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Compound Description

ID:   C1114 Common name:   Baicalein
IUPAC:  5,6,7-trihydroxy-2-phenylchromen-4-one CAS:  CAS:491-67-8
Chembl ID:   CHEMBL8260 Pubchem ID:   CID:5281605
Formula:  C15H10O5 TCM-ID:  TCMC755
Smiles:  C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O
Alias:

Baicalein;

Flavone, 5,6,7-trihydroxy-;

5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one;

5,6,7-Trihydroxyflavone;

Baikalein;

NSC 661431;

Noroxylin
Structure:

Related Targets  (Total: 53)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T84W8G Aryl hydrocarbon receptorAHR P35869
 A 1 Reference(s)
T91N2D Egl nine homolog 1EGLN1 Q9GZT9
 A 1 Reference(s)
T09H2Z Nitric oxide synthase, inducibleNOS2 P35228
 A 1 Reference(s)
T86D6K Polyunsaturated fatty acid lipoxygenase ALOX15ALOX15 P16050
 A 9 Reference(s)
T48NTH Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformPIK3CD O00329
 A 1 Reference(s)
T31JWV Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformPIK3CB P42338
 A 1 Reference(s)
T32SPJ Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformPIK3CG P48736
 A 1 Reference(s)
T12PIB Lysosomal alpha-glucosidaseGAA P10253
 A 1 Reference(s)
T61SU2 Coxsackievirus and adenovirus receptorCXADR P78310
 A 1 Reference(s)
T13KGH TyrosinaseTYR P14679
 A 2 Reference(s)
T41INV Nuclear receptor subfamily 1 group I member 3NR1I3 Q14994
 A 1 Reference(s)
T79WXA Mitogen-activated protein kinase 1MAPK1 P28482
 A 2 Reference(s)
T71KM2 TGF-beta receptor type-1TGFBR1 P36897
 A 1 Reference(s)
T32JN2 Beta-glucuronidaseGUSB P08236
 A 1 Reference(s)
T15ZAV Lymphocyte antigen 96LY96 Q9Y6Y9
 A 1 Reference(s)
T50WOV ATP-dependent translocase ABCB1ABCB1 P08183
 A 1 Reference(s)
T02QZI NADPH oxidase 5NOX5 Q96PH1
 B 1 Reference(s)
T88TDZ RAC-alpha serine/threonine-protein kinaseAKT1 P31749
 B 1 Reference(s)
T44LWL Transcription factor p65RELA Q04206
 B 2 Reference(s)
T63GUB Proto-oncogene c-FosFOS P01100
 B 1 Reference(s)
T87WH7 Fos-related antigen 2FOSL2 P15408
 B 2 Reference(s)
T16UHV Nuclear factor of activated T-cells, cytoplasmic 1NFATC1 O95644
 B 2 Reference(s)
T54N7G Fos-related antigen 1FOSL1 P15407
 B 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
 B 2 Reference(s)
T80TUC Apoptosis regulator BAXBAX Q07812
 B 4 Reference(s)
T35QZO Cytochrome cCYCS P99999
 B 2 Reference(s)
T85U8U Caspase-3CASP3 P42574
 B 3 Reference(s)
T88AJI Hypoxia-inducible factor 1-alphaHIF1A Q16665
 B 1 Reference(s)
T07TMB Cyclin-dependent kinase 1CDK1 P06493
 B 1 Reference(s)
T24LXT G2/mitotic-specific cyclin-B1CCNB1 P14635
 B 1 Reference(s)
T30VNV MyeloperoxidaseMPO P05164
 B 1 Reference(s)
T01QLH Estrogen receptorESR1 P03372
 B 1 Reference(s)
T26KIE Transcription factor AP-1JUN P05412
 B 1 Reference(s)
T20JZ2 Androgen receptorAR P10275
 B 1 Reference(s)
T42EAZ Vascular endothelial growth factor AVEGFA P15692
 C 1 Reference(s)
T87C5Q Polyunsaturated fatty acid lipoxygenase ALOX12ALOX12 P18054
 C 1 Reference(s)
T45G32 Proto-oncogene tyrosine-protein kinase SrcSRC P12931
 C 1 Reference(s)
T08Q7W Prostaglandin G/H synthase 2PTGS2 P35354
 C 1 Reference(s)
T10KMJ Insulin-like growth factor IIIGF2 P01344
 C 1 Reference(s)
T54WR0 Fatty acid-binding protein 5FABP5 Q01469
 C 1 Reference(s)
T58TOI Apolipoprotein DAPOD P05090
 C 1 Reference(s)
T82JWE Cellular tumor antigen p53TP53 P04637
 C 1 Reference(s)
T49TDM Matrix metalloproteinase-9MMP9 P14780
 C 1 Reference(s)
T86ROZ Heme oxygenase 1HMOX1 P09601
 C 1 Reference(s)
T43N2D Epidermal growth factor receptorEGFR P00533
 C 1 Reference(s)
T85AXP Cytochrome P450 3A4CYP3A4 P08684
 C 1 Reference(s)
T63YAO Caveolin-1CAV1 Q03135
 C 1 Reference(s)
T68OIU CREB-regulated transcription coactivator 1CRTC1 Q6UUV9
 C 1 Reference(s)
T03CZ8 Catechol O-methyltransferaseCOMT P21964
 C 1 Reference(s)
T22OPB Nuclear factor erythroid 2-related factor 2NFE2L2 Q16236
 C 2 Reference(s)
T74QXI Serine/threonine-protein kinase mTORMTOR P42345
 C 1 Reference(s)
T06Q1R Amine oxidase [flavin-containing] BMAOB P27338
 C 1 Reference(s)
T80GUN 72 kDa type IV collagenaseMMP2 P08253
 C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 24)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H1227 Huai Zhi槐枝 NASophora japonica
H0472 Shu Da Huang熟大黄 NARheum palmatum
H0527 Tao桃 PeachPrunus persica
H0926 Da Huang大黄 Medicinal rhubarbRheum officinale
H0784 Chi Shao赤芍 Red peony rootPaeonia obovata
H0927 Da Huang Jin Gao大黄浸膏 Medicinal rhubarbRheum officinale
H1251 Huang Qin黄芩 Root of Baikal skullcaapScutellaria baicalensis
H0270 Mu Hu Die木蝴蝶 Indian trumpetflowerOroxylum indicum
H0531 Tao Zhi桃枝 Peach juvenile branchPrunus persica
H0928 Da Huang Liu Jin Gao大黄流浸膏 Medicinal rhubarbRheum officinale
H0310 Pian Qin片芩 Scutellaria amoenaScutellaria baicalensis
H1253 Huang Qin Jin Gao Fen黄芩浸膏粉 Extract of root of Baikal skullcaapScutellaria baicalensis
H0429 Shao Yao芍药 Red peony rootPaeonia obovata
H0529 Tao Ren桃仁 Peach kernelPrunus persica
H1224 Huai Jiao槐角 pod of japanese pagodatreeSophora japonica
H1222 Huai Hua槐花 flower bud of japanese pagodatreeSophora japonica
H1252 Huang Qin Jin Gao黄芩浸膏 Extract of root of Baikal skullcaapScutellaria baicalensis
H1225 Huai Mi槐米 NASophora japonica
H1254 Huang Qin Tan黄芩炭 Extract of root of Baikal skullcaapScutellaria baicalensis
H1015 Du Zhong杜仲 EucommiaEucommia ulmoides
H1017 Du Zhong Ye杜仲叶 Eucommia leafEucommia ulmoides
H1016 Du Zhong Tan杜仲炭 EucommiaEucommia ulmoides
H0530 Tao Ren Shuang桃仁霜 Peach kernelPrunus persica
H0164 Ban Zhi Lian半枝莲 Barbed skullcapScutellaria barbata

Ckey description of the interaction between compound and target


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