Compound Description

ID:   C0443 Common name:   Theophylline
IUPAC:  1,3-dimethyl-7H-purine-2,6-dione CAS:  CAS:58-55-9
Chembl ID:   CHEMBL190 Pubchem ID:   CID:2153
Formula:  C7H8N4O2 TCM-ID:  TCMC2157
Smiles:  CN1C2=C(C(=O)N(C1=O)C)NC=N2
Alias:

1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-;

Theophylline;

3,9-Dihydro-1,3-dimethyl-1H-purine-2,6-dione;

1,3-Dimethyl-1H-purine-2,6(3H,7H)-dione;

1,3-Dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione;

1,3-Dimethyl-2,3,6,9-tetrahydro-1H-purine-2,6-dione;

1,3-Dimethyl-3,7-dihydro-purine-2,6-dione;

1,3-Dimethylxanthine;

Accurbron;

Aerobin;

Aerolate;

Afonilm;

Apnecut;

Armophylline;

Asmax;

Austyn;

Bilordyl;

Brochoretard;

Bronkodyl;

Cetraphylline;

Chronophyllin;

Constant T;

Controfilina 200;

Diffumal;

Duraphyl;

Duraphyllin;

Egifilin;

Elan;

Elixophyllin;

Elixophylline;

Etheophyl;

Euphylong;

GM 501 SpermMobil;

Insanovin;

LaBID;

Lanophyllin;

Lasma;

Liquophylline;

NSC 2066;

Nuelin;

Optiphyllin;

Parkophyllin;

Physpan;

Pro-Vent;

Pseudotheophylline;

PulmiDur;

Pulmo-Timelets;

Quibron T;

Quibron T/SR;

Respbid;

Respicur;

Slo-Bid;

Slo-Phyllin;

Solosin;

Somophyllin CRT;

Somophyllin T;

Spophyllin retard;

Sustaire;

Talotren;

Telb-DS;

Telbans;

Telbans Dry Syrup;

Teocen 200;

Teonova;

Teotard;

Teotard 350;

Tesona;

Theo 24;

Theo-DS;

Theo-Dur;

Theo-Nite;

Theo-Sav;

Theobid;

Theobid Duracap;

Theochron;

Theoclear;

Theodel;

Theodrip;

Theodur Dry Syrup;

Theofol;

Theograd;

Theolair;

Theon;

Theona P;

Theopek;

Theophyl;

Theophyllin;

Theoplus;

Theostat;

Theotard;

Theovent;

Throphylline;

Unicontin CR;

Unifyl;

Unilong;

Uniphyl;

Uniphyllin;

Xanthium;

phylobid
Structure:

Related Targets  (Total: 21)

Target idProtein NameGene SymbolUniprot IDTarget LevelNo.of Literature Evidence
T98QOA DNA-dependent protein kinase catalytic subunitPRKDC P78527
A 1 Reference(s)
T73LPO Poly [ADP-ribose] polymerase 1PARP1 P09874
A 1 Reference(s)
T23TJV Tyrosine 3-monooxygenaseTH P07101
A 1 Reference(s)
T56IUI Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPIK3CA P42336
A 1 Reference(s)
T48NTH Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformPIK3CD O00329
A 1 Reference(s)
T33SUB Alkaline phosphatase, tissue-nonspecific isozymeAlpl P09242
A 1 Reference(s)
T68DAN Histone deacetylase 9HDAC9 Q9UKV0
A 1 Reference(s)
T43D9G Alpha-aminoadipic semialdehyde dehydrogenaseALDH7A1 P49419
A 1 Reference(s)
T21Q0D 3-hydroxy-3-methylglutaryl-coenzyme A reductaseHMGCR P04035
A 1 Reference(s)
T65CQU Beta-2-microglobulinB2M P61769
B 1 Reference(s)
T06MXL NeprilysinMME P08473
B 1 Reference(s)
T71K92 Apoptosis regulator Bcl-2BCL2 P10415
B 1 Reference(s)
T65CWO Eosinophil cationic proteinRNASE3 P12724
B 1 Reference(s)
T18WSE L-selectinSELL P14151
B 1 Reference(s)
T02QBS Cytochrome P450 1A2CYP1A2 P05177
B 1 Reference(s)
T33OPP Interleukin-6IL6 P05231
C 1 Reference(s)
T82P0Z ReninREN P00797
C 1 Reference(s)
T10HL8 Intercellular adhesion molecule 1ICAM1 P05362
C 1 Reference(s)
T25VH1 Integrin beta-2ITGB2 P05107
C 1 Reference(s)
T95BM0 NATINCR NA
C 1 Reference(s)
T30VNV MyeloperoxidaseMPO P05164
C 1 Reference(s)

*In this table, target level represents the quality confidence indicators of targets.
Level 'A' represents "Directly inhibit/activate".
Level 'B' represents "Indirectly inhibit/ activate", "Enzyme substate" and "Enzyme product".
Level 'C' represents "Up/Down regulation" and "Others".

Related Herbs  (Total: 4)

Herb idChinese Pin YinChinese CharacterEnglish NameLatin Name
H0847 Zi He Che紫河车 Human placentaHomo sapiens
H1004 Bai Cha白茶 White teaCamellia sinensis
H0637 Cha Ye茶叶 Common teaCamellia sinensis
H0360 Ren Zhong Bai人中白 Human urine sedimentHomo sapiens