HIT-result

Type	Detail
Target ID	T56IUI
Protein Name	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Uniprot ID	P42336
Protein Name Alias	PI3-kinase subunit alpha; PI3K-alpha; PI3Kalpha; PtdIns-3-kinase subunit alpha; EC 2.7.1.137; EC 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA; EC 2.7.11.1
Gene ID	5290
Gene Symbol	PIK3CA
Gene Alias	NA
TTD	T80276: Successful target
Pfam	PF00792 ; PF00454 ; PF02192 ; PF00794 ; PF00613
GO	0030835:negative regulation of actin filament depolymerization 0030168:platelet activation 0035004:phosphatidylinositol 3-kinase activity 0001944:vasculature development 0060612:adipose tissue development 0014704:intercalated disc 0000165:MAPK cascade 0055119:relaxation of cardiac muscle 0005524:ATP binding 0038096:Fc-gamma receptor signaling pathway involved in phagocytosis 0043491:protein kinase B signaling 0016310:phosphorylation 0016020:membrane 0060048:cardiac muscle contraction 0016477:cell migration 0005944:phosphatidylinositol 3-kinase complex, class IB 0050900:leukocyte migration 0036092:phosphatidylinositol-3-phosphate biosynthetic process 0038028:insulin receptor signaling pathway via phosphatidylinositol 3-kinase 0033138:positive regulation of peptidyl-serine phosphorylation 0007186:G protein-coupled receptor signaling pathway 0106311:protein threonine kinase activity 0035994:response to muscle stretch 0007173:epidermal growth factor receptor signaling pathway 0031295:T cell costimulation 0010468:regulation of gene expression 0038128:ERBB2 signaling pathway 0001525:angiogenesis 0030036:actin cytoskeleton organization 0010592:positive regulation of lamellipodium assembly 0038095:Fc-epsilon receptor signaling pathway 0046934:phosphatidylinositol-4,5-bisphosphate 3-kinase activity 0005829:cytosol 0040014:regulation of multicellular organism growth 0052742:phosphatidylinositol kinase activity 0097009:energy homeostasis 0006006:glucose metabolic process 0110053:regulation of actin filament organization 0071333:cellular response to glucose stimulus 0005942:phosphatidylinositol 3-kinase complex 0043457:regulation of cellular respiration 0048010:vascular endothelial growth factor receptor signaling pathway 0043276:anoikis 0005886:plasma membrane 0005737:cytoplasm 0038084:vascular endothelial growth factor signaling pathway 0046854:phosphatidylinositol phosphorylation 2000270:negative regulation of fibroblast apoptotic process 0043560:insulin receptor substrate binding 0086003:cardiac muscle cell contraction 0043542:endothelial cell migration 0048471:perinuclear region of cytoplasm 0030295:protein kinase activator activity 0014065:phosphatidylinositol 3-kinase signaling 0052812:phosphatidylinositol-3,4-bisphosphate 5-kinase activity 0032008:positive regulation of TOR signaling 0005943:phosphatidylinositol 3-kinase complex, class IA 0048015:phosphatidylinositol-mediated signaling 0001889:liver development 2000653:regulation of genetic imprinting 0035005:1-phosphatidylinositol-4-phosphate 3-kinase activity 0019221:cytokine-mediated signaling pathway 0044029:hypomethylation of CpG island 0043524:negative regulation of neuron apoptotic process 0007411:axon guidance 0016242:negative regulation of macroautophagy 0014068:positive regulation of phosphatidylinositol 3-kinase signaling 0106310:protein serine kinase activity 0050852:T cell receptor signaling pathway 0016303:1-phosphatidylinositol-3-kinase activity 0071464:cellular response to hydrostatic pressure 0051897:positive regulation of protein kinase B signaling 0016301:kinase activity 0006661:phosphatidylinositol biosynthetic process 2000811:negative regulation of anoikis 0030027:lamellipodium
PDB	7K71 ; 4WAF ; 6GVH ; 4L2Y ; 4OVU ; 4ZOP ; 5UBR ; 6GVF ; 7K6M ; 5DXH ; 5ITD ; 4OVV ; 5SXC ; 5XGI ; 3HIZ ; 5SX9 ; 5SXA ; 5SXK ; 6GVG ; 4L23 ; 6OAC ; 5XGJ ; 5SXI ; 6GVI ; 6NCT ; 4TUU ; 7K6N ; 5UKJ ; 5SXB ; 5DXT ; 3ZIM ; 5SW8 ; 5SXD ; 7K6O ; 5SWT ; 4YKN ; 5FI4 ; 5SXE ; 5SWG ; 4JPS ; 5SX8 ; 5XGH ; 5UK8 ; 5SXF ; 5SWR ; 2ENQ ; 5SXJ ; 5SWO ; 5UL1 ; 6PYS ; 4TV3 ; 5SWP ; 2RD0 ; 4L1B ; 3HHM
Drugbank	DB12483 ; DB12015 ; DB00171 ; DB11772 ; DB00201 ; DB05241 ; DB08059
KEGG	hsa:5290

Go to browser

Name: Theophylline

Go to browser

Name: (1E,6E)-1,7-Bis(4-Hydroxy-3-Methoxyphenyl)Hepta-1,6-Diene-3,5-Dione

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0637	Cha Ye	茶叶	Common tea	Camellia sinensis
H0446	Sheng Jiang	生姜	Fresh common ginger	Zingiber officinale
H0895	Chuan Yu Jin	川郁金	Turmeric	Curcuma longa
H0761	Yu Jin	郁金	AromaticTurmeric	Curcuma aromatica
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0556	Tie Xian Cao	铁线草	NA	Adiantum capillus-veneris
H1004	Bai Cha	白茶	White tea	Camellia sinensis
H0028	Jiang Huang	姜黄	Common turmeric	Curcuma longa