HIT-result

Type	Detail
Target ID	T25VH1
Protein Name	Integrin beta-2
Uniprot ID	P05107
Protein Name Alias	Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD antigen CD18
Gene ID	3689
Gene Symbol	ITGB2
Gene Alias	CD18; MFI7
TTD	T10513: Clinical Trial target
Pfam	PF08725 ; PF07965 ; PF17205 ; PF00362
GO	0101003:ficolin-1-rich granule membrane 0071404:cellular response to low-density lipoprotein particle stimulus 0034687:integrin alphaL-beta2 complex 0045766:positive regulation of angiogenesis 0046872:metal ion binding 0019221:cytokine-mediated signaling pathway 0098742:cell-cell adhesion via plasma-membrane adhesion molecules 0009986:cell surface 0006911:phagocytosis, engulfment 0007159:leukocyte cell-cell adhesion 0043315:positive regulation of neutrophil degranulation 0032930:positive regulation of superoxide anion generation 0008360:regulation of cell shape 0030593:neutrophil chemotaxis 0016020:membrane 0035579:specific granule membrane 0097242:amyloid-beta clearance 0033627:cell adhesion mediated by integrin 0006954:inflammatory response 1904996:positive regulation of leukocyte adhesion to vascular endothelial cell 0045963:negative regulation of dopamine metabolic process 0009897:external side of plasma membrane 0043113:receptor clustering 1903561:extracellular vesicle 0030369:ICAM-3 receptor activity 0050900:leukocyte migration 0045429:positive regulation of nitric oxide biosynthetic process 0001851:complement component C3b binding 0007229:integrin-mediated signaling pathway 0070062:extracellular exosome 0031623:receptor internalization 0070821:tertiary granule membrane 0031072:heat shock protein binding 0034689:integrin alphaX-beta2 complex 0098609:cell-cell adhesion 0007160:cell-matrix adhesion 0035987:endodermal cell differentiation 0002523:leukocyte migration involved in inflammatory response 0001774:microglial cell activation 0006915:apoptotic process 2000363:positive regulation of prostaglandin-E synthase activity 0050776:regulation of immune response 0044853:plasma membrane raft 0050839:cell adhesion molecule binding 0005925:focal adhesion 0030198:extracellular matrix organization 0034113:heterotypic cell-cell adhesion 0043312:neutrophil degranulation 0016477:cell migration 0030101:natural killer cell activation 1990266:neutrophil migration 0043235:receptor complex 0006898:receptor-mediated endocytosis 0043542:endothelial cell migration 0001540:amyloid-beta binding 0005178:integrin binding 0005886:plasma membrane 0007155:cell adhesion 0051092:positive regulation of NF-kappaB transcription factor activity 0090314:positive regulation of protein targeting to membrane 0008305:integrin complex 0019901:protein kinase binding 0050730:regulation of peptidyl-tyrosine phosphorylation 0034142:toll-like receptor 4 signaling pathway 0007568:aging 0045123:cellular extravasation 1901216:positive regulation of neuron death 0034688:integrin alphaM-beta2 complex 0007267:cell-cell signaling
PDB	1L3Y ; 5E6W ; 5ES4 ; 5E6S ; 5E6R ; 4NEH ; 5E6V ; 2P28 ; 5ZAZ ; 2JF1 ; 5E6X ; 4NEN ; 1JX3 ; 3K71 ; 3K6S ; 1YUK ; 3K72 ; 2P26 ; 2V7D ; 5E6U ; 5XR1
Drugbank	NA
KEGG	hsa:3689

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Name: Theophylline

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Name: Atorvastatin

Herb id	Chinese Pin Yin	Chinese Character	English Name	Latin Name
H0637	Cha Ye	茶叶	Common tea	Camellia sinensis
H1004	Bai Cha	白茶	White tea	Camellia sinensis
H0847	Zi He Che	紫河车	Human placenta	Homo sapiens
H0360	Ren Zhong Bai	人中白	Human urine sediment	Homo sapiens