Target Description

Type Detail
Target ID T24OK4
Protein Name Rho-associated protein kinase 2
Uniprot ID Q62868
Protein Name Alias EC 2.7.11.1;  Rho-associated, coiled-coil-containing protein kinase 2;  Rho-associated, coiled-coil-containing protein kinase II;  ROCK-II;  RhoA-binding kinase 2;  p150 ROK-alpha;  ROKalpha;  p164 ROCK-2
Gene ID 25537
Gene Symbol Rock2
Gene Alias NA
TTD NA
Pfam PF00069 ; PF08912
GO
0005634:nucleus

0031644:regulation of nervous system process

0043410:positive regulation of MAPK cascade

0000281:mitotic cytokinesis

0016525:negative regulation of angiogenesis

1902961:positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

0004672:protein kinase activity

0090271:positive regulation of fibroblast growth factor production

0106310:protein serine kinase activity

0030335:positive regulation of cell migration

0002931:response to ischemia

0004674:protein serine/threonine kinase activity

0106311:protein threonine kinase activity

0051496:positive regulation of stress fiber assembly

0110061:regulation of angiotensin-activated signaling pathway

0031032:actomyosin structure organization

0098978:glutamatergic synapse

0061157:mRNA destabilization

0010595:positive regulation of endothelial cell migration

0005813:centrosome

0035509:negative regulation of myosin-light-chain-phosphatase activity

1905205:positive regulation of connective tissue replacement

0048813:dendrite morphogenesis

0042752:regulation of circadian rhythm

1903140:regulation of establishment of endothelial barrier

1990776:response to angiotensin

0030036:actin cytoskeleton organization

1901888:regulation of cell junction assembly

0016301:kinase activity

0036464:cytoplasmic ribonucleoprotein granule

0018105:peptidyl-serine phosphorylation

0071559:response to transforming growth factor beta

1902966:positive regulation of protein localization to early endosome

0005737:cytoplasm

0030261:chromosome condensation

0001843:neural tube closure

0039694:viral RNA genome replication

0006939:smooth muscle contraction

0045019:negative regulation of nitric oxide biosynthetic process

0005524:ATP binding

0032723:positive regulation of connective tissue growth factor production

0005886:plasma membrane

0048598:embryonic morphogenesis

0018107:peptidyl-threonine phosphorylation

0010628:positive regulation of gene expression

0098685:Schaffer collateral - CA1 synapse

0150033:negative regulation of protein localization to lysosome

0008625:extrinsic apoptotic signaling pathway via death domain receptors

0001934:positive regulation of protein phosphorylation

0005856:cytoskeleton

0010629:negative regulation of gene expression

0010825:positive regulation of centrosome duplication

0098974:postsynaptic actin cytoskeleton organization

1902993:positive regulation of amyloid precursor protein catabolic process

0048511:rhythmic process

1903347:negative regulation of bicellular tight junction assembly

0031267:small GTPase binding

0072659:protein localization to plasma membrane

0006468:protein phosphorylation

0072518:Rho-dependent protein serine/threonine kinase activity

0010613:positive regulation of cardiac muscle hypertrophy

0051298:centrosome duplication

0097746:blood vessel diameter maintenance

0045616:regulation of keratinocyte differentiation

0071394:cellular response to testosterone stimulus

0030866:cortical actin cytoskeleton organization

0046872:metal ion binding

1905145:cellular response to acetylcholine

1902004:positive regulation of amyloid-beta formation

0007249:I-kappaB kinase/NF-kappaB signaling

0051246:regulation of protein metabolic process

1900037:regulation of cellular response to hypoxia

0007266:Rho protein signal transduction

0031616:spindle pole centrosome

PDB 2ROW ; 2ROV
Drugbank NA
KEGG rno:25537

Related Compounds  (Total: 1)

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C0397
Name: Serotonin


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