HIT-result

Type	Detail
Target ID	T48NTH
Protein Name	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Uniprot ID	O00329
Protein Name Alias	PI3-kinase subunit delta; PI3K-delta; PI3Kdelta; PtdIns-3-kinase subunit delta; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; PtdIns-3-kinase subunit p110-delta; p110delta
Gene ID	5293
Gene Symbol	PIK3CD
Gene Alias	NA
TTD	T67849: Successful target
Pfam	PF00613 ; PF00794 ; PF00454 ; PF00792 ; PF02192
GO	0035005:1-phosphatidylinositol-4-phosphate 3-kinase activity 0033031:positive regulation of neutrophil apoptotic process 0014068:positive regulation of phosphatidylinositol 3-kinase signaling 0035747:natural killer cell chemotaxis 0036092:phosphatidylinositol-3-phosphate biosynthetic process 0002551:mast cell chemotaxis 0030335:positive regulation of cell migration 1905278:positive regulation of epithelial tube formation 0005829:cytosol 0002250:adaptive immune response 0060374:mast cell differentiation 0048015:phosphatidylinositol-mediated signaling 0050853:B cell receptor signaling pathway 0001938:positive regulation of endothelial cell proliferation 0042110:T cell activation 0010595:positive regulation of endothelial cell migration 0035004:phosphatidylinositol 3-kinase activity 0052812:phosphatidylinositol-3,4-bisphosphate 5-kinase activity 0010818:T cell chemotaxis 0035754:B cell chemotaxis 0051897:positive regulation of protein kinase B signaling 0016301:kinase activity 0006661:phosphatidylinositol biosynthetic process 0072672:neutrophil extravasation 0050852:T cell receptor signaling pathway 0030217:T cell differentiation 0046934:phosphatidylinositol-4,5-bisphosphate 3-kinase activity 0043303:mast cell degranulation 0046854:phosphatidylinositol phosphorylation 0010628:positive regulation of gene expression 0005524:ATP binding 0005886:plasma membrane 0005942:phosphatidylinositol 3-kinase complex 0038089:positive regulation of cell migration by vascular endothelial growth factor signaling pathway 0016303:1-phosphatidylinositol-3-kinase activity 0016020:membrane 0006954:inflammatory response 0001819:positive regulation of cytokine production 0014065:phosphatidylinositol 3-kinase signaling 0006468:protein phosphorylation 0045766:positive regulation of angiogenesis 0005737:cytoplasm 0002679:respiratory burst involved in defense response 0016310:phosphorylation 0007165:signal transduction 0016477:cell migration 0052742:phosphatidylinositol kinase activity 0019221:cytokine-mediated signaling pathway 0030593:neutrophil chemotaxis 0007411:axon guidance 0030101:natural killer cell activation 0001779:natural killer cell differentiation 0042113:B cell activation 0045087:innate immune response
PDB	6G6W ; 6PYR ; 7JIS ; 5T8F ; 5VLR ; 6OCO ; 5M6U ; 6PYU ; 5UBT ; 6OCU ; 5DXU
Drugbank	DB12010 ; DB05552 ; DB09054 ; DB12483 ; DB11952 ; DB05241 ; DB00201 ; DB06831
KEGG	hsa:5293

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Name: Theophylline

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Name: Baicalein

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Name: Baicalein

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H1227	Huai Zhi	槐枝	NA	Sophora japonica
H0472	Shu Da Huang	熟大黄	NA	Rheum palmatum
H0527	Tao	桃	Peach	Prunus persica
H0926	Da Huang	大黄	Medicinal rhubarb	Rheum officinale
H0784	Chi Shao	赤芍	Red peony root	Paeonia obovata
H0927	Da Huang Jin Gao	大黄浸膏	Medicinal rhubarb	Rheum officinale
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H1251	Huang Qin	黄芩	Root of Baikal skullcaap	Scutellaria baicalensis
H0155	Ban Xia	半夏	Ternate pinellia	Pinellia ternata
H0270	Mu Hu Die	木蝴蝶	Indian trumpetflower	Oroxylum indicum
H0531	Tao Zhi	桃枝	Peach juvenile branch	Prunus persica
H0928	Da Huang Liu Jin Gao	大黄流浸膏	Medicinal rhubarb	Rheum officinale
H0310	Pian Qin	片芩	Scutellaria amoena	Scutellaria baicalensis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H1253	Huang Qin Jin Gao Fen	黄芩浸膏粉	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0429	Shao Yao	芍药	Red peony root	Paeonia obovata
H0529	Tao Ren	桃仁	Peach kernel	Prunus persica
H1224	Huai Jiao	槐角	pod of japanese pagodatree	Sophora japonica
H1222	Huai Hua	槐花	flower bud of japanese pagodatree	Sophora japonica
H1252	Huang Qin Jin Gao	黄芩浸膏	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H1004	Bai Cha	白茶	White tea	Camellia sinensis
H1225	Huai Mi	槐米	NA	Sophora japonica
H1254	Huang Qin Tan	黄芩炭	Extract of root of Baikal skullcaap	Scutellaria baicalensis
H0637	Cha Ye	茶叶	Common tea	Camellia sinensis
H1017	Du Zhong Ye	杜仲叶	Eucommia leaf	Eucommia ulmoides
H1015	Du Zhong	杜仲	Eucommia	Eucommia ulmoides
H1016	Du Zhong Tan	杜仲炭	Eucommia	Eucommia ulmoides
H0530	Tao Ren Shuang	桃仁霜	Peach kernel	Prunus persica
H0164	Ban Zhi Lian	半枝莲	Barbed skullcap	Scutellaria barbata

Target Description

Related Compounds (Total: 3)

Related Herbs (Total: 29)