HIT-result

Target Description

Type	Detail
Target ID	T91N2D
Protein Name	Egl nine homolog 1
Uniprot ID	Q9GZT9
Protein Name Alias	EC 1.14.11.29; Hypoxia-inducible factor prolyl hydroxylase 2; HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2; Prolyl hydroxylase domain-containing protein 2; PHD2; SM-20
Gene ID	54583
Gene Symbol	EGLN1
Gene Alias	C1orf12
TTD	T32880: Patented target
Pfam	PF13640 ; PF01753
GO	0016706:2-oxoglutarate-dependent dioxygenase activity 0031418:L-ascorbic acid binding 0031543:peptidyl-proline dioxygenase activity 0019899:enzyme binding 0051344:negative regulation of cyclic-nucleotide phosphodiesterase activity 0018401:peptidyl-proline hydroxylation to 4-hydroxy-L-proline 0005829:cytosol 0045765:regulation of angiogenesis 0032364:oxygen homeostasis 0061418:regulation of transcription from RNA polymerase II promoter in response to hypoxia 0071456:cellular response to hypoxia 0008198:ferrous iron binding 0031545:peptidyl-proline 4-dioxygenase activity 0005737:cytoplasm 0001666:response to hypoxia 0071731:response to nitric oxide 0043433:negative regulation of DNA-binding transcription factor activity 0005634:nucleus
PDB	6YW0 ; 2HBU ; 5LA9 ; 5LBC ; 5LBE ; 6YVW ; 6ST3 ; 5LAT ; 6YW3 ; 5V18 ; 6QGV ; 5L9B ; 6YW4 ; 5LAS ; 4BQY ; 5OX5 ; 3OUI ; 3HQR ; 5L9V ; 6YVZ ; 5OX6 ; 6NMQ ; 4KBZ ; 2G1M ; 4BQX ; 2Y34 ; 5LBB ; 4JZR ; 4BQW ; 6YW2 ; 5L9R ; 5A3U ; 6YVX ; 3OUJ ; 3OUH ; 2Y33 ; 6YW1 ; 2HBT ; 2G19 ; 4UWD ; 5LBF ; 6YVT ; 3HQU ; 5LB6
Drugbank	DB00126 ; DB04847 ; DB01592 ; DB14489 ; DB14491 ; DB14488 ; DB08687 ; DB07112 ; DB14501 ; DB14490
KEGG	hsa:54583

Type

Detail

Target ID

T91N2D

Protein Name

Egl nine homolog 1

Uniprot ID

Q9GZT9

Protein Name Alias

EC 1.14.11.29; Hypoxia-inducible factor prolyl hydroxylase 2; HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2; Prolyl hydroxylase domain-containing protein 2; PHD2; SM-20

Gene ID

54583

Gene Symbol

EGLN1

Gene Alias

C1orf12

TTD

T32880: Patented target

Pfam

PF13640 ; PF01753

0016706:2-oxoglutarate-dependent dioxygenase activity

0031418:L-ascorbic acid binding

0031543:peptidyl-proline dioxygenase activity

0019899:enzyme binding

0051344:negative regulation of cyclic-nucleotide phosphodiesterase activity

0018401:peptidyl-proline hydroxylation to 4-hydroxy-L-proline

0005829:cytosol

0045765:regulation of angiogenesis

0032364:oxygen homeostasis

0061418:regulation of transcription from RNA polymerase II promoter in response to hypoxia

0071456:cellular response to hypoxia

0008198:ferrous iron binding

0031545:peptidyl-proline 4-dioxygenase activity

0005737:cytoplasm

0001666:response to hypoxia

0071731:response to nitric oxide

0043433:negative regulation of DNA-binding transcription factor activity

0005634:nucleus

PDB

6YW0 ; 2HBU ; 5LA9 ; 5LBC ; 5LBE ; 6YVW ; 6ST3 ; 5LAT ; 6YW3 ; 5V18 ; 6QGV ; 5L9B ; 6YW4 ; 5LAS ; 4BQY ; 5OX5 ; 3OUI ; 3HQR ; 5L9V ; 6YVZ ; 5OX6 ; 6NMQ ; 4KBZ ; 2G1M ; 4BQX ; 2Y34 ; 5LBB ; 4JZR ; 4BQW ; 6YW2 ; 5L9R ; 5A3U ; 6YVX ; 3OUJ ; 3OUH ; 2Y33 ; 6YW1 ; 2HBT ; 2G19 ; 4UWD ; 5LBF ; 6YVT ; 3HQU ; 5LB6

Drugbank

DB00126 ; DB04847 ; DB01592 ; DB14489 ; DB14491 ; DB14488 ; DB08687 ; DB07112 ; DB14501 ; DB14490

KEGG

hsa:54583

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0530	Tao Ren Shuang	桃仁霜	Peach kernel	Prunus persica
H1225	Huai Mi	槐米	NA	Sophora japonica
H1016	Du Zhong Tan	杜仲炭	Eucommia	Eucommia ulmoides
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H1015	Du Zhong	杜仲	Eucommia	Eucommia ulmoides
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H1254	Huang Qin Tan	黄芩炭	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H1017	Du Zhong Ye	杜仲叶	Eucommia leaf	Eucommia ulmoides
H0529	Tao Ren	桃仁	Peach kernel	Prunus persica
H0429	Shao Yao	芍药	Red peony root	Paeonia obovata
H0784	Chi Shao	赤芍	Red peony root	Paeonia obovata
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H0531	Tao Zhi	桃枝	Peach juvenile branch	Prunus persica
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H1251	Huang Qin	黄芩	Root of Baikal skullcaap	Scutellaria baicalensis
H1253	Huang Qin Jin Gao Fen	黄芩浸膏粉	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0310	Pian Qin	片芩	Scutellaria amoena	Scutellaria baicalensis
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H0527	Tao	桃	Peach	Prunus persica
H0164	Ban Zhi Lian	半枝莲	Barbed skullcap	Scutellaria barbata
H1252	Huang Qin Jin Gao	黄芩浸膏	Extract of root of Baikal skullcaap	Scutellaria baicalensis

Target Description

Related Compounds (Total: 1)

Related Herbs (Total: 24)