Target Description

Type Detail
Target ID T10KMJ
Protein Name Insulin-like growth factor II
Uniprot ID P01344
Protein Name Alias IGF-II;  Somatomedin-A;  T3M-11-derived growth factor
Gene ID 3481
Gene Symbol IGF2
Gene Alias NA
TTD T90572: Clinical Trial target
Pfam PF08365 ; PF00049
GO
0031093:platelet alpha granule lumen

0007275:multicellular organism development

0045725:positive regulation of glycogen biosynthetic process

0044267:cellular protein metabolic process

2000467:positive regulation of glycogen (starch) synthase activity

0001934:positive regulation of protein phosphorylation

0005179:hormone activity

0045840:positive regulation of mitotic nuclear division

0001501:skeletal system development

0009887:animal organ morphogenesis

0060720:spongiotrophoblast cell proliferation

0051147:regulation of muscle cell differentiation

0051148:negative regulation of muscle cell differentiation

0048633:positive regulation of skeletal muscle tissue growth

0008083:growth factor activity

0031017:exocrine pancreas development

0002576:platelet degranulation

0006006:glucose metabolic process

0050731:positive regulation of peptidyl-tyrosine phosphorylation

0031056:regulation of histone modification

0051146:striated muscle cell differentiation

0005615:extracellular space

0045944:positive regulation of transcription by RNA polymerase II

0005576:extracellular region

0043410:positive regulation of MAPK cascade

0043539:protein serine/threonine kinase activator activity

0048018:receptor ligand activity

0001649:osteoblast differentiation

0001701:in utero embryonic development

0000122:negative regulation of transcription by RNA polymerase II

0005158:insulin receptor binding

0001892:embryonic placenta development

0038028:insulin receptor signaling pathway via phosphatidylinositol 3-kinase

0060669:embryonic placenta morphogenesis

0043085:positive regulation of catalytic activity

1905564:positive regulation of vascular endothelial cell proliferation

0046622:positive regulation of organ growth

0040018:positive regulation of multicellular organism growth

0051897:positive regulation of protein kinase B signaling

0042104:positive regulation of activated T cell proliferation

0005178:integrin binding

0006349:regulation of gene expression by genetic imprinting

0005159:insulin-like growth factor receptor binding

0008284:positive regulation of cell population proliferation

0006355:regulation of transcription, DNA-templated

0008286:insulin receptor signaling pathway

0046628:positive regulation of insulin receptor signaling pathway

0051781:positive regulation of cell division

PDB 5L3L ; 5L3M ; 1IGL ; 6UM2 ; 1GF2 ; 6VWG ; 5L3N ; 6VWI ; 2L29 ; 2V5P ; 3E4Z ; 3KR3
Drugbank NA
KEGG hsa:3481

Related Compounds  (Total: 4)

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C0039
Name: Ellagic Acid
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C0081
Name: Folic Acid
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C1114
Name: Baicalein
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C1265
Name: Curcumin


Related Herbs  (Total: 101)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0556 Tie Xian Cao铁线草 NAAdiantum capillus-veneris
H0002 Hui Xiang茴香 Fennel fruitFoeniculum vulgare
H0344 Qing Guo青果 OliveCanarium album
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H1025 Fan Bai Cao翻白草 Discolor cinquefoilPotentilla discolor
H1091 Gao Li Shen高丽参 Korea ginsengRadix ginseng korea
H0142 Liang Jiang良姜 NAAlpinia officinarum
H0345 Qing Guo Tan青果炭 white oliveCanarium album
H0267 Mu Ding Xiang母丁香 Clove fruitFructus caryophylli
H0016 Ji Xue Cao积雪草 Asiatic pennywortCentella asiatica
H1035 Bai Fu Ling白茯苓 white indian breadWolfiporia cocos
H0066 Jin Ying Gen金樱根 root of cherokee roseRadix rosae laevigatae
H0288 Niu Bang Cao牛蒡草 greater burdockArctium lappa
H0461 Shi Jun Zi Ren使君子仁 NACombretum indicum
H0967 Di Er Cao地耳草 Japanese stJohn’swortHypericum japonicum
H0227 Mang Guo Ye芒果叶 Mango leafMangifera indica
H0784 Chi Shao赤芍 Red peony rootPaeonia obovata
H0761 Yu Jin郁金 AromaticTurmericCurcuma aromatica
H0462 Shi Liu石榴 Pomegranate fruitPunica granatum
H0956 Dang Gui Gan Jin Gao当归干浸膏 NAAngelica sinensis
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H1225 Huai Mi槐米 NASophora japonica
H1034 Fei Yang Cao飞杨草 NAEuphorbia hirta
H0429 Shao Yao芍药 Red peony rootPaeonia obovata
H0391 Sang Pi桑皮 Prepared root-bark white mulberryMorus alba
H1009 Du Huo独活 Doubleteeth pubescent angelicaAngelica pubescens
H1130 Guang Zao广枣 fruit of axillary choerospondiasFructus choerospondiatis
H0028 Jiang Huang姜黄 Common turmericCurcuma longa
H0219 Man Shan Hong满山红 Dahurian rhododendronRhododendron dauricum
H0396 Sang Ye桑叶 White mulberry leafMorus alba
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H0868 Chuan Du Huo川独活 Doubleteeth pubescent angelicaAngelica pubescens
H1227 Huai Zhi槐枝 NASophora japonica
H0500 Can Yong蚕蛹 Silkworm chrysalisBombyx mori
H0974 Di Jin Cao地锦草 Humifuse euphorbiaEuphorbia humifusa
H0069 Jin Ying Zi Ti Qu Ye金樱子提取液 Cherokee rose seedRosa laevigata
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H0472 Shu Da Huang熟大黄 NARheum palmatum
H1097 Gong Ding Xiang公丁香 NASyzygium aromaticum
H0060 Jin Si Ku Lian金丝苦楝 NACardiospermum halicacabum
H0070 Jing Da Ji京大戟 Peking euphorbia rootRadix euphorbiae pekinensis
H0463 Shi Liu Pi石榴皮 Pomegranate peelPunica granatum
H1221 Hua Xiang Shu Guo Xu化香树果序 NAPlatycarya strobilacea
H0162 Long Dan龙胆 Rough gentianGentiana scabra
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H1082 Gan Lan橄榄 CabbageCanarium album
H0515 Suan Shi Liu酸石榴 PomegranatePunica granatum
H1171 He Zi Rou诃子肉 Medicine terminaliaTerminalia chebula
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H0635 Xian He Cao Jin Gao Fen仙鹤草浸膏粉 Japanese argimoniaAgrimonia pilosa var. japonica
H0067 Jin Ying Zi金樱子 Cherokee rose seedRosa laevigata
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H0256 Ming Dang Shen明党参 Medicinal changiumChangium smyrnioides
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1170 He Zi诃子 Medicine terminaliaTerminalia chebula
H0895 Chuan Yu Jin川郁金 TurmericCurcuma longa
H0656 Xiao Bo Gen小檗根 Barberry rootBerberis julianae
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata
H0237 Mei Gui Hua玫瑰花 Rugose rose flowerRosa rugosa
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H1093 Gao Liang Jiang You高良姜油 Lesser galangalAlpinia officinarum
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H1137 Gui Yuan桂圆 NADimocarpus longan
H0464 Shi Liu Zi石榴子 NAPunica granatum
H0343 Qing Hao Zi青蒿子 sweet wormwoodArtemisia carvifolia
H0759 Yu Gan Zi余甘子 Emblic leafflower fruitFructus phyllanthi
H0959 Dang Shen Lu Tou党参芦头 Rhizome of pilose asiabellRhizoma codonopsis pilosulae
H0990 Ding Xiang丁香 Clove treeSyzygium aromaticum
H0934 Da Ji大戟 Peking spurge rootRadix euphorbiae pekinensis
H1134 Bai Jiang Can白僵蚕 Silkworm larvaBombyx mori
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H0634 Xian He Cao仙鹤草 Japanese argimoniaAgrimonia pilosa var. japonica
H0252 Mian Da Ji绵大戟 NAEuphorbia pekinensis
H0128 Lao Guan Cao老鹳草 Wilford cranesbillGeranium wilfordii
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H0104 Bai Zhu白术 Largehead atractylodesAtractylodes macrocephala
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H0342 Qing Hao青蒿 sweet wormwoodArtemisia carvifolia
H0772 Yue Ji Hua月季花 Chinese roseRosa chinensis
H0068 Jin Ying Zi Rou金樱子肉 Cherokee rose seedRosa laevigata
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H0163 Long Dan Jin Gao龙胆浸膏 Rough gentianGentiana scabra
H0195 Ma Chi Xian马齿苋 PurslanePortulaca oleracea
H0397 Sang Zhi桑枝 White mulberry branchMorus alba
H0975 Di Mian Cao地绵草 NAEuphorbia humifusa
H0941 Da Zao大枣 Chinese dateZiziphus jujuba
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens
H0490 Can Jian蚕茧 Silk cocoonBombyx mori
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0495 Can Sha蚕砂 Silkworm excrementBombyx mori
H0084 Jiu Li Xiang九里香 Common jasminorangeMurraya paniculata
H0527 Tao PeachPrunus persica
H1056 Fu Pen Zi覆盆子 Red-and-Yellow garden raspberryRubus idaeus
H1092 Gao Liang Jiang高良姜 Lesser galangalAlpinia officinarum
H0476 Can E蚕蛾 SilkwormBombyx mori
H1220 Hua Xiang Shu Guo化香树果 NAPlatycarya strobilacea
H0547 Cang Qing Guo藏青果 MyrobalanTerminalia chebula
H0955 Dang Gui当归 Chinese angelicaAngelica sinensis