HIT-result

Target Description

Type	Detail
Target ID	T91MWA
Protein Name	Disintegrin and metalloproteinase domain-containing protein 17
Uniprot ID	P78536
Protein Name Alias	ADAM 17; EC 3.4.24.86; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD antigen CD156b
Gene ID	6868
Gene Symbol	ADAM17
Gene Alias	CSVP; TACE
TTD	T82393: Clinical Trial target
Pfam	PF00200 ; PF01562 ; PF16698
GO	0051272:positive regulation of cellular component movement 0005112:Notch binding 0010820:positive regulation of T cell chemotaxis 0007155:cell adhesion 1902945:metalloendopeptidase activity involved in amyloid precursor protein catabolic process 0006508:proteolysis 0030335:positive regulation of cell migration 0005829:cytosol 0008237:metallopeptidase activity 0048870:cell motility 0033627:cell adhesion mediated by integrin 0006509:membrane protein ectodomain proteolysis 0120163:negative regulation of cold-induced thermogenesis 0016324:apical plasma membrane 1903265:positive regulation of tumor necrosis factor-mediated signaling pathway 0045737:positive regulation of cyclin-dependent protein serine/threonine kinase activity 0030511:positive regulation of transforming growth factor beta receptor signaling pathway 0033025:regulation of mast cell apoptotic process 0009986:cell surface 0008284:positive regulation of cell population proliferation 0001666:response to hypoxia 0005138:interleukin-6 receptor binding 0071403:cellular response to high density lipoprotein particle stimulus 1900087:positive regulation of G1/S transition of mitotic cell cycle 0000139:Golgi membrane 0004222:metalloendopeptidase activity 0002446:neutrophil mediated immunity 0005737:cytoplasm 0007220:Notch receptor processing 1905564:positive regulation of vascular endothelial cell proliferation 0035313:wound healing, spreading of epidermal cells 0033077:T cell differentiation in thymus 0005887:integral component of plasma membrane 0032722:positive regulation of chemokine production 0002862:negative regulation of inflammatory response to antigenic stimulus 0005886:plasma membrane 0042987:amyloid precursor protein catabolic process 0030183:B cell differentiation 0001934:positive regulation of protein phosphorylation 0048536:spleen development 0045121:membrane raft 0017124:SH3 domain binding 0002467:germinal center formation 0043536:positive regulation of blood vessel endothelial cell migration 0042493:response to drug 0016020:membrane 0030512:negative regulation of transforming growth factor beta receptor signaling pathway 0005178:integrin binding 0007173:epidermal growth factor receptor signaling pathway 0045741:positive regulation of epidermal growth factor-activated receptor activity 0008233:peptidase activity 0007219:Notch signaling pathway 0030307:positive regulation of cell growth 0050830:defense response to Gram-positive bacterium 0030165:PDZ domain binding 0016485:protein processing 0015629:actin cytoskeleton 0035624:receptor transactivation 0031293:membrane protein intracellular domain proteolysis 0032496:response to lipopolysaccharide 0046872:metal ion binding 0033209:tumor necrosis factor-mediated signaling pathway 0002690:positive regulation of leukocyte chemotaxis 0004175:endopeptidase activity 0005788:endoplasmic reticulum lumen
PDB	3EWJ ; 2DDF ; 3L0T ; 2FV5 ; 2FV9 ; 2M2F ; 3LEA ; 2A8H ; 3L0V ; 1ZXC ; 2I47 ; 1BKC ; 3KMC ; 2OI0 ; 3O64 ; 3B92 ; 3E8R ; 3LE9 ; 3LGP ; 3G42 ; 3KME ; 3EDZ ; 3CKI
Drugbank	DB07147 ; DB07964 ; DB07189 ; DB07079 ; DB07145 ; DB06943 ; DB07121 ; DB07233
KEGG	hsa:6868

Type

Detail

Target ID

T91MWA

Protein Name

Disintegrin and metalloproteinase domain-containing protein 17

Uniprot ID

P78536

Protein Name Alias

ADAM 17; EC 3.4.24.86; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD antigen CD156b

Gene ID

6868

Gene Symbol

ADAM17

Gene Alias

CSVP; TACE

TTD

T82393: Clinical Trial target

Pfam

PF00200 ; PF01562 ; PF16698

0051272:positive regulation of cellular component movement

0005112:Notch binding

0010820:positive regulation of T cell chemotaxis

0007155:cell adhesion

1902945:metalloendopeptidase activity involved in amyloid precursor protein catabolic process

0006508:proteolysis

0030335:positive regulation of cell migration

0005829:cytosol

0008237:metallopeptidase activity

0048870:cell motility

0033627:cell adhesion mediated by integrin

0006509:membrane protein ectodomain proteolysis

0120163:negative regulation of cold-induced thermogenesis

0016324:apical plasma membrane

1903265:positive regulation of tumor necrosis factor-mediated signaling pathway

0045737:positive regulation of cyclin-dependent protein serine/threonine kinase activity

0030511:positive regulation of transforming growth factor beta receptor signaling pathway

0033025:regulation of mast cell apoptotic process

0009986:cell surface

0008284:positive regulation of cell population proliferation

0001666:response to hypoxia

0005138:interleukin-6 receptor binding

0071403:cellular response to high density lipoprotein particle stimulus

1900087:positive regulation of G1/S transition of mitotic cell cycle

0000139:Golgi membrane

0004222:metalloendopeptidase activity

0002446:neutrophil mediated immunity

0005737:cytoplasm

0007220:Notch receptor processing

1905564:positive regulation of vascular endothelial cell proliferation

0035313:wound healing, spreading of epidermal cells

0033077:T cell differentiation in thymus

0005887:integral component of plasma membrane

0032722:positive regulation of chemokine production

0002862:negative regulation of inflammatory response to antigenic stimulus

0005886:plasma membrane

0042987:amyloid precursor protein catabolic process

0030183:B cell differentiation

0001934:positive regulation of protein phosphorylation

0048536:spleen development

0045121:membrane raft

0017124:SH3 domain binding

0002467:germinal center formation

0043536:positive regulation of blood vessel endothelial cell migration

0042493:response to drug

0016020:membrane

0030512:negative regulation of transforming growth factor beta receptor signaling pathway

0005178:integrin binding

0007173:epidermal growth factor receptor signaling pathway

0045741:positive regulation of epidermal growth factor-activated receptor activity

0008233:peptidase activity

0007219:Notch signaling pathway

0030307:positive regulation of cell growth

0050830:defense response to Gram-positive bacterium

0030165:PDZ domain binding

0016485:protein processing

0015629:actin cytoskeleton

0035624:receptor transactivation

0031293:membrane protein intracellular domain proteolysis

0032496:response to lipopolysaccharide

0046872:metal ion binding

0033209:tumor necrosis factor-mediated signaling pathway

0002690:positive regulation of leukocyte chemotaxis

0004175:endopeptidase activity

0005788:endoplasmic reticulum lumen

PDB

3EWJ ; 2DDF ; 3L0T ; 2FV5 ; 2FV9 ; 2M2F ; 3LEA ; 2A8H ; 3L0V ; 1ZXC ; 2I47 ; 1BKC ; 3KMC ; 2OI0 ; 3O64 ; 3B92 ; 3E8R ; 3LE9 ; 3LGP ; 3G42 ; 3KME ; 3EDZ ; 3CKI

Drugbank

DB07147 ; DB07964 ; DB07189 ; DB07079 ; DB07145 ; DB06943 ; DB07121 ; DB07233

KEGG

hsa:6868

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0677	Chan Chu	蟾蜍	Toad	Bufo melanostictus
H0269	Mu Gua	木瓜	Chinese floweringquince	Chaenomeles sinensis
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0590	Wei Ling	威灵	Chinese clematis	Clematis chinensis
H1168	He Tao Ren	核桃仁	English walnut seed	Semen juglandis
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0484	Shui Fei Ji	水飞蓟	St marys	Silybum marianum
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0832	Zhu Sha Gen	朱砂根	Coral ardisia	Ardisia crenata
H1173	Hei Chou	黑丑	Pharbitis seed	Semen pharbitidis
H0848	Zi Jin Niu	紫金牛	Japanese ardisia	Ardisia japonica
H1078	Gan Chan	干蟾	NA	Bufo melanostictus
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0888	Ba Dou Ye	巴豆叶	Pu rging croton	Croton tiglium
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0869	Ba Dou	巴豆	Pu rging croton	Croton tiglium
H1167	He Tao	核桃	English walnut seed	Semen juglandis
H0592	Wei Ling Xian	威灵仙	Chinese clematis	Clematis chinensis
H0582	Cao Dou Kou Ren	草豆蔻仁	Katsumada galangal	Alpinia katsumadai
H1011	Bai Chou	白丑	Pharbitis seed	Semen pharbitidis
H0329	Qian Niu Zi	牵牛子	Lobedleaf pharbitis seed	Pharbitis nil
H0574	Cao Dou Kou	草豆蔻	Katsumada galangal	Alpinia katsumadai
H0878	Ba Dou Shuang	巴豆霜	Defatted croton seed powder	Croton tiglium

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 23)