	Gan Chan	干蟾	NA	Bufo melanostictus
H0951	Dan Shen Jin Gao	丹参浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0950	Dan Shen Gan Jin Gao	丹参干浸膏	The root of red-rooted salvia	Salvia miltiorrhiza
H0677	Chan Chu	蟾蜍	Toad	Bufo melanostictus